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Schizoaffective disorder

MedGen UID:
11334
•Concept ID:
C0036337
•
Mental or Behavioral Dysfunction
Synonyms: Disorder, Schizoaffective; Disorders, Schizoaffective; Schizoaffective Disorder; Schizoaffective Disorders
SNOMED CT: Schizoaffective disorder (68890003); Schizoaffective schizophrenia (191567000)
 
Monarch Initiative: MONDO:0005487

Definition

A disorder in which the individual suffers from both symptoms that qualify as schizophrenia and symptoms that qualify as a mood disorder (e.g., depression or bipolar disorder) for a substantial portion (but not all) of the active period of the illness; for the remainder of the active period of the illness, the individual suffers from delusions or hallucinations in the absence of prominent mood symptoms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSchizoaffective disorder

Professional guidelines

PubMed

Comparative efficacy and tolerability of 32 oral and long-acting injectable antipsychotics for the maintenance treatment of adults with schizophrenia: a systematic review and network meta-analysis.
Schneider-Thoma J, Chalkou K, Dörries C, Bighelli I, Ceraso A, Huhn M, Siafis S, Davis JM, Cipriani A, Furukawa TA, Salanti G, Leucht S
Lancet 2022 Feb 26;399(10327):824-836. doi: 10.1016/S0140-6736(21)01997-8. PMID: 35219395
Long-acting injectable antipsychotics (LAIs) for maintenance treatment of bipolar and schizoaffective disorders: A systematic review.
Pacchiarotti I, Tiihonen J, Kotzalidis GD, Verdolini N, Murru A, Goikolea JM, Valentí M, Aedo A, Vieta E
Eur Neuropsychopharmacol 2019 Apr;29(4):457-470. Epub 2019 Feb 12 doi: 10.1016/j.euroneuro.2019.02.003. PMID: 30770235
Metformin in prevention and treatment of antipsychotic induced weight gain: a systematic review and meta-analysis.
de Silva VA, Suraweera C, Ratnatunga SS, Dayabandara M, Wanniarachchi N, Hanwella R
BMC Psychiatry 2016 Oct 3;16(1):341. doi: 10.1186/s12888-016-1049-5. PMID: 27716110Free PMC Article

Recent clinical studies

Etiology

Sublingual Dexmedetomidine for the Treatment of Acute Agitation in Adults With Schizophrenia or Schizoaffective Disorder: A Randomized Placebo-Controlled Trial.
Citrome L, Preskorn SH, Lauriello J, Krystal JH, Kakar R, Finman J, De Vivo M, Yocca FD, Risinger R, Rajachandran L
J Clin Psychiatry 2022 Oct 3;83(6) doi: 10.4088/JCP.22m14447. PMID: 36198061
A retrospective naturalistic study on the psychopharmacological treatment of schizoaffective disorder.
Muñoz-Negro JE, Aguado Bailón L, Calvo Rivera P, Cervilla JA
Int Clin Psychopharmacol 2021 Sep 1;36(5):257-263. doi: 10.1097/YIC.0000000000000374. PMID: 34270506
Life events in schizoaffective disorder: A systematic review.
Vardaxi CC, Gonda X, Fountoulakis KN
J Affect Disord 2018 Feb;227:563-570. Epub 2017 Nov 15 doi: 10.1016/j.jad.2017.11.076. PMID: 29172048
Schizoaffective disorder and metabolic syndrome: A meta-analytic comparison with schizophrenia and other non-affective psychoses.
Bartoli F, Crocamo C, Caslini M, Clerici M, Carrà G
J Psychiatr Res 2015 Jul-Aug;66-67:127-34. Epub 2015 May 11 doi: 10.1016/j.jpsychires.2015.04.028. PMID: 26004300
Genetic relationships between schizophrenia, bipolar disorder, and schizoaffective disorder.
Cardno AG, Owen MJ
Schizophr Bull 2014 May;40(3):504-15. Epub 2014 Feb 24 doi: 10.1093/schbul/sbu016. PMID: 24567502Free PMC Article

Diagnosis

Psychotic Disorders in the Elderly: Diagnosis, Epidemiology, and Treatment.
Fischer CE, Namasivayam A, Crawford-Holland L, Hakobyan N, Schweizer TA, Munoz DG, Pollock BG
Psychiatr Clin North Am 2022 Dec;45(4):691-705. Epub 2022 Oct 14 doi: 10.1016/j.psc.2022.07.001. PMID: 36396273
Current Evidences on Psychopharmacology of Schizoaffective Disorder.
Muñoz-Negro JE, Cuadrado L, Cervilla JA
Actas Esp Psiquiatr 2019 Sep;47(5):190-201. Epub 2019 Sep 1 PMID: 31648341
Schizoaffective disorder: A review.
Miller JN, Black DW
Ann Clin Psychiatry 2019 Feb;31(1):47-53. PMID: 30699217
Definition and description of schizophrenia in the DSM-5.
Tandon R, Gaebel W, Barch DM, Bustillo J, Gur RE, Heckers S, Malaspina D, Owen MJ, Schultz S, Tsuang M, Van Os J, Carpenter W
Schizophr Res 2013 Oct;150(1):3-10. Epub 2013 Jun 22 doi: 10.1016/j.schres.2013.05.028. PMID: 23800613
Schizoaffective Disorder in the DSM-5.
Malaspina D, Owen MJ, Heckers S, Tandon R, Bustillo J, Schultz S, Barch DM, Gaebel W, Gur RE, Tsuang M, Van Os J, Carpenter W
Schizophr Res 2013 Oct;150(1):21-5. Epub 2013 May 23 doi: 10.1016/j.schres.2013.04.026. PMID: 23707642

Therapy

Sublingual Dexmedetomidine for the Treatment of Acute Agitation in Adults With Schizophrenia or Schizoaffective Disorder: A Randomized Placebo-Controlled Trial.
Citrome L, Preskorn SH, Lauriello J, Krystal JH, Kakar R, Finman J, De Vivo M, Yocca FD, Risinger R, Rajachandran L
J Clin Psychiatry 2022 Oct 3;83(6) doi: 10.4088/JCP.22m14447. PMID: 36198061
Current Evidences on Psychopharmacology of Schizoaffective Disorder.
Muñoz-Negro JE, Cuadrado L, Cervilla JA
Actas Esp Psiquiatr 2019 Sep;47(5):190-201. Epub 2019 Sep 1 PMID: 31648341
Improving Pleasure and Motivation in Schizophrenia: A Randomized Controlled Clinical Trial.
Favrod J, Nguyen A, Chaix J, Pellet J, Frobert L, Fankhauser C, Ismailaj A, Brana A, Tamic G, Suter C, Rexhaj S, Golay P, Bonsack C
Psychother Psychosom 2019;88(2):84-95. Epub 2019 Feb 18 doi: 10.1159/000496479. PMID: 30783071Free PMC Article
KINECT 3: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Trial of Valbenazine for Tardive Dyskinesia.
Hauser RA, Factor SA, Marder SR, Knesevich MA, Ramirez PM, Jimenez R, Burke J, Liang GS, O'Brien CF
Am J Psychiatry 2017 May 1;174(5):476-484. Epub 2017 Mar 21 doi: 10.1176/appi.ajp.2017.16091037. PMID: 28320223
Family intervention for schizophrenia.
Pharoah F, Mari J, Rathbone J, Wong W
Cochrane Database Syst Rev 2010 Dec 8;(12):CD000088. doi: 10.1002/14651858.CD000088.pub2. PMID: 21154340Free PMC Article

Prognosis

Alcohol Use Disorder and Schizophrenia or Schizoaffective Disorder.
Archibald L, Brunette MF, Wallin DJ, Green AI
Alcohol Res 2019;40(1) Epub 2019 Dec 20 doi: 10.35946/arcr.v40.1.06. PMID: 31886105Free PMC Article
Hippocampal volume and vasculature before and after exercise in treatment-resistant schizophrenia.
Woodward ML, Gicas KM, Warburton DE, White RF, Rauscher A, Leonova O, Su W, Smith GN, Thornton AE, Vertinsky AT, Phillips AA, Goghari VM, Honer WG, Lang DJ
Schizophr Res 2018 Dec;202:158-165. Epub 2018 Jun 29 doi: 10.1016/j.schres.2018.06.054. PMID: 30539767
Life events in schizoaffective disorder: A systematic review.
Vardaxi CC, Gonda X, Fountoulakis KN
J Affect Disord 2018 Feb;227:563-570. Epub 2017 Nov 15 doi: 10.1016/j.jad.2017.11.076. PMID: 29172048
Definition and description of schizophrenia in the DSM-5.
Tandon R, Gaebel W, Barch DM, Bustillo J, Gur RE, Heckers S, Malaspina D, Owen MJ, Schultz S, Tsuang M, Van Os J, Carpenter W
Schizophr Res 2013 Oct;150(1):3-10. Epub 2013 Jun 22 doi: 10.1016/j.schres.2013.05.028. PMID: 23800613
Schizoaffective Disorder in the DSM-5.
Malaspina D, Owen MJ, Heckers S, Tandon R, Bustillo J, Schultz S, Barch DM, Gaebel W, Gur RE, Tsuang M, Van Os J, Carpenter W
Schizophr Res 2013 Oct;150(1):21-5. Epub 2013 May 23 doi: 10.1016/j.schres.2013.04.026. PMID: 23707642

Clinical prediction guides

Sublingual Dexmedetomidine for the Treatment of Acute Agitation in Adults With Schizophrenia or Schizoaffective Disorder: A Randomized Placebo-Controlled Trial.
Citrome L, Preskorn SH, Lauriello J, Krystal JH, Kakar R, Finman J, De Vivo M, Yocca FD, Risinger R, Rajachandran L
J Clin Psychiatry 2022 Oct 3;83(6) doi: 10.4088/JCP.22m14447. PMID: 36198061
Electrocardiographic abnormalities and psychotropic polypharmacy in schizophrenia and schizoaffective disorders.
Tirupati S, Gulati S
Australas Psychiatry 2022 Apr;30(2):243-246. Epub 2021 Nov 27 doi: 10.1177/10398562211047462. PMID: 34839745
The Effects of Psychoeducation on Long-term Inpatients with Schizophrenia and Schizoaffective Disorder.
Yanagida N, Uchino T, Uchimura N
Kurume Med J 2017 May 8;63(3.4):61-67. Epub 2017 Apr 3 doi: 10.2739/kurumemedj.MS00011. PMID: 28381728
Characteristics of patients diagnosed with schizoaffective disorder compared with schizophrenia and bipolar disorder.
Pagel T, Baldessarini RJ, Franklin J, Baethge C
Bipolar Disord 2013 May;15(3):229-39. Epub 2013 Mar 26 doi: 10.1111/bdi.12057. PMID: 23528024
The MacCAT-T: a clinical tool to assess patients' capacities to make treatment decisions.
Grisso T, Appelbaum PS, Hill-Fotouhi C
Psychiatr Serv 1997 Nov;48(11):1415-9. doi: 10.1176/ps.48.11.1415. PMID: 9355168

Recent systematic reviews

Comparative efficacy and tolerability of 32 oral and long-acting injectable antipsychotics for the maintenance treatment of adults with schizophrenia: a systematic review and network meta-analysis.
Schneider-Thoma J, Chalkou K, Dörries C, Bighelli I, Ceraso A, Huhn M, Siafis S, Davis JM, Cipriani A, Furukawa TA, Salanti G, Leucht S
Lancet 2022 Feb 26;399(10327):824-836. doi: 10.1016/S0140-6736(21)01997-8. PMID: 35219395
Clozapine in patients with schizoaffective disorder: A systematic review.
Rey Souto D, Pinzón Espinosa J, Vieta E, Benabarre Hernández A
Rev Psiquiatr Salud Ment (Engl Ed) 2021 Jul-Sep;14(3):148-156. Epub 2021 Aug 13 doi: 10.1016/j.rpsmen.2021.07.001. PMID: 34400122
Long-acting injectable antipsychotics (LAIs) for maintenance treatment of bipolar and schizoaffective disorders: A systematic review.
Pacchiarotti I, Tiihonen J, Kotzalidis GD, Verdolini N, Murru A, Goikolea JM, Valentí M, Aedo A, Vieta E
Eur Neuropsychopharmacol 2019 Apr;29(4):457-470. Epub 2019 Feb 12 doi: 10.1016/j.euroneuro.2019.02.003. PMID: 30770235
Life events in schizoaffective disorder: A systematic review.
Vardaxi CC, Gonda X, Fountoulakis KN
J Affect Disord 2018 Feb;227:563-570. Epub 2017 Nov 15 doi: 10.1016/j.jad.2017.11.076. PMID: 29172048
Metformin in prevention and treatment of antipsychotic induced weight gain: a systematic review and meta-analysis.
de Silva VA, Suraweera C, Ratnatunga SS, Dayabandara M, Wanniarachchi N, Hanwella R
BMC Psychiatry 2016 Oct 3;16(1):341. doi: 10.1186/s12888-016-1049-5. PMID: 27716110Free PMC Article

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