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MedGen UID:
Concept ID:
Mental Process
Synonym: Euphorias
SNOMED CT: Euphoria (85949006); Feeling high (307074005)
HPO: HP:0031844


Euphoria is a feeling of intense joy, happiness, excitement, or elation that surpasses what would typically be anticipated in a given situation. [from HPO]

Term Hierarchy

Conditions with this feature

Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1
MedGen UID:
Concept ID:
Disease or Syndrome
Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) is characterized by fractures (resulting from radiologically demonstrable polycystic osseous lesions), frontal lobe syndrome, and progressive presenile dementia beginning in the fourth decade. The clinical course of PLOSL can be divided into four stages: 1. The latent stage is characterized by normal early development. 2. The osseous stage (3rd decade of life) is characterized by pain and tenderness, mostly in ankles and feet, usually following strain or injury. Fractures are typically diagnosed several years later, most commonly in the bones of the extremities. 3. In the early neurologic stage (4th decade of life), a change of personality begins to develop insidiously. Affected individuals show a frontal lobe syndrome (loss of judgment, euphoria, loss of social inhibitions, disturbance of concentration, and lack of insight, libido, and motor persistence) leading to serious social problems. 4. The late neurologic stage is characterized by progressive dementia and loss of mobility. Death usually occurs before age 50 years.

Professional guidelines


Onakpoya IJ, Thomas ET, Lee JJ, Goldacre B, Heneghan CJ
BMJ Open 2019 Jan 21;9(1):e023600. doi: 10.1136/bmjopen-2018-023600. PMID: 30670513Free PMC Article
Savaskan E, Mueller H, Hoerr R, von Gunten A, Gauthier S
Int Psychogeriatr 2018 Mar;30(3):285-293. Epub 2017 Sep 21 doi: 10.1017/S1041610217001892. PMID: 28931444
Busardò FP, Jones AW
Curr Neuropharmacol 2015 Jan;13(1):47-70. doi: 10.2174/1570159X13666141210215423. PMID: 26074743Free PMC Article

Recent systematic reviews

Liu J, Wang LN
Cochrane Database Syst Rev 2017 Aug 20;8(8):CD008502. doi: 10.1002/14651858.CD008502.pub5. PMID: 28822350Free PMC Article
Feast A, Moniz-Cook E, Stoner C, Charlesworth G, Orrell M
Int Psychogeriatr 2016 Nov;28(11):1761-1774. Epub 2016 Jun 27 doi: 10.1017/S1041610216000922. PMID: 27345942
Zhao QF, Tan L, Wang HF, Jiang T, Tan MS, Tan L, Xu W, Li JQ, Wang J, Lai TJ, Yu JT
J Affect Disord 2016 Jan 15;190:264-271. Epub 2015 Oct 24 doi: 10.1016/j.jad.2015.09.069. PMID: 26540080
Whiting PF, Wolff RF, Deshpande S, Di Nisio M, Duffy S, Hernandez AV, Keurentjes JC, Lang S, Misso K, Ryder S, Schmidlkofer S, Westwood M, Kleijnen J
JAMA 2015 Jun 23-30;313(24):2456-73. doi: 10.1001/jama.2015.6358. PMID: 26103030
Rosti-Otajärvi E, Hämäläinen P
Mult Scler 2013 Jan;19(1):31-45. Epub 2012 Mar 1 doi: 10.1177/1352458512439437. PMID: 22383231

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