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Abnormal circulating organic compound concentration

MedGen UID:
1052687
•Concept ID:
CN376481
•
Finding
HPO: HP:0430071

Definition

Any deviation of the concentration of an orrganic compound from the normal range. An organic compound is defined as any compound that contains a carbon atom. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating organic compound concentration

Professional guidelines

PubMed

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Ibuprofen lysine for the prevention and treatment of patent ductus arteriosus.
Pai VB, Sakadjian A, Puthoff TD
Pharmacotherapy 2008 Sep;28(9):1162-82. doi: 10.1592/phco.28.9.1162. PMID: 18752387
Diagnostic and therapeutic uses of inhaled nitric oxide in neonatal Ebstein's anomaly.
Atz AM, Munoz RA, Adatia I, Wessel DL
Am J Cardiol 2003 Apr 1;91(7):906-8. doi: 10.1016/s0002-9149(03)00036-5. PMID: 12667588

Recent clinical studies

Etiology

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Homocysteine, intracellular signaling and thrombotic disorders.
Dionisio N, Jardín I, Salido GM, Rosado JA
Curr Med Chem 2010;17(27):3109-19. doi: 10.2174/092986710791959783. PMID: 20629621
A proposed inhalation reference concentration for methanol.
Starr TB, Festa JL
Regul Toxicol Pharmacol 2003 Oct;38(2):224-31. doi: 10.1016/s0273-2300(03)00095-3. PMID: 14550762
Putative mechanisms for vascular damage by homocysteine.
Bellamy MF, McDowell IF
J Inherit Metab Dis 1997 Jun;20(2):307-15. doi: 10.1023/a:1005377310872. PMID: 9211203
Pharmacology of antineoplastic agents in pregnancy.
Wiebe VJ, Sipila PE
Crit Rev Oncol Hematol 1994 Apr;16(2):75-112. doi: 10.1016/1040-8428(94)90043-4. PMID: 8068213

Diagnosis

Multifunctional Liposomes.
Aryasomayajula B, Salzano G, Torchilin VP
Methods Mol Biol 2017;1530:41-61. doi: 10.1007/978-1-4939-6646-2_3. PMID: 28150195
Brain imaging in idiopathic generalized epilepsies.
Duncan JS
Epilepsia 2005;46 Suppl 9:108-11. doi: 10.1111/j.1528-1167.2005.00321.x. PMID: 16302883
The pharmacology of letrozole.
Haynes BP, Dowsett M, Miller WR, Dixon JM, Bhatnagar AS
J Steroid Biochem Mol Biol 2003 Oct;87(1):35-45. doi: 10.1016/s0960-0760(03)00384-4. PMID: 14630089
A proposed inhalation reference concentration for methanol.
Starr TB, Festa JL
Regul Toxicol Pharmacol 2003 Oct;38(2):224-31. doi: 10.1016/s0273-2300(03)00095-3. PMID: 14550762
Lung serotonin metabolism.
Hart CM, Block ER
Clin Chest Med 1989 Mar;10(1):59-70. PMID: 2650964

Therapy

Multifunctional Liposomes.
Aryasomayajula B, Salzano G, Torchilin VP
Methods Mol Biol 2017;1530:41-61. doi: 10.1007/978-1-4939-6646-2_3. PMID: 28150195
Dialysate and serum potassium in hemodialysis.
Hung AM, Hakim RM
Am J Kidney Dis 2015 Jul;66(1):125-32. Epub 2015 Mar 28 doi: 10.1053/j.ajkd.2015.02.322. PMID: 25828570
A proposed inhalation reference concentration for methanol.
Starr TB, Festa JL
Regul Toxicol Pharmacol 2003 Oct;38(2):224-31. doi: 10.1016/s0273-2300(03)00095-3. PMID: 14550762
Anabolic effects of fluoride on bone.
Pak CY, Zerwekh JE, Antich P
Trends Endocrinol Metab 1995 Sep;6(7):229-34. doi: 10.1016/1043-2760(95)00111-t. PMID: 11540313
Concise review: methemoglobinemia.
Mansouri A, Lurie AA
Am J Hematol 1993 Jan;42(1):7-12. doi: 10.1002/ajh.2830420104. PMID: 8416301

Prognosis

Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Dialysate and serum potassium in hemodialysis.
Hung AM, Hakim RM
Am J Kidney Dis 2015 Jul;66(1):125-32. Epub 2015 Mar 28 doi: 10.1053/j.ajkd.2015.02.322. PMID: 25828570
Effect of food fortification on folic acid intake in the United States.
Quinlivan EP, Gregory JF 3rd
Am J Clin Nutr 2003 Jan;77(1):221-5. doi: 10.1093/ajcn/77.1.221. PMID: 12499345
Catecholamine levels and treatment in chronic heart failure.
Anker SD
Eur Heart J 1998 Jun;19 Suppl F:F56-61. PMID: 9651737
Lung serotonin metabolism.
Hart CM, Block ER
Clin Chest Med 1989 Mar;10(1):59-70. PMID: 2650964

Clinical prediction guides

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Microfluidic studies of hydrostatic pressure-enhanced doxorubicin resistance in human breast cancer cells.
Shang M, Lim SB, Jiang K, Yap YS, Khoo BL, Han J, Lim CT
Lab Chip 2021 Feb 23;21(4):746-754. doi: 10.1039/d0lc01103g. PMID: 33502419
Association between dopamine and cerebral autoregulation in preterm neonates.
Solanki NS, Hoffman SB
Pediatr Res 2020 Oct;88(4):618-622. Epub 2020 Jan 31 doi: 10.1038/s41390-020-0790-0. PMID: 32005034Free PMC Article
Glucocorticoids and 11beta-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome.
Stimson RH, Walker BR
Minerva Endocrinol 2007 Sep;32(3):141-59. PMID: 17912154

Recent systematic reviews

Micronutrient Status in Adult Crohn's Disease during Clinical Remission: A Systematic Review.
McDonnell M, Sartain S, Westoby C, Katarachia V, Wootton SA, Cummings JRF
Nutrients 2023 Nov 14;15(22) doi: 10.3390/nu15224777. PMID: 38004171Free PMC Article
Association between Maternal Choline, Fetal Brain Development, and Child Neurocognition: Systematic Review and Meta-Analysis of Human Studies.
Obeid R, Derbyshire E, Schön C
Adv Nutr 2022 Dec 22;13(6):2445-2457. doi: 10.1093/advances/nmac082. PMID: 36041182Free PMC Article
Alcohol use disorder and circulating cytokines: A systematic review and meta-analysis.
Adams C, Conigrave JH, Lewohl J, Haber P, Morley KC
Brain Behav Immun 2020 Oct;89:501-512. Epub 2020 Aug 14 doi: 10.1016/j.bbi.2020.08.002. PMID: 32805393
Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies.
Oussalah A, Levy J, Filhine-Trésarrieu P, Namour F, Guéant JL
Am J Clin Nutr 2017 Oct;106(4):1142-1156. Epub 2017 Aug 16 doi: 10.3945/ajcn.117.156349. PMID: 28814397Free PMC Article
Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis.
Murri M, Luque-Ramírez M, Insenser M, Ojeda-Ojeda M, Escobar-Morreale HF
Hum Reprod Update 2013 May-Jun;19(3):268-88. Epub 2013 Jan 9 doi: 10.1093/humupd/dms059. PMID: 23303572

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