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Schizoaffective disorder

MedGen UID:
11334
Concept ID:
C0036337
Mental or Behavioral Dysfunction
Synonyms: Disorder, Schizoaffective; Disorders, Schizoaffective; Schizoaffective Disorder; Schizoaffective Disorders
SNOMED CT: Schizoaffective disorder (68890003); Schizoaffective schizophrenia (191567000)
 
Monarch Initiative: MONDO:0005487

Definition

A disorder in which the individual suffers from both symptoms that qualify as schizophrenia and symptoms that qualify as a mood disorder (e.g., depression or bipolar disorder) for a substantial portion (but not all) of the active period of the illness; for the remainder of the active period of the illness, the individual suffers from delusions or hallucinations in the absence of prominent mood symptoms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSchizoaffective disorder

Professional guidelines

PubMed

Ramain J, Conus P, Golay P
Psychiatry Res 2022 Aug;314:114690. Epub 2022 Jun 21 doi: 10.1016/j.psychres.2022.114690. PMID: 35753221
Schneider-Thoma J, Chalkou K, Dörries C, Bighelli I, Ceraso A, Huhn M, Siafis S, Davis JM, Cipriani A, Furukawa TA, Salanti G, Leucht S
Lancet 2022 Feb 26;399(10327):824-836. doi: 10.1016/S0140-6736(21)01997-8. PMID: 35219395
Pacchiarotti I, Tiihonen J, Kotzalidis GD, Verdolini N, Murru A, Goikolea JM, Valentí M, Aedo A, Vieta E
Eur Neuropsychopharmacol 2019 Apr;29(4):457-470. Epub 2019 Feb 12 doi: 10.1016/j.euroneuro.2019.02.003. PMID: 30770235

Recent clinical studies

Etiology

Lawrence RE, Bernstein A
Emerg Med Clin North Am 2024 Feb;42(1):93-104. Epub 2023 Jul 28 doi: 10.1016/j.emc.2023.06.012. PMID: 37977755
Citrome L, Preskorn SH, Lauriello J, Krystal JH, Kakar R, Finman J, De Vivo M, Yocca FD, Risinger R, Rajachandran L
J Clin Psychiatry 2022 Oct 3;83(6) doi: 10.4088/JCP.22m14447. PMID: 36198061
Tondo L, Vázquez GH, Baethge C, Baronessa C, Bolzani L, Koukopoulos A, Mazzarini L, Murru A, Pacchiarotti I, Pinna M, Salvatore P, Sani G, Selle V, Spalletta G, Girardi P, Tohen M, Vieta E, Baldessarini RJ
Acta Psychiatr Scand 2016 Jan;133(1):34-43. Epub 2015 Jun 11 doi: 10.1111/acps.12447. PMID: 26096273
Houthoofd SA, Morrens M, Sabbe BG
Clin Ther 2008 Sep;30(9):1565-89. doi: 10.1016/j.clinthera.2008.09.014. PMID: 18840365
Marneros A
Acta Psychiatr Scand Suppl 2003;(418):29-33. doi: 10.1034/j.1600-0447.108.s418.7.x. PMID: 12956811

Diagnosis

Fischer CE, Namasivayam A, Crawford-Holland L, Hakobyan N, Schweizer TA, Munoz DG, Pollock BG
Psychiatr Clin North Am 2022 Dec;45(4):691-705. Epub 2022 Oct 14 doi: 10.1016/j.psc.2022.07.001. PMID: 36396273
Muñoz-Negro JE, Cuadrado L, Cervilla JA
Actas Esp Psiquiatr 2019 Sep;47(5):190-201. Epub 2019 Sep 1 PMID: 31648341
Miller JN, Black DW
Ann Clin Psychiatry 2019 Feb;31(1):47-53. PMID: 30699217
Tandon R, Gaebel W, Barch DM, Bustillo J, Gur RE, Heckers S, Malaspina D, Owen MJ, Schultz S, Tsuang M, Van Os J, Carpenter W
Schizophr Res 2013 Oct;150(1):3-10. Epub 2013 Jun 22 doi: 10.1016/j.schres.2013.05.028. PMID: 23800613
Malaspina D, Owen MJ, Heckers S, Tandon R, Bustillo J, Schultz S, Barch DM, Gaebel W, Gur RE, Tsuang M, Van Os J, Carpenter W
Schizophr Res 2013 Oct;150(1):21-5. Epub 2013 May 23 doi: 10.1016/j.schres.2013.04.026. PMID: 23707642

Therapy

Efthimiou O, Taipale H, Radua J, Schneider-Thoma J, Pinzón-Espinosa J, Ortuño M, Vinkers CH, Mittendorfer-Rutz E, Cardoner N, Tanskanen A, Fusar-Poli P, Cipriani A, Vieta E, Leucht S, Tiihonen J, Luykx JJ
Lancet Psychiatry 2024 Feb;11(2):102-111. Epub 2024 Jan 9 doi: 10.1016/S2215-0366(23)00366-8. PMID: 38215784
Muñoz-Negro JE, Cuadrado L, Cervilla JA
Actas Esp Psiquiatr 2019 Sep;47(5):190-201. Epub 2019 Sep 1 PMID: 31648341
Favrod J, Nguyen A, Chaix J, Pellet J, Frobert L, Fankhauser C, Ismailaj A, Brana A, Tamic G, Suter C, Rexhaj S, Golay P, Bonsack C
Psychother Psychosom 2019;88(2):84-95. Epub 2019 Feb 18 doi: 10.1159/000496479. PMID: 30783071Free PMC Article
Plosker GL, Deeks ED
CNS Drugs 2016 Jul;30(7):655-66. doi: 10.1007/s40263-016-0363-2. PMID: 27356921
McGavin JK, Goa KL
CNS Drugs 2002;16(11):779-86; discussion 787-8. doi: 10.2165/00023210-200216110-00008. PMID: 12383035

Prognosis

Chan SKW, Chan HYV, Honer WG, Bastiampillai T, Suen YN, Yeung WS, Lam M, Lee WK, Ng RMK, Hui CLM, Chang WC, Lee EHM, Chen EYH
Schizophr Bull 2021 Mar 16;47(2):485-494. doi: 10.1093/schbul/sbaa145. PMID: 33043960Free PMC Article
Archibald L, Brunette MF, Wallin DJ, Green AI
Alcohol Res 2019;40(1) Epub 2019 Dec 20 doi: 10.35946/arcr.v40.1.06. PMID: 31886105Free PMC Article
Tandon R, Gaebel W, Barch DM, Bustillo J, Gur RE, Heckers S, Malaspina D, Owen MJ, Schultz S, Tsuang M, Van Os J, Carpenter W
Schizophr Res 2013 Oct;150(1):3-10. Epub 2013 Jun 22 doi: 10.1016/j.schres.2013.05.028. PMID: 23800613
Malaspina D, Owen MJ, Heckers S, Tandon R, Bustillo J, Schultz S, Barch DM, Gaebel W, Gur RE, Tsuang M, Van Os J, Carpenter W
Schizophr Res 2013 Oct;150(1):21-5. Epub 2013 May 23 doi: 10.1016/j.schres.2013.04.026. PMID: 23707642
Baer L, Jenike MA
Psychiatr Clin North Am 1992 Dec;15(4):803-12. PMID: 1461797

Clinical prediction guides

Sethi S, Wakeham D, Ketter T, Hooshmand F, Bjornstad J, Richards B, Westman E, Krauss RM, Saslow L
Psychiatry Res 2024 May;335:115866. Epub 2024 Mar 20 doi: 10.1016/j.psychres.2024.115866. PMID: 38547601
Citrome L, Preskorn SH, Lauriello J, Krystal JH, Kakar R, Finman J, De Vivo M, Yocca FD, Risinger R, Rajachandran L
J Clin Psychiatry 2022 Oct 3;83(6) doi: 10.4088/JCP.22m14447. PMID: 36198061
Orr C, Deshpande S, Sawh S, Jones PM, Vasudev K
Can J Psychiatry 2017 Feb;62(2):123-137. Epub 2016 Aug 6 doi: 10.1177/0706743716661324. PMID: 27481921Free PMC Article
Niculescu AB, Levey DF, Phalen PL, Le-Niculescu H, Dainton HD, Jain N, Belanger E, James A, George S, Weber H, Graham DL, Schweitzer R, Ladd TB, Learman R, Niculescu EM, Vanipenta NP, Khan FN, Mullen J, Shankar G, Cook S, Humbert C, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR
Mol Psychiatry 2015 Nov;20(11):1266-85. Epub 2015 Aug 18 doi: 10.1038/mp.2015.112. PMID: 26283638Free PMC Article
Grisso T, Appelbaum PS, Hill-Fotouhi C
Psychiatr Serv 1997 Nov;48(11):1415-9. doi: 10.1176/ps.48.11.1415. PMID: 9355168

Recent systematic reviews

Guaiana G, Abbatecola M, Aali G, Tarantino F, Ebuenyi ID, Lucarini V, Li W, Zhang C, Pinto A
Cochrane Database Syst Rev 2022 Jul 12;7(7):CD009608. doi: 10.1002/14651858.CD009608.pub2. PMID: 35866377Free PMC Article
Schneider-Thoma J, Chalkou K, Dörries C, Bighelli I, Ceraso A, Huhn M, Siafis S, Davis JM, Cipriani A, Furukawa TA, Salanti G, Leucht S
Lancet 2022 Feb 26;399(10327):824-836. doi: 10.1016/S0140-6736(21)01997-8. PMID: 35219395
Hagi K, Nosaka T, Dickinson D, Lindenmayer JP, Lee J, Friedman J, Boyer L, Han M, Abdul-Rashid NA, Correll CU
JAMA Psychiatry 2021 May 1;78(5):510-518. doi: 10.1001/jamapsychiatry.2021.0015. PMID: 33656533Free PMC Article
Pacchiarotti I, Tiihonen J, Kotzalidis GD, Verdolini N, Murru A, Goikolea JM, Valentí M, Aedo A, Vieta E
Eur Neuropsychopharmacol 2019 Apr;29(4):457-470. Epub 2019 Feb 12 doi: 10.1016/j.euroneuro.2019.02.003. PMID: 30770235
de Silva VA, Suraweera C, Ratnatunga SS, Dayabandara M, Wanniarachchi N, Hanwella R
BMC Psychiatry 2016 Oct 3;16(1):341. doi: 10.1186/s12888-016-1049-5. PMID: 27716110Free PMC Article

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