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Carcinoid Tumor of Uncertain Malignant Potential

MedGen UID:
109014
•Concept ID:
C0600176
•
Neoplastic Process
Synonyms: Argentaffinoma; Argentaffinomas
SNOMED CT: Argentaffinoma (274904007); Carcinoid tumor - argentaffin (274904007)

Definition

A carcinoid tumor that shows atypical characteristics and has borderline malignant potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCarcinoid Tumor of Uncertain Malignant Potential

Professional guidelines

PubMed

Perspectives on the current pharmacotherapeutic strategies for management of functional neuroendocrine tumor syndromes.
Ito T, Jensen RT
Expert Opin Pharmacother 2021 Apr;22(6):685-693. Epub 2020 Nov 11 doi: 10.1080/14656566.2020.1845651. PMID: 33131345Free PMC Article
Carcinoid Heart Disease: Pathophysiology, Pathology, Clinical Manifestations, and Management.
Jin C, Sharma AN, Thevakumar B, Majid M, Al Chalaby S, Takahashi N, Tanious A, Arockiam AD, Beri N, Amsterdam EA
Cardiology 2021;146(1):65-73. Epub 2020 Oct 16 doi: 10.1159/000507847. PMID: 33070143
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

Recent clinical studies

Etiology

Carcinoid tumors outside the abdomen.
Koehler K, Iams WT
Cancer Med 2023 Apr;12(7):7893-7903. Epub 2022 Dec 22 doi: 10.1002/cam4.5564. PMID: 36560885Free PMC Article
Shifting Paradigms in the Pathophysiology and Treatment of Carcinoid Crisis.
Maxwell JE, Naraev B, Halperin DM, Choti MA, Halfdanarson TR
Ann Surg Oncol 2022 May;29(5):3072-3084. Epub 2022 Feb 14 doi: 10.1245/s10434-022-11371-0. PMID: 35165817
Pulmonary Neuroendocrine Tumors.
Borczuk AC
Surg Pathol Clin 2020 Mar;13(1):35-55. Epub 2019 Nov 29 doi: 10.1016/j.path.2019.10.002. PMID: 32005434
The Problem of Appendiceal Carcinoids.
Galanopoulos M, Toumpanakis C
Endocrinol Metab Clin North Am 2018 Sep;47(3):661-669. Epub 2018 Jul 13 doi: 10.1016/j.ecl.2018.04.004. PMID: 30098722
Neuroendocrine tumours.
Barakat MT, Meeran K, Bloom SR
Endocr Relat Cancer 2004 Mar;11(1):1-18. doi: 10.1677/erc.0.0110001. PMID: 15027882

Diagnosis

Pulmonary Neuroendocrine Tumors.
Borczuk AC
Surg Pathol Clin 2020 Mar;13(1):35-55. Epub 2019 Nov 29 doi: 10.1016/j.path.2019.10.002. PMID: 32005434
Carcinoid-syndrome: recent advances, current status and controversies.
Ito T, Lee L, Jensen RT
Curr Opin Endocrinol Diabetes Obes 2018 Feb;25(1):22-35. doi: 10.1097/MED.0000000000000376. PMID: 29120923Free PMC Article
Carcinoid tumors.
Robertson RG, Geiger WJ, Davis NB
Am Fam Physician 2006 Aug 1;74(3):429-34. PMID: 16913162
Rectal carcinoids.
Wang AY, Ahmad NA
Curr Opin Gastroenterol 2006 Sep;22(5):529-35. doi: 10.1097/01.mog.0000239868.27328.1d. PMID: 16891885
Gastric carcinoid.
Mulkeen A, Cha C
Curr Opin Oncol 2005 Jan;17(1):1-6. doi: 10.1097/01.cco.0000147899.04701.c6. PMID: 15608504

Therapy

Shifting Paradigms in the Pathophysiology and Treatment of Carcinoid Crisis.
Maxwell JE, Naraev B, Halperin DM, Choti MA, Halfdanarson TR
Ann Surg Oncol 2022 May;29(5):3072-3084. Epub 2022 Feb 14 doi: 10.1245/s10434-022-11371-0. PMID: 35165817
Recent Advances in the Diagnosis and Management of Carcinoid Syndrome.
Subash N, Papali MM, Bahadur KP, Avanthika C, Jhaveri S, Thannir S, Joshi M, Valisekka SS
Dis Mon 2022 Jul;68(7):101304. Epub 2021 Dec 28 doi: 10.1016/j.disamonth.2021.101304. PMID: 34972546
Carcinoid-syndrome: recent advances, current status and controversies.
Ito T, Lee L, Jensen RT
Curr Opin Endocrinol Diabetes Obes 2018 Feb;25(1):22-35. doi: 10.1097/MED.0000000000000376. PMID: 29120923Free PMC Article
Gastric carcinoid.
Mulkeen A, Cha C
Curr Opin Oncol 2005 Jan;17(1):1-6. doi: 10.1097/01.cco.0000147899.04701.c6. PMID: 15608504
Carcinoid tumors.
Boushey RP, Dackiw AP
Curr Treat Options Oncol 2002 Aug;3(4):319-26. doi: 10.1007/s11864-002-0031-2. PMID: 12074768

Prognosis

Characterization, Prognosis, and Treatment of Patients With Metastatic Lung Carcinoid Tumors.
Robelin P, Hadoux J, Forestier J, Planchard D, Hervieu V, Berdelou A, Scoazec JY, Valette PJ, Leboulleux S, Ducreux M, Lombard-Bohas C, Baudin E, Walter T
J Thorac Oncol 2019 Jun;14(6):993-1002. Epub 2019 Feb 13 doi: 10.1016/j.jtho.2019.02.002. PMID: 30771520
The Diagnosis and Treatment of Bronchopulmonary Carcinoid.
Kaifi JT, Kayser G, Ruf J, Passlick B
Dtsch Arztebl Int 2015 Jul 6;112(27-28):479-85. doi: 10.3238/arztebl.2015.0479. PMID: 26214234Free PMC Article
Carcinoid tumors.
Pinchot SN, Holen K, Sippel RS, Chen H
Oncologist 2008 Dec;13(12):1255-69. Epub 2008 Dec 17 doi: 10.1634/theoncologist.2008-0207. PMID: 19091780Free PMC Article
One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States.
Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, Abdalla EK, Fleming JB, Vauthey JN, Rashid A, Evans DB
J Clin Oncol 2008 Jun 20;26(18):3063-72. doi: 10.1200/JCO.2007.15.4377. PMID: 18565894
Rectal carcinoids.
Wang AY, Ahmad NA
Curr Opin Gastroenterol 2006 Sep;22(5):529-35. doi: 10.1097/01.mog.0000239868.27328.1d. PMID: 16891885

Clinical prediction guides

Cardiac Imaging in Carcinoid Heart Disease.
Baron T, Bergsten J, Albåge A, Lundin L, Sörensen J, Öberg K, Flachskampf FA
JACC Cardiovasc Imaging 2021 Nov;14(11):2240-2253. Epub 2021 Apr 14 doi: 10.1016/j.jcmg.2020.12.030. PMID: 33865761
Clinical implications of lung neuroendocrine neoplasm classification.
Metovic J, Barella M, Harari S, Pattini L, Albini A, Sonzogni A, Veronesi G, Papotti M, Pelosi G
Expert Rev Anticancer Ther 2021 Apr;21(4):377-387. Epub 2020 Dec 24 doi: 10.1080/14737140.2021.1862654. PMID: 33306420
Appendix Tumor Microenvironment.
Roncati L, Gasparri P, Gallo G, Bernardelli G, Zanelli G, Manenti A
Adv Exp Med Biol 2020;1226:87-95. doi: 10.1007/978-3-030-36214-0_7. PMID: 32030678
Characterization, Prognosis, and Treatment of Patients With Metastatic Lung Carcinoid Tumors.
Robelin P, Hadoux J, Forestier J, Planchard D, Hervieu V, Berdelou A, Scoazec JY, Valette PJ, Leboulleux S, Ducreux M, Lombard-Bohas C, Baudin E, Walter T
J Thorac Oncol 2019 Jun;14(6):993-1002. Epub 2019 Feb 13 doi: 10.1016/j.jtho.2019.02.002. PMID: 30771520
Rectal carcinoids.
Wang AY, Ahmad NA
Curr Opin Gastroenterol 2006 Sep;22(5):529-35. doi: 10.1097/01.mog.0000239868.27328.1d. PMID: 16891885

Recent systematic reviews

A Systematic Review of Economic and Quality-of-Life Research in Carcinoid Syndrome.
Pan IW, Halperin DM, Kim B, Yao JC, Shih YT
Pharmacoeconomics 2021 Nov;39(11):1271-1297. Epub 2021 Aug 11 doi: 10.1007/s40273-021-01071-0. PMID: 34378163Free PMC Article
Management and outcome of middle ear adenomatous neuroendocrine tumours: A systematic review.
Engel MSD, van der Lans RJL, Jansen JC, Leemans CR, Bloemena E, Lissenberg-Witte BI, Rijken JA, Smit CF, Hensen EF
Oral Oncol 2021 Oct;121:105465. Epub 2021 Aug 2 doi: 10.1016/j.oraloncology.2021.105465. PMID: 34352556
Endometriosis and its correlation with carcinoid tumor of the appendix: a systematic review.
Villaescusa M, Andres MP, Amaral AC, Barbosa RN, Abrão MS
Minerva Obstet Gynecol 2021 Oct;73(5):606-613. Epub 2021 Apr 27 doi: 10.23736/S2724-606X.21.04792-4. PMID: 33904692
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366
Ectopic ACTH syndrome.
Isidori AM, Lenzi A
Arq Bras Endocrinol Metabol 2007 Nov;51(8):1217-25. doi: 10.1590/s0004-27302007000800007. PMID: 18209859

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