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Spongiotic dermatitis

MedGen UID:
120468
•Concept ID:
C0262984
•
Disease or Syndrome
Synonyms: Spongiotic Dermatitis; spongiotic dermatitis
SNOMED CT: Spongiotic dermatitis (23615008)
 
Monarch Initiative: MONDO:0002987

Definition

A chronic inflammatory skin condition characterized by itchiness and a rash in the chest and abdominal areas. It affects males more than females and is usually contracted at a relatively young age. It is thought to be caused by an allergic reaction to food, insect bites, or medication. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpongiotic dermatitis

Professional guidelines

PubMed

'Eczematous' dermatitis of the nipple: clinical and histopathological differential diagnosis of Paget disease.
Zengin HB, Tan PH, Liu R, Smoller BR
Pathology 2024 Apr;56(3):300-312. Epub 2024 Jan 6 doi: 10.1016/j.pathol.2023.10.018. PMID: 38307774
Management of immune-related cutaneous adverse events with dupilumab.
Kuo AM, Gu S, Stoll J, Moy AP, Dusza SW, Gordon A, Haliasos EC, Janjigian Y, Kraehenbuehl L, Quigley EA, Chapman P, Lacouture ME, Markova A
J Immunother Cancer 2023 Jun;11(6) doi: 10.1136/jitc-2023-007324. PMID: 37270183Free PMC Article
The role of eosinophils in the differential diagnosis of inflammatory skin diseases.
Caro-Chang LA, Fung MA
Hum Pathol 2023 Oct;140:101-128. Epub 2023 Mar 30 doi: 10.1016/j.humpath.2023.03.017. PMID: 37003367

Recent clinical studies

Etiology

Management of immune-related cutaneous adverse events with dupilumab.
Kuo AM, Gu S, Stoll J, Moy AP, Dusza SW, Gordon A, Haliasos EC, Janjigian Y, Kraehenbuehl L, Quigley EA, Chapman P, Lacouture ME, Markova A
J Immunother Cancer 2023 Jun;11(6) doi: 10.1136/jitc-2023-007324. PMID: 37270183Free PMC Article
Increased MxA protein expression and dendritic cells in spongiotic dermatitis differentiates dermatomyositis from eczema in a single-center case-control study.
Zeidi M, Chen KL, Patel B, Ravishankar A, Lim R, Werth VP
J Cutan Pathol 2021 Mar;48(3):364-373. Epub 2020 Oct 23 doi: 10.1111/cup.13880. PMID: 32954523Free PMC Article
Dermatologic Reactions to Immune Checkpoint Inhibitors : Skin Toxicities and Immunotherapy.
Sibaud V
Am J Clin Dermatol 2018 Jun;19(3):345-361. doi: 10.1007/s40257-017-0336-3. PMID: 29256113
Reflectance Confocal Microscopy Algorithms for Inflammatory and Hair Diseases.
Ardigo M, Agozzino M, Franceschini C, Lacarrubba F
Dermatol Clin 2016 Oct;34(4):487-496. doi: 10.1016/j.det.2016.05.011. PMID: 27692454
Reflectance Confocal Microscopy for Inflammatory Skin Diseases.
Agozzino M, Gonzalez S, Ardigò M
Actas Dermosifiliogr 2016 Oct;107(8):631-9. Epub 2016 Mar 17 doi: 10.1016/j.ad.2016.01.010. PMID: 26996333

Diagnosis

Dermatologic Reactions to Immune Checkpoint Inhibitors : Skin Toxicities and Immunotherapy.
Sibaud V
Am J Clin Dermatol 2018 Jun;19(3):345-361. doi: 10.1007/s40257-017-0336-3. PMID: 29256113
Psoriasiform dermatitides: A brief review.
Wick MR
Semin Diagn Pathol 2017 May;34(3):220-225. Epub 2016 Dec 14 doi: 10.1053/j.semdp.2016.12.006. PMID: 28094165
Reflectance Confocal Microscopy Algorithms for Inflammatory and Hair Diseases.
Ardigo M, Agozzino M, Franceschini C, Lacarrubba F
Dermatol Clin 2016 Oct;34(4):487-496. doi: 10.1016/j.det.2016.05.011. PMID: 27692454
Reflectance Confocal Microscopy for Inflammatory Skin Diseases.
Agozzino M, Gonzalez S, Ardigò M
Actas Dermosifiliogr 2016 Oct;107(8):631-9. Epub 2016 Mar 17 doi: 10.1016/j.ad.2016.01.010. PMID: 26996333
Juvenile spongiotic gingivitis.
Darling MR, Daley TD, Wilson A, Wysocki GP
J Periodontol 2007 Jul;78(7):1235-40. doi: 10.1902/jop.2007.060502. PMID: 17608578

Therapy

Management of immune-related cutaneous adverse events with dupilumab.
Kuo AM, Gu S, Stoll J, Moy AP, Dusza SW, Gordon A, Haliasos EC, Janjigian Y, Kraehenbuehl L, Quigley EA, Chapman P, Lacouture ME, Markova A
J Immunother Cancer 2023 Jun;11(6) doi: 10.1136/jitc-2023-007324. PMID: 37270183Free PMC Article
Real-Time Reflectance Confocal Microscopy of Cutaneous Graft-versus-Host Disease Correlates with Histopathology.
Reingold RE, Monnier J, Ardigò M, Stoll JR, Pena MC, Nanda JK, Dusza SW, Ruiz JD, Flynn L, Afrin A, Klein EG, Prockop SE, Pulitzer MP, Ponce DM, Markova A, Jain M
Transplant Cell Ther 2022 Jan;28(1):51.e1-51.e14. Epub 2021 Sep 24 doi: 10.1016/j.jtct.2021.09.014. PMID: 34571213Free PMC Article
Psoriasiform spongiotic dermatitis.
Sutarjono B, Lebovitch H
BMJ Case Rep 2019 Mar 7;12(3) doi: 10.1136/bcr-2018-228690. PMID: 30850572Free PMC Article
Dermatologic Reactions to Immune Checkpoint Inhibitors : Skin Toxicities and Immunotherapy.
Sibaud V
Am J Clin Dermatol 2018 Jun;19(3):345-361. doi: 10.1007/s40257-017-0336-3. PMID: 29256113
New histopathologic findings in drug eruptions.
Fitzpatrick JE
Dermatol Clin 1992 Jan;10(1):19-36. PMID: 1530913

Prognosis

Real-Time Reflectance Confocal Microscopy of Cutaneous Graft-versus-Host Disease Correlates with Histopathology.
Reingold RE, Monnier J, Ardigò M, Stoll JR, Pena MC, Nanda JK, Dusza SW, Ruiz JD, Flynn L, Afrin A, Klein EG, Prockop SE, Pulitzer MP, Ponce DM, Markova A, Jain M
Transplant Cell Ther 2022 Jan;28(1):51.e1-51.e14. Epub 2021 Sep 24 doi: 10.1016/j.jtct.2021.09.014. PMID: 34571213Free PMC Article
Histopathological Spectrum and Immunophenotypic Characterization of Symmetrical Drug-Related Intertriginous and Flexural Exanthema.
Muresan AM, Metze D, Böer-Auer A, Braun SA
Am J Dermatopathol 2021 Feb 1;43(2):103-111. doi: 10.1097/DAD.0000000000001722. PMID: 32618703
Dermatologic Reactions to Immune Checkpoint Inhibitors : Skin Toxicities and Immunotherapy.
Sibaud V
Am J Clin Dermatol 2018 Jun;19(3):345-361. doi: 10.1007/s40257-017-0336-3. PMID: 29256113
Dermatopathology of the female breast.
Peters MS, Lehman JS, Comfere NI
Am J Dermatopathol 2013 May;35(3):289-304; quiz 305-7. doi: 10.1097/DAD.0b013e318267caa3. PMID: 23598853
The commonest causes of symptomatic vulvar disease: a dermatologist's perspective.
Fischer GO
Australas J Dermatol 1996 Feb;37(1):12-8. doi: 10.1111/j.1440-0960.1996.tb00988.x. PMID: 8936065

Clinical prediction guides

Management of immune-related cutaneous adverse events with dupilumab.
Kuo AM, Gu S, Stoll J, Moy AP, Dusza SW, Gordon A, Haliasos EC, Janjigian Y, Kraehenbuehl L, Quigley EA, Chapman P, Lacouture ME, Markova A
J Immunother Cancer 2023 Jun;11(6) doi: 10.1136/jitc-2023-007324. PMID: 37270183Free PMC Article
Real-Time Reflectance Confocal Microscopy of Cutaneous Graft-versus-Host Disease Correlates with Histopathology.
Reingold RE, Monnier J, Ardigò M, Stoll JR, Pena MC, Nanda JK, Dusza SW, Ruiz JD, Flynn L, Afrin A, Klein EG, Prockop SE, Pulitzer MP, Ponce DM, Markova A, Jain M
Transplant Cell Ther 2022 Jan;28(1):51.e1-51.e14. Epub 2021 Sep 24 doi: 10.1016/j.jtct.2021.09.014. PMID: 34571213Free PMC Article
Clinicopathologic overlap of psoriasis, eczema, and psoriasiform dermatoses: A retrospective study of T helper type 2 and 17 subsets, interleukin 36, and β-defensin 2 in spongiotic psoriasiform dermatitis, sebopsoriasis, and tumor necrosis factor α inhibitor-associated dermatitis.
Cohen JN, Bowman S, Laszik ZG, North JP
J Am Acad Dermatol 2020 Feb;82(2):430-439. Epub 2019 Dec 16 doi: 10.1016/j.jaad.2019.08.023. PMID: 31859047
Dermatologic Reactions to Immune Checkpoint Inhibitors : Skin Toxicities and Immunotherapy.
Sibaud V
Am J Clin Dermatol 2018 Jun;19(3):345-361. doi: 10.1007/s40257-017-0336-3. PMID: 29256113
Dermatopathology of the female breast.
Peters MS, Lehman JS, Comfere NI
Am J Dermatopathol 2013 May;35(3):289-304; quiz 305-7. doi: 10.1097/DAD.0b013e318267caa3. PMID: 23598853

Recent systematic reviews

Dermoscopy, confocal microscopy and optical coherence tomography features of main inflammatory and autoimmune skin diseases: A systematic review.
Guida S, Longhitano S, Ardigò M, Pampena R, Ciardo S, Bigi L, Mandel VD, Vaschieri C, Manfredini M, Pezzini C, Arginelli F, Farnetani F, Zerbinati N, Longo C, Pellacani G
Australas J Dermatol 2022 Feb;63(1):15-26. Epub 2021 Aug 23 doi: 10.1111/ajd.13695. PMID: 34423852

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