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Prurigo

MedGen UID:
10986
•Concept ID:
C0033771
•
Disease or Syndrome
Synonyms: Itchy skin eruption; itchy skin eruption; prurigo; Pruritic rash; pruritic rash
SNOMED CT: Prurigo (64144002); Pruritic rash (64144002); Itchy skin eruption (64144002)
 
Monarch Initiative: MONDO:0021739

Definition

A name applied to several itchy skin eruptions of unknown cause. The characteristic course is the formation of a dome-shaped papule with a small transient vesicle on top, followed by crusting over or lichenification. (From Dorland, 27th ed) [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrurigo

Professional guidelines

PubMed

Nemolizumab: a new key player in the treatment of prurigo nodularis.
Reich A
Br J Dermatol 2024 Jul 16;191(2):154-155. doi: 10.1093/bjd/ljae189. PMID: 38703061
Dupilumab as a novel treatment option for prurigo nodularis.
Nakajima S, Yonekura S, Nakamizo S, Egawa G, Kabashima K
J Allergy Clin Immunol 2023 Oct;152(4):870-872. Epub 2023 Aug 23 doi: 10.1016/j.jaci.2023.08.011. PMID: 37625462
Prurigo nodularis: Pathogenesis and management.
Williams KA, Huang AH, Belzberg M, Kwatra SG
J Am Acad Dermatol 2020 Dec;83(6):1567-1575. Epub 2020 May 24 doi: 10.1016/j.jaad.2020.04.182. PMID: 32461078

Recent clinical studies

Etiology

Prurigo pigmentosa: A multi-institutional retrospective study.
Shen A, Cheng CE, Malik R, Mark E, Vecerek N, Maloney N, Leavens J, Nambudiri VE, Saavedra AP, Hogeling M, Worswick S
J Am Acad Dermatol 2023 Aug;89(2):376-378. Epub 2023 Mar 30 doi: 10.1016/j.jaad.2023.03.034. PMID: 37001731
Cutaneous reactive B-cell lymphoid proliferations.
Khalil S, Donthi D, Gru AA
J Cutan Pathol 2022 Oct;49(10):898-916. Epub 2022 Aug 4 doi: 10.1111/cup.14264. PMID: 35656820
Dermal hyperneury.
Marušić Z, Korša L, Calonje E
Clin Dermatol 2021 Mar-Apr;39(2):291-294. Epub 2020 Oct 16 doi: 10.1016/j.clindermatol.2020.10.008. PMID: 34272024
Eosinophilic dermatoses.
Peckruhn M, Elsner P, Tittelbach J
J Dtsch Dermatol Ges 2019 Oct;17(10):1039-1051. Epub 2019 Sep 27 doi: 10.1111/ddg.13943. PMID: 31562692
Itch Management: Treatments under Development.
Pereira MP, Ständer S
Curr Probl Dermatol 2016;50:71-6. Epub 2016 Aug 23 doi: 10.1159/000446046. PMID: 27578074

Diagnosis

Molecular mechanisms of pruritus in prurigo nodularis.
Shao Y, Wang D, Zhu Y, Xiao Z, Jin T, Peng L, Shen Y, Tang H
Front Immunol 2023;14:1301817. Epub 2023 Nov 23 doi: 10.3389/fimmu.2023.1301817. PMID: 38077377Free PMC Article
Prurigo pigmentosa: A multi-institutional retrospective study.
Shen A, Cheng CE, Malik R, Mark E, Vecerek N, Maloney N, Leavens J, Nambudiri VE, Saavedra AP, Hogeling M, Worswick S
J Am Acad Dermatol 2023 Aug;89(2):376-378. Epub 2023 Mar 30 doi: 10.1016/j.jaad.2023.03.034. PMID: 37001731
Cutaneous reactive B-cell lymphoid proliferations.
Khalil S, Donthi D, Gru AA
J Cutan Pathol 2022 Oct;49(10):898-916. Epub 2022 Aug 4 doi: 10.1111/cup.14264. PMID: 35656820
Actinic Prurigo.
Rodríguez-Carreón AA, Rodríguez-Lobato E, Rodríguez-Gutiérrez G, Cuevas-González JC, Mancheno-Valencia A, Solís-Arias MP, Vega-Memije ME, Hojyo-Tomoka MT, Domínguez-Soto L
Skinmed 2015 Jul-Aug;13(4):287-95; quiz 296. Epub 2015 Aug 1 PMID: 26861426
Atopic dermatitis/atopic eczema.
Wallach D, Taïeb A
Chem Immunol Allergy 2014;100:81-96. Epub 2014 May 22 doi: 10.1159/000358606. PMID: 24925387

Therapy

Dupilumab: Mechanism of action, clinical, and translational science.
McCann MR, Kosloski MP, Xu C, Davis JD, Kamal MA
Clin Transl Sci 2024 Aug;17(8):e13899. doi: 10.1111/cts.13899. PMID: 39080841Free PMC Article
Ketogenic Diet and the Skin.
Harb D, Abdullah L, Kurban M, Abbas O
Skinmed 2023;21(5):315-320. Epub 2023 Nov 10 PMID: 37945356
Nemolizumab: First Approval.
Keam SJ
Drugs 2022 Jul;82(10):1143-1150. Epub 2022 Jul 14 doi: 10.1007/s40265-022-01741-z. PMID: 35834124
Prurigo Nodularis: Review and Emerging Treatments.
Leis M, Fleming P, Lynde CW
Skin Therapy Lett 2021 May;26(3):5-8. PMID: 34077168
Prurigo nodularis: Pathogenesis and management.
Williams KA, Huang AH, Belzberg M, Kwatra SG
J Am Acad Dermatol 2020 Dec;83(6):1567-1575. Epub 2020 May 24 doi: 10.1016/j.jaad.2020.04.182. PMID: 32461078

Prognosis

Clinical aspects and management of chronic itch.
Zeidler C, Raap U, Witte F, Ständer S
J Allergy Clin Immunol 2023 Jul;152(1):1-10. Epub 2023 May 11 doi: 10.1016/j.jaci.2023.04.018. PMID: 37178730
Children atopic dermatitis: Diagnosis, mimics, overlaps, and therapeutic implication.
Napolitano M, Fabbrocini G, Martora F, Genco L, Noto M, Patruno C
Dermatol Ther 2022 Dec;35(12):e15901. Epub 2022 Oct 13 doi: 10.1111/dth.15901. PMID: 36200594Free PMC Article
Non-dermatological Challenges of Chronic Itch.
Kremer AE, Mettang T, Weisshaar E
Acta Derm Venereol 2020 Jan 7;100(2):adv00025. doi: 10.2340/00015555-3345. PMID: 31940045Free PMC Article
Actinic Prurigo.
Rodríguez-Carreón AA, Rodríguez-Lobato E, Rodríguez-Gutiérrez G, Cuevas-González JC, Mancheno-Valencia A, Solís-Arias MP, Vega-Memije ME, Hojyo-Tomoka MT, Domínguez-Soto L
Skinmed 2015 Jul-Aug;13(4):287-95; quiz 296. Epub 2015 Aug 1 PMID: 26861426
Polymorphous light eruption.
Epstein JH
J Am Acad Dermatol 1980 Oct;3(4):329-43. doi: 10.1016/s0190-9622(80)80324-0. PMID: 7000864

Clinical prediction guides

Chronic Prurigo Including Prurigo Nodularis: New Insights and Treatments.
Müller S, Zeidler C, Ständer S
Am J Clin Dermatol 2024 Jan;25(1):15-33. Epub 2023 Sep 17 doi: 10.1007/s40257-023-00818-z. PMID: 37717255Free PMC Article
Clinical characteristics of elderly patients with atopic dermatitis - a retrospective observational study.
Jaworek AK, Hałubiec P, Kachnic N, Podolska A, Radzikowska J, Kozłowska A, Wojas-Pelc A
Folia Med Cracov 2023 Jul 30;63(2):29-40. doi: 10.24425/fmc.2023.145911. PMID: 37903377
The use of dupilumab in patients with HIV.
Edmonds N, Zhao P, Flowers RH
Int J STD AIDS 2022 Dec;33(14):1165-1173. Epub 2022 Oct 14 doi: 10.1177/09564624221129406. PMID: 36240731
Cutaneous reactive B-cell lymphoid proliferations.
Khalil S, Donthi D, Gru AA
J Cutan Pathol 2022 Oct;49(10):898-916. Epub 2022 Aug 4 doi: 10.1111/cup.14264. PMID: 35656820
Bullous prurigo pigmentosa.
De Francesco V, Quinkenstein E, Mariuzzi L, Frattasio A, Pillon B, Patrone P
Eur J Dermatol 2006 Mar-Apr;16(2):184-6. PMID: 16581574

Recent systematic reviews

Systemic Medication for the Treatment of Prurigo Nodularis-A Systematic Review.
McCampbell LE, Zaino ML, Ranpariya M, Patel T, Feldman SR
J Cutan Med Surg 2023 Nov;27(6):641-645. Epub 2023 Nov 21 doi: 10.1177/12034754231211797. PMID: 37987710
Dupilumab in Inflammatory Skin Diseases: A Systematic Review.
Olbrich H, Sadik CD, Ludwig RJ, Thaçi D, Boch K
Biomolecules 2023 Mar 31;13(4) doi: 10.3390/biom13040634. PMID: 37189381Free PMC Article
Dupilumab for the treatment of prurigo nodularis: A systematic review.
Cao P, Xu W, Jiang S, Zhang L
Front Immunol 2023;14:1092685. Epub 2023 Jan 20 doi: 10.3389/fimmu.2023.1092685. PMID: 36742321Free PMC Article
The use of dupilumab in patients with HIV.
Edmonds N, Zhao P, Flowers RH
Int J STD AIDS 2022 Dec;33(14):1165-1173. Epub 2022 Oct 14 doi: 10.1177/09564624221129406. PMID: 36240731
A systematic review and meta-analysis of the regional and age-related differences in atopic dermatitis clinical characteristics.
Yew YW, Thyssen JP, Silverberg JI
J Am Acad Dermatol 2019 Feb;80(2):390-401. Epub 2018 Oct 1 doi: 10.1016/j.jaad.2018.09.035. PMID: 30287309

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