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Carcinoid Tumor of Uncertain Malignant Potential

MedGen UID:
109014
•Concept ID:
C0600176
•
Neoplastic Process
Synonyms: Argentaffinoma; Argentaffinomas
SNOMED CT: Argentaffinoma (274904007); Carcinoid tumor - argentaffin (274904007)

Definition

A carcinoid tumor that shows atypical characteristics and has borderline malignant potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCarcinoid Tumor of Uncertain Malignant Potential

Professional guidelines

PubMed

Advances in Management of Nonfunctional Pancreas Neuroendocrine Tumors.
Acher AW, Hallet J
Surg Clin North Am 2024 Oct;104(5):1095-1111. Epub 2024 Apr 23 doi: 10.1016/j.suc.2024.03.010. PMID: 39237166
Carcinoid Heart Disease: Pathophysiology, Pathology, Clinical Manifestations, and Management.
Jin C, Sharma AN, Thevakumar B, Majid M, Al Chalaby S, Takahashi N, Tanious A, Arockiam AD, Beri N, Amsterdam EA
Cardiology 2021;146(1):65-73. Epub 2020 Oct 16 doi: 10.1159/000507847. PMID: 33070143
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

Recent clinical studies

Etiology

Lung and thymic carcinoids: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up(☆).
Baudin E, Caplin M, Garcia-Carbonero R, Fazio N, Ferolla P, Filosso PL, Frilling A, de Herder WW, Hörsch D, Knigge U, Korse CM, Lim E, Lombard-Bohas C, Pavel M, Scoazec JY, Sundin A, Berruti A; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2021 Apr;32(4):439-451. Epub 2021 Jan 19 doi: 10.1016/j.annonc.2021.01.003. PMID: 33482246
Carcinoid tumors.
Pasieka JL
Surg Clin North Am 2009 Oct;89(5):1123-37. doi: 10.1016/j.suc.2009.06.008. PMID: 19836488
Carcinoid tumors: what should increase our suspicion?
Aggarwal G, Obideen K, Wehbi M
Cleve Clin J Med 2008 Dec;75(12):849-55. doi: 10.3949/ccjm.75a.08002. PMID: 19088003
Carcinoids of the appendix.
Kvols L
Neuroendocrinology 2004;80 Suppl 1:33-4. doi: 10.1159/000080738. PMID: 15477714
Retrorectal carcinoid tumor.
Gorski T, Khubchandani IT, Stasik JJ, Riether R
South Med J 1999 Apr;92(4):417-20. doi: 10.1097/00007611-199904000-00014. PMID: 10219364

Diagnosis

Carcinoid syndrome-Symptoms and therapeutic approaches.
Chrisoulidou A
Hell J Nucl Med 2023 May-Aug;26 Suppl:52-56. PMID: 37658565
mTOR Inhibitor-Induced Transient Acantholytic Dermatitis.
Nussbaum D, Glass L, Friedman A
J Drugs Dermatol 2022 Mar 1;21(3):315-316. doi: 10.36849/JDD.5956. PMID: 35254759
Carcinoid-syndrome: recent advances, current status and controversies.
Ito T, Lee L, Jensen RT
Curr Opin Endocrinol Diabetes Obes 2018 Feb;25(1):22-35. doi: 10.1097/MED.0000000000000376. PMID: 29120923Free PMC Article
Clinical features and management of type I gastric carcinoids.
Sato Y
Clin J Gastroenterol 2014 Oct;7(5):381-6. Epub 2014 Sep 17 doi: 10.1007/s12328-014-0528-9. PMID: 26184015
Carcinoid tumor.
Chowsanitphon J
Oncol Nurs Forum 2010 Nov;37(6):677-9. doi: 10.1188/10.ONF.677-679. PMID: 21059581

Therapy

Carcinoid syndrome and somatostatin analogues.
Varas Lorenzo M
Rev Esp Enferm Dig 2023 Dec;115(12):726-727. doi: 10.17235/reed.2023.9525/2023. PMID: 36896924
Lung and Thymic Carcinoids.
Hann CL, Forde PM
Endocrinol Metab Clin North Am 2018 Sep;47(3):699-709. doi: 10.1016/j.ecl.2018.04.011. PMID: 30098725
Carcinoid-syndrome: recent advances, current status and controversies.
Ito T, Lee L, Jensen RT
Curr Opin Endocrinol Diabetes Obes 2018 Feb;25(1):22-35. doi: 10.1097/MED.0000000000000376. PMID: 29120923Free PMC Article
Carcinoid syndrome.
Zambrzycki JK, Elliott CG
Nurse Anesth 1993 Dec;4(4):198-201. PMID: 7907889
Carcinoid syndrome.
Tilson MD
Surg Clin North Am 1974 Apr;54(2):409-23. doi: 10.1016/s0039-6109(16)40288-4. PMID: 4593912

Prognosis

Lung and thymic carcinoids: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up(☆).
Baudin E, Caplin M, Garcia-Carbonero R, Fazio N, Ferolla P, Filosso PL, Frilling A, de Herder WW, Hörsch D, Knigge U, Korse CM, Lim E, Lombard-Bohas C, Pavel M, Scoazec JY, Sundin A, Berruti A; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2021 Apr;32(4):439-451. Epub 2021 Jan 19 doi: 10.1016/j.annonc.2021.01.003. PMID: 33482246
A Typical Carcinoid of the Nasopharynx.
Ngo DQ, Ngo QX, Van Le Q
Ear Nose Throat J 2020 Jan;99(1):34-36. Epub 2019 Mar 5 doi: 10.1177/0145561319834516. PMID: 30832504
One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States.
Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, Abdalla EK, Fleming JB, Vauthey JN, Rashid A, Evans DB
J Clin Oncol 2008 Jun 20;26(18):3063-72. doi: 10.1200/JCO.2007.15.4377. PMID: 18565894
Carcinoids of the appendix.
Kvols L
Neuroendocrinology 2004;80 Suppl 1:33-4. doi: 10.1159/000080738. PMID: 15477714
Carcinoid tumors.
Kulke MH, Mayer RJ
N Engl J Med 1999 Mar 18;340(11):858-68. doi: 10.1056/NEJM199903183401107. PMID: 10080850

Clinical prediction guides

Appendix Tumor Microenvironment.
Roncati L, Gasparri P, Gallo G, Bernardelli G, Zanelli G, Manenti A
Adv Exp Med Biol 2020;1226:87-95. doi: 10.1007/978-3-030-36214-0_7. PMID: 32030678
Multiple atypical thymic carcinoids with paraneoplastic giant cell arteritis.
Nakayama T, Katagiri S, Kikkawa T, Obara T, Mori T, Kiriu T
Gen Thorac Cardiovasc Surg 2020 Oct;68(10):1212-1215. Epub 2019 Oct 17 doi: 10.1007/s11748-019-01230-3. PMID: 31625085
Partial nephrectomy in horseshoe kidney: Primary carcinoid tumor.
Seker KG, Sam E, Sahin S, Yenice MG, Aktas AG, Simsek A, Tugcu V
Arch Ital Urol Androl 2017 Dec 31;89(4):316-318. doi: 10.4081/aiua.2017.4.316. PMID: 29473385
Primary renal carcinoid metastatic to the orbit.
Parikh D, Shinder R
Ophthalmic Plast Reconstr Surg 2015 Mar-Apr;31(2):e37-8. doi: 10.1097/IOP.0000000000000061. PMID: 24807802
Treatment of metastatic carcinoid tumors with radiolabeled biologic molecules.
Bushnell D
J Natl Compr Canc Netw 2009 Jul;7(7):760-4. doi: 10.6004/jnccn.2009.0052. PMID: 19635228

Recent systematic reviews

What Is Carcinoid Syndrome? A Critical Appraisal of Its Proposed Mediators.
Mulders MCF, de Herder WW, Hofland J
Endocr Rev 2024 May 7;45(3):351-360. doi: 10.1210/endrev/bnad035. PMID: 38038364Free PMC Article
A Systematic Review of Economic and Quality-of-Life Research in Carcinoid Syndrome.
Pan IW, Halperin DM, Kim B, Yao JC, Shih YT
Pharmacoeconomics 2021 Nov;39(11):1271-1297. Epub 2021 Aug 11 doi: 10.1007/s40273-021-01071-0. PMID: 34378163Free PMC Article
Endometriosis and its correlation with carcinoid tumor of the appendix: a systematic review.
Villaescusa M, Andres MP, Amaral AC, Barbosa RN, Abrão MS
Minerva Obstet Gynecol 2021 Oct;73(5):606-613. Epub 2021 Apr 27 doi: 10.23736/S2724-606X.21.04792-4. PMID: 33904692
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366
Ectopic ACTH syndrome.
Isidori AM, Lenzi A
Arq Bras Endocrinol Metabol 2007 Nov;51(8):1217-25. doi: 10.1590/s0004-27302007000800007. PMID: 18209859

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