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Prurigo

MedGen UID:
10986
•Concept ID:
C0033771
•
Disease or Syndrome
Synonyms: Itchy skin eruption; itchy skin eruption; prurigo; Pruritic rash; pruritic rash
SNOMED CT: Prurigo (64144002); Pruritic rash (64144002); Itchy skin eruption (64144002)
 
Monarch Initiative: MONDO:0021739

Definition

A name applied to several itchy skin eruptions of unknown cause. The characteristic course is the formation of a dome-shaped papule with a small transient vesicle on top, followed by crusting over or lichenification. (From Dorland, 27th ed) [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrurigo

Professional guidelines

PubMed

Pathophysiology, diagnosis, and pharmacological treatment of prurigo nodularis.
Williams KA, Roh YS, Brown I, Sutaria N, Bakhshi P, Choi J, Gabriel S, Chavda R, Kwatra SG
Expert Rev Clin Pharmacol 2021 Jan;14(1):67-77. Epub 2020 Dec 11 doi: 10.1080/17512433.2021.1852080. PMID: 33191806
Prurigo nodularis: Pathogenesis and management.
Williams KA, Huang AH, Belzberg M, Kwatra SG
J Am Acad Dermatol 2020 Dec;83(6):1567-1575. Epub 2020 May 24 doi: 10.1016/j.jaad.2020.04.182. PMID: 32461078
Diagnostic and treatment algorithm for chronic nodular prurigo.
Ständer HF, Elmariah S, Zeidler C, Spellman M, Ständer S
J Am Acad Dermatol 2020 Feb;82(2):460-468. Epub 2019 Jul 13 doi: 10.1016/j.jaad.2019.07.022. PMID: 31310842

Recent clinical studies

Etiology

Children atopic dermatitis: Diagnosis, mimics, overlaps, and therapeutic implication.
Napolitano M, Fabbrocini G, Martora F, Genco L, Noto M, Patruno C
Dermatol Ther 2022 Dec;35(12):e15901. Epub 2022 Oct 13 doi: 10.1111/dth.15901. PMID: 36200594Free PMC Article
Dermal hyperneury.
Marušić Z, Korša L, Calonje E
Clin Dermatol 2021 Mar-Apr;39(2):291-294. Epub 2020 Oct 16 doi: 10.1016/j.clindermatol.2020.10.008. PMID: 34272024
Trial of Nemolizumab in Moderate-to-Severe Prurigo Nodularis.
Ständer S, Yosipovitch G, Legat FJ, Lacour JP, Paul C, Narbutt J, Bieber T, Misery L, Wollenberg A, Reich A, Ahmad F, Piketty C
N Engl J Med 2020 Feb 20;382(8):706-716. doi: 10.1056/NEJMoa1908316. PMID: 32074418
Eosinophilic dermatoses.
Peckruhn M, Elsner P, Tittelbach J
J Dtsch Dermatol Ges 2019 Oct;17(10):1039-1051. Epub 2019 Sep 27 doi: 10.1111/ddg.13943. PMID: 31562692
A systematic review and meta-analysis of the regional and age-related differences in atopic dermatitis clinical characteristics.
Yew YW, Thyssen JP, Silverberg JI
J Am Acad Dermatol 2019 Feb;80(2):390-401. Epub 2018 Oct 1 doi: 10.1016/j.jaad.2018.09.035. PMID: 30287309

Diagnosis

Chronic prurigo.
Misery L
Br J Dermatol 2022 Oct;187(4):464-471. Epub 2022 Jul 12 doi: 10.1111/bjd.21698. PMID: 35656799
2020 guidelines for the diagnosis and treatment of prurigo.
Satoh T, Yokozeki H, Murota H, Tokura Y, Kabashima K, Takamori K, Shiohara T, Morita E, Aiba S, Aoyama Y, Hashimoto T, Katayama I
J Dermatol 2021 Sep;48(9):e414-e431. Epub 2021 Jul 27 doi: 10.1111/1346-8138.16067. PMID: 34314056
Pathophysiology, diagnosis, and pharmacological treatment of prurigo nodularis.
Williams KA, Roh YS, Brown I, Sutaria N, Bakhshi P, Choi J, Gabriel S, Chavda R, Kwatra SG
Expert Rev Clin Pharmacol 2021 Jan;14(1):67-77. Epub 2020 Dec 11 doi: 10.1080/17512433.2021.1852080. PMID: 33191806
Prurigo nodularis: Pathogenesis and management.
Williams KA, Huang AH, Belzberg M, Kwatra SG
J Am Acad Dermatol 2020 Dec;83(6):1567-1575. Epub 2020 May 24 doi: 10.1016/j.jaad.2020.04.182. PMID: 32461078
Prurigo nodularis: Epidemiology and clinical features.
Huang AH, Williams KA, Kwatra SG
J Am Acad Dermatol 2020 Dec;83(6):1559-1565. Epub 2020 May 23 doi: 10.1016/j.jaad.2020.04.183. PMID: 32454098

Therapy

Nemolizumab: First Approval.
Keam SJ
Drugs 2022 Jul;82(10):1143-1150. Epub 2022 Jul 14 doi: 10.1007/s40265-022-01741-z. PMID: 35834124
Therapeutic potential of biologics in prurigo nodularis.
Müller S, Bieber T, Ständer S
Expert Opin Biol Ther 2022 Jan;22(1):47-58. Epub 2021 Aug 4 doi: 10.1080/14712598.2021.1958777. PMID: 34289753
Dupilumab: A Review of Present Indications and Off-Label Uses.
Muñoz-Bellido FJ, Moreno E, Dávila I
J Investig Allergol Clin Immunol 2022 Apr 19;32(2):97-115. Epub 2021 Mar 3 doi: 10.18176/jiaci.0682. PMID: 33661102
Prurigo Nodularis: Review and Emerging Treatments.
Leis M, Fleming P, Lynde CW
Skin Therapy Lett 2021 May;26(3):5-8. PMID: 34077168
Prurigo nodularis: Pathogenesis and management.
Williams KA, Huang AH, Belzberg M, Kwatra SG
J Am Acad Dermatol 2020 Dec;83(6):1567-1575. Epub 2020 May 24 doi: 10.1016/j.jaad.2020.04.182. PMID: 32461078

Prognosis

Children atopic dermatitis: Diagnosis, mimics, overlaps, and therapeutic implication.
Napolitano M, Fabbrocini G, Martora F, Genco L, Noto M, Patruno C
Dermatol Ther 2022 Dec;35(12):e15901. Epub 2022 Oct 13 doi: 10.1111/dth.15901. PMID: 36200594Free PMC Article
Dupilumab in prurigo nodularis: a systematic review of current evidence and analysis of predictive factors to response.
Husein-ElAhmed H, Steinhoff M
J Dermatolog Treat 2022 May;33(3):1547-1553. Epub 2020 Dec 3 doi: 10.1080/09546634.2020.1853024. PMID: 33200955
A systematic review and meta-analysis of the regional and age-related differences in atopic dermatitis clinical characteristics.
Yew YW, Thyssen JP, Silverberg JI
J Am Acad Dermatol 2019 Feb;80(2):390-401. Epub 2018 Oct 1 doi: 10.1016/j.jaad.2018.09.035. PMID: 30287309
Actinic Prurigo.
Rodríguez-Carreón AA, Rodríguez-Lobato E, Rodríguez-Gutiérrez G, Cuevas-González JC, Mancheno-Valencia A, Solís-Arias MP, Vega-Memije ME, Hojyo-Tomoka MT, Domínguez-Soto L
Skinmed 2015 Jul-Aug;13(4):287-95; quiz 296. Epub 2015 Aug 1 PMID: 26861426
Prurigo Pigmentosa: Literature Review.
Beutler BD, Cohen PR, Lee RA
Am J Clin Dermatol 2015 Dec;16(6):533-43. doi: 10.1007/s40257-015-0154-4. PMID: 26334426

Clinical prediction guides

Cutaneous reactive B-cell lymphoid proliferations.
Khalil S, Donthi D, Gru AA
J Cutan Pathol 2022 Oct;49(10):898-916. Epub 2022 Aug 4 doi: 10.1111/cup.14264. PMID: 35656820
Body dysmorphia in common skin diseases: results of an observational, cross-sectional multicentre study among dermatological outpatients in 17 European countries.
Schut C, Dalgard FJ, Bewley A, Evers AWM, Gieler U, Lien L, Sampogna F, Ständer S, Tomás-Aragonés L, Vulink N, Finlay AY, Legat FJ, Titeca G, Jemec GB, Misery L, Szabó C, Grivcheva-Panovska V, Spillekom-van Koulil S, Balieva F, Szepietowski JC, Reich A, Roque Ferreira B, Lvov A, Romanov D, Marron SE, Gracia-Cazaña T, Svensson A, Altunay IK, Thompson AR, Zeidler C, Kupfer J; ESDAP Study collaborators
Br J Dermatol 2022 Jul;187(1):115-125. Epub 2022 May 22 doi: 10.1111/bjd.21021. PMID: 35041211Free PMC Article
Dupilumab in prurigo nodularis: a systematic review of current evidence and analysis of predictive factors to response.
Husein-ElAhmed H, Steinhoff M
J Dermatolog Treat 2022 May;33(3):1547-1553. Epub 2020 Dec 3 doi: 10.1080/09546634.2020.1853024. PMID: 33200955
Phototherapy for Prurigo Nodularis: Our Experience and a Review of the Literature.
Arrieta A, Jaka A, Del Alcázar E, Blanco M, Carrascosa JM
Actas Dermosifiliogr (Engl Ed) 2021 Apr;112(4):339-344. Epub 2020 Nov 19 doi: 10.1016/j.ad.2020.11.007. PMID: 33221272
Trial of Nemolizumab in Moderate-to-Severe Prurigo Nodularis.
Ständer S, Yosipovitch G, Legat FJ, Lacour JP, Paul C, Narbutt J, Bieber T, Misery L, Wollenberg A, Reich A, Ahmad F, Piketty C
N Engl J Med 2020 Feb 20;382(8):706-716. doi: 10.1056/NEJMoa1908316. PMID: 32074418

Recent systematic reviews

Dupilumab in Inflammatory Skin Diseases: A Systematic Review.
Olbrich H, Sadik CD, Ludwig RJ, Thaçi D, Boch K
Biomolecules 2023 Mar 31;13(4) doi: 10.3390/biom13040634. PMID: 37189381Free PMC Article
Efficacy of dupilumab in chronic prurigo and chronic idiopathic pruritus: a systematic review of current evidence and analysis of response predictors.
Gael M, Adam T, Mariano-Bourin M, Bursztejn AC
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1541-1551. Epub 2022 May 31 doi: 10.1111/jdv.18221. PMID: 35569006
Non-Atopic Chronic Nodular Prurigo (Prurigo Nodularis Hyde): A Systematic Review of Best-Evidenced Treatment Options.
Frølunde AS, Wiis MAK, Ben Abdallah H, Elsgaard S, Danielsen AK, Deleuran M, Vestergaard C
Dermatology 2022;238(5):950-960. Epub 2022 Apr 13 doi: 10.1159/000523700. PMID: 35417906
Dupilumab in prurigo nodularis: a systematic review of current evidence and analysis of predictive factors to response.
Husein-ElAhmed H, Steinhoff M
J Dermatolog Treat 2022 May;33(3):1547-1553. Epub 2020 Dec 3 doi: 10.1080/09546634.2020.1853024. PMID: 33200955
A systematic review and meta-analysis of the regional and age-related differences in atopic dermatitis clinical characteristics.
Yew YW, Thyssen JP, Silverberg JI
J Am Acad Dermatol 2019 Feb;80(2):390-401. Epub 2018 Oct 1 doi: 10.1016/j.jaad.2018.09.035. PMID: 30287309

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