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Microcalcifications of the breast

MedGen UID:
105455
•Concept ID:
C0520594
•
Pathologic Function
Synonym: Microcalcification
SNOMED CT: Microcalcifications of the breast (44771000)

Definition

Tiny deposits of calcium in tissue. In the breast they can be seen using mammography, and if found in clusters may be indicative of breast cancer. [from NCI]

Professional guidelines

PubMed

Interdisciplinary consensus recommendations for the use of vacuum-assisted breast biopsy under sonographic guidance: first update 2012.
Hahn M, Krainick-Strobel U, Toellner T, Gissler J, Kluge S, Krapfl E, Peisker U, Duda V, Degenhardt F, Sinn HP, Wallwiener D, Gruber IV; Minimally Invasive Breast Intervention Study Group (AG MiMi) of the German Society of Senology (DGS); Study Group for Breast Ultrasonography of the German Society for Ultrasound in Medicine (DEGUM)
Ultraschall Med 2012 Aug;33(4):366-71. Epub 2012 Jun 21 doi: 10.1055/s-0032-1312831. PMID: 22723042
Guidelines from the European Society of Breast Imaging for diagnostic interventional breast procedures.
Wallis M, Tardivon A, Helbich T, Schreer I; European Society of Breast Imaging
Eur Radiol 2007 Feb;17(2):581-8. doi: 10.1007/s00330-006-0408-x. PMID: 17013595
Optimal management of ductal carcinoma in situ of the breast.
Sakorafas GH, Farley DR
Surg Oncol 2003 Dec;12(4):221-40. doi: 10.1016/S0960-7404(03)00031-8. PMID: 14998563

Recent clinical studies

Etiology

Value of Shear Wave Elastography for the Differentiation of Benign and Malignant Microcalcifications of the Breast.
Chamming's F, Mesurolle B, Antonescu R, Aldis A, Kao E, Thériault M, Omeroglu A, Pinel-Giroux F, Seidler M, Solorzano S, Reinhold C, Gallix B
AJR Am J Roentgenol 2019 Aug;213(2):W85-W92. Epub 2019 Apr 30 doi: 10.2214/AJR.18.20899. PMID: 31039014
Microcalcifications of the breast: size matters! A mammographic-histologic correlation study.
Liu X, Inciardi M, Bradley JP, Fan F, Thomas P, Smith W, Tawfik O
Pathologica 2007 Feb;99(1):5-10. PMID: 17566305
Microcalcifications of the breast: how does radiologic classification correlate with histology?
Müller-Schimpfle M, Wersebe A, Xydeas T, Fischmann A, Vogel U, Fersis N, Claussen CD, Siegmann K
Acta Radiol 2005 Dec;46(8):774-81. doi: 10.1080/02841850500270274. PMID: 16392601
Sonographically guided biopsy of suspicious microcalcifications of the breast: a pilot study.
Soo MS, Baker JA, Rosen EL, Vo TT
AJR Am J Roentgenol 2002 Apr;178(4):1007-15. doi: 10.2214/ajr.178.4.1781007. PMID: 11906892
Selection of patients with early-stage breast cancer for conservative surgery and radiation.
Recht A, Harris JR
Oncology (Williston Park) 1990 Feb;4(2):23-30; discussion 31-2. PMID: 2143667

Diagnosis

Parasitic Microcalcifications of the Breast.
Bhele S, Stoddart L, Petersen C, Baum J, Otis CN
Int J Surg Pathol 2020 Sep;28(6):645-646. Epub 2019 Dec 18 doi: 10.1177/1066896919894687. PMID: 31852339
Value of Shear Wave Elastography for the Differentiation of Benign and Malignant Microcalcifications of the Breast.
Chamming's F, Mesurolle B, Antonescu R, Aldis A, Kao E, Thériault M, Omeroglu A, Pinel-Giroux F, Seidler M, Solorzano S, Reinhold C, Gallix B
AJR Am J Roentgenol 2019 Aug;213(2):W85-W92. Epub 2019 Apr 30 doi: 10.2214/AJR.18.20899. PMID: 31039014
Microcalcifications of the breast: a mammographic-histologic correlation study using a newly designed Path/Rad Tissue Tray.
Gallagher R, Schafer G, Redick M, Inciradi M, Smith W, Fan F, Tawfik O
Ann Diagn Pathol 2012 Jun;16(3):196-201. Epub 2012 Jan 4 doi: 10.1016/j.anndiagpath.2011.10.007. PMID: 22225905
Microcalcifications of the breast: how does radiologic classification correlate with histology?
Müller-Schimpfle M, Wersebe A, Xydeas T, Fischmann A, Vogel U, Fersis N, Claussen CD, Siegmann K
Acta Radiol 2005 Dec;46(8):774-81. doi: 10.1080/02841850500270274. PMID: 16392601
Sonographically guided biopsy of suspicious microcalcifications of the breast: a pilot study.
Soo MS, Baker JA, Rosen EL, Vo TT
AJR Am J Roentgenol 2002 Apr;178(4):1007-15. doi: 10.2214/ajr.178.4.1781007. PMID: 11906892

Prognosis

Value of Shear Wave Elastography for the Differentiation of Benign and Malignant Microcalcifications of the Breast.
Chamming's F, Mesurolle B, Antonescu R, Aldis A, Kao E, Thériault M, Omeroglu A, Pinel-Giroux F, Seidler M, Solorzano S, Reinhold C, Gallix B
AJR Am J Roentgenol 2019 Aug;213(2):W85-W92. Epub 2019 Apr 30 doi: 10.2214/AJR.18.20899. PMID: 31039014
Role of magnetic resonance imaging in probably benign (BI-RADS category 3) microcalcifications of the breast.
Linda A, Zuiani C, Londero V, Di Gaetano E, Dal Col A, Girometti R, Bazzocchi M
Radiol Med 2014 Jun;119(6):393-9. Epub 2013 Dec 3 doi: 10.1007/s11547-013-0361-0. PMID: 24297595
Microcalcifications of the breast: how does radiologic classification correlate with histology?
Müller-Schimpfle M, Wersebe A, Xydeas T, Fischmann A, Vogel U, Fersis N, Claussen CD, Siegmann K
Acta Radiol 2005 Dec;46(8):774-81. doi: 10.1080/02841850500270274. PMID: 16392601
Selection of patients with early-stage breast cancer for conservative surgery and radiation.
Recht A, Harris JR
Oncology (Williston Park) 1990 Feb;4(2):23-30; discussion 31-2. PMID: 2143667

Clinical prediction guides

Value of Shear Wave Elastography for the Differentiation of Benign and Malignant Microcalcifications of the Breast.
Chamming's F, Mesurolle B, Antonescu R, Aldis A, Kao E, Thériault M, Omeroglu A, Pinel-Giroux F, Seidler M, Solorzano S, Reinhold C, Gallix B
AJR Am J Roentgenol 2019 Aug;213(2):W85-W92. Epub 2019 Apr 30 doi: 10.2214/AJR.18.20899. PMID: 31039014
Role of magnetic resonance imaging in probably benign (BI-RADS category 3) microcalcifications of the breast.
Linda A, Zuiani C, Londero V, Di Gaetano E, Dal Col A, Girometti R, Bazzocchi M
Radiol Med 2014 Jun;119(6):393-9. Epub 2013 Dec 3 doi: 10.1007/s11547-013-0361-0. PMID: 24297595
Microcalcifications of the breast: how does radiologic classification correlate with histology?
Müller-Schimpfle M, Wersebe A, Xydeas T, Fischmann A, Vogel U, Fersis N, Claussen CD, Siegmann K
Acta Radiol 2005 Dec;46(8):774-81. doi: 10.1080/02841850500270274. PMID: 16392601

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