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Synesthesia(SYNSTH)

MedGen UID:
115936
Concept ID:
C0233778
Mental or Behavioral Dysfunction
Synonym: SYNSTH
SNOMED CT: Synesthesia (8488006)
 
HPO: HP:6000024
OMIM®: 612759

Definition

Synesthesia is broadly defined as the experience of involuntary sensory crossactivation in which the presentation of a particular stimulus elicits a secondary sensory-perceptual experience (Barnett et al., 2008). Although this phenomenon can be acquired or transient due to trauma or drugs, there is a congenital or developmental form that shows familial patterns. Synesthesia can occur between any 2 sensory modalities, but the most common and best-studied forms of synesthesia involve the association of color with linguistic stimuli such as letters, numbers, or words, or with music ('colored hearing,' 'colored music'; Baron-Cohen et al., 1996). Other less common forms include the induction of tastes by words, the induction of touch by vision, the induction of shapes by tastes, and the personification of numbers (Barnett et al., 2008). [from OMIM]

Recent clinical studies

Etiology

Aoki Y, Shibasaki M, Nakata H
Sci Rep 2023 Apr 15;13(1):6172. doi: 10.1038/s41598-023-32389-8. PMID: 37061536Free PMC Article
Luke DP, Lungu L, Friday R, Terhune DB
Hum Psychopharmacol 2022 Jul;37(4):e2832. Epub 2022 Jan 19 doi: 10.1002/hup.2832. PMID: 35044677
Maurer D, Ghloum JK, Gibson LC, Watson MR, Chen LM, Akins K, Enns JT, Hensch TK, Werker JF
Proc Natl Acad Sci U S A 2020 May 5;117(18):10089-10096. Epub 2020 Apr 22 doi: 10.1073/pnas.1914668117. PMID: 32321833Free PMC Article
Gosavi RS, Hubbard EM
Cognition 2019 Jun;187:32-37. Epub 2019 Feb 22 doi: 10.1016/j.cognition.2019.02.009. PMID: 30802627
Berman B, Serper M
J Nerv Ment Dis 2016 Aug;204(8):614-9. doi: 10.1097/NMD.0000000000000532. PMID: 27218222

Diagnosis

van Petersen E, Altgassen M, van Lier R, van Leeuwen TM
Cortex 2020 Sep;130:49-63. Epub 2020 May 28 doi: 10.1016/j.cortex.2020.04.034. PMID: 32640374
Rinaldi LJ, Smees R, Carmichael DA, Simner J
Front Biosci (Elite Ed) 2020 Mar 1;12(1):162-182. doi: 10.2741/E865. PMID: 32114456
Lalwani P, Brang D
Philos Trans R Soc Lond B Biol Sci 2019 Dec 9;374(1787):20190029. Epub 2019 Oct 21 doi: 10.1098/rstb.2019.0029. PMID: 31630652Free PMC Article
Rouw R, Scholte HS
Neuropsychologia 2016 Jul 29;88:35-48. Epub 2016 Jan 6 doi: 10.1016/j.neuropsychologia.2016.01.006. PMID: 26772146
Ishida H, Suzuki K, Grandi LC
Neuropsychologia 2015 Apr;70:442-54. Epub 2014 Oct 24 doi: 10.1016/j.neuropsychologia.2014.10.020. PMID: 25447372

Therapy

Luke DP, Lungu L, Friday R, Terhune DB
Hum Psychopharmacol 2022 Jul;37(4):e2832. Epub 2022 Jan 19 doi: 10.1002/hup.2832. PMID: 35044677
Spence C
Cogn Res Princ Implic 2020 Oct 28;5(1):52. doi: 10.1186/s41235-020-00246-1. PMID: 33113051Free PMC Article
Rinaldi LJ, Smees R, Carmichael DA, Simner J
Front Biosci (Elite Ed) 2020 Mar 1;12(1):162-182. doi: 10.2741/E865. PMID: 32114456
Schwartzman DJ, Bor D, Rothen N, Seth AK
Philos Trans R Soc Lond B Biol Sci 2019 Dec 9;374(1787):20190030. Epub 2019 Oct 21 doi: 10.1098/rstb.2019.0030. PMID: 31630656Free PMC Article
Liechti ME
Neuropsychopharmacology 2017 Oct;42(11):2114-2127. Epub 2017 Apr 27 doi: 10.1038/npp.2017.86. PMID: 28447622Free PMC Article

Prognosis

Luke DP, Lungu L, Friday R, Terhune DB
Hum Psychopharmacol 2022 Jul;37(4):e2832. Epub 2022 Jan 19 doi: 10.1002/hup.2832. PMID: 35044677
van Leeuwen TM, Sauer A, Jurjut AM, Wibral M, Uhlhaas PJ, Singer W, Melloni L
Schizophr Bull 2021 Apr 29;47(3):722-730. doi: 10.1093/schbul/sbaa162. PMID: 33150444Free PMC Article
Maurer D, Ghloum JK, Gibson LC, Watson MR, Chen LM, Akins K, Enns JT, Hensch TK, Werker JF
Proc Natl Acad Sci U S A 2020 May 5;117(18):10089-10096. Epub 2020 Apr 22 doi: 10.1073/pnas.1914668117. PMID: 32321833Free PMC Article
Lalwani P, Brang D
Philos Trans R Soc Lond B Biol Sci 2019 Dec 9;374(1787):20190029. Epub 2019 Oct 21 doi: 10.1098/rstb.2019.0029. PMID: 31630652Free PMC Article
Safran AB, Sanda N
Curr Opin Neurol 2015 Feb;28(1):36-44. doi: 10.1097/WCO.0000000000000169. PMID: 25545055Free PMC Article

Clinical prediction guides

Luke DP, Lungu L, Friday R, Terhune DB
Hum Psychopharmacol 2022 Jul;37(4):e2832. Epub 2022 Jan 19 doi: 10.1002/hup.2832. PMID: 35044677
van Leeuwen TM, Sauer A, Jurjut AM, Wibral M, Uhlhaas PJ, Singer W, Melloni L
Schizophr Bull 2021 Apr 29;47(3):722-730. doi: 10.1093/schbul/sbaa162. PMID: 33150444Free PMC Article
Maurer D, Ghloum JK, Gibson LC, Watson MR, Chen LM, Akins K, Enns JT, Hensch TK, Werker JF
Proc Natl Acad Sci U S A 2020 May 5;117(18):10089-10096. Epub 2020 Apr 22 doi: 10.1073/pnas.1914668117. PMID: 32321833Free PMC Article
Lalwani P, Brang D
Philos Trans R Soc Lond B Biol Sci 2019 Dec 9;374(1787):20190029. Epub 2019 Oct 21 doi: 10.1098/rstb.2019.0029. PMID: 31630652Free PMC Article
Liechti ME
Neuropsychopharmacology 2017 Oct;42(11):2114-2127. Epub 2017 Apr 27 doi: 10.1038/npp.2017.86. PMID: 28447622Free PMC Article

Recent systematic reviews

Di Stefano N, Spence C
Cognition 2024 Aug;249:105805. Epub 2024 May 17 doi: 10.1016/j.cognition.2024.105805. PMID: 38761646

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