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Elevated circulating CXCL9 concentration

MedGen UID:
1054798
•Concept ID:
CN378047
•
Finding
Synonym: Elevated circulating monokine induced by gamma-interferon concentration
 
HPO: HP:6000704

Definition

The concentration of chemokine (C-X-C motif) ligand 9 in the blood circulation is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating CXCL9 concentration

Recent clinical studies

Etiology

The identification of CCL18 as biomarker of disease activity in localized scleroderma.
Mertens JS, de Jong EMGJ, van den Hoogen LL, Wienke J, Thurlings RM, Seyger MMB, Hoppenreijs EPAH, Wijngaarde CA, van Vlijmen-Willems IMJJ, van den Bogaard E, Giovannone B, van Wijk F, van Royen-Kerkhof A, Marut W, Radstake TRD
J Autoimmun 2019 Jul;101:86-93. Epub 2019 Apr 18 doi: 10.1016/j.jaut.2019.04.008. PMID: 31006523
CXC chemokines CXCL1, CXCL9, CXCL10 and CXCL12 are variably expressed in patients with sickle cell disease and carriers: are they predictive tools for disease complications?
Ostadebrahimi H, Jamali Z, Nazari M, Bahri M, Farahmandnia Z, Khandany BK, Taheri M, Khorramdelazad H, Hakimizadeh E, Zaker F, Rezaeian M, Hassanshahi G
Clin Lab 2014;60(1):99-104. doi: 10.7754/clin.lab.2013.121237. PMID: 24600982
Altered profile of chemokines in fibromyalgia patients.
García JJ, Cidoncha A, Bote ME, Hinchado MD, Ortega E
Ann Clin Biochem 2014 Sep;51(Pt 5):576-81. Epub 2013 Oct 8 doi: 10.1177/0004563213506413. PMID: 24106344
BAFF/APRIL system in pediatric OMS: relation to severity, neuroinflammation, and immunotherapy.
Pranzatelli MR, Tate ED, McGee NR, Travelstead AL, Colliver JA, Ness JM, Ransohoff RM
J Neuroinflammation 2013 Jan 16;10:10. doi: 10.1186/1742-2094-10-10. PMID: 23324534Free PMC Article

Diagnosis

The identification of CCL18 as biomarker of disease activity in localized scleroderma.
Mertens JS, de Jong EMGJ, van den Hoogen LL, Wienke J, Thurlings RM, Seyger MMB, Hoppenreijs EPAH, Wijngaarde CA, van Vlijmen-Willems IMJJ, van den Bogaard E, Giovannone B, van Wijk F, van Royen-Kerkhof A, Marut W, Radstake TRD
J Autoimmun 2019 Jul;101:86-93. Epub 2019 Apr 18 doi: 10.1016/j.jaut.2019.04.008. PMID: 31006523
Altered profile of chemokines in fibromyalgia patients.
García JJ, Cidoncha A, Bote ME, Hinchado MD, Ortega E
Ann Clin Biochem 2014 Sep;51(Pt 5):576-81. Epub 2013 Oct 8 doi: 10.1177/0004563213506413. PMID: 24106344
Selective up-regulation of the soluble pattern-recognition receptor pentraxin 3 and of vascular endothelial growth factor in giant cell arteritis: relevance for recent optic nerve ischemia.
Baldini M, Maugeri N, Ramirez GA, Giacomassi C, Castiglioni A, Prieto-González S, Corbera-Bellalta M, Di Comite G, Papa I, Dell'antonio G, Ammirati E, Cuccovillo I, Vecchio V, Mantovani A, Rovere-Querini P, Sabbadini MG, Cid MC, Manfredi AA
Arthritis Rheum 2012 Mar;64(3):854-65. doi: 10.1002/art.33411. PMID: 21989653

Therapy

BAFF/APRIL system in pediatric OMS: relation to severity, neuroinflammation, and immunotherapy.
Pranzatelli MR, Tate ED, McGee NR, Travelstead AL, Colliver JA, Ness JM, Ransohoff RM
J Neuroinflammation 2013 Jan 16;10:10. doi: 10.1186/1742-2094-10-10. PMID: 23324534Free PMC Article

Prognosis

Elevation of Metrnβ and Its Association with Disease Activity in Systemic Lupus Erythematosus.
Zhang C, Cai S, Li Y, Xu X, Liu Y, Qiao H, Wong CK, Wu G, Jin H, Gao X
Int J Mol Sci 2023 Sep 2;24(17) doi: 10.3390/ijms241713607. PMID: 37686413Free PMC Article
CXC chemokines CXCL1, CXCL9, CXCL10 and CXCL12 are variably expressed in patients with sickle cell disease and carriers: are they predictive tools for disease complications?
Ostadebrahimi H, Jamali Z, Nazari M, Bahri M, Farahmandnia Z, Khandany BK, Taheri M, Khorramdelazad H, Hakimizadeh E, Zaker F, Rezaeian M, Hassanshahi G
Clin Lab 2014;60(1):99-104. doi: 10.7754/clin.lab.2013.121237. PMID: 24600982

Clinical prediction guides

Elevation of Metrnβ and Its Association with Disease Activity in Systemic Lupus Erythematosus.
Zhang C, Cai S, Li Y, Xu X, Liu Y, Qiao H, Wong CK, Wu G, Jin H, Gao X
Int J Mol Sci 2023 Sep 2;24(17) doi: 10.3390/ijms241713607. PMID: 37686413Free PMC Article
Circulating Cytokines and Lower Body Muscle Performance in Older Adults at Hospital Admission.
Ramírez-Vélez R, Sáez De Asteasu ML, Martínez-Velilla N, Zambon-Ferraresi F, García-Hermoso A, Recarey AE, Fernández-Irigoyen J, Santamaría E, Palomino-Echeverría S, Izquierdo M
J Nutr Health Aging 2020;24(10):1131-1139. doi: 10.1007/s12603-020-1480-7. PMID: 33244573
The identification of CCL18 as biomarker of disease activity in localized scleroderma.
Mertens JS, de Jong EMGJ, van den Hoogen LL, Wienke J, Thurlings RM, Seyger MMB, Hoppenreijs EPAH, Wijngaarde CA, van Vlijmen-Willems IMJJ, van den Bogaard E, Giovannone B, van Wijk F, van Royen-Kerkhof A, Marut W, Radstake TRD
J Autoimmun 2019 Jul;101:86-93. Epub 2019 Apr 18 doi: 10.1016/j.jaut.2019.04.008. PMID: 31006523
CXC chemokines CXCL1, CXCL9, CXCL10 and CXCL12 are variably expressed in patients with sickle cell disease and carriers: are they predictive tools for disease complications?
Ostadebrahimi H, Jamali Z, Nazari M, Bahri M, Farahmandnia Z, Khandany BK, Taheri M, Khorramdelazad H, Hakimizadeh E, Zaker F, Rezaeian M, Hassanshahi G
Clin Lab 2014;60(1):99-104. doi: 10.7754/clin.lab.2013.121237. PMID: 24600982

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