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Psoriasis

MedGen UID:
10997
•Concept ID:
C0033860
•
Disease or Syndrome
Synonym: Psoriases
SNOMED CT: Psoriasis (9014002)
 
Monarch Initiative: MONDO:0005083
OMIM® Phenotypic series: PS177900

Definition

An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp. [from NCI]

Professional guidelines

PubMed

Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management.
Rogler G, Singh A, Kavanaugh A, Rubin DT
Gastroenterology 2021 Oct;161(4):1118-1132. Epub 2021 Aug 3 doi: 10.1053/j.gastro.2021.07.042. PMID: 34358489Free PMC Article
Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics.
Menter A, Strober BE, Kaplan DH, Kivelevitch D, Prater EF, Stoff B, Armstrong AW, Connor C, Cordoro KM, Davis DMR, Elewski BE, Gelfand JM, Gordon KB, Gottlieb AB, Kavanaugh A, Kiselica M, Korman NJ, Kroshinsky D, Lebwohl M, Leonardi CL, Lichten J, Lim HW, Mehta NN, Paller AS, Parra SL, Pathy AL, Rupani RN, Siegel M, Wong EB, Wu JJ, Hariharan V, Elmets CA
J Am Acad Dermatol 2019 Apr;80(4):1029-1072. Epub 2019 Feb 13 doi: 10.1016/j.jaad.2018.11.057. PMID: 30772098
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article

Recent clinical studies

Etiology

Management of psoriasis as a systemic disease: what is the evidence?
Korman NJ
Br J Dermatol 2020 Apr;182(4):840-848. Epub 2019 Oct 15 doi: 10.1111/bjd.18245. PMID: 31225638Free PMC Article
Risk Factors for the Development of Psoriasis.
Kamiya K, Kishimoto M, Sugai J, Komine M, Ohtsuki M
Int J Mol Sci 2019 Sep 5;20(18) doi: 10.3390/ijms20184347. PMID: 31491865Free PMC Article
Stress and psoriasis.
Rousset L, Halioua B
Int J Dermatol 2018 Oct;57(10):1165-1172. Epub 2018 May 4 doi: 10.1111/ijd.14032. PMID: 29729012
Psoriasis.
Weigle N, McBane S
Am Fam Physician 2013 May 1;87(9):626-33. PMID: 23668525
Psoriasis: epidemiology, clinical features, and quality of life.
Langley RG, Krueger GG, Griffiths CE
Ann Rheum Dis 2005 Mar;64 Suppl 2(Suppl 2):ii18-23; discussion ii24-5. doi: 10.1136/ard.2004.033217. PMID: 15708928Free PMC Article

Diagnosis

Psoriasis Pathogenesis and Treatment.
Rendon A, Schäkel K
Int J Mol Sci 2019 Mar 23;20(6) doi: 10.3390/ijms20061475. PMID: 30909615Free PMC Article
Childhood psoriasis.
Mahé E
Eur J Dermatol 2016 Dec 1;26(6):537-548. doi: 10.1684/ejd.2016.2932. PMID: 27900946
Psoriasis.
Boehncke WH, Schön MP
Lancet 2015 Sep 5;386(9997):983-94. Epub 2015 May 27 doi: 10.1016/S0140-6736(14)61909-7. PMID: 26025581
Psoriasis.
Weigle N, McBane S
Am Fam Physician 2013 May 1;87(9):626-33. PMID: 23668525
Psoriasis: epidemiology, clinical features, and quality of life.
Langley RG, Krueger GG, Griffiths CE
Ann Rheum Dis 2005 Mar;64 Suppl 2(Suppl 2):ii18-23; discussion ii24-5. doi: 10.1136/ard.2004.033217. PMID: 15708928Free PMC Article

Therapy

Long-term Safety of Secukinumab Over Five Years in Patients with Moderate-to-severe Plaque Psoriasis, Psoriatic Arthritis and Ankylosing Spondylitis: Update on Integrated Pooled Clinical Trial and Post-marketing Surveillance Data.
Gottlieb AB, Deodhar A, Mcinnes IB, Baraliakos X, Reich K, Schreiber S, Bao W, Marfo K, Richards HB, Pricop L, Shete A, Trivedi V, Keefe D, Papavassilis CC, Jagiello P, Papanastasiou P, Mease PJ, Lebwohl M
Acta Derm Venereol 2022 Apr 27;102:adv00698. doi: 10.2340/actadv.v102.563. PMID: 35146532Free PMC Article
Role of nutritional supplements in selected dermatological disorders: A review.
Sardana K, Sachdeva S
J Cosmet Dermatol 2022 Jan;21(1):85-98. Epub 2021 Sep 26 doi: 10.1111/jocd.14436. PMID: 34564936
IL-23 blockade with guselkumab potentially modifies psoriasis pathogenesis: rationale and study protocol of a phase 3b, randomised, double-blind, multicentre study in participants with moderate-to-severe plaque-type psoriasis (GUIDE).
Eyerich K, Weisenseel P, Pinter A, Schäkel K, Asadullah K, Wegner S, Muñoz-Elias EJ, Bartz H, Taut FJH, Reich K
BMJ Open 2021 Sep 13;11(9):e049822. doi: 10.1136/bmjopen-2021-049822. PMID: 34518264Free PMC Article
Switching biologics in psoriasis - practical guidance and evidence to support.
Tsai YC, Tsai TF
Expert Rev Clin Pharmacol 2020 May;13(5):493-503. Epub 2020 May 27 doi: 10.1080/17512433.2020.1767590. PMID: 32394765
Psoriasis Area Severity Index (PASI) and the Dermatology Life Quality Index (DLQI): the correlation between disease severity and psychological burden in patients treated with biological therapies.
Mattei PL, Corey KC, Kimball AB
J Eur Acad Dermatol Venereol 2014 Mar;28(3):333-7. Epub 2013 Feb 21 doi: 10.1111/jdv.12106. PMID: 23425140

Prognosis

Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial.
Hahn J, Cook NR, Alexander EK, Friedman S, Walter J, Bubes V, Kotler G, Lee IM, Manson JE, Costenbader KH
BMJ 2022 Jan 26;376:e066452. doi: 10.1136/bmj-2021-066452. PMID: 35082139Free PMC Article
National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study.
Parisi R, Iskandar IYK, Kontopantelis E, Augustin M, Griffiths CEM, Ashcroft DM; Global Psoriasis Atlas
BMJ 2020 May 28;369:m1590. doi: 10.1136/bmj.m1590. PMID: 32467098Free PMC Article
Prevalence, Incidence, and Risk of Cancer in Patients With Psoriasis and Psoriatic Arthritis: A Systematic Review and Meta-analysis.
Vaengebjerg S, Skov L, Egeberg A, Loft ND
JAMA Dermatol 2020 Apr 1;156(4):421-429. doi: 10.1001/jamadermatol.2020.0024. PMID: 32074260Free PMC Article
A systematic review of worldwide epidemiology of psoriasis.
Michalek IM, Loring B, John SM
J Eur Acad Dermatol Venereol 2017 Feb;31(2):205-212. Epub 2016 Aug 30 doi: 10.1111/jdv.13854. PMID: 27573025
Global epidemiology of psoriasis: a systematic review of incidence and prevalence.
Parisi R, Symmons DP, Griffiths CE, Ashcroft DM; Identification and Management of Psoriasis and Associated ComorbidiTy (IMPACT) project team
J Invest Dermatol 2013 Feb;133(2):377-85. Epub 2012 Sep 27 doi: 10.1038/jid.2012.339. PMID: 23014338

Clinical prediction guides

Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management.
Rogler G, Singh A, Kavanaugh A, Rubin DT
Gastroenterology 2021 Oct;161(4):1118-1132. Epub 2021 Aug 3 doi: 10.1053/j.gastro.2021.07.042. PMID: 34358489Free PMC Article
Nail Psoriasis: Diagnosis, Assessment, Treatment Options, and Unmet Clinical Needs.
Kaeley GS, Eder L, Aydin SZ, Rich P, Bakewell CJ
J Rheumatol 2021 Aug;48(8):1208-1220. Epub 2021 Feb 15 doi: 10.3899/jrheum.201471. PMID: 33589557
Psoriasis and male sexuality.
Dauendorffer JN, Ly S, Beylot-Barry M
Ann Dermatol Venereol 2019 Apr;146(4):273-278. Epub 2019 Mar 28 doi: 10.1016/j.annder.2019.01.021. PMID: 30928124
The skin in psoriasis: assessment and challenges.
Oji V, Luger TA
Clin Exp Rheumatol 2015 Sep-Oct;33(5 Suppl 93):S14-9. Epub 2015 Oct 15 PMID: 26472560
Assessing psoriasis severity and outcomes for clinical trials and routine clinical practice.
Chalmers RJ
Dermatol Clin 2015 Jan;33(1):57-71. doi: 10.1016/j.det.2014.09.005. PMID: 25412783

Recent systematic reviews

Antihypertensive drug use and psoriasis: A systematic review, meta- and network meta-analysis.
Song G, Yoon HY, Yee J, Kim MG, Gwak HS
Br J Clin Pharmacol 2022 Mar;88(3):933-941. Epub 2021 Oct 5 doi: 10.1111/bcp.15060. PMID: 34611920
National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study.
Parisi R, Iskandar IYK, Kontopantelis E, Augustin M, Griffiths CEM, Ashcroft DM; Global Psoriasis Atlas
BMJ 2020 May 28;369:m1590. doi: 10.1136/bmj.m1590. PMID: 32467098Free PMC Article
Comparison of Biologics and Oral Treatments for Plaque Psoriasis: A Meta-analysis.
Armstrong AW, Puig L, Joshi A, Skup M, Williams D, Li J, Betts KA, Augustin M
JAMA Dermatol 2020 Mar 1;156(3):258-269. doi: 10.1001/jamadermatol.2019.4029. PMID: 32022825Free PMC Article
Treatment preferences and treatment satisfaction among psoriasis patients: a systematic review.
Florek AG, Wang CJ, Armstrong AW
Arch Dermatol Res 2018 May;310(4):271-319. Epub 2018 Feb 13 doi: 10.1007/s00403-018-1808-x. PMID: 29442137
Global epidemiology of psoriasis: a systematic review of incidence and prevalence.
Parisi R, Symmons DP, Griffiths CE, Ashcroft DM; Identification and Management of Psoriasis and Associated ComorbidiTy (IMPACT) project team
J Invest Dermatol 2013 Feb;133(2):377-85. Epub 2012 Sep 27 doi: 10.1038/jid.2012.339. PMID: 23014338

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