U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cytopathic effect

MedGen UID:
1219
•Concept ID:
C0010827
•
Cell or Molecular Dysfunction
Synonyms: Cytopathic Effect, Viral; Cytopathic Effects, Viral; Cytopathogenic Effect, Viral; Cytopathogenic Effects, Viral; Effect, Viral Cytopathic; Effect, Viral Cytopathogenic; Effects, Viral Cytopathic; Effects, Viral Cytopathogenic; Viral Cytopathic Effect; Viral Cytopathic Effects; Viral Cytopathogenic Effect; Viral Cytopathogenic Effects
SNOMED CT: Cytopathic effect (112652003); Cytopathic degeneration (112652003); Cell degeneration (112652003); Cytologic degeneration (112652003); Cytopathic change (112652003)

Definition

Structural changes in host cells that are caused by viral invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCytopathic effect

Professional guidelines

PubMed

Exploration of SARS-CoV-2 3CL(pro) Inhibitors by Virtual Screening Methods, FRET Detection, and CPE Assay.
Zhao J, Ma Q, Zhang B, Guo P, Wang Z, Liu Y, Meng M, Liu A, Yang Z, Du G
J Chem Inf Model 2021 Dec 27;61(12):5763-5773. Epub 2021 Nov 19 doi: 10.1021/acs.jcim.1c01089. PMID: 34797660
Treatment of COVID-19 Pneumonia: the Case for Placenta-derived Cell Therapy.
Berishvili E, Kaiser L, Cohen M, Berney T, Scholz H, Floisand Y, Mattsson J
Stem Cell Rev Rep 2021 Feb;17(1):63-70. doi: 10.1007/s12015-020-10004-x. PMID: 32696426Free PMC Article
Antiretroviral drug-related toxicities - clinical spectrum, prevention, and management.
Fernandez-Montero JV, Eugenia E, Barreiro P, Labarga P, Soriano V
Expert Opin Drug Saf 2013 Sep;12(5):697-707. Epub 2013 Jun 4 doi: 10.1517/14740338.2013.806480. PMID: 23730950

Recent clinical studies

Etiology

Self-sampling monkeypox virus testing in high-risk populations, asymptomatic or with unrecognized Mpox, in Spain.
Agustí C, Martínez-Riveros H, Hernández-Rodríguez À, Casañ C, Díaz Y, Alonso L, Martró E, Muñoz-Basagoiti J, Gallemí M, Folch C, Sönmez I, Adell H, Villar M, París de León A, Martinez-Puchol S, Pelegrin AC, Perez-Zsolt D, Raïch-Regué D, Mora R, Villegas L, Clotet B, Izquierdo-Useros N, Cardona PJ, Casabona J
Nat Commun 2023 Oct 2;14(1):5998. doi: 10.1038/s41467-023-40490-9. PMID: 37783731Free PMC Article
The kidney in COVID-19: protagonist or figurant?
Staico MF, Zaffanello M, DI Pietro G, Fanos V, Marcialis MA
Panminerva Med 2023 Mar;65(1):65-75. Epub 2020 May 20 doi: 10.23736/S0031-0808.20.03965-8. PMID: 32432445
Coronavirus disease 2019 and the liver.
Esteban JP, Sobotka L, Rockey DC
Curr Opin Gastroenterol 2022 May 1;38(3):191-199. Epub 2022 Mar 11 doi: 10.1097/MOG.0000000000000826. PMID: 35275902
Acute kidney damage in COVID-19 patients.
Chebotareva N, Berns S, Androsova T, Moiseev S
Clin Nephrol 2021 May;95(5):227-239. doi: 10.5414/CN110357. PMID: 33749581
COVID-19 and the liver.
Jothimani D, Venugopal R, Abedin MF, Kaliamoorthy I, Rela M
J Hepatol 2020 Nov;73(5):1231-1240. Epub 2020 Jun 15 doi: 10.1016/j.jhep.2020.06.006. PMID: 32553666Free PMC Article

Diagnosis

A nano-luciferase expressing human coronavirus OC43 for countermeasure development.
Diefenbacher MV, Baric TJ, Martinez DR, Baric RS, Catanzaro NJ, Sheahan TP
Virus Res 2024 Jan 2;339:199286. Epub 2023 Dec 5 doi: 10.1016/j.virusres.2023.199286. PMID: 38016504Free PMC Article
Tecovirimat Resistance in Mpox Patients, United States, 2022-2023.
Smith TG, Gigante CM, Wynn NT, Matheny A, Davidson W, Yang Y, Condori RE, O'Connell K, Kovar L, Williams TL, Yu YC, Petersen BW, Baird N, Lowe D, Li Y, Satheshkumar PS, Hutson CL
Emerg Infect Dis 2023 Dec;29(12):2426-2432. Epub 2023 Oct 19 doi: 10.3201/eid2912.231146. PMID: 37856204Free PMC Article
Measuring the Success of HIV-1 Cure Strategies.
Thomas J, Ruggiero A, Paxton WA, Pollakis G
Front Cell Infect Microbiol 2020;10:134. Epub 2020 Apr 7 doi: 10.3389/fcimb.2020.00134. PMID: 32318356Free PMC Article
Cytomegalovirus and the eye.
Carmichael A
Eye (Lond) 2012 Feb;26(2):237-40. Epub 2011 Dec 16 doi: 10.1038/eye.2011.327. PMID: 22173076Free PMC Article
Monkeypox virus: histologic, immunohistochemical and electron-microscopic findings.
Bayer-Garner IB
J Cutan Pathol 2005 Jan;32(1):28-34. doi: 10.1111/j.0303-6987.2005.00254.x. PMID: 15660652

Therapy

Extrahepatic manifestations of HCV where do we stand?
Mokhles MA
Med Clin (Barc) 2024 Mar 8;162(5):231-237. Epub 2023 Nov 18 doi: 10.1016/j.medcli.2023.10.011. PMID: 37980213
Tecovirimat Resistance in Mpox Patients, United States, 2022-2023.
Smith TG, Gigante CM, Wynn NT, Matheny A, Davidson W, Yang Y, Condori RE, O'Connell K, Kovar L, Williams TL, Yu YC, Petersen BW, Baird N, Lowe D, Li Y, Satheshkumar PS, Hutson CL
Emerg Infect Dis 2023 Dec;29(12):2426-2432. Epub 2023 Oct 19 doi: 10.3201/eid2912.231146. PMID: 37856204Free PMC Article
Repurposing drugs as COVID-19 therapies: A toxicity evaluation.
Ngan DK, Xu T, Xia M, Zheng W, Huang R
Drug Discov Today 2022 Jul;27(7):1983-1993. Epub 2022 Apr 6 doi: 10.1016/j.drudis.2022.04.001. PMID: 35395401Free PMC Article
Monocytes and Macrophages as Viral Targets and Reservoirs.
Nikitina E, Larionova I, Choinzonov E, Kzhyshkowska J
Int J Mol Sci 2018 Sep 18;19(9) doi: 10.3390/ijms19092821. PMID: 30231586Free PMC Article
Hantavirus pulmonary syndrome.
Macneil A, Nichol ST, Spiropoulou CF
Virus Res 2011 Dec;162(1-2):138-47. Epub 2011 Sep 17 doi: 10.1016/j.virusres.2011.09.017. PMID: 21945215

Prognosis

Tecovirimat Resistance in Mpox Patients, United States, 2022-2023.
Smith TG, Gigante CM, Wynn NT, Matheny A, Davidson W, Yang Y, Condori RE, O'Connell K, Kovar L, Williams TL, Yu YC, Petersen BW, Baird N, Lowe D, Li Y, Satheshkumar PS, Hutson CL
Emerg Infect Dis 2023 Dec;29(12):2426-2432. Epub 2023 Oct 19 doi: 10.3201/eid2912.231146. PMID: 37856204Free PMC Article
SARS-CoV-2, alcohol consumption and liver injury.
Testino G, DI Biagio A, Fagoonee S, Pellicano R
Minerva Med 2022 Apr;113(2):333-342. Epub 2021 Oct 21 doi: 10.23736/S0026-4806.21.07809-5. PMID: 34672164
Cytokine Overproduction and Immune System Dysregulation in alloHSCT and COVID-19 Patients.
Lange A, Lange J, Jaskuła E
Front Immunol 2021;12:658896. Epub 2021 Jun 2 doi: 10.3389/fimmu.2021.658896. PMID: 34149697Free PMC Article
Acute kidney damage in COVID-19 patients.
Chebotareva N, Berns S, Androsova T, Moiseev S
Clin Nephrol 2021 May;95(5):227-239. doi: 10.5414/CN110357. PMID: 33749581
Herpetic esophagitis.
Shortsleeve MJ, Gauvin GP, Gardner RC, Greenberg MS
Radiology 1981 Dec;141(3):611-7. doi: 10.1148/radiology.141.3.7302212. PMID: 7302212

Clinical prediction guides

A nano-luciferase expressing human coronavirus OC43 for countermeasure development.
Diefenbacher MV, Baric TJ, Martinez DR, Baric RS, Catanzaro NJ, Sheahan TP
Virus Res 2024 Jan 2;339:199286. Epub 2023 Dec 5 doi: 10.1016/j.virusres.2023.199286. PMID: 38016504Free PMC Article
Papaverine: A Miraculous Alkaloid from Opium and Its Multimedicinal Application.
Ashrafi S, Alam S, Sultana A, Raj A, Emon NU, Richi FT, Sharmin T, Moon M, Park MN, Kim B
Molecules 2023 Mar 31;28(7) doi: 10.3390/molecules28073149. PMID: 37049912Free PMC Article
Reflectance confocal microscopy in infectious diseases.
Cinotti E, Labeille B, Cambazard F, Perrot JL
G Ital Dermatol Venereol 2015 Oct;150(5):575-83. Epub 2015 Jul 1 PMID: 26129682
The immunobiology of mushrooms.
Borchers AT, Krishnamurthy A, Keen CL, Meyers FJ, Gershwin ME
Exp Biol Med (Maywood) 2008 Mar;233(3):259-76. doi: 10.3181/0708-MR-227. PMID: 18296732
Teratogen update: congenital rubella.
Webster WS
Teratology 1998 Jul;58(1):13-23. doi: 10.1002/(SICI)1096-9926(199807)58:1<13::AID-TERA5>3.0.CO;2-2. PMID: 9699240

Recent systematic reviews

Type I interferon pathway assays in studies of rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider.
Burska A, Rodríguez-Carrio J, Biesen R, Dik WA, Eloranta ML, Cavalli G, Visser M, Boumpas DT, Bertsias G, Wahren-Herlenius M, Rehwinkel J, Frémond ML, Crow MK, Ronnblom L, Conaghan PG, Versnel M, Vital E
RMD Open 2023 Mar;9(1) doi: 10.1136/rmdopen-2022-002876. PMID: 36863752Free PMC Article
Viral cultures for assessing fomite transmission of SARS-CoV-2: a systematic review and meta-analysis.
Onakpoya IJ, Heneghan CJ, Spencer EA, Brassey J, Rosca EC, Maltoni S, Plüddemann A, Evans DH, Conly JM, Jefferson T
J Hosp Infect 2022 Dec;130:63-94. Epub 2022 Sep 14 doi: 10.1016/j.jhin.2022.09.007. PMID: 36115620Free PMC Article
SARS-CoV-2 and the role of fomite transmission: a systematic review.
Onakpoya IJ, Heneghan CJ, Spencer EA, Brassey J, Plüddemann A, Evans DH, Conly JM, Jefferson T
F1000Res 2021;10:233. Epub 2021 Mar 24 doi: 10.12688/f1000research.51590.3. PMID: 34136133Free PMC Article
Postmortem Findings Associated With SARS-CoV-2: Systematic Review and Meta-analysis.
Satturwar S, Fowkes M, Farver C, Wilson AM, Eccher A, Girolami I, Pujadas E, Bryce C, Salem F, El Jamal SM, Paniz-Mondolfi A, Petersen B, Gordon RE, Reidy J, Fraggetta F, Marshall DA, Pantanowitz L
Am J Surg Pathol 2021 May 1;45(5):587-603. doi: 10.1097/PAS.0000000000001650. PMID: 33481385Free PMC Article
Reflectance confocal microscopy for cutaneous infections and infestations.
Cinotti E, Perrot JL, Labeille B, Cambazard F
J Eur Acad Dermatol Venereol 2016 May;30(5):754-63. Epub 2015 Sep 21 doi: 10.1111/jdv.13254. PMID: 26387660

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...