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Cryptococcosis

MedGen UID:
8189
•Concept ID:
C0010414
•
Disease or Syndrome
Synonyms: C neoformans Infection; C neoformans Infections; C. neoformans Infection; C. neoformans Infections; Cryptococcus neoformans Infection; Cryptococcus neoformans Infections; Infection, C neoformans; Infection, C. neoformans; Infection, Cryptococcus neoformans; Infections, C. neoformans
SNOMED CT: European cryptococcosis (42386007); European blastomycosis (42386007); Busse-Buschke's disease (42386007); Busse-Buschke disease (42386007); Cryptococcosis (42386007); Torula (42386007); Torulosis (42386007); Infection by Cryptococcus neoformans (42386007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0005724
Orphanet: ORPHA1546

Definition

A cosmopolitan fungal infection due to <i>Cryptococcus neoformans</i>. [from ORDO]

Professional guidelines

PubMed

Pharmacokinetics of antifungal drugs: practical implications for optimized treatment of patients.
Bellmann R, Smuszkiewicz P
Infection 2017 Dec;45(6):737-779. Epub 2017 Jul 12 doi: 10.1007/s15010-017-1042-z. PMID: 28702763Free PMC Article
An official American Thoracic Society statement: Treatment of fungal infections in adult pulmonary and critical care patients.
Limper AH, Knox KS, Sarosi GA, Ampel NM, Bennett JE, Catanzaro A, Davies SF, Dismukes WE, Hage CA, Marr KA, Mody CH, Perfect JR, Stevens DA; American Thoracic Society Fungal Working Group
Am J Respir Crit Care Med 2011 Jan 1;183(1):96-128. doi: 10.1164/rccm.2008-740ST. PMID: 21193785
Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.
Perfect JR, Dismukes WE, Dromer F, Goldman DL, Graybill JR, Hamill RJ, Harrison TS, Larsen RA, Lortholary O, Nguyen MH, Pappas PG, Powderly WG, Singh N, Sobel JD, Sorrell TC
Clin Infect Dis 2010 Feb 1;50(3):291-322. doi: 10.1086/649858. PMID: 20047480Free PMC Article

Recent clinical studies

Etiology

Cutaneous Cryptococcosis.
Noguchi H, Matsumoto T, Kimura U, Hiruma M, Kusuhara M, Ihn H
Med Mycol J 2019;60(4):101-107. doi: 10.3314/mmj.19.008. PMID: 31787730
Pulmonary cryptococcosis: A review of pathobiology and clinical aspects.
Setianingrum F, Rautemaa-Richardson R, Denning DW
Med Mycol 2019 Feb 1;57(2):133-150. doi: 10.1093/mmy/myy086. PMID: 30329097
Common invasive fungal diseases: an overview of invasive candidiasis, aspergillosis, cryptococcosis, and Pneumocystis pneumonia.
Schmiedel Y, Zimmerli S
Swiss Med Wkly 2016;146:w14281. Epub 2016 Feb 22 doi: 10.4414/smw.2016.14281. PMID: 26901377
Pulmonary Cryptococcosis.
Chang CC, Sorrell TC, Chen SC
Semin Respir Crit Care Med 2015 Oct;36(5):681-91. Epub 2015 Sep 23 doi: 10.1055/s-0035-1562895. PMID: 26398535
Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.
Perfect JR, Dismukes WE, Dromer F, Goldman DL, Graybill JR, Hamill RJ, Harrison TS, Larsen RA, Lortholary O, Nguyen MH, Pappas PG, Powderly WG, Singh N, Sobel JD, Sorrell TC
Clin Infect Dis 2010 Feb 1;50(3):291-322. doi: 10.1086/649858. PMID: 20047480Free PMC Article

Diagnosis

Cutaneous Cryptococcosis.
Noguchi H, Matsumoto T, Kimura U, Hiruma M, Kusuhara M, Ihn H
Med Mycol J 2019;60(4):101-107. doi: 10.3314/mmj.19.008. PMID: 31787730
Cryptococcosis in solid organ transplantation-Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.
Baddley JW, Forrest GN; AST Infectious Diseases Community of Practice
Clin Transplant 2019 Sep;33(9):e13543. Epub 2019 Apr 14 doi: 10.1111/ctr.13543. PMID: 30900315
Pulmonary cryptococcosis: A review of pathobiology and clinical aspects.
Setianingrum F, Rautemaa-Richardson R, Denning DW
Med Mycol 2019 Feb 1;57(2):133-150. doi: 10.1093/mmy/myy086. PMID: 30329097
Cryptococcosis.
Maziarz EK, Perfect JR
Infect Dis Clin North Am 2016 Mar;30(1):179-206. doi: 10.1016/j.idc.2015.10.006. PMID: 26897067Free PMC Article
Pulmonary Cryptococcosis.
Chang CC, Sorrell TC, Chen SC
Semin Respir Crit Care Med 2015 Oct;36(5):681-91. Epub 2015 Sep 23 doi: 10.1055/s-0035-1562895. PMID: 26398535

Therapy

Cryptococcosis.
Zavala S, Baddley JW
Semin Respir Crit Care Med 2020 Feb;41(1):69-79. Epub 2020 Jan 30 doi: 10.1055/s-0039-3400280. PMID: 32000285
Cryptococcosis in solid organ transplantation-Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.
Baddley JW, Forrest GN; AST Infectious Diseases Community of Practice
Clin Transplant 2019 Sep;33(9):e13543. Epub 2019 Apr 14 doi: 10.1111/ctr.13543. PMID: 30900315
Common invasive fungal diseases: an overview of invasive candidiasis, aspergillosis, cryptococcosis, and Pneumocystis pneumonia.
Schmiedel Y, Zimmerli S
Swiss Med Wkly 2016;146:w14281. Epub 2016 Feb 22 doi: 10.4414/smw.2016.14281. PMID: 26901377
Cryptococcosis.
Maziarz EK, Perfect JR
Infect Dis Clin North Am 2016 Mar;30(1):179-206. doi: 10.1016/j.idc.2015.10.006. PMID: 26897067Free PMC Article
Pulmonary Cryptococcosis.
Chang CC, Sorrell TC, Chen SC
Semin Respir Crit Care Med 2015 Oct;36(5):681-91. Epub 2015 Sep 23 doi: 10.1055/s-0035-1562895. PMID: 26398535

Prognosis

Cryptococcosis.
Gushiken AC, Saharia KK, Baddley JW
Infect Dis Clin North Am 2021 Jun;35(2):493-514. doi: 10.1016/j.idc.2021.03.012. PMID: 34016288
Fungal infections in HIV/AIDS.
Limper AH, Adenis A, Le T, Harrison TS
Lancet Infect Dis 2017 Nov;17(11):e334-e343. Epub 2017 Jul 31 doi: 10.1016/S1473-3099(17)30303-1. PMID: 28774701
Other HIV-associated pneumonias.
Pupaibool J, Limper AH
Clin Chest Med 2013 Jun;34(2):243-54. Epub 2013 Apr 8 doi: 10.1016/j.ccm.2013.01.007. PMID: 23702174Free PMC Article
Cryptococcosis.
Perfect JR, Casadevall A
Infect Dis Clin North Am 2002 Dec;16(4):837-74, v-vi. doi: 10.1016/s0891-5520(02)00036-3. PMID: 12512184
Cryptococcosis.
Perfect JR
Infect Dis Clin North Am 1989 Mar;3(1):77-102. PMID: 2647836

Clinical prediction guides

Epidemiology of Cryptococcus and cryptococcosis in Western Africa.
Akaihe CL, Nweze EI
Mycoses 2021 Jan;64(1):4-17. Epub 2020 Oct 8 doi: 10.1111/myc.13188. PMID: 32969547
Cryptococcus: from environmental saprophyte to global pathogen.
May RC, Stone NR, Wiesner DL, Bicanic T, Nielsen K
Nat Rev Microbiol 2016 Feb;14(2):106-17. Epub 2015 Dec 21 doi: 10.1038/nrmicro.2015.6. PMID: 26685750Free PMC Article
Cryptococcosis.
Negroni R
Clin Dermatol 2012 Nov-Dec;30(6):599-609. doi: 10.1016/j.clindermatol.2012.01.005. PMID: 23068147
Pulmonary cryptococcosis.
Patz EF Jr, Goodman PC
J Thorac Imaging 1992 Sep;7(4):51-5. doi: 10.1097/00005382-199209000-00008. PMID: 1404545
Zoonoses.
Goscienski PJ
Pediatr Infect Dis 1983 Jan-Feb;2(1):69-81. doi: 10.1097/00006454-198301000-00018. PMID: 6340080

Recent systematic reviews

Cryptococcosis in the Democratic Republic of Congo from 1953 to 2021: A systematic review and meta-analysis.
Zono BB, Kasumba DM, Situakibanza Nani-Tuma H, Bepouka Izizag B, Yambayamba Kapenga M, Nsuka Yanga R, Tshimanga Yona T, Kamangu Ntambwe E, Hayette MP, Mvumbi Lelo G
Mycoses 2022 Jun;65(6):580-589. Epub 2022 Apr 17 doi: 10.1111/myc.13440. PMID: 35363896
The microbiome of bat guano: for what is this knowledge important?
Dimkić I, Fira D, Janakiev T, Kabić J, Stupar M, Nenadić M, Unković N, Grbić ML
Appl Microbiol Biotechnol 2021 Feb;105(4):1407-1419. Epub 2021 Jan 29 doi: 10.1007/s00253-021-11143-y. PMID: 33512572Free PMC Article
Cryptococcus and cryptococcosis in Iran during 1969-2019: A systematic review and meta-analysis.
Bandalizadeh Z, Javidnia J, Hosseini SA, Moosazadeh M, Amouei A, Kermani F, Seyedmousavi S, Shokohi T
J Mycol Med 2020 Apr;30(1):100917. Epub 2019 Dec 6 doi: 10.1016/j.mycmed.2019.100917. PMID: 31864801
Cryptococcosis in pregnancy and the postpartum period: Case series and systematic review with recommendations for management.
Pastick KA, Nalintya E, Tugume L, Ssebambulidde K, Stephens N, Evans EE, Ndyetukira JF, Nuwagira E, Skipper C, Muzoora C, Meya DB, Rhein J, Boulware DR, Rajasingham R
Med Mycol 2020 Apr 1;58(3):282-292. doi: 10.1093/mmy/myz084. PMID: 31689712Free PMC Article
Evaluation of a new cryptococcal antigen lateral flow immunoassay in serum, cerebrospinal fluid and urine for the diagnosis of cryptococcosis: a meta-analysis and systematic review.
Huang HR, Fan LC, Rajbanshi B, Xu JF
PLoS One 2015;10(5):e0127117. Epub 2015 May 14 doi: 10.1371/journal.pone.0127117. PMID: 25974018Free PMC Article

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