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Elevated circulating 27-hydroxycholesterol concentration

MedGen UID:
1054777
•Concept ID:
CN376998
•
Finding
HPO: HP:6000402

Definition

The concentration of 27-hydroxycholesterol in the blood circulation is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating 27-hydroxycholesterol concentration

Professional guidelines

PubMed

High-dose statin treatment does not alter plasma marker for brain cholesterol metabolism in patients with moderately elevated plasma cholesterol levels.
Thelen KM, Laaksonen R, Päivä H, Lehtimäki T, Lütjohann D
J Clin Pharmacol 2006 Jul;46(7):812-6. doi: 10.1177/0091270006289851. PMID: 16809807

Recent clinical studies

Therapy

High-dose statin treatment does not alter plasma marker for brain cholesterol metabolism in patients with moderately elevated plasma cholesterol levels.
Thelen KM, Laaksonen R, Päivä H, Lehtimäki T, Lütjohann D
J Clin Pharmacol 2006 Jul;46(7):812-6. doi: 10.1177/0091270006289851. PMID: 16809807

Clinical prediction guides

Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.
Bodin K, Bretillon L, Aden Y, Bertilsson L, Broomé U, Einarsson C, Diczfalusy U
J Biol Chem 2001 Oct 19;276(42):38685-9. Epub 2001 Aug 20 doi: 10.1074/jbc.M105127200. PMID: 11514559

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