U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Constitutional symptom

MedGen UID:
3593
Concept ID:
C0009812
Sign or Symptom
Synonyms: Constitutional Finding; Constitutional Symptom
 
HPO: HP:0025142

Definition

A symptom or manifestation indicating a systemic or general effect of a disease and that may affect the general well-being or status of an individual. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVConstitutional symptom

Professional guidelines

PubMed

Padrnos L, Mesa R
Expert Opin Investig Drugs 2020 Aug;29(8):809-817. Epub 2020 Jul 16 doi: 10.1080/13543784.2020.1782886. PMID: 32552220Free PMC Article
Bettis R, Iacuzio D, Jung T, Fuchs R, Aultman R, Gyldmark M
Clin Drug Investig 2006;26(6):329-40. doi: 10.2165/00044011-200626060-00004. PMID: 17163267

Recent clinical studies

Etiology

Olivieri G, Ceccarelli F, Perricone C, Ciccacci C, Pirone C, Natalucci F, Spinelli FR, Alessandri C, Borgiani P, Conti F
Clin Exp Rheumatol 2022 Nov;40(11):2141-2146. Epub 2022 Mar 23 doi: 10.55563/clinexprheumatol/7x37pf. PMID: 35349414
Pata D, Buonsenso D, Frasca G, Lazzareschi I, Salerno G, Turriziani Colonna A, Mariotti P, Valentini P
Pediatr Infect Dis J 2021 Jun 1;40(6):513-517. doi: 10.1097/INF.0000000000003070. PMID: 33902074
Sung J, Choudry N, Bachour R
Epidemiol Infect 2020 Nov 13;148:e273. doi: 10.1017/S0950268820002769. PMID: 33183384Free PMC Article
Padrnos L, Mesa R
Expert Opin Investig Drugs 2020 Aug;29(8):809-817. Epub 2020 Jul 16 doi: 10.1080/13543784.2020.1782886. PMID: 32552220Free PMC Article
Seynaeve D, Augusseau-Rivière B, Couturier P, Morel-Baccard C, Landelle C, Bosson JL, Gavazzi G, Mallaret MR
J Am Med Dir Assoc 2020 Jan;21(1):104-109.e1. Epub 2019 May 14 doi: 10.1016/j.jamda.2019.03.015. PMID: 31101588Free PMC Article

Diagnosis

Le Gall-Ianotto C, Ficheux AS, Lippert E, Herbreteau L, Rio L, Pan-Petesch B, Misery L, Ianotto JC
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1175-1183. Epub 2023 Mar 9 doi: 10.1111/jdv.18990. PMID: 36808754
Olivieri G, Ceccarelli F, Perricone C, Ciccacci C, Pirone C, Natalucci F, Spinelli FR, Alessandri C, Borgiani P, Conti F
Clin Exp Rheumatol 2022 Nov;40(11):2141-2146. Epub 2022 Mar 23 doi: 10.55563/clinexprheumatol/7x37pf. PMID: 35349414
Pata D, Buonsenso D, Frasca G, Lazzareschi I, Salerno G, Turriziani Colonna A, Mariotti P, Valentini P
Pediatr Infect Dis J 2021 Jun 1;40(6):513-517. doi: 10.1097/INF.0000000000003070. PMID: 33902074
Sung J, Choudry N, Bachour R
Epidemiol Infect 2020 Nov 13;148:e273. doi: 10.1017/S0950268820002769. PMID: 33183384Free PMC Article
Seynaeve D, Augusseau-Rivière B, Couturier P, Morel-Baccard C, Landelle C, Bosson JL, Gavazzi G, Mallaret MR
J Am Med Dir Assoc 2020 Jan;21(1):104-109.e1. Epub 2019 May 14 doi: 10.1016/j.jamda.2019.03.015. PMID: 31101588Free PMC Article

Therapy

Le Gall-Ianotto C, Ficheux AS, Lippert E, Herbreteau L, Rio L, Pan-Petesch B, Misery L, Ianotto JC
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1175-1183. Epub 2023 Mar 9 doi: 10.1111/jdv.18990. PMID: 36808754
Padrnos L, Mesa R
Expert Opin Investig Drugs 2020 Aug;29(8):809-817. Epub 2020 Jul 16 doi: 10.1080/13543784.2020.1782886. PMID: 32552220Free PMC Article
Haffizulla J, Hartman A, Hoppers M, Resnick H, Samudrala S, Ginocchio C, Bardin M, Rossignol JF; US Nitazoxanide Influenza Clinical Study Group
Lancet Infect Dis 2014 Jul;14(7):609-18. Epub 2014 May 19 doi: 10.1016/S1473-3099(14)70717-0. PMID: 24852376Free PMC Article
Dummer R, Quaglino P, Becker JC, Hasan B, Karrasch M, Whittaker S, Morris S, Weichenthal M, Stadler R, Bagot M, Cozzio A, Bernengo MG, Knobler R
J Clin Oncol 2012 Nov 20;30(33):4091-7. Epub 2012 Oct 8 doi: 10.1200/JCO.2011.39.8065. PMID: 23045580
Treanor JJ, Hayden FG, Vrooman PS, Barbarash R, Bettis R, Riff D, Singh S, Kinnersley N, Ward P, Mills RG
JAMA 2000 Feb 23;283(8):1016-24. doi: 10.1001/jama.283.8.1016. PMID: 10697061

Prognosis

Pata D, Buonsenso D, Frasca G, Lazzareschi I, Salerno G, Turriziani Colonna A, Mariotti P, Valentini P
Pediatr Infect Dis J 2021 Jun 1;40(6):513-517. doi: 10.1097/INF.0000000000003070. PMID: 33902074
Sung J, Choudry N, Bachour R
Epidemiol Infect 2020 Nov 13;148:e273. doi: 10.1017/S0950268820002769. PMID: 33183384Free PMC Article
Mulazzani E, Wagner D, Havla J, Schlüter M, Meinl I, Gerdes LA, Kümpfel T
J Neuroinflammation 2020 Jun 20;17(1):196. doi: 10.1186/s12974-020-01867-5. PMID: 32563262Free PMC Article
McLornan DP, Malpassuti V, Lippinkhof-Kozijn A, Potter V, Beelen D, Bunjes D, Sengeloev H, Radujkovic A, Passweg J, Chalandon Y, Kröger N, Wulf GG, Johansson JE, Ciceri F, Bornhäuser M, Holler E, Guffroy B, Martin S, Neubauer A, Gramatski M, Robin M, Iacobelli S, Hayden P, Hernández Boluda JC, Czerw T, Yakoub-Agha I
Br J Haematol 2020 Aug;190(3):437-441. Epub 2020 Feb 28 doi: 10.1111/bjh.16537. PMID: 32108327
Bellei N, Carraro E, Perosa A, Watanabe A, Arruda E, Granato C
J Med Virol 2008 Oct;80(10):1824-7. doi: 10.1002/jmv.21295. PMID: 18712837Free PMC Article

Clinical prediction guides

Noor SM, Ahmad MM, Anwar KMR, Chowdhury MF, Sultana M, Kader MA, Khan MAS
Mymensingh Med J 2024 Oct;33(4):1211-1218. PMID: 39351745
Le Gall-Ianotto C, Ficheux AS, Lippert E, Herbreteau L, Rio L, Pan-Petesch B, Misery L, Ianotto JC
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1175-1183. Epub 2023 Mar 9 doi: 10.1111/jdv.18990. PMID: 36808754
Olivieri G, Ceccarelli F, Perricone C, Ciccacci C, Pirone C, Natalucci F, Spinelli FR, Alessandri C, Borgiani P, Conti F
Clin Exp Rheumatol 2022 Nov;40(11):2141-2146. Epub 2022 Mar 23 doi: 10.55563/clinexprheumatol/7x37pf. PMID: 35349414
Sung J, Choudry N, Bachour R
Epidemiol Infect 2020 Nov 13;148:e273. doi: 10.1017/S0950268820002769. PMID: 33183384Free PMC Article
Kuiper JR, Hirsch AG, Bandeen-Roche K, Sundaresan AS, Tan BK, Kern RC, Schleimer RP, Schwartz BS
J Occup Environ Med 2019 Aug;61(8):e333-e339. doi: 10.1097/JOM.0000000000001636. PMID: 31205204Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...