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Decreased circulating beta-carotene concentration

MedGen UID:
1054726
•Concept ID:
CN376483
•
Finding
HPO: HP:0430073

Definition

The concentration of beta-carotene in the blood circulation is below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating beta-carotene concentration

Professional guidelines

PubMed

Changes in micronutrient concentrations following anti-inflammatory treatment in patients with gastrointestinal cancer.
McMillan DC, Sattar N, Talwar D, O'Reilly DS, McArdle CS
Nutrition 2000 Jun;16(6):425-8. doi: 10.1016/s0899-9007(00)00270-7. PMID: 10869897

Recent clinical studies

Etiology

Diet-Derived Antioxidants Do Not Decrease Risk of Ischemic Stroke: A Mendelian Randomization Study in 1 Million People.
Martens LG, Luo J, Willems van Dijk K, Jukema JW, Noordam R, van Heemst D
J Am Heart Assoc 2021 Dec 7;10(23):e022567. Epub 2021 Nov 19 doi: 10.1161/JAHA.121.022567. PMID: 34796734Free PMC Article
Relationship between Serum Antioxidative Vitamin Concentrations and Type 2 Diabetes in Japanese Subjects.
Yamada C, Kishimoto N, Urata N, Kimura M, Toyoda M, Masuda Y, Takashimizu S, Ishii N, Kubo A, Nishizaki Y
J Nutr Sci Vitaminol (Tokyo) 2020;66(4):289-295. doi: 10.3177/jnsv.66.289. PMID: 32863300
Serum cytokines are increased and circulating micronutrients are not altered in subjects with early compared to advanced knee osteoarthritis.
Barker T, Rogers VE, Henriksen VT, Aguirre D, Trawick RH, Rasmussen GL, Momberger NG
Cytokine 2014 Aug;68(2):133-6. Epub 2014 Apr 29 doi: 10.1016/j.cyto.2014.04.004. PMID: 24787465
Pre-diagnostic circulating vitamin D and risk of melanoma in men.
Major JM, Kiruthu C, Weinstein SJ, Horst RL, Snyder K, Virtamo J, Albanes D
PLoS One 2012;7(4):e35112. Epub 2012 Apr 25 doi: 10.1371/journal.pone.0035112. PMID: 22558121Free PMC Article
Evidence for oxidative stress during in vitro dialysis.
Westhuyzen J, Adams CE, Fleming SJ
Nephron 1995;70(1):49-54. doi: 10.1159/000188543. PMID: 7617117

Diagnosis

Associations Between Prediagnostic Concentrations of Circulating Sex Steroid Hormones and Esophageal/Gastric Cardia Adenocarcinoma Among Men.
Petrick JL, Hyland PL, Caron P, Falk RT, Pfeiffer RM, Dawsey SM, Abnet CC, Taylor PR, Weinstein SJ, Albanes D, Freedman ND, Gapstur SM, Bradwin G, Guillemette C, Campbell PT, Cook MB
J Natl Cancer Inst 2019 Jan 1;111(1):34-41. doi: 10.1093/jnci/djy082. PMID: 29788475Free PMC Article
Prediagnostic circulating adipokine concentrations and risk of renal cell carcinoma in male smokers.
Liao LM, Weinstein SJ, Pollak M, Li Z, Virtamo J, Albanes D, Chow WH, Purdue MP
Carcinogenesis 2013 Jan;34(1):109-12. Epub 2012 Oct 6 doi: 10.1093/carcin/bgs322. PMID: 23042303Free PMC Article
Pre-diagnostic circulating vitamin D and risk of melanoma in men.
Major JM, Kiruthu C, Weinstein SJ, Horst RL, Snyder K, Virtamo J, Albanes D
PLoS One 2012;7(4):e35112. Epub 2012 Apr 25 doi: 10.1371/journal.pone.0035112. PMID: 22558121Free PMC Article
Prediagnostic total and high-density lipoprotein cholesterol and risk of cancer.
Ahn J, Lim U, Weinstein SJ, Schatzkin A, Hayes RB, Virtamo J, Albanes D
Cancer Epidemiol Biomarkers Prev 2009 Nov;18(11):2814-21. Epub 2009 Nov 3 doi: 10.1158/1055-9965.EPI-08-1248. PMID: 19887581Free PMC Article
Relationship between plasma carotenoids and prostate cancer.
Chang S, Erdman JW Jr, Clinton SK, Vadiveloo M, Strom SS, Yamamura Y, Duphorne CM, Spitz MR, Amos CI, Contois JH, Gu X, Babaian RJ, Scardino PT, Hursting SD
Nutr Cancer 2005;53(2):127-34. doi: 10.1207/s15327914nc5302_1. PMID: 16573373

Therapy

Diet-Derived Antioxidants Do Not Decrease Risk of Ischemic Stroke: A Mendelian Randomization Study in 1 Million People.
Martens LG, Luo J, Willems van Dijk K, Jukema JW, Noordam R, van Heemst D
J Am Heart Assoc 2021 Dec 7;10(23):e022567. Epub 2021 Nov 19 doi: 10.1161/JAHA.121.022567. PMID: 34796734Free PMC Article
Carotenoid Intake and Circulating Carotenoids Are Inversely Associated with the Risk of Bladder Cancer: A Dose-Response Meta-analysis.
Wu S, Liu Y, Michalek JE, Mesa RA, Parma DL, Rodriguez R, Mansour AM, Svatek R, Tucker TC, Ramirez AG
Adv Nutr 2020 May 1;11(3):630-643. doi: 10.1093/advances/nmz120. PMID: 31800007Free PMC Article
Intervention study with a high or low antioxidant capacity diet: effects on circulating beta-carotene.
Del Rio D, Valtueña S, Pellegrini N, Bianchi MA, Ardigò D, Franzini L, Scazzina F, Monti L, Zavaroni I, Brighenti F
Eur J Clin Nutr 2009 Oct;63(10):1220-5. Epub 2009 Jun 17 doi: 10.1038/ejcn.2009.46. PMID: 19536163
Effect of beta-carotene supplementation and lactation on carotenoid metabolism and mitogenic T lymphocyte proliferation.
Gossage C, Deyhim M, Moser-Veillon PB, Douglas LW, Kramer TR
Am J Clin Nutr 2000 Apr;71(4):950-5. doi: 10.1093/ajcn/71.4.950. PMID: 10731502
Beta-carotene and lycopene, but not lutein, supplementation changes the plasma fatty acid profile of healthy male non-smokers.
Wright AJ, Hughes DA, Bailey AL, Southon S
J Lab Clin Med 1999 Dec;134(6):592-8. doi: 10.1016/s0022-2143(99)90098-7. PMID: 10595786

Prognosis

Appraising the role of circulating concentrations of micro-nutrients in epithelial ovarian cancer risk: A Mendelian randomization analysis.
Guo Y, Lu Y, Jin H
Sci Rep 2020 Apr 30;10(1):7356. doi: 10.1038/s41598-020-63909-5. PMID: 32355161Free PMC Article
Associations Between Prediagnostic Concentrations of Circulating Sex Steroid Hormones and Esophageal/Gastric Cardia Adenocarcinoma Among Men.
Petrick JL, Hyland PL, Caron P, Falk RT, Pfeiffer RM, Dawsey SM, Abnet CC, Taylor PR, Weinstein SJ, Albanes D, Freedman ND, Gapstur SM, Bradwin G, Guillemette C, Campbell PT, Cook MB
J Natl Cancer Inst 2019 Jan 1;111(1):34-41. doi: 10.1093/jnci/djy082. PMID: 29788475Free PMC Article
Effects of an Antioxidant-enriched Multivitamin in Cystic Fibrosis. A Randomized, Controlled, Multicenter Clinical Trial.
Sagel SD, Khan U, Jain R, Graff G, Daines CL, Dunitz JM, Borowitz D, Orenstein DM, Abdulhamid I, Noe J, Clancy JP, Slovis B, Rock MJ, McCoy KS, Strausbaugh S, Livingston FR, Papas KA, Shaffer ML
Am J Respir Crit Care Med 2018 Sep 1;198(5):639-647. doi: 10.1164/rccm.201801-0105OC. PMID: 29688760Free PMC Article
Vitamin D-binding protein, circulating vitamin D and risk of renal cell carcinoma.
Mondul AM, Weinstein SJ, Moy KA, Männistö S, Albanes D
Int J Cancer 2014 Jun 1;134(11):2699-706. Epub 2014 Jan 30 doi: 10.1002/ijc.28596. PMID: 24214881Free PMC Article
Prediagnostic total and high-density lipoprotein cholesterol and risk of cancer.
Ahn J, Lim U, Weinstein SJ, Schatzkin A, Hayes RB, Virtamo J, Albanes D
Cancer Epidemiol Biomarkers Prev 2009 Nov;18(11):2814-21. Epub 2009 Nov 3 doi: 10.1158/1055-9965.EPI-08-1248. PMID: 19887581Free PMC Article

Clinical prediction guides

Low Levels of Serum β-Carotene and β-Carotene/Retinol Ratio Are Associated with Histological Severity in Nonalcoholic Fatty Liver Disease Patients.
Wang L, Ding C, Zeng F, Zhu H
Ann Nutr Metab 2019;74(2):156-164. Epub 2019 Feb 13 doi: 10.1159/000496458. PMID: 30759431
Vitamin D-binding protein, circulating vitamin D and risk of renal cell carcinoma.
Mondul AM, Weinstein SJ, Moy KA, Männistö S, Albanes D
Int J Cancer 2014 Jun 1;134(11):2699-706. Epub 2014 Jan 30 doi: 10.1002/ijc.28596. PMID: 24214881Free PMC Article
Pre-diagnostic circulating vitamin D and risk of melanoma in men.
Major JM, Kiruthu C, Weinstein SJ, Horst RL, Snyder K, Virtamo J, Albanes D
PLoS One 2012;7(4):e35112. Epub 2012 Apr 25 doi: 10.1371/journal.pone.0035112. PMID: 22558121Free PMC Article
Intervention study with a high or low antioxidant capacity diet: effects on circulating beta-carotene.
Del Rio D, Valtueña S, Pellegrini N, Bianchi MA, Ardigò D, Franzini L, Scazzina F, Monti L, Zavaroni I, Brighenti F
Eur J Clin Nutr 2009 Oct;63(10):1220-5. Epub 2009 Jun 17 doi: 10.1038/ejcn.2009.46. PMID: 19536163
Beta-carotene and lycopene, but not lutein, supplementation changes the plasma fatty acid profile of healthy male non-smokers.
Wright AJ, Hughes DA, Bailey AL, Southon S
J Lab Clin Med 1999 Dec;134(6):592-8. doi: 10.1016/s0022-2143(99)90098-7. PMID: 10595786

Recent systematic reviews

Carotenoid Intake and Circulating Carotenoids Are Inversely Associated with the Risk of Bladder Cancer: A Dose-Response Meta-analysis.
Wu S, Liu Y, Michalek JE, Mesa RA, Parma DL, Rodriguez R, Mansour AM, Svatek R, Tucker TC, Ramirez AG
Adv Nutr 2020 May 1;11(3):630-643. doi: 10.1093/advances/nmz120. PMID: 31800007Free PMC Article

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