U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Serum sickness

MedGen UID:
11390
Concept ID:
C0036830
Disease or Syndrome
Synonyms: Serum Sickness; Serum Sicknesses; Sickness, Serum; Sicknesses, Serum
SNOMED CT: Transfusion reaction due to serum protein reaction (72284000); Protein sickness (72284000); Intoxication by serum (72284000); Serum reaction (72284000); Serum rash (213323001); Urticaria due to serum (213325008); Urticaria caused by serum (213325008); Serum sickness due to transfusion (72284000)
 
Monarch Initiative: MONDO:0043789

Definition

Delayed-type hypersensitivity reaction to foreign proteins derived from an animal serum. It occurs approximately six to twenty one days following the administration of the foreign antigen. Symptoms include fever, arthralgias, myalgias, skin eruptions, lymphadenopathy, chest pain, and dyspnea. Certain drugs (e.g., antibiotics, anticancer agents, and anti-inflammatory medications) and infectious disorders (e.g., hepatitis B) may also cause serum sickness-like reaction. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSerum sickness

Professional guidelines

PubMed

Lalosevic MS, Lalosevic J, Stjepanovic M, Stojanovic M, Stojkovic M
Curr Drug Metab 2021;22(2):99-107. doi: 10.2174/1389200221999201116143109. PMID: 33198613
Stroud CR, Hegde A, Cherry C, Naqash AR, Sharma N, Addepalli S, Cherukuri S, Parent T, Hardin J, Walker P
J Oncol Pharm Pract 2019 Apr;25(3):551-557. Epub 2017 Dec 5 doi: 10.1177/1078155217745144. PMID: 29207939
de Silva HA, Ryan NM, de Silva HJ
Br J Clin Pharmacol 2016 Mar;81(3):446-52. Epub 2015 Sep 16 doi: 10.1111/bcp.12739. PMID: 26256124Free PMC Article

Recent clinical studies

Etiology

Cozzani E, Herzum A, Burlando M, Parodi A
Ital J Dermatol Venerol 2021 Feb;156(1):5-12. Epub 2019 Dec 4 doi: 10.23736/S2784-8671.19.06488-5. PMID: 31804053
Dhar C, Sasmal A, Varki A
Front Immunol 2019;10:807. Epub 2019 Apr 17 doi: 10.3389/fimmu.2019.00807. PMID: 31057542Free PMC Article
Yorulmaz A, Akın F, Sert A, Ağır MA, Yılmaz R, Arslan Ş
Clin Rheumatol 2018 May;37(5):1389-1394. Epub 2017 Aug 9 doi: 10.1007/s10067-017-3777-4. PMID: 28795234
Dodiuk-Gad RP, Laws PM, Shear NH
Semin Cutan Med Surg 2014 Mar;33(1):2-9. doi: 10.12788/j.sder.0057. PMID: 25037253
Hansel TT, Kropshofer H, Singer T, Mitchell JA, George AJ
Nat Rev Drug Discov 2010 Apr;9(4):325-38. Epub 2010 Mar 22 doi: 10.1038/nrd3003. PMID: 20305665

Diagnosis

Dilley M, Geng B
Clin Rev Allergy Immunol 2022 Jun;62(3):463-475. Epub 2021 Dec 15 doi: 10.1007/s12016-021-08878-x. PMID: 34910281Free PMC Article
Nguyen E, Gabel CK, Yu J
Clin Dermatol 2020 Nov-Dec;38(6):629-640. Epub 2020 Jun 29 doi: 10.1016/j.clindermatol.2020.06.014. PMID: 33341197
Guvenir H, Arikoglu T, Vezir E, Misirlioglu ED
Curr Pharm Des 2019;25(36):3840-3854. doi: 10.2174/1381612825666191107162921. PMID: 31696807
Khan DA, Banerji A, Bernstein JA, Bilgicer B, Blumenthal K, Castells M, Ein D, Lang DM, Phillips E
J Allergy Clin Immunol Pract 2019 Sep-Oct;7(7):2105-2114. doi: 10.1016/j.jaip.2019.06.001. PMID: 31495420Free PMC Article
Sala-Cunill A, Luengo O, Cardona V
Curr Opin Allergy Clin Immunol 2019 Oct;19(5):439-446. doi: 10.1097/ACI.0000000000000550. PMID: 31169597

Therapy

Dilley M, Geng B
Clin Rev Allergy Immunol 2022 Jun;62(3):463-475. Epub 2021 Dec 15 doi: 10.1007/s12016-021-08878-x. PMID: 34910281Free PMC Article
Sala-Cunill A, Luengo O, Cardona V
Curr Opin Allergy Clin Immunol 2019 Oct;19(5):439-446. doi: 10.1097/ACI.0000000000000550. PMID: 31169597
Karmacharya P, Poudel DR, Pathak R, Donato AA, Ghimire S, Giri S, Aryal MR, Bingham CO 3rd
Semin Arthritis Rheum 2015 Dec;45(3):334-40. Epub 2015 Jun 26 doi: 10.1016/j.semarthrit.2015.06.014. PMID: 26199061
Hansel TT, Kropshofer H, Singer T, Mitchell JA, George AJ
Nat Rev Drug Discov 2010 Apr;9(4):325-38. Epub 2010 Mar 22 doi: 10.1038/nrd3003. PMID: 20305665
Grammer L
Clin Rev Allergy 1986 May;4(2):189-200. doi: 10.1007/BF02991108. PMID: 2421863

Prognosis

Gouni-Berthold I, Alexander VJ, Yang Q, Hurh E, Steinhagen-Thiessen E, Moriarty PM, Hughes SG, Gaudet D, Hegele RA, O'Dea LSL, Stroes ESG, Tsimikas S, Witztum JL; COMPASS study group
Lancet Diabetes Endocrinol 2021 May;9(5):264-275. Epub 2021 Mar 30 doi: 10.1016/S2213-8587(21)00046-2. PMID: 33798466
Guvenir H, Arikoglu T, Vezir E, Misirlioglu ED
Curr Pharm Des 2019;25(36):3840-3854. doi: 10.2174/1381612825666191107162921. PMID: 31696807
Khan DA, Banerji A, Bernstein JA, Bilgicer B, Blumenthal K, Castells M, Ein D, Lang DM, Phillips E
J Allergy Clin Immunol Pract 2019 Sep-Oct;7(7):2105-2114. doi: 10.1016/j.jaip.2019.06.001. PMID: 31495420Free PMC Article
Stroud CR, Hegde A, Cherry C, Naqash AR, Sharma N, Addepalli S, Cherukuri S, Parent T, Hardin J, Walker P
J Oncol Pharm Pract 2019 Apr;25(3):551-557. Epub 2017 Dec 5 doi: 10.1177/1078155217745144. PMID: 29207939
O'Donnell B, Black AK
Int Angiol 1995 Jun;14(2):166-74. PMID: 8609443

Clinical prediction guides

Griffiths OR, Landon J, Coxon RE, Morris K, James P, Adams R
Adv Protein Chem Struct Biol 2020;119:157-198. Epub 2020 Jan 10 doi: 10.1016/bs.apcsb.2019.08.009. PMID: 31997768
Khan DA, Banerji A, Bernstein JA, Bilgicer B, Blumenthal K, Castells M, Ein D, Lang DM, Phillips E
J Allergy Clin Immunol Pract 2019 Sep-Oct;7(7):2105-2114. doi: 10.1016/j.jaip.2019.06.001. PMID: 31495420Free PMC Article
de Silva HA, Ryan NM, de Silva HJ
Br J Clin Pharmacol 2016 Mar;81(3):446-52. Epub 2015 Sep 16 doi: 10.1111/bcp.12739. PMID: 26256124Free PMC Article
Klotz U, Teml A, Schwab M
Clin Pharmacokinet 2007;46(8):645-60. doi: 10.2165/00003088-200746080-00002. PMID: 17655372
De Heer E, Sijpkens YW, Verkade M, den Dulk M, Langers A, Schutrups J, Bruijn JA, van Es LA
Nephrol Dial Transplant 2000;15 Suppl 6:72-3. doi: 10.1093/ndt/15.suppl_6.72. PMID: 11143998

Recent systematic reviews

Abouyannis M, Esmail H, Hamaluba M, Ngama M, Mwangudzah H, Mumba N, Yeri BK, Mwalukore S, Alphan HJ, Aggarwal D, Alcoba G, Cammack N, Chippaux JP, Coldiron ME, Gutiérrez JM, Habib AG, Harrison RA, Isbister GK, Lavonas EJ, Martins D, Ribeiro I, Watson JA, Williams DJ, Casewell NR, Walker SA, Lalloo DG; Snakebite Global Core Outcome Set Study Group
Lancet Glob Health 2023 Feb;11(2):e296-e300. doi: 10.1016/S2214-109X(22)00479-X. PMID: 36669810
Karmacharya P, Poudel DR, Pathak R, Donato AA, Ghimire S, Giri S, Aryal MR, Bingham CO 3rd
Semin Arthritis Rheum 2015 Dec;45(3):334-40. Epub 2015 Jun 26 doi: 10.1016/j.semarthrit.2015.06.014. PMID: 26199061
Iudici M, van der Goes MC, Valentini G, Bijlsma JW
Clin Exp Rheumatol 2013 Mar-Apr;31(2 Suppl 76):157-65. Epub 2013 Jul 23 PMID: 23910618
Atteritano M, David A, Bagnato G, Beninati C, Frisina A, Iaria C, Bagnato G, Cascio A
Eur Rev Med Pharmacol Sci 2012 Oct;16(10):1414-24. PMID: 23104659
Schaeffer TH, Khatri V, Reifler LM, Lavonas EJ
Acad Emerg Med 2012 Feb;19(2):121-31. doi: 10.1111/j.1553-2712.2011.01276.x. PMID: 22320362

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...