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Psoriasis

MedGen UID:
10997
•Concept ID:
C0033860
•
Disease or Syndrome
Synonym: Psoriases
SNOMED CT: Psoriasis (9014002)
 
Monarch Initiative: MONDO:0005083
OMIM® Phenotypic series: PS177900

Definition

An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp. [from NCI]

Professional guidelines

PubMed

Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management.
Rogler G, Singh A, Kavanaugh A, Rubin DT
Gastroenterology 2021 Oct;161(4):1118-1132. Epub 2021 Aug 3 doi: 10.1053/j.gastro.2021.07.042. PMID: 34358489Free PMC Article
Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics.
Menter A, Strober BE, Kaplan DH, Kivelevitch D, Prater EF, Stoff B, Armstrong AW, Connor C, Cordoro KM, Davis DMR, Elewski BE, Gelfand JM, Gordon KB, Gottlieb AB, Kavanaugh A, Kiselica M, Korman NJ, Kroshinsky D, Lebwohl M, Leonardi CL, Lichten J, Lim HW, Mehta NN, Paller AS, Parra SL, Pathy AL, Rupani RN, Siegel M, Wong EB, Wu JJ, Hariharan V, Elmets CA
J Am Acad Dermatol 2019 Apr;80(4):1029-1072. Epub 2019 Feb 13 doi: 10.1016/j.jaad.2018.11.057. PMID: 30772098
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article

Recent clinical studies

Etiology

Psoriasis.
Griffiths CEM, Armstrong AW, Gudjonsson JE, Barker JNWN
Lancet 2021 Apr 3;397(10281):1301-1315. doi: 10.1016/S0140-6736(20)32549-6. PMID: 33812489
Risk Factors for the Development of Psoriasis.
Kamiya K, Kishimoto M, Sugai J, Komine M, Ohtsuki M
Int J Mol Sci 2019 Sep 5;20(18) doi: 10.3390/ijms20184347. PMID: 31491865Free PMC Article
Psoriasis risk factors and triggers.
Lee EB, Wu KK, Lee MP, Bhutani T, Wu JJ
Cutis 2018 Nov;102(5S):18-20. PMID: 30566552
Stress and psoriasis.
Rousset L, Halioua B
Int J Dermatol 2018 Oct;57(10):1165-1172. Epub 2018 May 4 doi: 10.1111/ijd.14032. PMID: 29729012
Psoriasis: epidemiology, clinical features, and quality of life.
Langley RG, Krueger GG, Griffiths CE
Ann Rheum Dis 2005 Mar;64 Suppl 2(Suppl 2):ii18-23; discussion ii24-5. doi: 10.1136/ard.2004.033217. PMID: 15708928Free PMC Article

Diagnosis

Psoriasis.
Heath CR, Usatine RP
Cutis 2021 Jul;108(1):56. doi: 10.12788/cutis.0298. PMID: 34397361
Psoriasis Pathogenesis and Treatment.
Rendon A, Schäkel K
Int J Mol Sci 2019 Mar 23;20(6) doi: 10.3390/ijms20061475. PMID: 30909615Free PMC Article
Psoriasis.
Yetto T
J Spec Oper Med 2015 Summer;15(2):132-135. doi: 10.55460/5U7D-YUYC. PMID: 26125177
Psoriasis.
Boehncke WH, Schön MP
Lancet 2015 Sep 5;386(9997):983-94. Epub 2015 May 27 doi: 10.1016/S0140-6736(14)61909-7. PMID: 26025581
Nail Psoriasis Severity Index: a useful tool for evaluation of nail psoriasis.
Rich P, Scher RK
J Am Acad Dermatol 2003 Aug;49(2):206-12. doi: 10.1067/s0190-9622(03)00910-1. PMID: 12894066

Therapy

Guselkumab for the treatment of palmoplantar pustulosis.
Murakami M
Expert Opin Biol Ther 2020 Aug;20(8):841-852. Epub 2020 May 12 doi: 10.1080/14712598.2020.1760244. PMID: 32321322
The Psoriatic Disease Payer Advisory Panel.
Greb JE, Merola J, Garg A, Latella J, Howard L, Acharya N, Gottlieb AB
J Drugs Dermatol 2016 May 1;15(5):641-4. PMID: 27168273
Ustekinumab for the treatment of psoriasis.
Laws PM, Warren RB
Expert Rev Clin Immunol 2011 Mar;7(2):155-64. doi: 10.1586/eci.11.4. PMID: 21426253
Psoriasis: emerging therapeutic strategies.
Gottlieb AB
Nat Rev Drug Discov 2005 Jan;4(1):19-34. doi: 10.1038/nrd1607. PMID: 15688070
Corticosteroids.
Hughes J, Rustin M
Clin Dermatol 1997 Sep-Oct;15(5):715-21. doi: 10.1016/s0738-081x(97)00020-5. PMID: 9313970

Prognosis

Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial.
Hahn J, Cook NR, Alexander EK, Friedman S, Walter J, Bubes V, Kotler G, Lee IM, Manson JE, Costenbader KH
BMJ 2022 Jan 26;376:e066452. doi: 10.1136/bmj-2021-066452. PMID: 35082139Free PMC Article
National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study.
Parisi R, Iskandar IYK, Kontopantelis E, Augustin M, Griffiths CEM, Ashcroft DM; Global Psoriasis Atlas
BMJ 2020 May 28;369:m1590. doi: 10.1136/bmj.m1590. PMID: 32467098Free PMC Article
Epidemiological characteristics of psoriatic arthritis.
Migkos MP, Somarakis GP, Markatseli TE, Voulgari PV, Drosos AA
Clin Exp Rheumatol 2019 Mar-Apr;37(2):324-332. Epub 2018 Oct 8 PMID: 30299245
Association between obesity and pediatric psoriasis.
Hunjan MK, Maradit Kremers H, Lohse C, Tollefson M
Pediatr Dermatol 2018 Sep;35(5):e304-e305. Epub 2018 Jul 19 doi: 10.1111/pde.13539. PMID: 30024063Free PMC Article
Neonatal erythroderma.
Fraitag S, Bodemer C
Curr Opin Pediatr 2010 Aug;22(4):438-44. doi: 10.1097/MOP.0b013e32833bc396. PMID: 20616730

Clinical prediction guides

Evaluation of corticophobia in patients with atopic dermatitis and psoriasis using the TOPICOP© score.
Starbek Zorko M, Benko M, Rakuša M, Prunk Zdravković T
Acta Dermatovenerol Alp Pannonica Adriat 2023 Dec;32(4):135-139. PMID: 38126095
Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management.
Rogler G, Singh A, Kavanaugh A, Rubin DT
Gastroenterology 2021 Oct;161(4):1118-1132. Epub 2021 Aug 3 doi: 10.1053/j.gastro.2021.07.042. PMID: 34358489Free PMC Article
Nail Psoriasis: Diagnosis, Assessment, Treatment Options, and Unmet Clinical Needs.
Kaeley GS, Eder L, Aydin SZ, Rich P, Bakewell CJ
J Rheumatol 2021 Aug;48(8):1208-1220. Epub 2021 Feb 15 doi: 10.3899/jrheum.201471. PMID: 33589557
The skin in psoriasis: assessment and challenges.
Oji V, Luger TA
Clin Exp Rheumatol 2015 Sep-Oct;33(5 Suppl 93):S14-9. Epub 2015 Oct 15 PMID: 26472560
Pathogenetic overview of psoriatic disease.
Haroon M, Fitzgerald O
J Rheumatol Suppl 2012 Jul;89:7-10. doi: 10.3899/jrheum.120232. PMID: 22751581

Recent systematic reviews

Palmoplantar Pustulosis: Therapy Update.
Devjani S, Smith B, Javadi SS, Engel PV, Han G, Wu JJ
J Drugs Dermatol 2024 Aug 1;23(8):626-631. doi: 10.36849/JDD.7612. PMID: 39093642
Physiological roles of human interleukin-17 family.
Liu Y, Ouyang Y, You W, Liu W, Cheng Y, Mai X, Shen Z
Exp Dermatol 2024 Jan;33(1):e14964. Epub 2023 Oct 31 doi: 10.1111/exd.14964. PMID: 37905720
Paradoxical eruptions to targeted therapies in dermatology: A systematic review and analysis.
Murphy MJ, Cohen JM, Vesely MD, Damsky W
J Am Acad Dermatol 2022 May;86(5):1080-1091. Epub 2020 Dec 8 doi: 10.1016/j.jaad.2020.12.010. PMID: 33307146
National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study.
Parisi R, Iskandar IYK, Kontopantelis E, Augustin M, Griffiths CEM, Ashcroft DM; Global Psoriasis Atlas
BMJ 2020 May 28;369:m1590. doi: 10.1136/bmj.m1590. PMID: 32467098Free PMC Article
A systematic review of worldwide epidemiology of psoriasis.
Michalek IM, Loring B, John SM
J Eur Acad Dermatol Venereol 2017 Feb;31(2):205-212. Epub 2016 Aug 30 doi: 10.1111/jdv.13854. PMID: 27573025

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