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Pathogeneses

MedGen UID:
195936
•Concept ID:
C0699748
•
Pathologic Function
Synonym: pathogenesis
SNOMED CT: Pathogenesis (263547006); Pathogeneses (303109001)

Definition

The pathologic, physiologic, or biochemical mechanism resulting in the development of a disease or morbid process. [from NCI]

Professional guidelines

PubMed

Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment.
Zhao H, Zhang J, Cheng X, Nie X, He B
J Ovarian Res 2023 Jan 11;16(1):9. doi: 10.1186/s13048-022-01091-0. PMID: 36631836Free PMC Article
Diagnosis and Management of Myocarditis in Children: A Scientific Statement From the American Heart Association.
Law YM, Lal AK, Chen S, Čiháková D, Cooper LT Jr, Deshpande S, Godown J, Grosse-Wortmann L, Robinson JD, Towbin JA; American Heart Association Pediatric Heart Failure and Transplantation Committee of the Council on Lifelong Congenital Heart Disease and Heart Health in the Young and Stroke Council
Circulation 2021 Aug 10;144(6):e123-e135. Epub 2021 Jul 7 doi: 10.1161/CIR.0000000000001001. PMID: 34229446
Association of Late Life Depression, (Non-) Modifiable Risk and Protective Factors with Dementia and Alzheimer's Disease: Literature Review on Current Evidences, Preventive Interventions and Possible Future Trends in Prevention and Treatment of Dementia.
Kuo CY, Stachiv I, Nikolai T
Int J Environ Res Public Health 2020 Oct 14;17(20) doi: 10.3390/ijerph17207475. PMID: 33066592Free PMC Article

Recent clinical studies

Etiology

Diagnosis and Management of Myocarditis in Children: A Scientific Statement From the American Heart Association.
Law YM, Lal AK, Chen S, Čiháková D, Cooper LT Jr, Deshpande S, Godown J, Grosse-Wortmann L, Robinson JD, Towbin JA; American Heart Association Pediatric Heart Failure and Transplantation Committee of the Council on Lifelong Congenital Heart Disease and Heart Health in the Young and Stroke Council
Circulation 2021 Aug 10;144(6):e123-e135. Epub 2021 Jul 7 doi: 10.1161/CIR.0000000000001001. PMID: 34229446
Hypoxia and brain aging: Neurodegeneration or neuroprotection?
Burtscher J, Mallet RT, Burtscher M, Millet GP
Ageing Res Rev 2021 Jul;68:101343. Epub 2021 Apr 15 doi: 10.1016/j.arr.2021.101343. PMID: 33862277
Post-transplant lymphoproliferative disorders, Epstein-Barr virus infection, and disease in solid organ transplantation: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.
Allen UD, Preiksaitis JK; AST Infectious Diseases Community of Practice
Clin Transplant 2019 Sep;33(9):e13652. Epub 2019 Jul 23 doi: 10.1111/ctr.13652. PMID: 31230381
Central retinal artery occlusion.
Hayreh SS
Indian J Ophthalmol 2018 Dec;66(12):1684-1694. doi: 10.4103/ijo.IJO_1446_18. PMID: 30451166Free PMC Article
Ischemic optic neuropathy.
Hayreh SS
Prog Retin Eye Res 2009 Jan;28(1):34-62. Epub 2008 Nov 27 doi: 10.1016/j.preteyeres.2008.11.002. PMID: 19063989

Diagnosis

Diagnosis and Management of Myocarditis in Children: A Scientific Statement From the American Heart Association.
Law YM, Lal AK, Chen S, Čiháková D, Cooper LT Jr, Deshpande S, Godown J, Grosse-Wortmann L, Robinson JD, Towbin JA; American Heart Association Pediatric Heart Failure and Transplantation Committee of the Council on Lifelong Congenital Heart Disease and Heart Health in the Young and Stroke Council
Circulation 2021 Aug 10;144(6):e123-e135. Epub 2021 Jul 7 doi: 10.1161/CIR.0000000000001001. PMID: 34229446
MicroRNAs as regulators, biomarkers and therapeutic targets in liver diseases.
Wang X, He Y, Mackowiak B, Gao B
Gut 2021 Apr;70(4):784-795. Epub 2020 Oct 30 doi: 10.1136/gutjnl-2020-322526. PMID: 33127832
Pathogenesis of Atypical Hemolytic Uremic Syndrome.
Yoshida Y, Kato H, Ikeda Y, Nangaku M
J Atheroscler Thromb 2019 Feb 1;26(2):99-110. Epub 2018 Nov 2 doi: 10.5551/jat.RV17026. PMID: 30393246Free PMC Article
Central retinal artery occlusion.
Hayreh SS
Indian J Ophthalmol 2018 Dec;66(12):1684-1694. doi: 10.4103/ijo.IJO_1446_18. PMID: 30451166Free PMC Article
Inflammation and cancer.
Murata M
Environ Health Prev Med 2018 Oct 20;23(1):50. doi: 10.1186/s12199-018-0740-1. PMID: 30340457Free PMC Article

Therapy

Aging exaggerates acute-on-chronic alcohol-induced liver injury in mice and humans by inhibiting neutrophilic sirtuin 1-C/EBPα-miRNA-223 axis.
Ren R, He Y, Ding D, Cui A, Bao H, Ma J, Hou X, Li Y, Feng D, Li X, Liangpunsakul S, Gao B, Wang H
Hepatology 2022 Mar;75(3):646-660. Epub 2021 Dec 5 doi: 10.1002/hep.32152. PMID: 34510484Free PMC Article
Post-transplant lymphoproliferative disorders, Epstein-Barr virus infection, and disease in solid organ transplantation: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.
Allen UD, Preiksaitis JK; AST Infectious Diseases Community of Practice
Clin Transplant 2019 Sep;33(9):e13652. Epub 2019 Jul 23 doi: 10.1111/ctr.13652. PMID: 31230381
Keratosis Pilaris and its Subtypes: Associations, New Molecular and Pharmacologic Etiologies, and Therapeutic Options.
Wang JF, Orlow SJ
Am J Clin Dermatol 2018 Oct;19(5):733-757. doi: 10.1007/s40257-018-0368-3. PMID: 30043128
Donor-Specific Antibodies in Kidney Transplant Recipients.
Zhang R
Clin J Am Soc Nephrol 2018 Jan 6;13(1):182-192. Epub 2017 Apr 26 doi: 10.2215/CJN.00700117. PMID: 28446536Free PMC Article
Minocycline selectively inhibits M1 polarization of microglia.
Kobayashi K, Imagama S, Ohgomori T, Hirano K, Uchimura K, Sakamoto K, Hirakawa A, Takeuchi H, Suzumura A, Ishiguro N, Kadomatsu K
Cell Death Dis 2013 Mar 7;4(3):e525. doi: 10.1038/cddis.2013.54. PMID: 23470532Free PMC Article

Prognosis

Diagnosis and Management of Myocarditis in Children: A Scientific Statement From the American Heart Association.
Law YM, Lal AK, Chen S, Čiháková D, Cooper LT Jr, Deshpande S, Godown J, Grosse-Wortmann L, Robinson JD, Towbin JA; American Heart Association Pediatric Heart Failure and Transplantation Committee of the Council on Lifelong Congenital Heart Disease and Heart Health in the Young and Stroke Council
Circulation 2021 Aug 10;144(6):e123-e135. Epub 2021 Jul 7 doi: 10.1161/CIR.0000000000001001. PMID: 34229446
MicroRNAs as regulators, biomarkers and therapeutic targets in liver diseases.
Wang X, He Y, Mackowiak B, Gao B
Gut 2021 Apr;70(4):784-795. Epub 2020 Oct 30 doi: 10.1136/gutjnl-2020-322526. PMID: 33127832
Pathogenesis of Atypical Hemolytic Uremic Syndrome.
Yoshida Y, Kato H, Ikeda Y, Nangaku M
J Atheroscler Thromb 2019 Feb 1;26(2):99-110. Epub 2018 Nov 2 doi: 10.5551/jat.RV17026. PMID: 30393246Free PMC Article
Donor-Specific Antibodies in Kidney Transplant Recipients.
Zhang R
Clin J Am Soc Nephrol 2018 Jan 6;13(1):182-192. Epub 2017 Apr 26 doi: 10.2215/CJN.00700117. PMID: 28446536Free PMC Article
Minocycline selectively inhibits M1 polarization of microglia.
Kobayashi K, Imagama S, Ohgomori T, Hirano K, Uchimura K, Sakamoto K, Hirakawa A, Takeuchi H, Suzumura A, Ishiguro N, Kadomatsu K
Cell Death Dis 2013 Mar 7;4(3):e525. doi: 10.1038/cddis.2013.54. PMID: 23470532Free PMC Article

Clinical prediction guides

Aging exaggerates acute-on-chronic alcohol-induced liver injury in mice and humans by inhibiting neutrophilic sirtuin 1-C/EBPα-miRNA-223 axis.
Ren R, He Y, Ding D, Cui A, Bao H, Ma J, Hou X, Li Y, Feng D, Li X, Liangpunsakul S, Gao B, Wang H
Hepatology 2022 Mar;75(3):646-660. Epub 2021 Dec 5 doi: 10.1002/hep.32152. PMID: 34510484Free PMC Article
Diagnosis and Management of Myocarditis in Children: A Scientific Statement From the American Heart Association.
Law YM, Lal AK, Chen S, Čiháková D, Cooper LT Jr, Deshpande S, Godown J, Grosse-Wortmann L, Robinson JD, Towbin JA; American Heart Association Pediatric Heart Failure and Transplantation Committee of the Council on Lifelong Congenital Heart Disease and Heart Health in the Young and Stroke Council
Circulation 2021 Aug 10;144(6):e123-e135. Epub 2021 Jul 7 doi: 10.1161/CIR.0000000000001001. PMID: 34229446
Association of Late Life Depression, (Non-) Modifiable Risk and Protective Factors with Dementia and Alzheimer's Disease: Literature Review on Current Evidences, Preventive Interventions and Possible Future Trends in Prevention and Treatment of Dementia.
Kuo CY, Stachiv I, Nikolai T
Int J Environ Res Public Health 2020 Oct 14;17(20) doi: 10.3390/ijerph17207475. PMID: 33066592Free PMC Article
Pathogenesis of Atypical Hemolytic Uremic Syndrome.
Yoshida Y, Kato H, Ikeda Y, Nangaku M
J Atheroscler Thromb 2019 Feb 1;26(2):99-110. Epub 2018 Nov 2 doi: 10.5551/jat.RV17026. PMID: 30393246Free PMC Article
Donor-Specific Antibodies in Kidney Transplant Recipients.
Zhang R
Clin J Am Soc Nephrol 2018 Jan 6;13(1):182-192. Epub 2017 Apr 26 doi: 10.2215/CJN.00700117. PMID: 28446536Free PMC Article

Recent systematic reviews

Xiaoyao Powder in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis.
Liu N, Yang J, Ma W, Li C, An L, Zhang X, Zou Q
J Ethnopharmacol 2022 Apr 24;288:114999. Epub 2022 Jan 17 doi: 10.1016/j.jep.2022.114999. PMID: 35051605
New Insights in Coagulation and Fibrinolysis in Patients with Primary Brain Cancer: A Systematic Review.
Winther-Larsen A, Sandfeld-Paulsen B, Hvas AM
Semin Thromb Hemost 2022 Apr;48(3):323-337. Epub 2021 Oct 8 doi: 10.1055/s-0041-1733961. PMID: 34624915
The efficacy of botulinum toxin A treatment for tension-type or cervicogenic headache: a systematic review and meta-analysis of randomized, placebo-controlled trials.
Roland SB, Pripp AH, Msomphora MR, Kvarstein G
Scand J Pain 2021 Oct 26;21(4):635-652. Epub 2021 Jun 7 doi: 10.1515/sjpain-2021-0038. PMID: 34090319
Hemorrhagic and ischemic stroke in patients with coronavirus disease 2019: incidence, risk factors, and pathogenesis - a systematic review and meta-analysis.
Syahrul S, Maliga HA, Ilmawan M, Fahriani M, Mamada SS, Fajar JK, Frediansyah A, Syahrul FN, Imran I, Haris S, Rambe AS, Emran TB, Rabaan AA, Tiwari R, Dhama K, Nainu F, Mutiawati E, Harapan H
F1000Res 2021;10:34. Epub 2021 Jan 19 doi: 10.12688/f1000research.42308.1. PMID: 33708378Free PMC Article
Stigmatization caused by hair loss - a systematic literature review.
Schielein MC, Tizek L, Ziehfreund S, Sommer R, Biedermann T, Zink A
J Dtsch Dermatol Ges 2020 Dec;18(12):1357-1368. Epub 2020 Oct 4 doi: 10.1111/ddg.14234. PMID: 33015951

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