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Aortic root dilatation

MedGen UID:
116069
•Concept ID:
C0238669
•
Anatomical Abnormality
SNOMED CT: Aortic root dilatation (251036003)

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

The role of genetic testing in Marfan syndrome.
Monda E, Caiazza M, Limongelli G
Curr Opin Cardiol 2024 May 1;39(3):162-169. Epub 2024 Feb 21 doi: 10.1097/HCO.0000000000001126. PMID: 38386349
Current and future pharmacological treatment strategies with regard to aortic disease in Marfan syndrome.
Hartog AW, Franken R, Zwinderman AH, Groenink M, Mulder BJ
Expert Opin Pharmacother 2012 Apr;13(5):647-62. Epub 2012 Mar 7 doi: 10.1517/14656566.2012.665446. PMID: 22397493
Turner syndrome: diagnosis and management.
Morgan T
Am Fam Physician 2007 Aug 1;76(3):405-10. PMID: 17708142

Recent clinical studies

Etiology

Eyes and the heart: what a clinician should know.
Ng JY, Zarook E, Nicholson L; Oculi-Cordis group, Khanji MY, Chahal CAA
Heart 2023 Oct 26;109(22):1670-1676. doi: 10.1136/heartjnl-2022-322081. PMID: 37507215Free PMC Article
Childhood rheumatic diseases: bites not only the joint, but also the heart.
Thomas KN, Aggarwal A
Clin Rheumatol 2023 Oct;42(10):2703-2715. Epub 2023 May 9 doi: 10.1007/s10067-023-06621-9. PMID: 37160484Free PMC Article
Root Dilatation Is More Malignant Than Ascending Aortic Dilation.
Kalogerakos PD, Zafar MA, Li Y, Mukherjee SK, Ziganshin BA, Rizzo JA, Elefteriades JA
J Am Heart Assoc 2021 Jul 20;10(14):e020645. Epub 2021 Jul 9 doi: 10.1161/JAHA.120.020645. PMID: 34238012Free PMC Article
Biomarkers of Aortopathy in Marfan Syndrome.
Iskandar Z, Mordi I, Lang CC, Huang JTJ, Choy AM
Cardiol Rev 2020 Mar/Apr;28(2):92-97. doi: 10.1097/CRD.0000000000000289. PMID: 31985522
Turner syndrome: diagnosis and management.
Morgan T
Am Fam Physician 2007 Aug 1;76(3):405-10. PMID: 17708142

Diagnosis

Eyes and the heart: what a clinician should know.
Ng JY, Zarook E, Nicholson L; Oculi-Cordis group, Khanji MY, Chahal CAA
Heart 2023 Oct 26;109(22):1670-1676. doi: 10.1136/heartjnl-2022-322081. PMID: 37507215Free PMC Article
Childhood rheumatic diseases: bites not only the joint, but also the heart.
Thomas KN, Aggarwal A
Clin Rheumatol 2023 Oct;42(10):2703-2715. Epub 2023 May 9 doi: 10.1007/s10067-023-06621-9. PMID: 37160484Free PMC Article
The Relationship Between Aortic Root Size and Hypertension: An Unsolved Conundrum.
Mulè G, Nardi E, Morreale M, Castiglia A, Geraci G, Altieri D, Cacciatore V, Schillaci M, Vaccaro F, Cottone S
Adv Exp Med Biol 2017;956:427-445. doi: 10.1007/5584_2016_86. PMID: 27873227
Turner syndrome: diagnosis and management.
Morgan T
Am Fam Physician 2007 Aug 1;76(3):405-10. PMID: 17708142
Aortic pain.
Wooley CF, Sparks EH, Boudoulas H
Prog Cardiovasc Dis 1998 May-Jun;40(6):563-89. doi: 10.1016/s0033-0620(98)80004-2. PMID: 9647610

Therapy

Outcomes of neo-aortic valve and root surgery late after arterial switch operation.
Zhu MZL, Fricke TA, Buratto E, Chowdhuri KR, Brizard CP, Konstantinov IE
J Thorac Cardiovasc Surg 2024 Apr;167(4):1391-1401.e3. Epub 2023 Sep 26 doi: 10.1016/j.jtcvs.2023.09.038. PMID: 37757970
Growth of the aortic root in children and young adults with Marfan syndrome.
van Elsäcker E, Vink AS, Menke LA, Pals G, Bokenkamp R, Backx ACPM, Hilhorst-Hofstee Y, Blom NA, van der Hulst AE
Open Heart 2022 Dec;9(2) doi: 10.1136/openhrt-2022-002097. PMID: 36543362Free PMC Article
Alcohol Consumption and Aortic Root Dilatation: Insights from the Corinthia Study.
Oikonomou E, Lazaros G, Tsalamandris S, Vogiatzi G, Christoforatou E, Papakonstantinou M, Goliopoulou A, Tousouli M, Chasikidis C, Tousoulis D
Angiology 2019 Nov;70(10):969-977. Epub 2019 May 7 doi: 10.1177/0003319719848172. PMID: 31064194
Turner syndrome: diagnosis and management.
Morgan T
Am Fam Physician 2007 Aug 1;76(3):405-10. PMID: 17708142
Marfan's syndrome and the heart.
Stuart AG, Williams A
Arch Dis Child 2007 Apr;92(4):351-6. doi: 10.1136/adc.2006.097469. PMID: 17376944Free PMC Article

Prognosis

Growth of the Neo-Aortic Root and Prognosis of Transposition of the Great Arteries.
Sengupta A, Carreon CK, Gauvreau K, Lee JM, Sanders SP, Colan SD, Del Nido PJ, Mayer JE Jr, Nathan M
J Am Coll Cardiol 2024 Jan 30;83(4):516-527. Epub 2023 Nov 6 doi: 10.1016/j.jacc.2023.10.023. PMID: 37939977
Outcomes of neo-aortic valve and root surgery late after arterial switch operation.
Zhu MZL, Fricke TA, Buratto E, Chowdhuri KR, Brizard CP, Konstantinov IE
J Thorac Cardiovasc Surg 2024 Apr;167(4):1391-1401.e3. Epub 2023 Sep 26 doi: 10.1016/j.jtcvs.2023.09.038. PMID: 37757970
Eyes and the heart: what a clinician should know.
Ng JY, Zarook E, Nicholson L; Oculi-Cordis group, Khanji MY, Chahal CAA
Heart 2023 Oct 26;109(22):1670-1676. doi: 10.1136/heartjnl-2022-322081. PMID: 37507215Free PMC Article
Root Dilatation Is More Malignant Than Ascending Aortic Dilation.
Kalogerakos PD, Zafar MA, Li Y, Mukherjee SK, Ziganshin BA, Rizzo JA, Elefteriades JA
J Am Heart Assoc 2021 Jul 20;10(14):e020645. Epub 2021 Jul 9 doi: 10.1161/JAHA.120.020645. PMID: 34238012Free PMC Article
The Relationship Between Aortic Root Size and Hypertension: An Unsolved Conundrum.
Mulè G, Nardi E, Morreale M, Castiglia A, Geraci G, Altieri D, Cacciatore V, Schillaci M, Vaccaro F, Cottone S
Adv Exp Med Biol 2017;956:427-445. doi: 10.1007/5584_2016_86. PMID: 27873227

Clinical prediction guides

Growth of the Neo-Aortic Root and Prognosis of Transposition of the Great Arteries.
Sengupta A, Carreon CK, Gauvreau K, Lee JM, Sanders SP, Colan SD, Del Nido PJ, Mayer JE Jr, Nathan M
J Am Coll Cardiol 2024 Jan 30;83(4):516-527. Epub 2023 Nov 6 doi: 10.1016/j.jacc.2023.10.023. PMID: 37939977
"Big Data" Analyses Underlie Clinical Discoveries at the Aortic Institute.
Zafar MA, Ziganshin BA, Li Y, Ostberg NP, Rizzo JA, Tranquilli M, Mukherjee SK, Elefteriades JA
Yale J Biol Med 2023 Sep;96(3):427-440. Epub 2023 Sep 29 doi: 10.59249/LNDZ2964. PMID: 37780996Free PMC Article
Aortic root dilatation and dilated cardiomyopathy in an adult with Tatton-Brown-Rahman syndrome.
Cecchi AC, Haidar A, Marin I, Kwartler CS, Prakash SK, Milewicz DM
Am J Med Genet A 2022 Feb;188(2):628-634. Epub 2021 Oct 13 doi: 10.1002/ajmg.a.62541. PMID: 34644003Free PMC Article
Root Dilatation Is More Malignant Than Ascending Aortic Dilation.
Kalogerakos PD, Zafar MA, Li Y, Mukherjee SK, Ziganshin BA, Rizzo JA, Elefteriades JA
J Am Heart Assoc 2021 Jul 20;10(14):e020645. Epub 2021 Jul 9 doi: 10.1161/JAHA.120.020645. PMID: 34238012Free PMC Article
The Relationship Between Aortic Root Size and Hypertension: An Unsolved Conundrum.
Mulè G, Nardi E, Morreale M, Castiglia A, Geraci G, Altieri D, Cacciatore V, Schillaci M, Vaccaro F, Cottone S
Adv Exp Med Biol 2017;956:427-445. doi: 10.1007/5584_2016_86. PMID: 27873227

Recent systematic reviews

Is Osteogenesis Imperfecta Associated with Cardiovascular Abnormalities? A Systematic Review of the Literature.
Verdonk SJE, Storoni S, Micha D, van den Aardweg JG, Versacci P, Celli L, de Vries R, Zhytnik L, Kamp O, Bugiani M, Eekhoff EMW
Calcif Tissue Int 2024 Mar;114(3):210-221. Epub 2024 Jan 19 doi: 10.1007/s00223-023-01171-3. PMID: 38243143Free PMC Article
Aortic Valve Intervention During Aortic Root Surgery in Children: A Systematic Review.
Rodriguez M, Malvea A, McNally D, Bijelic V, Guo M, Momoli F, Boodhwani M
World J Pediatr Congenit Heart Surg 2020 Sep;11(5):611-618. doi: 10.1177/2150135120926979. PMID: 32853070
Beta-blockers for preventing aortic dissection in Marfan syndrome.
Koo HK, Lawrence KA, Musini VM
Cochrane Database Syst Rev 2017 Nov 7;11(11):CD011103. doi: 10.1002/14651858.CD011103.pub2. PMID: 29110304Free PMC Article
Annular management during aortic valve repair: a systematic review.
Kunihara T
Gen Thorac Cardiovasc Surg 2016 Feb;64(2):63-71. Epub 2015 Nov 25 doi: 10.1007/s11748-015-0602-3. PMID: 26608703
Echocardiographic aortic root dilatation in hypertensive patients: a systematic review and meta-analysis.
Covella M, Milan A, Totaro S, Cuspidi C, Re A, Rabbia F, Veglio F
J Hypertens 2014 Oct;32(10):1928-35; discussion 1935. doi: 10.1097/HJH.0000000000000286. PMID: 24979304

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