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Serum sickness

MedGen UID:
11390
Concept ID:
C0036830
Disease or Syndrome
Synonyms: Serum Sickness; Serum Sicknesses; Sickness, Serum; Sicknesses, Serum
SNOMED CT: Transfusion reaction due to serum protein reaction (72284000); Protein sickness (72284000); Intoxication by serum (72284000); Serum reaction (72284000); Serum rash (213323001); Urticaria caused by serum (213325008); Serum sickness due to transfusion (72284000)
 
Monarch Initiative: MONDO:0043789

Definition

Delayed-type hypersensitivity reaction to foreign proteins derived from an animal serum. It occurs approximately six to twenty one days following the administration of the foreign antigen. Symptoms include fever, arthralgias, myalgias, skin eruptions, lymphadenopathy, chest pain, and dyspnea. Certain drugs (e.g., antibiotics, anticancer agents, and anti-inflammatory medications) and infectious disorders (e.g., hepatitis B) may also cause serum sickness-like reaction. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSerum sickness

Professional guidelines

PubMed

Gay K, Smink G, Mulieri K, Dandekar S
Pediatr Blood Cancer 2024 May;71(5):e30922. Epub 2024 Feb 20 doi: 10.1002/pbc.30922. PMID: 38379154
Stroud CR, Hegde A, Cherry C, Naqash AR, Sharma N, Addepalli S, Cherukuri S, Parent T, Hardin J, Walker P
J Oncol Pharm Pract 2019 Apr;25(3):551-557. Epub 2017 Dec 5 doi: 10.1177/1078155217745144. PMID: 29207939
Fan G, Li J
Adv Exp Med Biol 2017;1053:207-220. doi: 10.1007/978-3-319-72077-7_10. PMID: 29549641Free PMC Article

Recent clinical studies

Etiology

Pal R, Singh K, Khan SA, Chawla P, Kumar B, Akhtar MJ
Eur J Med Chem 2021 Dec 15;226:113890. Epub 2021 Oct 2 doi: 10.1016/j.ejmech.2021.113890. PMID: 34628237
Dodiuk-Gad RP, Laws PM, Shear NH
Semin Cutan Med Surg 2014 Mar;33(1):2-9. doi: 10.12788/j.sder.0057. PMID: 25037253
Baldo BA, Pagani M
Immunol Allergy Clin North Am 2014 Aug;34(3):565-96, viii. doi: 10.1016/j.iac.2014.04.003. PMID: 25017678
Hansel TT, Kropshofer H, Singer T, Mitchell JA, George AJ
Nat Rev Drug Discov 2010 Apr;9(4):325-38. Epub 2010 Mar 22 doi: 10.1038/nrd3003. PMID: 20305665
Tamburro JE, Esterly NB
Adolesc Med 2001 Jun;12(2):vii, 323-41. PMID: 11404204

Diagnosis

Shanshal M, Ebadian M
N Engl J Med 2023 Aug 24;389(8):749. doi: 10.1056/NEJMicm2216266. PMID: 37611124
Dilley M, Geng B
Clin Rev Allergy Immunol 2022 Jun;62(3):463-475. Epub 2021 Dec 15 doi: 10.1007/s12016-021-08878-x. PMID: 34910281Free PMC Article
Khan DA, Banerji A, Bernstein JA, Bilgicer B, Blumenthal K, Castells M, Ein D, Lang DM, Phillips E
J Allergy Clin Immunol Pract 2019 Sep-Oct;7(7):2105-2114. doi: 10.1016/j.jaip.2019.06.001. PMID: 31495420Free PMC Article
Tamburro JE, Esterly NB
Adolesc Med 2001 Jun;12(2):vii, 323-41. PMID: 11404204
Erffmeyer JE
Ann Allergy 1986 Feb;56(2):105-9. PMID: 3511779

Therapy

Dilley M, Geng B
Clin Rev Allergy Immunol 2022 Jun;62(3):463-475. Epub 2021 Dec 15 doi: 10.1007/s12016-021-08878-x. PMID: 34910281Free PMC Article
Karmacharya P, Poudel DR, Pathak R, Donato AA, Ghimire S, Giri S, Aryal MR, Bingham CO 3rd
Semin Arthritis Rheum 2015 Dec;45(3):334-40. Epub 2015 Jun 26 doi: 10.1016/j.semarthrit.2015.06.014. PMID: 26199061
Hansel TT, Kropshofer H, Singer T, Mitchell JA, George AJ
Nat Rev Drug Discov 2010 Apr;9(4):325-38. Epub 2010 Mar 22 doi: 10.1038/nrd3003. PMID: 20305665
Valle E, Gross M, Bickston SJ
Expert Opin Pharmacother 2001 Jun;2(6):1015-25. doi: 10.1517/14656566.2.6.1015. PMID: 11585004
Erffmeyer JE
Ann Allergy 1986 Feb;56(2):105-9. PMID: 3511779

Prognosis

Lalosevic MS, Lalosevic J, Stjepanovic M, Stojanovic M, Stojkovic M
Curr Drug Metab 2021;22(2):99-107. doi: 10.2174/1389200221999201116143109. PMID: 33198613
Khan DA, Banerji A, Bernstein JA, Bilgicer B, Blumenthal K, Castells M, Ein D, Lang DM, Phillips E
J Allergy Clin Immunol Pract 2019 Sep-Oct;7(7):2105-2114. doi: 10.1016/j.jaip.2019.06.001. PMID: 31495420Free PMC Article
Tamminga RY, Bruin MC
Pediatr Blood Cancer 2006 Oct 15;47(5 Suppl):714-6. doi: 10.1002/pbc.20967. PMID: 16933264
O'Donnell B, Black AK
Int Angiol 1995 Jun;14(2):166-74. PMID: 8609443
Dubost JJ, Souteyrand P, Sauvezie B
Baillieres Clin Rheumatol 1991 Apr;5(1):119-38. doi: 10.1016/s0950-3579(05)80299-7. PMID: 2070425

Clinical prediction guides

Neunie OAM, Rabbani W, Baker D, Chambers ES, Pfeffer PE, Kang AS
Hum Antibodies 2024;32(3):121-128. doi: 10.3233/HAB-240002. PMID: 38905039
Kalincik T, Sharmin S, Roos I, Massey J, Sutton I, Withers B, Freedman MS, Atkins H, Krasulova E, Kubala Havrdova E, Trneny M, Kozak T, Burman J, Macdonell R, Torkildsen Ø, Bø L, Lehmann AK, Sharrack B, Snowden J
J Neurol Neurosurg Psychiatry 2024 Jul 15;95(8):775-783. doi: 10.1136/jnnp-2023-332790. PMID: 38538060
Khan DA, Banerji A, Bernstein JA, Bilgicer B, Blumenthal K, Castells M, Ein D, Lang DM, Phillips E
J Allergy Clin Immunol Pract 2019 Sep-Oct;7(7):2105-2114. doi: 10.1016/j.jaip.2019.06.001. PMID: 31495420Free PMC Article
Moon JM, Chun BJ
J Emerg Med 2016 Jun;50(6):848-51. Epub 2016 Jan 25 doi: 10.1016/j.jemermed.2015.11.037. PMID: 26823133
de Silva HA, Ryan NM, de Silva HJ
Br J Clin Pharmacol 2016 Mar;81(3):446-52. Epub 2015 Sep 16 doi: 10.1111/bcp.12739. PMID: 26256124Free PMC Article

Recent systematic reviews

Abouyannis M, Esmail H, Hamaluba M, Ngama M, Mwangudzah H, Mumba N, Yeri BK, Mwalukore S, Alphan HJ, Aggarwal D, Alcoba G, Cammack N, Chippaux JP, Coldiron ME, Gutiérrez JM, Habib AG, Harrison RA, Isbister GK, Lavonas EJ, Martins D, Ribeiro I, Watson JA, Williams DJ, Casewell NR, Walker SA, Lalloo DG; Snakebite Global Core Outcome Set Study Group
Lancet Glob Health 2023 Feb;11(2):e296-e300. doi: 10.1016/S2214-109X(22)00479-X. PMID: 36669810
Griese SE, Kisselburgh HM, Bartenfeld MT, Thomas E, Rao AK, Sobel J, Dziuban EJ
Clin Infect Dis 2017 Dec 27;66(suppl_1):S17-S29. doi: 10.1093/cid/cix812. PMID: 29293924
Karmacharya P, Poudel DR, Pathak R, Donato AA, Ghimire S, Giri S, Aryal MR, Bingham CO 3rd
Semin Arthritis Rheum 2015 Dec;45(3):334-40. Epub 2015 Jun 26 doi: 10.1016/j.semarthrit.2015.06.014. PMID: 26199061
Atteritano M, David A, Bagnato G, Beninati C, Frisina A, Iaria C, Bagnato G, Cascio A
Eur Rev Med Pharmacol Sci 2012 Oct;16(10):1414-24. PMID: 23104659
Schaeffer TH, Khatri V, Reifler LM, Lavonas EJ
Acad Emerg Med 2012 Feb;19(2):121-31. doi: 10.1111/j.1553-2712.2011.01276.x. PMID: 22320362

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