U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cytopathic effect

MedGen UID:
1219
•Concept ID:
C0010827
•
Cell or Molecular Dysfunction
Synonyms: Cytopathic Effect, Viral; Cytopathic Effects, Viral; Cytopathogenic Effect, Viral; Cytopathogenic Effects, Viral; Effect, Viral Cytopathic; Effect, Viral Cytopathogenic; Effects, Viral Cytopathic; Effects, Viral Cytopathogenic; Viral Cytopathic Effect; Viral Cytopathic Effects; Viral Cytopathogenic Effect; Viral Cytopathogenic Effects
SNOMED CT: Cytopathic effect (112652003); Cytopathic degeneration (112652003); Cell degeneration (112652003); Cytologic degeneration (112652003); Cytopathic change (112652003)

Definition

Structural changes in host cells that are caused by viral invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCytopathic effect

Professional guidelines

PubMed

Treatment of COVID-19 Pneumonia: the Case for Placenta-derived Cell Therapy.
Berishvili E, Kaiser L, Cohen M, Berney T, Scholz H, Floisand Y, Mattsson J
Stem Cell Rev Rep 2021 Feb;17(1):63-70. doi: 10.1007/s12015-020-10004-x. PMID: 32696426Free PMC Article
Antiretroviral drug-related toxicities - clinical spectrum, prevention, and management.
Fernandez-Montero JV, Eugenia E, Barreiro P, Labarga P, Soriano V
Expert Opin Drug Saf 2013 Sep;12(5):697-707. Epub 2013 Jun 4 doi: 10.1517/14740338.2013.806480. PMID: 23730950
Suramin in the treatment of AIDS: mechanism of action.
De Clercq E
Antiviral Res 1987 Jan;7(1):1-10. doi: 10.1016/0166-3542(87)90034-9. PMID: 2432836

Recent clinical studies

Etiology

Coronavirus disease 2019 and the liver.
Esteban JP, Sobotka L, Rockey DC
Curr Opin Gastroenterol 2022 May 1;38(3):191-199. Epub 2022 Mar 11 doi: 10.1097/MOG.0000000000000826. PMID: 35275902
Review of human pegivirus: Prevalence, transmission, pathogenesis, and clinical implication.
Yu Y, Wan Z, Wang JH, Yang X, Zhang C
Virulence 2022 Dec;13(1):324-341. doi: 10.1080/21505594.2022.2029328. PMID: 35132924Free PMC Article
SARS-CoV-2 and the role of fomite transmission: a systematic review.
Onakpoya IJ, Heneghan CJ, Spencer EA, Brassey J, Plüddemann A, Evans DH, Conly JM, Jefferson T
F1000Res 2021;10:233. Epub 2021 Mar 24 doi: 10.12688/f1000research.51590.3. PMID: 34136133Free PMC Article
Acute kidney damage in COVID-19 patients.
Chebotareva N, Berns S, Androsova T, Moiseev S
Clin Nephrol 2021 May;95(5):227-239. doi: 10.5414/CN110357. PMID: 33749581
COVID-19 and the liver.
Jothimani D, Venugopal R, Abedin MF, Kaliamoorthy I, Rela M
J Hepatol 2020 Nov;73(5):1231-1240. Epub 2020 Jun 15 doi: 10.1016/j.jhep.2020.06.006. PMID: 32553666Free PMC Article

Diagnosis

SARS-CoV-2 coronavirus in water and wastewater: A critical review about presence and concern.
Tran HN, Le GT, Nguyen DT, Juang RS, Rinklebe J, Bhatnagar A, Lima EC, Iqbal HMN, Sarmah AK, Chao HP
Environ Res 2021 Feb;193:110265. Epub 2020 Oct 1 doi: 10.1016/j.envres.2020.110265. PMID: 33011225Free PMC Article
Measuring the Success of HIV-1 Cure Strategies.
Thomas J, Ruggiero A, Paxton WA, Pollakis G
Front Cell Infect Microbiol 2020;10:134. Epub 2020 Apr 7 doi: 10.3389/fcimb.2020.00134. PMID: 32318356Free PMC Article
Cytomegalovirus and the eye.
Carmichael A
Eye (Lond) 2012 Feb;26(2):237-40. Epub 2011 Dec 16 doi: 10.1038/eye.2011.327. PMID: 22173076Free PMC Article
Pathogenesis of acanthamoeba keratitis.
Panjwani N
Ocul Surf 2010 Apr;8(2):70-9. doi: 10.1016/s1542-0124(12)70071-x. PMID: 20427010Free PMC Article
Monkeypox virus: histologic, immunohistochemical and electron-microscopic findings.
Bayer-Garner IB
J Cutan Pathol 2005 Jan;32(1):28-34. doi: 10.1111/j.0303-6987.2005.00254.x. PMID: 15660652

Therapy

Repurposing drugs as COVID-19 therapies: A toxicity evaluation.
Ngan DK, Xu T, Xia M, Zheng W, Huang R
Drug Discov Today 2022 Jul;27(7):1983-1993. Epub 2022 Apr 6 doi: 10.1016/j.drudis.2022.04.001. PMID: 35395401Free PMC Article
Niclosamide for Covid-19: bridging the gap.
Al-Kuraishy HM, Al-Gareeb AI, Alzahrani KJ, Alexiou A, Batiha GE
Mol Biol Rep 2021 Dec;48(12):8195-8202. Epub 2021 Oct 18 doi: 10.1007/s11033-021-06770-7. PMID: 34664162Free PMC Article
Inhibitory Activity of Honeysuckle Extracts against Influenza A Virus In Vitro and In Vivo.
Li M, Wang Y, Jin J, Dou J, Guo Q, Ke X, Zhou C, Guo M
Virol Sin 2021 Jun;36(3):490-500. Epub 2020 Oct 12 doi: 10.1007/s12250-020-00302-6. PMID: 33044658Free PMC Article
Monocytes and Macrophages as Viral Targets and Reservoirs.
Nikitina E, Larionova I, Choinzonov E, Kzhyshkowska J
Int J Mol Sci 2018 Sep 18;19(9) doi: 10.3390/ijms19092821. PMID: 30231586Free PMC Article
Hantavirus pulmonary syndrome.
Macneil A, Nichol ST, Spiropoulou CF
Virus Res 2011 Dec;162(1-2):138-47. Epub 2011 Sep 17 doi: 10.1016/j.virusres.2011.09.017. PMID: 21945215

Prognosis

Impaired coagulation, liver dysfunction and COVID-19: Discovering an intriguing relationship.
D'Ardes D, Boccatonda A, Cocco G, Fabiani S, Rossi I, Bucci M, Guagnano MT, Schiavone C, Cipollone F
World J Gastroenterol 2022 Mar 21;28(11):1102-1112. doi: 10.3748/wjg.v28.i11.1102. PMID: 35431501Free PMC Article
COVID-19 and comorbidities of hepatic diseases in a global perspective.
Ahmad A, Ishtiaq SM, Khan JA, Aslam R, Ali S, Arshad MI
World J Gastroenterol 2021 Apr 7;27(13):1296-1310. doi: 10.3748/wjg.v27.i13.1296. PMID: 33833483Free PMC Article
Acute kidney damage in COVID-19 patients.
Chebotareva N, Berns S, Androsova T, Moiseev S
Clin Nephrol 2021 May;95(5):227-239. doi: 10.5414/CN110357. PMID: 33749581
Immunity and immune response, pathology and pathologic changes: progress and challenges in the immunopathology of yellow fever.
Quaresma JA, Pagliari C, Medeiros DB, Duarte MI, Vasconcelos PF
Rev Med Virol 2013 Sep;23(5):305-18. Epub 2013 Jul 22 doi: 10.1002/rmv.1752. PMID: 23873723
Herpetic esophagitis.
Shortsleeve MJ, Gauvin GP, Gardner RC, Greenberg MS
Radiology 1981 Dec;141(3):611-7. doi: 10.1148/radiology.141.3.7302212. PMID: 7302212

Clinical prediction guides

Papaverine: A Miraculous Alkaloid from Opium and Its Multimedicinal Application.
Ashrafi S, Alam S, Sultana A, Raj A, Emon NU, Richi FT, Sharmin T, Moon M, Park MN, Kim B
Molecules 2023 Mar 31;28(7) doi: 10.3390/molecules28073149. PMID: 37049912Free PMC Article
Impaired coagulation, liver dysfunction and COVID-19: Discovering an intriguing relationship.
D'Ardes D, Boccatonda A, Cocco G, Fabiani S, Rossi I, Bucci M, Guagnano MT, Schiavone C, Cipollone F
World J Gastroenterol 2022 Mar 21;28(11):1102-1112. doi: 10.3748/wjg.v28.i11.1102. PMID: 35431501Free PMC Article
"Hairiness" is a Facsimile of Reorganized Cytoskeletons: A Cytopathic Effect of Coxiella burnetii.
Lee WY
Yonsei Med J 2019 Oct;60(10):890-897. doi: 10.3349/ymj.2019.60.10.890. PMID: 31538423Free PMC Article
Reflectance confocal microscopy in infectious diseases.
Cinotti E, Labeille B, Cambazard F, Perrot JL
G Ital Dermatol Venereol 2015 Oct;150(5):575-83. Epub 2015 Jul 1 PMID: 26129682
The immunobiology of mushrooms.
Borchers AT, Krishnamurthy A, Keen CL, Meyers FJ, Gershwin ME
Exp Biol Med (Maywood) 2008 Mar;233(3):259-76. doi: 10.3181/0708-MR-227. PMID: 18296732

Recent systematic reviews

Type I interferon pathway assays in studies of rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider.
Burska A, Rodríguez-Carrio J, Biesen R, Dik WA, Eloranta ML, Cavalli G, Visser M, Boumpas DT, Bertsias G, Wahren-Herlenius M, Rehwinkel J, Frémond ML, Crow MK, Ronnblom L, Conaghan PG, Versnel M, Vital E
RMD Open 2023 Mar;9(1) doi: 10.1136/rmdopen-2022-002876. PMID: 36863752Free PMC Article
Viral cultures for assessing fomite transmission of SARS-CoV-2: a systematic review and meta-analysis.
Onakpoya IJ, Heneghan CJ, Spencer EA, Brassey J, Rosca EC, Maltoni S, Plüddemann A, Evans DH, Conly JM, Jefferson T
J Hosp Infect 2022 Dec;130:63-94. Epub 2022 Sep 14 doi: 10.1016/j.jhin.2022.09.007. PMID: 36115620Free PMC Article
SARS-CoV-2 and the role of fomite transmission: a systematic review.
Onakpoya IJ, Heneghan CJ, Spencer EA, Brassey J, Plüddemann A, Evans DH, Conly JM, Jefferson T
F1000Res 2021;10:233. Epub 2021 Mar 24 doi: 10.12688/f1000research.51590.3. PMID: 34136133Free PMC Article
Postmortem Findings Associated With SARS-CoV-2: Systematic Review and Meta-analysis.
Satturwar S, Fowkes M, Farver C, Wilson AM, Eccher A, Girolami I, Pujadas E, Bryce C, Salem F, El Jamal SM, Paniz-Mondolfi A, Petersen B, Gordon RE, Reidy J, Fraggetta F, Marshall DA, Pantanowitz L
Am J Surg Pathol 2021 May 1;45(5):587-603. doi: 10.1097/PAS.0000000000001650. PMID: 33481385Free PMC Article
Reflectance confocal microscopy for cutaneous infections and infestations.
Cinotti E, Perrot JL, Labeille B, Cambazard F
J Eur Acad Dermatol Venereol 2016 May;30(5):754-63. Epub 2015 Sep 21 doi: 10.1111/jdv.13254. PMID: 26387660

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...