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Thyrotoxic periodic paralysis

MedGen UID:
120639
•Concept ID:
C0268446
•
Disease or Syndrome
Synonyms: Hashitoxic periodic paralysis; Thyrotoxic hypokalemic periodic paralysis; thyrotoxic hypokalemic periodic paralysis; thyrotoxic periodic paralysis
SNOMED CT: Thyrotoxic periodic paralysis (30967002); Hashitoxic periodic paralysis (30967002)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Non-Mendelian inheritance (Orphanet)
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019201
OMIM® Phenotypic series: PS188580
Orphanet: ORPHA79102

Definition

Thyrotoxic periodic paralysis (TPP) is a rare neurological disease characterized by recurrent episodes of paralysis and hypokalemia during a thyrotoxic state. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyrotoxic periodic paralysis
Follow this link to review classifications for Thyrotoxic periodic paralysis in Orphanet.

Professional guidelines

PubMed

Hyperthyroidism: aetiology, pathogenesis, diagnosis, management, complications, and prognosis.
Wiersinga WM, Poppe KG, Effraimidis G
Lancet Diabetes Endocrinol 2023 Apr;11(4):282-298. Epub 2023 Feb 24 doi: 10.1016/S2213-8587(23)00005-0. PMID: 36848916

Recent clinical studies

Etiology

Hyperthyroidism: aetiology, pathogenesis, diagnosis, management, complications, and prognosis.
Wiersinga WM, Poppe KG, Effraimidis G
Lancet Diabetes Endocrinol 2023 Apr;11(4):282-298. Epub 2023 Feb 24 doi: 10.1016/S2213-8587(23)00005-0. PMID: 36848916
Periodic paralysis.
Fialho D, Griggs RC, Matthews E
Handb Clin Neurol 2018;148:505-520. doi: 10.1016/B978-0-444-64076-5.00032-6. PMID: 29478596
Thyrotoxic Channelopathies.
Singhai P, Krishnan S, Patil VU
J Assoc Physicians India 2017 Nov;65(11):98-99. PMID: 29322723
Mechanism of thyrotoxic periodic paralysis.
Lin SH, Huang CL
J Am Soc Nephrol 2012 Jun;23(6):985-8. Epub 2012 Mar 29 doi: 10.1681/ASN.2012010046. PMID: 22460532Free PMC Article
Thyrotoxic periodic paralysis.
Lin SH
Mayo Clin Proc 2005 Jan;80(1):99-105. doi: 10.1016/S0025-6196(11)62965-0. PMID: 15667036

Diagnosis

Hyperthyroidism: aetiology, pathogenesis, diagnosis, management, complications, and prognosis.
Wiersinga WM, Poppe KG, Effraimidis G
Lancet Diabetes Endocrinol 2023 Apr;11(4):282-298. Epub 2023 Feb 24 doi: 10.1016/S2213-8587(23)00005-0. PMID: 36848916
Thyrotoxic Periodic Paralysis.
Fralick M, Sarma S
N Engl J Med 2021 May 13;384(19):e71. Epub 2021 May 8 doi: 10.1056/NEJMicm2030770. PMID: 33983691
Thyrotoxic Channelopathies.
Singhai P, Krishnan S, Patil VU
J Assoc Physicians India 2017 Nov;65(11):98-99. PMID: 29322723
Thyrotoxic Periodic Paralysis: A Concise Review of the Literature.
Chaudhry MA, Wayangankar S
Curr Rheumatol Rev 2016;12(3):190-194. doi: 10.2174/1573397112666160404124822. PMID: 27041083
Thyrotoxic periodic paralysis.
Lin SH
Mayo Clin Proc 2005 Jan;80(1):99-105. doi: 10.1016/S0025-6196(11)62965-0. PMID: 15667036

Therapy

Hyperthyroidism: aetiology, pathogenesis, diagnosis, management, complications, and prognosis.
Wiersinga WM, Poppe KG, Effraimidis G
Lancet Diabetes Endocrinol 2023 Apr;11(4):282-298. Epub 2023 Feb 24 doi: 10.1016/S2213-8587(23)00005-0. PMID: 36848916
Thyrotoxic Periodic Paralysis.
Fralick M, Sarma S
N Engl J Med 2021 May 13;384(19):e71. Epub 2021 May 8 doi: 10.1056/NEJMicm2030770. PMID: 33983691
Thyrotoxic Channelopathies.
Singhai P, Krishnan S, Patil VU
J Assoc Physicians India 2017 Nov;65(11):98-99. PMID: 29322723
Sudden flaccid paralysis.
Tariq M, Peshin R, Ellis O, Grover K
BMJ Case Rep 2015 Jan 7;2015 doi: 10.1136/bcr-2014-206872. PMID: 25566931Free PMC Article
Mechanism of thyrotoxic periodic paralysis.
Lin SH, Huang CL
J Am Soc Nephrol 2012 Jun;23(6):985-8. Epub 2012 Mar 29 doi: 10.1681/ASN.2012010046. PMID: 22460532Free PMC Article

Prognosis

Hyperthyroidism: aetiology, pathogenesis, diagnosis, management, complications, and prognosis.
Wiersinga WM, Poppe KG, Effraimidis G
Lancet Diabetes Endocrinol 2023 Apr;11(4):282-298. Epub 2023 Feb 24 doi: 10.1016/S2213-8587(23)00005-0. PMID: 36848916
Unique Presentation of Thyrotoxic Periodic Paralysis With Urticarial Dermographia.
Minns RM, Barranco-Trabi JJ, Siemann DN, Chamas A, Shin T
Mil Med 2023 Aug 29;188(9-10):e3252-e3255. doi: 10.1093/milmed/usac342. PMID: 36383068
Thyrotoxic Periodic Paralysis: A Concise Review of the Literature.
Chaudhry MA, Wayangankar S
Curr Rheumatol Rev 2016;12(3):190-194. doi: 10.2174/1573397112666160404124822. PMID: 27041083
Thyroid disease and the nervous system.
Wood-Allum CA, Shaw PJ
Handb Clin Neurol 2014;120:703-35. doi: 10.1016/B978-0-7020-4087-0.00048-6. PMID: 24365348
Mechanism of thyrotoxic periodic paralysis.
Lin SH, Huang CL
J Am Soc Nephrol 2012 Jun;23(6):985-8. Epub 2012 Mar 29 doi: 10.1681/ASN.2012010046. PMID: 22460532Free PMC Article

Clinical prediction guides

Thyrotoxic periodic paralysis in two sexagenarian men: A case report.
Lu A, Lin SH
Medicine (Baltimore) 2021 Nov 24;100(47):e27795. doi: 10.1097/MD.0000000000027795. PMID: 34964743Free PMC Article
Thyrotoxic Periodic Paralysis and Complicated Thyrotoxicosis, Two Presentations of Hyperthyroidism with Notable Differences in their Clinical Manifestations: An Experience from a Tertiary Care Hospital in the United States.
Rivas AM, Thavaraputta S, Orellana-Barrios MA, Payne JD, Sotello D, Vinan-Vega M, Lado-Abeal J
Endocr Pract 2020 Jul;26(7):699-706. Epub 2020 Nov 24 doi: 10.4158/EP-2019-0454. PMID: 33471637
Thyrotoxic periodic paralysis: A retrospective, observational study from India.
Verma V, Kumar Y, Kotwal N, Upreti V, Hari Kumar KVS, Singh Y, Menon AS
Indian J Med Res 2020 Jan;151(1):42-46. doi: 10.4103/ijmr.IJMR_335_18. PMID: 32134013Free PMC Article
Is thyrotoxic periodic paralysis a disease caused by muscle membrane dysfunction?
Son YR, Kim NH, Kim DG, Park KS
Muscle Nerve 2017 Oct;56(4):780-786. Epub 2017 Mar 21 doi: 10.1002/mus.25532. PMID: 28006864
Clinical features and recovery patterns of acquired non-thyrotoxic hypokalemic paralysis.
Hiraga A, Kamitsukasa I, Kojima K, Kuwabara S
J Neurol Sci 2012 Feb 15;313(1-2):42-5. Epub 2011 Oct 13 doi: 10.1016/j.jns.2011.09.034. PMID: 22000401

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