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Morbilliform rash

MedGen UID:
115972
Concept ID:
C0234918
Finding
Synonym: Morbilliform eruption
SNOMED CT: Morbilliform eruption (50495000); Morbilliform eruption (247470007); Morbilliform rash (247470007); Morbilliform rash (50495000)
 
HPO: HP:0012282

Definition

An exanthema consisting of widespread pink-to-red macules (flat spots of 2-10 mm in diameter) or papules (red bumps) that blanch with pressure. The macules and papules may cluster and merge to form sheets over several days. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMorbilliform rash

Conditions with this feature

Mevalonic aciduria
MedGen UID:
368373
Concept ID:
C1959626
Disease or Syndrome
Mevalonic aciduria (MEVA), the first recognized defect in the biosynthesis of cholesterol and isoprenoids, is a consequence of a deficiency of mevalonate kinase (ATP:mevalonate 5-phosphotransferase; EC 2.7.1.36). Mevalonic acid accumulates because of failure of conversion to 5-phosphomevalonic acid, which is catalyzed by mevalonate kinase. Mevalonic acid is synthesized from 3-hydroxy-3-methylglutaryl-CoA, a reaction catalyzed by HMG-CoA reductase (142910). Mevalonic aciduria is characterized by dysmorphology, psychomotor retardation, progressive cerebellar ataxia, and recurrent febrile crises, usually manifesting in early infancy, accompanied by hepatosplenomegaly, lymphadenopathy, arthralgia, and skin rash. The febrile crises are similar to those observed in hyperimmunoglobulinemia D and to periodic fever syndrome (HIDS; 260920), which is also caused by mutation in the MVK gene (summary by Prietsch et al., 2003).

Professional guidelines

PubMed

Masood W, Ahmad S, Khan NA, Shakir A, Rokni GR, Gold MH, Cockerell CJ, Schwartz RA, Goldust M
Viruses 2022 Sep 6;14(9) doi: 10.3390/v14091972. PMID: 36146777Free PMC Article
Luther J, Glesby MJ
Am J Clin Dermatol 2007;8(4):221-33. doi: 10.2165/00128071-200708040-00004. PMID: 17645377

Recent clinical studies

Etiology

Seirafianpour F, Pourriyahi H, Gholizadeh Mesgarha M, Pour Mohammad A, Shaka Z, Goodarzi A
Dermatol Ther 2022 Jun;35(6):e15461. Epub 2022 Apr 11 doi: 10.1111/dth.15461. PMID: 35316551Free PMC Article
Palhares D
An Bras Dermatol 2021 Jan-Feb;96(1):88-90. Epub 2020 Nov 20 doi: 10.1016/j.abd.2020.06.006. PMID: 33288365Free PMC Article
Genovese G, Moltrasio C, Berti E, Marzano AV
Dermatology 2021;237(1):1-12. Epub 2020 Nov 24 doi: 10.1159/000512932. PMID: 33232965Free PMC Article
Marzano AV, Cassano N, Genovese G, Moltrasio C, Vena GA
Br J Dermatol 2020 Sep;183(3):431-442. Epub 2020 Jul 5 doi: 10.1111/bjd.19264. PMID: 32479680Free PMC Article
Ricketts EK, Willcox MJ, Steele RW
Clin Pediatr (Phila) 2018 Feb;57(2):235-237. Epub 2017 Jan 12 doi: 10.1177/0009922816687333. PMID: 28081619

Diagnosis

Lins KA, Drummond MR, Velho PENF
An Bras Dermatol 2019 Sep-Oct;94(5):594-602. Epub 2019 Oct 2 doi: 10.1016/j.abd.2019.09.024. PMID: 31780437Free PMC Article
Ricketts EK, Willcox MJ, Steele RW
Clin Pediatr (Phila) 2018 Feb;57(2):235-237. Epub 2017 Jan 12 doi: 10.1177/0009922816687333. PMID: 28081619
Thongsri T, Chularojanamontri L, Pichler WJ
Asian Pac J Allergy Immunol 2017 Mar;35(1):3-10. doi: 10.12932/AP0847. PMID: 27996289
de Golian E, Kwong BY, Swetter SM, Pugliese SB
Curr Treat Options Oncol 2016 Nov;17(11):57. doi: 10.1007/s11864-016-0434-0. PMID: 27645330
Furness C, Sharma R, Harnden A
BMJ 2004 Sep 25;329(7468):719. doi: 10.1136/bmj.329.7468.719. PMID: 15388614Free PMC Article

Therapy

Dao EA, George SJ, Heberton MM, Pacha O, Kovitz CA, Patel AB, Phillips RM
Cancer Treat Res Commun 2022;32:100596. Epub 2022 Jun 22 doi: 10.1016/j.ctarc.2022.100596. PMID: 35834907
Seirafianpour F, Pourriyahi H, Gholizadeh Mesgarha M, Pour Mohammad A, Shaka Z, Goodarzi A
Dermatol Ther 2022 Jun;35(6):e15461. Epub 2022 Apr 11 doi: 10.1111/dth.15461. PMID: 35316551Free PMC Article
Ricketts EK, Willcox MJ, Steele RW
Clin Pediatr (Phila) 2018 Feb;57(2):235-237. Epub 2017 Jan 12 doi: 10.1177/0009922816687333. PMID: 28081619
de Golian E, Kwong BY, Swetter SM, Pugliese SB
Curr Treat Options Oncol 2016 Nov;17(11):57. doi: 10.1007/s11864-016-0434-0. PMID: 27645330
Borok J, Hau J, Worswick S
Dermatol Online J 2016 Mar 16;22(3) PMID: 27136636

Prognosis

Dao EA, George SJ, Heberton MM, Pacha O, Kovitz CA, Patel AB, Phillips RM
Cancer Treat Res Commun 2022;32:100596. Epub 2022 Jun 22 doi: 10.1016/j.ctarc.2022.100596. PMID: 35834907
Polly S, Fernandez AP
Cleve Clin J Med 2022 Mar 1;89(3):161-167. doi: 10.3949/ccjm.89a.21126. PMID: 35232829
Stoll JR, Vaidya TS, Mori S, Dusza SW, Lacouture ME, Markova A
J Am Acad Dermatol 2021 Feb;84(2):273-282. Epub 2020 Mar 12 doi: 10.1016/j.jaad.2020.03.010. PMID: 32171811Free PMC Article
Marzano AV, Cassano N, Genovese G, Moltrasio C, Vena GA
Br J Dermatol 2020 Sep;183(3):431-442. Epub 2020 Jul 5 doi: 10.1111/bjd.19264. PMID: 32479680Free PMC Article
Ricketts EK, Willcox MJ, Steele RW
Clin Pediatr (Phila) 2018 Feb;57(2):235-237. Epub 2017 Jan 12 doi: 10.1177/0009922816687333. PMID: 28081619

Clinical prediction guides

Masood W, Ahmad S, Khan NA, Shakir A, Rokni GR, Gold MH, Cockerell CJ, Schwartz RA, Goldust M
Viruses 2022 Sep 6;14(9) doi: 10.3390/v14091972. PMID: 36146777Free PMC Article
Seirafianpour F, Pourriyahi H, Gholizadeh Mesgarha M, Pour Mohammad A, Shaka Z, Goodarzi A
Dermatol Ther 2022 Jun;35(6):e15461. Epub 2022 Apr 11 doi: 10.1111/dth.15461. PMID: 35316551Free PMC Article
Downs JW, Gould KT, Mclaughlin RC, Cumpston KL, Rose SR
Clin Toxicol (Phila) 2021 Mar;59(3):260-264. Epub 2020 Aug 6 doi: 10.1080/15563650.2020.1798980. PMID: 32757843
Stoll JR, Vaidya TS, Mori S, Dusza SW, Lacouture ME, Markova A
J Am Acad Dermatol 2021 Feb;84(2):273-282. Epub 2020 Mar 12 doi: 10.1016/j.jaad.2020.03.010. PMID: 32171811Free PMC Article
Mori S, Hickey A, Dusza SW, Lacouture ME, Markova A
J Am Acad Dermatol 2019 Mar;80(3):608-616. Epub 2018 Oct 26 doi: 10.1016/j.jaad.2018.10.039. PMID: 30612984Free PMC Article

Recent systematic reviews

Seirafianpour F, Pourriyahi H, Gholizadeh Mesgarha M, Pour Mohammad A, Shaka Z, Goodarzi A
Dermatol Ther 2022 Jun;35(6):e15461. Epub 2022 Apr 11 doi: 10.1111/dth.15461. PMID: 35316551Free PMC Article

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