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Ankle pain

MedGen UID:
116068
Concept ID:
C0238656
Sign or Symptom
Synonym: Ankle arthralgia
SNOMED CT: Arthralgia of ankle (202490009); Ankle joint pain (202490009); Ankle pain (247373008)
 
HPO: HP:0030840

Definition

An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the ankle. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnkle pain

Conditions with this feature

Deficiency of hyaluronoglucosaminidase
MedGen UID:
226942
Concept ID:
C1291490
Disease or Syndrome
Mucopolysaccharidosis type IX (MPS9) is a rare progressive lysosomal storage disorder caused by the deficiency of the enzyme hyaluronoglucosaminidase-1, which degrades hyaluronan (summary by Imundo et al., 2011).
Multiple epiphyseal dysplasia type 1
MedGen UID:
325376
Concept ID:
C1838280
Disease or Syndrome
Autosomal dominant multiple epiphyseal dysplasia (MED) presents in early childhood, usually with pain in the hips and/or knees after exercise. Affected children complain of fatigue with long-distance walking. Waddling gait may be present. Adult height is either in the lower range of normal or mildly shortened. The limbs are relatively short in comparison to the trunk. Pain and joint deformity progress, resulting in early-onset osteoarthritis, particularly of the large weight-bearing joints.
Multicentric carpo-tarsal osteolysis with or without nephropathy
MedGen UID:
436237
Concept ID:
C2674705
Disease or Syndrome
Multicentric carpotarsal osteolysis syndrome is a rare skeletal disorder, usually presenting in early childhood with a clinical picture mimicking juvenile rheumatoid arthritis. Progressive destruction of the carpal and tarsal bone usually occurs and other bones may also be involved. Chronic renal failure is a frequent component of the syndrome. Mental retardation and minor facial anomalies have been noted in some patients. Autosomal dominant inheritance has been documented in many families (Pai and Macpherson, 1988). See also Torg-Winchester syndrome (259600), an autosomal recessive multicentric osteolysis syndrome.

Professional guidelines

PubMed

Gopinath R, Pigott M, Lindsey B, Finney FT, Holmes JR, Walton DM, Talusan PG
Foot Ankle Spec 2022 Dec;15(6):573-578. Epub 2022 Oct 10 doi: 10.1177/1938640021992915. PMID: 36210762
Powers RT, Dowd TC, Giza E
Arthroscopy 2021 Dec;37(12):3393-3396. doi: 10.1016/j.arthro.2021.10.002. PMID: 34863377
Talusan PG, Toy J, Perez JL, Milewski MD, Reach JS Jr
J Am Acad Orthop Surg 2014 May;22(5):333-9. doi: 10.5435/JAAOS-22-05-333. PMID: 24788449

Recent clinical studies

Etiology

Deu RS, Coslick AM, Dreher G
Am Fam Physician 2022 May 1;105(5):479-486. PMID: 35559641
Izaola-Azkona L, Vicenzino B, Olabarrieta-Eguia I, Saez M, Lascurain-Aguirrebeña I
Phys Ther 2021 Aug 1;101(8) doi: 10.1093/ptj/pzab111. PMID: 33877325
Giannini S, Buda R, Mosca M, Parma A, Di Caprio F
Foot Ankle Int 2013 Mar;34(3):459-65. doi: 10.1177/1071100713477609. PMID: 23520307
Golanó P, Vega J, de Leeuw PA, Malagelada F, Manzanares MC, Götzens V, van Dijk CN
Knee Surg Sports Traumatol Arthrosc 2010 May;18(5):557-69. Epub 2010 Mar 23 doi: 10.1007/s00167-010-1100-x. PMID: 20309522Free PMC Article
Bleakley CM, McDonough SM, MacAuley DC, Bjordal J
Br J Sports Med 2006 Aug;40(8):700-5; discussion 705. Epub 2006 Apr 12 doi: 10.1136/bjsm.2006.025932. PMID: 16611722Free PMC Article

Diagnosis

Cerezal A, Ocampo R, Llopis E, Cerezal L
Semin Musculoskelet Radiol 2023 Jun;27(3):231-244. Epub 2023 May 25 doi: 10.1055/s-0043-1767767. PMID: 37230124
Gopinath R, Pigott M, Lindsey B, Finney FT, Holmes JR, Walton DM, Talusan PG
Foot Ankle Spec 2022 Dec;15(6):573-578. Epub 2022 Oct 10 doi: 10.1177/1938640021992915. PMID: 36210762
Deu RS, Coslick AM, Dreher G
Am Fam Physician 2022 May 1;105(5):479-486. PMID: 35559641
Golanó P, Vega J, de Leeuw PA, Malagelada F, Manzanares MC, Götzens V, van Dijk CN
Knee Surg Sports Traumatol Arthrosc 2010 May;18(5):557-69. Epub 2010 Mar 23 doi: 10.1007/s00167-010-1100-x. PMID: 20309522Free PMC Article
Simpson MR, Howard TM
Am Fam Physician 2009 Nov 15;80(10):1107-14. PMID: 19904895

Therapy

Izaola-Azkona L, Vicenzino B, Olabarrieta-Eguia I, Saez M, Lascurain-Aguirrebeña I
Phys Ther 2021 Aug 1;101(8) doi: 10.1093/ptj/pzab111. PMID: 33877325
Bock BC, Thind H, Fava JL, Dunsiger S, Guthrie KM, Stroud L, Gopalakrishnan G, Sillice M, Wu W
Complement Ther Med 2019 Feb;42:125-131. Epub 2018 Sep 26 doi: 10.1016/j.ctim.2018.09.019. PMID: 30670230Free PMC Article
Miniaci-Coxhead SL, Flemister AS Jr
Med Clin North Am 2014 Mar;98(2):291-9. Epub 2013 Dec 18 doi: 10.1016/j.mcna.2013.10.006. PMID: 24559875
Rao S, Riskowski JL, Hannan MT
Best Pract Res Clin Rheumatol 2012 Jun;26(3):345-68. doi: 10.1016/j.berh.2012.05.009. PMID: 22867931Free PMC Article
Bleakley CM, McDonough SM, MacAuley DC, Bjordal J
Br J Sports Med 2006 Aug;40(8):700-5; discussion 705. Epub 2006 Apr 12 doi: 10.1136/bjsm.2006.025932. PMID: 16611722Free PMC Article

Prognosis

Gopinath R, Pigott M, Lindsey B, Finney FT, Holmes JR, Walton DM, Talusan PG
Foot Ankle Spec 2022 Dec;15(6):573-578. Epub 2022 Oct 10 doi: 10.1177/1938640021992915. PMID: 36210762
Powers RT, Dowd TC, Giza E
Arthroscopy 2021 Dec;37(12):3393-3396. doi: 10.1016/j.arthro.2021.10.002. PMID: 34863377
Kampen WU, Westphal F, Van den Wyngaert T, Strobel K, Kuwert T, Van der Bruggen W, Gnanasegaran G, Jens JH, Paycha F
Semin Nucl Med 2018 Sep;48(5):454-468. Epub 2018 Apr 18 doi: 10.1053/j.semnuclmed.2018.03.003. PMID: 30193651
Bleakley CM, McDonough SM, MacAuley DC, Bjordal J
Br J Sports Med 2006 Aug;40(8):700-5; discussion 705. Epub 2006 Apr 12 doi: 10.1136/bjsm.2006.025932. PMID: 16611722Free PMC Article
Hirose CB, McGarvey WC
Foot Ankle Clin 2004 Jun;9(2):255-69. doi: 10.1016/j.fcl.2004.02.001. PMID: 15165581

Clinical prediction guides

Khan MJ, Asif N, Aziz MH, Shaikh SAH, Siddiqui FB, Moizuddin K, Nuhmani S
J Med Life 2023 Aug;16(8):1235-1239. doi: 10.25122/jml-2023-0117. PMID: 38024814Free PMC Article
Lundeen AL, Raduan FC, Stone McGaver R, Seiffert KJ, Fritz JE, Giveans MR, Coetzee JC
Foot Ankle Int 2022 Nov;43(11):1402-1409. Epub 2022 Aug 9 doi: 10.1177/10711007221115170. PMID: 35942917
Cotchett M, Frescos N, Whittaker GA, Bonanno DR
J Foot Ankle Res 2022 Feb 3;15(1):10. doi: 10.1186/s13047-021-00506-3. PMID: 35115024Free PMC Article
Izaola-Azkona L, Vicenzino B, Olabarrieta-Eguia I, Saez M, Lascurain-Aguirrebeña I
Phys Ther 2021 Aug 1;101(8) doi: 10.1093/ptj/pzab111. PMID: 33877325
Murphy JS, Mubarak SJ
Foot Ankle Clin 2015 Dec;20(4):681-91. Epub 2015 Oct 23 doi: 10.1016/j.fcl.2015.07.009. PMID: 26589086

Recent systematic reviews

Chapman LS, Flurey CA, Redmond AC, Richards P, Hofstetter C, Tapster B, Emmel J, Helliwell PS, Menz HB, Hannan MT, Shea B, Siddle HJ
Semin Arthritis Rheum 2023 Aug;61:152212. Epub 2023 May 11 doi: 10.1016/j.semarthrit.2023.152212. PMID: 37207417
Valentijn PP, Tymchenko L, Jacobson T, Kromann J, Biermann CW, AlMoslemany MA, Arends RY
J Med Internet Res 2022 Sep 6;24(9):e37869. doi: 10.2196/37869. PMID: 36066943Free PMC Article
Cotchett M, Frescos N, Whittaker GA, Bonanno DR
J Foot Ankle Res 2022 Feb 3;15(1):10. doi: 10.1186/s13047-021-00506-3. PMID: 35115024Free PMC Article
Murray C, Marshall M, Rathod T, Bowen CJ, Menz HB, Roddy E
PLoS One 2018;13(4):e0193662. Epub 2018 Apr 30 doi: 10.1371/journal.pone.0193662. PMID: 29708977Free PMC Article
Thomas MJ, Roddy E, Zhang W, Menz HB, Hannan MT, Peat GM
Pain 2011 Dec;152(12):2870-2880. Epub 2011 Oct 21 doi: 10.1016/j.pain.2011.09.019. PMID: 22019150

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