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Hepatitis D, Chronic

MedGen UID:
105624
•Concept ID:
C0524911
•
Disease or Syndrome
Synonyms: Chronic Delta Hepatitides; Chronic Delta Hepatitis; Chronic Hepatitis D; Delta Hepatitides, Chronic; Delta Hepatitis, Chronic; Hepatitides, Chronic Delta; Hepatitis, Chronic Delta

Definition

INFLAMMATION of the LIVER in humans caused by HEPATITIS DELTA VIRUS in conjunction with HEPATITIS B VIRUS and lasting six months or more. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatitis D, Chronic

Professional guidelines

PubMed

EASL Clinical Practice Guidelines on hepatitis delta virus.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2023 Aug;79(2):433-460. Epub 2023 Jun 24 doi: 10.1016/j.jhep.2023.05.001. PMID: 37364791
Treatment endpoints for chronic hepatitis D.
Metin O, Zeybel M, Yurdaydin C
Liver Int 2023 Aug;43 Suppl 1:60-68. Epub 2022 Oct 13 doi: 10.1111/liv.15447. PMID: 36196680
Interferon-based treatment of chronic hepatitis D.
Sandmann L, Wedemeyer H
Liver Int 2023 Aug;43 Suppl 1:69-79. Epub 2022 Sep 2 doi: 10.1111/liv.15410. PMID: 36002390

Recent clinical studies

Etiology

A Phase 3, Randomized Trial of Bulevirtide in Chronic Hepatitis D.
Wedemeyer H, Aleman S, Brunetto MR, Blank A, Andreone P, Bogomolov P, Chulanov V, Mamonova N, Geyvandova N, Morozov V, Sagalova O, Stepanova T, Berger A, Manuilov D, Suri V, An Q, Da B, Flaherty J, Osinusi A, Liu Y, Merle U, Schulze Zur Wiesch J, Zeuzem S, Ciesek S, Cornberg M, Lampertico P; MYR 301 Study Group
N Engl J Med 2023 Jul 6;389(1):22-32. Epub 2023 Jun 22 doi: 10.1056/NEJMoa2213429. PMID: 37345876
Treatment endpoints for chronic hepatitis D.
Metin O, Zeybel M, Yurdaydin C
Liver Int 2023 Aug;43 Suppl 1:60-68. Epub 2022 Oct 13 doi: 10.1111/liv.15447. PMID: 36196680
Safety and efficacy of bulevirtide in combination with tenofovir disoproxil fumarate in patients with hepatitis B virus and hepatitis D virus coinfection (MYR202): a multicentre, randomised, parallel-group, open-label, phase 2 trial.
Wedemeyer H, Schöneweis K, Bogomolov P, Blank A, Voronkova N, Stepanova T, Sagalova O, Chulanov V, Osipenko M, Morozov V, Geyvandova N, Sleptsova S, Bakulin IG, Khaertynova I, Rusanova M, Pathil A, Merle U, Bremer B, Allweiss L, Lempp FA, Port K, Haag M, Schwab M, Zur Wiesch JS, Cornberg M, Haefeli WE, Dandri M, Alexandrov A, Urban S
Lancet Infect Dis 2023 Jan;23(1):117-129. Epub 2022 Sep 13 doi: 10.1016/S1473-3099(22)00318-8. PMID: 36113537
Chronic hepatitis D-What is changing?
Yardeni D, Heller T, Koh C
J Viral Hepat 2022 Apr;29(4):240-251. Epub 2022 Feb 19 doi: 10.1111/jvh.13651. PMID: 35122369
Guidance for design and endpoints of clinical trials in chronic hepatitis B - Report from the 2019 EASL-AASLD HBV Treatment Endpoints Conference(‡).
Cornberg M, Lok AS, Terrault NA, Zoulim F; 2019 EASL-AASLD HBV Treatment Endpoints Conference Faculty
J Hepatol 2020 Mar;72(3):539-557. Epub 2019 Nov 12 doi: 10.1016/j.jhep.2019.11.003. PMID: 31730789

Diagnosis

Hepatitis D: A Review.
Negro F, Lok AS
JAMA 2023 Dec 26;330(24):2376-2387. doi: 10.1001/jama.2023.23242. PMID: 37943548
Epidemiology, presentation, and therapeutic approaches for hepatitis D infections.
Blaney H, Khalid M, Heller T, Koh C
Expert Rev Anti Infect Ther 2023 Feb;21(2):127-142. Epub 2022 Dec 28 doi: 10.1080/14787210.2023.2159379. PMID: 36519386Free PMC Article
HBV/HDV Coinfection: A Challenge for Therapeutics.
Koh C, Da BL, Glenn JS
Clin Liver Dis 2019 Aug;23(3):557-572. Epub 2019 May 24 doi: 10.1016/j.cld.2019.04.005. PMID: 31266627Free PMC Article
Targeting Hepatitis D.
Rizzetto M
Semin Liver Dis 2018 Feb;38(1):66-72. Epub 2018 Feb 22 doi: 10.1055/s-0037-1621711. PMID: 29471567
Therapy of Delta Hepatitis.
Yurdaydin C, Idilman R
Cold Spring Harb Perspect Med 2015 Aug 7;5(10) doi: 10.1101/cshperspect.a021543. PMID: 26253093Free PMC Article

Therapy

Hepatitis D: A Review.
Negro F, Lok AS
JAMA 2023 Dec 26;330(24):2376-2387. doi: 10.1001/jama.2023.23242. PMID: 37943548
A Phase 3, Randomized Trial of Bulevirtide in Chronic Hepatitis D.
Wedemeyer H, Aleman S, Brunetto MR, Blank A, Andreone P, Bogomolov P, Chulanov V, Mamonova N, Geyvandova N, Morozov V, Sagalova O, Stepanova T, Berger A, Manuilov D, Suri V, An Q, Da B, Flaherty J, Osinusi A, Liu Y, Merle U, Schulze Zur Wiesch J, Zeuzem S, Ciesek S, Cornberg M, Lampertico P; MYR 301 Study Group
N Engl J Med 2023 Jul 6;389(1):22-32. Epub 2023 Jun 22 doi: 10.1056/NEJMoa2213429. PMID: 37345876
Safety and efficacy of bulevirtide in combination with tenofovir disoproxil fumarate in patients with hepatitis B virus and hepatitis D virus coinfection (MYR202): a multicentre, randomised, parallel-group, open-label, phase 2 trial.
Wedemeyer H, Schöneweis K, Bogomolov P, Blank A, Voronkova N, Stepanova T, Sagalova O, Chulanov V, Osipenko M, Morozov V, Geyvandova N, Sleptsova S, Bakulin IG, Khaertynova I, Rusanova M, Pathil A, Merle U, Bremer B, Allweiss L, Lempp FA, Port K, Haag M, Schwab M, Zur Wiesch JS, Cornberg M, Haefeli WE, Dandri M, Alexandrov A, Urban S
Lancet Infect Dis 2023 Jan;23(1):117-129. Epub 2022 Sep 13 doi: 10.1016/S1473-3099(22)00318-8. PMID: 36113537
Guidance for design and endpoints of clinical trials in chronic hepatitis B - Report from the 2019 EASL-AASLD HBV Treatment Endpoints Conference(‡).
Cornberg M, Lok AS, Terrault NA, Zoulim F; 2019 EASL-AASLD HBV Treatment Endpoints Conference Faculty
J Hepatol 2020 Mar;72(3):539-557. Epub 2019 Nov 12 doi: 10.1016/j.jhep.2019.11.003. PMID: 31730789
Targeting Hepatitis D.
Rizzetto M
Semin Liver Dis 2018 Feb;38(1):66-72. Epub 2018 Feb 22 doi: 10.1055/s-0037-1621711. PMID: 29471567

Prognosis

Hepatitis D: A Review.
Negro F, Lok AS
JAMA 2023 Dec 26;330(24):2376-2387. doi: 10.1001/jama.2023.23242. PMID: 37943548
Epidemiology, presentation, and therapeutic approaches for hepatitis D infections.
Blaney H, Khalid M, Heller T, Koh C
Expert Rev Anti Infect Ther 2023 Feb;21(2):127-142. Epub 2022 Dec 28 doi: 10.1080/14787210.2023.2159379. PMID: 36519386Free PMC Article
Guidance for design and endpoints of clinical trials in chronic hepatitis B - Report from the 2019 EASL-AASLD HBV Treatment Endpoints Conference(‡).
Cornberg M, Lok AS, Terrault NA, Zoulim F; 2019 EASL-AASLD HBV Treatment Endpoints Conference Faculty
J Hepatol 2020 Mar;72(3):539-557. Epub 2019 Nov 12 doi: 10.1016/j.jhep.2019.11.003. PMID: 31730789
HBV/HDV Coinfection: A Challenge for Therapeutics.
Koh C, Da BL, Glenn JS
Clin Liver Dis 2019 Aug;23(3):557-572. Epub 2019 May 24 doi: 10.1016/j.cld.2019.04.005. PMID: 31266627Free PMC Article
Chronic viral hepatitis.
Chang MH
Indian J Pediatr 1995 Nov-Dec;62(6):673-9. doi: 10.1007/BF02825113. PMID: 10829942

Clinical prediction guides

Hepatitis D: A Review.
Negro F, Lok AS
JAMA 2023 Dec 26;330(24):2376-2387. doi: 10.1001/jama.2023.23242. PMID: 37943548
Hepatocellular Carcinoma in Chronic Viral Hepatitis: Where Do We Stand?
Russo FP, Zanetto A, Pinto E, Battistella S, Penzo B, Burra P, Farinati F
Int J Mol Sci 2022 Jan 2;23(1) doi: 10.3390/ijms23010500. PMID: 35008926Free PMC Article
The changing context of hepatitis D.
Rizzetto M, Hamid S, Negro F
J Hepatol 2021 May;74(5):1200-1211. Epub 2021 Jan 20 doi: 10.1016/j.jhep.2021.01.014. PMID: 33484770
Guidance for design and endpoints of clinical trials in chronic hepatitis B - Report from the 2019 EASL-AASLD HBV Treatment Endpoints Conference(‡).
Cornberg M, Lok AS, Terrault NA, Zoulim F; 2019 EASL-AASLD HBV Treatment Endpoints Conference Faculty
J Hepatol 2020 Mar;72(3):539-557. Epub 2019 Nov 12 doi: 10.1016/j.jhep.2019.11.003. PMID: 31730789
Hepatitis delta virus and hepatocellular carcinoma: an update.
Romeo R, Petruzziello A, Pecheur EI, Facchetti F, Perbellini R, Galmozzi E, Khan NU, Di Capua L, Sabatino R, Botti G, Loquercio G
Epidemiol Infect 2018 Oct;146(13):1612-1618. Epub 2018 Jul 11 doi: 10.1017/S0950268818001942. PMID: 29991359Free PMC Article

Recent systematic reviews

Comparative effectiveness of seven interventions for chronic hepatitis D: a systematic review and network meta-analysis of randomized controlled trials.
Rong Y, Ju X, Sun P, Wang Y
BMC Infect Dis 2023 Oct 25;23(1):726. doi: 10.1186/s12879-023-08718-7. PMID: 37880598Free PMC Article
Chronic hepatitis D and hepatocellular carcinoma: A systematic review and meta-analysis of observational studies.
Alfaiate D, Clément S, Gomes D, Goossens N, Negro F
J Hepatol 2020 Sep;73(3):533-539. Epub 2020 Mar 6 doi: 10.1016/j.jhep.2020.02.030. PMID: 32151618
Erectile dysfunction in patients with chronic viral hepatitis: a systematic review of the literature.
Fusco F, D'Anzeo G, Rossi A, Sciorio C, Buonomo AR, d'Emmanuele di Villa Bianca R, Borgia G, Mirone V, Gentile I
Expert Opin Pharmacother 2013 Dec;14(18):2533-44. Epub 2013 Nov 12 doi: 10.1517/14656566.2013.850073. PMID: 24215104
Interferon-α for patients with chronic hepatitis delta: a systematic review of randomized clinical trials.
Lamers MH, Kirgiz ÖÖ, Heidrich B, Wedemeyer H, Drenth JP
Antivir Ther 2012;17(6):1029-37. Epub 2012 Aug 15 doi: 10.3851/IMP2306. PMID: 22892440
Interferon alpha for chronic hepatitis D.
Abbas Z, Khan MA, Salih M, Jafri W
Cochrane Database Syst Rev 2011 Dec 7;2011(12):CD006002. doi: 10.1002/14651858.CD006002.pub2. PMID: 22161394Free PMC Article

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    Practice guidelines

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