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Pulmonary cryptococcosis

MedGen UID:
124445
•Concept ID:
C0276688
•
Disease or Syndrome
Synonyms: Cryptococcal Pneumonia; Cryptococcal pneumonitis
SNOMED CT: Pulmonary cryptococcosis (20953001); Cryptococcal pneumonitis (20953001)

Definition

Fungal pneumonia caused by inhalation of particles of Cryptococcus. It usually occurs in immunocompromised patients such as persons with AIDS, transplant recipients, patients receiving cytotoxic chemotherapy, and patients with hematologic malignancies. It is rare in immunocompetent individuals. Signs and symptoms include fever, cough, and dyspnea. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPulmonary cryptococcosis

Professional guidelines

PubMed

Clinical Diagnosis, Treatment, and Laboratory Detection of 50 Cases of Pulmonary Cryptococcosis.
Wang T, Liu M, Zhang F
Comput Math Methods Med 2022;2022:7981472. Epub 2022 Jul 25 doi: 10.1155/2022/7981472. PMID: 35924106Free PMC Article
Recommendations for the management of pulmonary fungal infections in patients with rheumatoid arthritis.
Galli M, Antinori S, Atzeni F, Meroni L, Riva A, Scirè C, Adorni F, Quartuccio L, Sebastiani M, Airò P, Bazzichi L, Cristini F, Del Bono V, Manfredi A, Viapiana O, De Rosa F, Favalli E, Petrelli E, Salvarani C, Govoni M, Corcione S, Scrivo R, Sarmati L, Lazzarin A, Grassi W, Mastroianni C, Gaeta GB, Ferraccioli G, Cutolo M, De Vita S, Lapadula G, Matucci-Cerinic M, Armignacco O, Sarzi-Puttini P
Clin Exp Rheumatol 2017 Nov-Dec;35(6):1018-1028. Epub 2017 Nov 28 PMID: 29185961
Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.
Perfect JR, Dismukes WE, Dromer F, Goldman DL, Graybill JR, Hamill RJ, Harrison TS, Larsen RA, Lortholary O, Nguyen MH, Pappas PG, Powderly WG, Singh N, Sobel JD, Sorrell TC
Clin Infect Dis 2010 Feb 1;50(3):291-322. doi: 10.1086/649858. PMID: 20047480Free PMC Article

Recent clinical studies

Etiology

Glucocorticoids, COVID-19 and Cryptococcosis.
Dos Santos WM, Rogerio AP
Antiinflamm Antiallergy Agents Med Chem 2023;22(2):67-70. doi: 10.2174/1871523022666230912142540. PMID: 37702231
Pulmonary Cryptococcosis: comparison of Cryptococcal antigen detection and radiography in Immunocompetent and Immunocompromised patients.
Min J, Huang K, Shi C, Li L, Li F, Zhu T, Deng H
BMC Infect Dis 2020 Jan 30;20(1):91. doi: 10.1186/s12879-020-4818-1. PMID: 32000709Free PMC Article
Pulmonary cryptococcosis: A review of pathobiology and clinical aspects.
Setianingrum F, Rautemaa-Richardson R, Denning DW
Med Mycol 2019 Feb 1;57(2):133-150. doi: 10.1093/mmy/myy086. PMID: 30329097
Pulmonary Cryptococcosis.
Chang CC, Sorrell TC, Chen SC
Semin Respir Crit Care Med 2015 Oct;36(5):681-91. Epub 2015 Sep 23 doi: 10.1055/s-0035-1562895. PMID: 26398535
Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.
Perfect JR, Dismukes WE, Dromer F, Goldman DL, Graybill JR, Hamill RJ, Harrison TS, Larsen RA, Lortholary O, Nguyen MH, Pappas PG, Powderly WG, Singh N, Sobel JD, Sorrell TC
Clin Infect Dis 2010 Feb 1;50(3):291-322. doi: 10.1086/649858. PMID: 20047480Free PMC Article

Diagnosis

Glucocorticoids, COVID-19 and Cryptococcosis.
Dos Santos WM, Rogerio AP
Antiinflamm Antiallergy Agents Med Chem 2023;22(2):67-70. doi: 10.2174/1871523022666230912142540. PMID: 37702231
Pulmonary cryptococcosis: A review of pathobiology and clinical aspects.
Setianingrum F, Rautemaa-Richardson R, Denning DW
Med Mycol 2019 Feb 1;57(2):133-150. doi: 10.1093/mmy/myy086. PMID: 30329097
Pulmonary cryptococcosis.
Brizendine KD, Baddley JW, Pappas PG
Semin Respir Crit Care Med 2011 Dec;32(6):727-34. Epub 2011 Dec 13 doi: 10.1055/s-0031-1295720. PMID: 22167400
Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.
Perfect JR, Dismukes WE, Dromer F, Goldman DL, Graybill JR, Hamill RJ, Harrison TS, Larsen RA, Lortholary O, Nguyen MH, Pappas PG, Powderly WG, Singh N, Sobel JD, Sorrell TC
Clin Infect Dis 2010 Feb 1;50(3):291-322. doi: 10.1086/649858. PMID: 20047480Free PMC Article
Pulmonary cryptococcosis.
Jarvis JN, Harrison TS
Semin Respir Crit Care Med 2008 Apr;29(2):141-50. doi: 10.1055/s-2008-1063853. PMID: 18365996

Therapy

Glucocorticoids, COVID-19 and Cryptococcosis.
Dos Santos WM, Rogerio AP
Antiinflamm Antiallergy Agents Med Chem 2023;22(2):67-70. doi: 10.2174/1871523022666230912142540. PMID: 37702231
Pulmonary Cryptococcosis: comparison of Cryptococcal antigen detection and radiography in Immunocompetent and Immunocompromised patients.
Min J, Huang K, Shi C, Li L, Li F, Zhu T, Deng H
BMC Infect Dis 2020 Jan 30;20(1):91. doi: 10.1186/s12879-020-4818-1. PMID: 32000709Free PMC Article
Pulmonary cryptococcosis: A review of pathobiology and clinical aspects.
Setianingrum F, Rautemaa-Richardson R, Denning DW
Med Mycol 2019 Feb 1;57(2):133-150. doi: 10.1093/mmy/myy086. PMID: 30329097
Pulmonary Cryptococcosis.
Chang CC, Sorrell TC, Chen SC
Semin Respir Crit Care Med 2015 Oct;36(5):681-91. Epub 2015 Sep 23 doi: 10.1055/s-0035-1562895. PMID: 26398535
Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.
Perfect JR, Dismukes WE, Dromer F, Goldman DL, Graybill JR, Hamill RJ, Harrison TS, Larsen RA, Lortholary O, Nguyen MH, Pappas PG, Powderly WG, Singh N, Sobel JD, Sorrell TC
Clin Infect Dis 2010 Feb 1;50(3):291-322. doi: 10.1086/649858. PMID: 20047480Free PMC Article

Prognosis

Cerebrospinal fluid cytokine and chemokine patterns correlate with prognosis of HIV-uninfected cryptococcal meningitis: A prospective observational study.
Jiang YK, Wang RY, Zhou LH, Cheng JH, Luo Y, Zhu RS, Qiu WJ, Zhao HZ, Wang X, Harrison TS, Zhu LP
Front Immunol 2022;13:993495. Epub 2022 Aug 12 doi: 10.3389/fimmu.2022.993495. PMID: 36032125Free PMC Article
Pulmonary Cryptococcosis: comparison of Cryptococcal antigen detection and radiography in Immunocompetent and Immunocompromised patients.
Min J, Huang K, Shi C, Li L, Li F, Zhu T, Deng H
BMC Infect Dis 2020 Jan 30;20(1):91. doi: 10.1186/s12879-020-4818-1. PMID: 32000709Free PMC Article
Pulmonary cryptococcosis: A review of pathobiology and clinical aspects.
Setianingrum F, Rautemaa-Richardson R, Denning DW
Med Mycol 2019 Feb 1;57(2):133-150. doi: 10.1093/mmy/myy086. PMID: 30329097
Reversed Halo Sign: Presents in Different Pulmonary Diseases.
Zhan X, Zhang L, Wang Z, Jin M, Liu M, Tong Z
PLoS One 2015;10(6):e0128153. Epub 2015 Jun 17 doi: 10.1371/journal.pone.0128153. PMID: 26083865Free PMC Article
Pulmonary cryptococcosis: comparison of clinical and radiographic characteristics in immunocompetent and immunocompromised patients.
Chang WC, Tzao C, Hsu HH, Lee SC, Huang KL, Tung HJ, Chen CY
Chest 2006 Feb;129(2):333-340. doi: 10.1378/chest.129.2.333. PMID: 16478849

Clinical prediction guides

Aggressive systemic mastocytosis of colon and lymph node: A case report.
Xun-Ze S, Liu F, Lin C, Sun YF
Medicine (Baltimore) 2023 May 26;102(21):e33813. doi: 10.1097/MD.0000000000033813. PMID: 37233424Free PMC Article
Cerebrospinal fluid cytokine and chemokine patterns correlate with prognosis of HIV-uninfected cryptococcal meningitis: A prospective observational study.
Jiang YK, Wang RY, Zhou LH, Cheng JH, Luo Y, Zhu RS, Qiu WJ, Zhao HZ, Wang X, Harrison TS, Zhu LP
Front Immunol 2022;13:993495. Epub 2022 Aug 12 doi: 10.3389/fimmu.2022.993495. PMID: 36032125Free PMC Article
Recommendations for the management of pulmonary fungal infections in patients with rheumatoid arthritis.
Galli M, Antinori S, Atzeni F, Meroni L, Riva A, Scirè C, Adorni F, Quartuccio L, Sebastiani M, Airò P, Bazzichi L, Cristini F, Del Bono V, Manfredi A, Viapiana O, De Rosa F, Favalli E, Petrelli E, Salvarani C, Govoni M, Corcione S, Scrivo R, Sarmati L, Lazzarin A, Grassi W, Mastroianni C, Gaeta GB, Ferraccioli G, Cutolo M, De Vita S, Lapadula G, Matucci-Cerinic M, Armignacco O, Sarzi-Puttini P
Clin Exp Rheumatol 2017 Nov-Dec;35(6):1018-1028. Epub 2017 Nov 28 PMID: 29185961
Pulmonary cryptococcosis.
Patz EF Jr, Goodman PC
J Thorac Imaging 1992 Sep;7(4):51-5. doi: 10.1097/00005382-199209000-00008. PMID: 1404545
Pulmonary cryptococcosis.
McDonnell JM, Hutchins GM
Hum Pathol 1985 Feb;16(2):121-8. doi: 10.1016/s0046-8177(85)80060-5. PMID: 3972394

Recent systematic reviews

Pulmonary cryptococcosis complicated with pulmonary aspergillosis: a series of studies and a literature review.
Wang X, Li S, Zhu M, Qiu Y, Hui Y, Li Y, Zhan Y, Wang Y, Ye F, Li Z
BMC Infect Dis 2024 Jan 16;24(1):92. doi: 10.1186/s12879-024-09014-8. PMID: 38229026Free PMC Article
Comparison of the clinical manifestations and chest CT findings of pulmonary cryptococcosis in immunocompetent and immunocompromised patients: a systematic review and meta-analysis.
Xiong C, Lu J, Chen T, Xu R
BMC Pulm Med 2022 Nov 11;22(1):415. doi: 10.1186/s12890-022-02175-9. PMID: 36369001Free PMC Article

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