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Complex regional pain syndrome type 1

MedGen UID:
11159
•Concept ID:
C0034931
•
Disease or Syndrome
Synonym: Reflex sympathetic dystrophy
SNOMED CT: Complex regional pain syndrome type I (734947007); Complex regional pain syndrome type 1 (734947007); CRPS (complex regional pain syndrome) type I (734947007); Reflex sympathetic dystrophy (734947007)
 
Monarch Initiative: MONDO:0011441
OMIM®: 604335
Orphanet: ORPHA99995

Definition

Complex regional pain syndrome type 1 (CRPS1) is a form of complex regional pain syndrome (see this term) in which the pain is disproportionate to any known inciting event and is characterized by continuous pain, allodynia, or hyperalgesia as well as edema, coloration (changes in skin blood flow), or abnormal sudomotor activity in the region of pain. Onset of CRPS1 symptoms may occur within a few days to a month after an injury or trauma to the affected limb. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVComplex regional pain syndrome type 1
Follow this link to review classifications for Complex regional pain syndrome type 1 in Orphanet.

Professional guidelines

PubMed

Bisphosphonates in the treatment of complex regional pain syndrome: is bone the main player at early stage of the disease?
Varenna M, Crotti C
Rheumatol Int 2018 Nov;38(11):1959-1962. Epub 2018 Jul 14 doi: 10.1007/s00296-018-4101-6. PMID: 30008128
Complex Regional Pain Syndrome Type 1: Diagnosis and Management.
Lee JW, Lee SK, Choy WS
J Hand Surg Asian Pac Vol 2018 Mar;23(1):1-10. doi: 10.1142/S2424835518300013. PMID: 29409405
Stroke, complex regional pain syndrome and phantom limb pain: can commonalities direct future management?
Acerra NE, Souvlis T, Moseley GL
J Rehabil Med 2007 Mar;39(2):109-14. doi: 10.2340/16501977-0027. PMID: 17351691

Recent clinical studies

Etiology

Antidepressants for chronic non-cancer pain in children and adolescents.
Cooper TE, Heathcote LC, Clinch J, Gold JI, Howard R, Lord SM, Schechter N, Wood C, Wiffen PJ
Cochrane Database Syst Rev 2017 Aug 5;8(8):CD012535. doi: 10.1002/14651858.CD012535.pub2. PMID: 28779487Free PMC Article
Update on the effects of graded motor imagery and mirror therapy on complex regional pain syndrome type 1: A systematic review.
Méndez-Rebolledo G, Gatica-Rojas V, Torres-Cueco R, Albornoz-Verdugo M, Guzmán-Muñoz E
J Back Musculoskelet Rehabil 2017;30(3):441-449. doi: 10.3233/BMR-150500. PMID: 27858687
Complex regional pain syndrome type 1: Analysis of 108 patients.
Pendón G, Salas A, García M, Pereira D
Reumatol Clin 2017 Mar-Apr;13(2):73-77. Epub 2016 Apr 28 doi: 10.1016/j.reuma.2016.03.015. PMID: 27132482
Effects of Mirror Therapy in Stroke Patients With Complex Regional Pain Syndrome Type 1: A Randomized Controlled Study.
Pervane Vural S, Nakipoglu Yuzer GF, Sezgin Ozcan D, Demir Ozbudak S, Ozgirgin N
Arch Phys Med Rehabil 2016 Apr;97(4):575-581. Epub 2015 Dec 23 doi: 10.1016/j.apmr.2015.12.008. PMID: 26723854
Pain exposure physical therapy (PEPT) compared to conventional treatment in complex regional pain syndrome type 1: a randomised controlled trial.
Barnhoorn KJ, van de Meent H, van Dongen RT, Klomp FP, Groenewoud H, Samwel H, Nijhuis-van der Sanden MW, Frölke JP, Staal JB
BMJ Open 2015 Dec 1;5(12):e008283. doi: 10.1136/bmjopen-2015-008283. PMID: 26628523Free PMC Article

Diagnosis

Malingering and factitious disorder.
Bass C, Wade DT
Pract Neurol 2019 Apr;19(2):96-105. Epub 2018 Nov 13 doi: 10.1136/practneurol-2018-001950. PMID: 30425128
Complex Regional Pain Syndrome Type 1: Diagnosis and Management.
Lee JW, Lee SK, Choy WS
J Hand Surg Asian Pac Vol 2018 Mar;23(1):1-10. doi: 10.1142/S2424835518300013. PMID: 29409405
Complex regional pain syndrome type 1: Analysis of 108 patients.
Pendón G, Salas A, García M, Pereira D
Reumatol Clin 2017 Mar-Apr;13(2):73-77. Epub 2016 Apr 28 doi: 10.1016/j.reuma.2016.03.015. PMID: 27132482
Complex Regional Pain Type 1.
Barrett MJ, Barnett PL
Pediatr Emerg Care 2016 Mar;32(3):185-9; quiz 190-1. doi: 10.1097/PEC.0000000000000731. PMID: 26928099
Pain exposure physical therapy (PEPT) compared to conventional treatment in complex regional pain syndrome type 1: a randomised controlled trial.
Barnhoorn KJ, van de Meent H, van Dongen RT, Klomp FP, Groenewoud H, Samwel H, Nijhuis-van der Sanden MW, Frölke JP, Staal JB
BMJ Open 2015 Dec 1;5(12):e008283. doi: 10.1136/bmjopen-2015-008283. PMID: 26628523Free PMC Article

Therapy

Effect of Perioperative Vitamin C on the Incidence of Complex Regional Pain Syndrome: A Systematic Review and Meta-Analysis.
Seth I, Bulloch G, Seth N, Siu A, Clayton S, Lower K, Roshan S, Nara N
J Foot Ankle Surg 2022 Jul-Aug;61(4):748-754. Epub 2021 Nov 21 doi: 10.1053/j.jfas.2021.11.008. PMID: 34961681
Complex Regional Pain Syndrome Type 1: Diagnosis and Management.
Lee JW, Lee SK, Choy WS
J Hand Surg Asian Pac Vol 2018 Mar;23(1):1-10. doi: 10.1142/S2424835518300013. PMID: 29409405
Update on the effects of graded motor imagery and mirror therapy on complex regional pain syndrome type 1: A systematic review.
Méndez-Rebolledo G, Gatica-Rojas V, Torres-Cueco R, Albornoz-Verdugo M, Guzmán-Muñoz E
J Back Musculoskelet Rehabil 2017;30(3):441-449. doi: 10.3233/BMR-150500. PMID: 27858687
Effects of Mirror Therapy in Stroke Patients With Complex Regional Pain Syndrome Type 1: A Randomized Controlled Study.
Pervane Vural S, Nakipoglu Yuzer GF, Sezgin Ozcan D, Demir Ozbudak S, Ozgirgin N
Arch Phys Med Rehabil 2016 Apr;97(4):575-581. Epub 2015 Dec 23 doi: 10.1016/j.apmr.2015.12.008. PMID: 26723854
Pain exposure physical therapy (PEPT) compared to conventional treatment in complex regional pain syndrome type 1: a randomised controlled trial.
Barnhoorn KJ, van de Meent H, van Dongen RT, Klomp FP, Groenewoud H, Samwel H, Nijhuis-van der Sanden MW, Frölke JP, Staal JB
BMJ Open 2015 Dec 1;5(12):e008283. doi: 10.1136/bmjopen-2015-008283. PMID: 26628523Free PMC Article

Prognosis

Effect of Perioperative Vitamin C on the Incidence of Complex Regional Pain Syndrome: A Systematic Review and Meta-Analysis.
Seth I, Bulloch G, Seth N, Siu A, Clayton S, Lower K, Roshan S, Nara N
J Foot Ankle Surg 2022 Jul-Aug;61(4):748-754. Epub 2021 Nov 21 doi: 10.1053/j.jfas.2021.11.008. PMID: 34961681
Complex regional pain syndrome type 1: Analysis of 108 patients.
Pendón G, Salas A, García M, Pereira D
Reumatol Clin 2017 Mar-Apr;13(2):73-77. Epub 2016 Apr 28 doi: 10.1016/j.reuma.2016.03.015. PMID: 27132482
The outcome of complex regional pain syndrome type 1: a systematic review.
Bean DJ, Johnson MH, Kydd RR
J Pain 2014 Jul;15(7):677-90. Epub 2014 Feb 12 doi: 10.1016/j.jpain.2014.01.500. PMID: 24530407
Thermal pain in complex regional pain syndrome type I.
Grothusen JR, Alexander G, Erwin K, Schwartzman R
Pain Physician 2014 Jan-Feb;17(1):71-9. PMID: 24452647
Diagnosis of partial complex regional pain syndrome type 1 of the hand: retrospective study of 16 cases and literature review.
Konzelmann M, Deriaz O, Luthi F
BMC Neurol 2013 Mar 18;13:28. doi: 10.1186/1471-2377-13-28. PMID: 23506090Free PMC Article

Clinical prediction guides

Effect of Perioperative Vitamin C on the Incidence of Complex Regional Pain Syndrome: A Systematic Review and Meta-Analysis.
Seth I, Bulloch G, Seth N, Siu A, Clayton S, Lower K, Roshan S, Nara N
J Foot Ankle Surg 2022 Jul-Aug;61(4):748-754. Epub 2021 Nov 21 doi: 10.1053/j.jfas.2021.11.008. PMID: 34961681
Complex regional pain syndrome type 1: Analysis of 108 patients.
Pendón G, Salas A, García M, Pereira D
Reumatol Clin 2017 Mar-Apr;13(2):73-77. Epub 2016 Apr 28 doi: 10.1016/j.reuma.2016.03.015. PMID: 27132482
Effects of Mirror Therapy in Stroke Patients With Complex Regional Pain Syndrome Type 1: A Randomized Controlled Study.
Pervane Vural S, Nakipoglu Yuzer GF, Sezgin Ozcan D, Demir Ozbudak S, Ozgirgin N
Arch Phys Med Rehabil 2016 Apr;97(4):575-581. Epub 2015 Dec 23 doi: 10.1016/j.apmr.2015.12.008. PMID: 26723854
Pain exposure physical therapy (PEPT) compared to conventional treatment in complex regional pain syndrome type 1: a randomised controlled trial.
Barnhoorn KJ, van de Meent H, van Dongen RT, Klomp FP, Groenewoud H, Samwel H, Nijhuis-van der Sanden MW, Frölke JP, Staal JB
BMJ Open 2015 Dec 1;5(12):e008283. doi: 10.1136/bmjopen-2015-008283. PMID: 26628523Free PMC Article
The outcome of complex regional pain syndrome type 1: a systematic review.
Bean DJ, Johnson MH, Kydd RR
J Pain 2014 Jul;15(7):677-90. Epub 2014 Feb 12 doi: 10.1016/j.jpain.2014.01.500. PMID: 24530407

Recent systematic reviews

Effect of Perioperative Vitamin C on the Incidence of Complex Regional Pain Syndrome: A Systematic Review and Meta-Analysis.
Seth I, Bulloch G, Seth N, Siu A, Clayton S, Lower K, Roshan S, Nara N
J Foot Ankle Surg 2022 Jul-Aug;61(4):748-754. Epub 2021 Nov 21 doi: 10.1053/j.jfas.2021.11.008. PMID: 34961681
Antidepressants for chronic non-cancer pain in children and adolescents.
Cooper TE, Heathcote LC, Clinch J, Gold JI, Howard R, Lord SM, Schechter N, Wood C, Wiffen PJ
Cochrane Database Syst Rev 2017 Aug 5;8(8):CD012535. doi: 10.1002/14651858.CD012535.pub2. PMID: 28779487Free PMC Article
Bisphosphonates for treatment of Complex Regional Pain Syndrome type 1: A systematic literature review and meta-analysis of randomized controlled trials versus placebo.
Chevreau M, Romand X, Gaudin P, Juvin R, Baillet A
Joint Bone Spine 2017 Jul;84(4):393-399. Epub 2017 Apr 11 doi: 10.1016/j.jbspin.2017.03.009. PMID: 28408275
Update on the effects of graded motor imagery and mirror therapy on complex regional pain syndrome type 1: A systematic review.
Méndez-Rebolledo G, Gatica-Rojas V, Torres-Cueco R, Albornoz-Verdugo M, Guzmán-Muñoz E
J Back Musculoskelet Rehabil 2017;30(3):441-449. doi: 10.3233/BMR-150500. PMID: 27858687
The outcome of complex regional pain syndrome type 1: a systematic review.
Bean DJ, Johnson MH, Kydd RR
J Pain 2014 Jul;15(7):677-90. Epub 2014 Feb 12 doi: 10.1016/j.jpain.2014.01.500. PMID: 24530407

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