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Nasal flaring

MedGen UID:
124453
Concept ID:
C0277873
Sign or Symptom
Synonyms: Flared alae nasi; Flaring nostrils; Flaring of nasal alae
SNOMED CT: Alar flare, nose (21558008); Flared nostrils (21558008); Flaring of alae nasi (21558008); Nasal flaring (248568003)
 
HPO: HP:0030863

Definition

Widening of the nostrils upon inhalation as a manifestation of respiratory distress. [from HPO]

Term Hierarchy

Conditions with this feature

Ectodermal dysplasia-blindness syndrome
MedGen UID:
340297
Concept ID:
C1849332
Disease or Syndrome
A rare multiple congenital anomalies/dysmorphic syndrome characterized by intellectual disability, severe visual impairment due to ocular malformations (microphthalmos and microcornea with sclerocornea), short stature, hypotrichosis, dental anomalies, and dysmorphic facial features (such as a narrow nasal bridge with marked distal flaring and low-set, protruding ears). There have been no further descriptions in the literature since 1992.
Alfadhel syndrome
MedGen UID:
1845825
Concept ID:
C5882735
Disease or Syndrome
Alfadhel syndrome (AFDL) is an autosomal recessive neurodevelopmental disorder with features of global developmental delay, hypotonia, and facial dysmorphism (Asiri et al., 2020, Bertoli-Avella et al., 2021).

Professional guidelines

PubMed

Lirette MP, Kuppermann N, Finkelstein Y, Zemek R, Plint AC, Florin TA, Babl FE, Dalziel S, Freedman S, Roland D, Lyttle MD, Schnadower D, Steele D, Fernandes RM, Stephens D, Kharbanda A, Johnson DW, Macias C, Benito J, Schuh S; Pediatric Emergency Research Networks (PERN)
BMJ Open 2022 Dec 7;12(12):e059784. doi: 10.1136/bmjopen-2021-059784. PMID: 36600373Free PMC Article
Nascimento-Carvalho CM
J Pediatr (Rio J) 2020 Mar-Apr;96 Suppl 1(Suppl 1):29-38. Epub 2019 Sep 10 doi: 10.1016/j.jped.2019.08.003. PMID: 31518547Free PMC Article
McNaughten B, Bourke TW
Practitioner 2015 Jul-Aug;259(1784):13-5, 2. PMID: 26514055

Recent clinical studies

Etiology

Zorrilla-Riveiro JG, Arnau-Bartés A, Rafat-Sellarés R, García-Pérez D, Mas-Serra A, Fernández-Fernández R
Am J Emerg Med 2017 Apr;35(4):548-553. Epub 2016 Dec 10 doi: 10.1016/j.ajem.2016.12.008. PMID: 28007319
Reuter S, Moser C, Baack M
Pediatr Rev 2014 Oct;35(10):417-28; quiz 429. doi: 10.1542/pir.35-10-417. PMID: 25274969Free PMC Article
Chaves GS, Fregonezi GA, Dias FA, Ribeiro CT, Guerra RO, Freitas DA, Parreira VF, Mendonca KM
Cochrane Database Syst Rev 2013 Sep 20;(9):CD010277. doi: 10.1002/14651858.CD010277.pub2. PMID: 24057988
Guilleminault C, Pelayo R
Ann Med 1998 Aug;30(4):350-6. doi: 10.3109/07853899809029934. PMID: 9783833
Carlo WA, Martin RJ, Bruce EN, Strohl KP, Fanaroff AA
Pediatrics 1983 Sep;72(3):338-43. PMID: 6684277

Diagnosis

Lirette MP, Kuppermann N, Finkelstein Y, Zemek R, Plint AC, Florin TA, Babl FE, Dalziel S, Freedman S, Roland D, Lyttle MD, Schnadower D, Steele D, Fernandes RM, Stephens D, Kharbanda A, Johnson DW, Macias C, Benito J, Schuh S; Pediatric Emergency Research Networks (PERN)
BMJ Open 2022 Dec 7;12(12):e059784. doi: 10.1136/bmjopen-2021-059784. PMID: 36600373Free PMC Article
Nascimento-Carvalho CM
J Pediatr (Rio J) 2020 Mar-Apr;96 Suppl 1(Suppl 1):29-38. Epub 2019 Sep 10 doi: 10.1016/j.jped.2019.08.003. PMID: 31518547Free PMC Article
Hermansen CL, Mahajan A
Am Fam Physician 2015 Dec 1;92(11):994-1002. PMID: 26760414
Reuter S, Moser C, Baack M
Pediatr Rev 2014 Oct;35(10):417-28; quiz 429. doi: 10.1542/pir.35-10-417. PMID: 25274969Free PMC Article
Guilleminault C, Pelayo R
Ann Med 1998 Aug;30(4):350-6. doi: 10.3109/07853899809029934. PMID: 9783833

Therapy

Nascimento-Carvalho CM
J Pediatr (Rio J) 2020 Mar-Apr;96 Suppl 1(Suppl 1):29-38. Epub 2019 Sep 10 doi: 10.1016/j.jped.2019.08.003. PMID: 31518547Free PMC Article
Binks AP, Desjardin S, Riker R
Respir Care 2017 Feb;62(2):150-155. Epub 2016 Dec 13 doi: 10.4187/respcare.04927. PMID: 27965421
Hermansen CL, Mahajan A
Am Fam Physician 2015 Dec 1;92(11):994-1002. PMID: 26760414
Reuter S, Moser C, Baack M
Pediatr Rev 2014 Oct;35(10):417-28; quiz 429. doi: 10.1542/pir.35-10-417. PMID: 25274969Free PMC Article
Chaves GS, Fregonezi GA, Dias FA, Ribeiro CT, Guerra RO, Freitas DA, Parreira VF, Mendonca KM
Cochrane Database Syst Rev 2013 Sep 20;(9):CD010277. doi: 10.1002/14651858.CD010277.pub2. PMID: 24057988

Prognosis

Nascimento-Carvalho CM
J Pediatr (Rio J) 2020 Mar-Apr;96 Suppl 1(Suppl 1):29-38. Epub 2019 Sep 10 doi: 10.1016/j.jped.2019.08.003. PMID: 31518547Free PMC Article
Freire G, Kuppermann N, Zemek R, Plint AC, Babl FE, Dalziel SR, Freedman SB, Atenafu EG, Stephens D, Steele DW, Fernandes RM, Florin TA, Kharbanda A, Lyttle MD, Johnson DW, Schnadower D, Macias CG, Benito J, Schuh S; Pediatric Emergency Research Networks (PERN)
Pediatrics 2018 Sep;142(3) Epub 2018 Aug 20 doi: 10.1542/peds.2017-4253. PMID: 30126934
Schuh S, Babl FE, Dalziel SR, Freedman SB, Macias CG, Stephens D, Steele DW, Fernandes RM, Zemek R, Plint AC, Florin TA, Lyttle MD, Johnson DW, Gouin S, Schnadower D, Klassen TP, Bajaj L, Benito J, Kharbanda A, Kuppermann N; Pediatric Emergency Research Networks (PERN)
Pediatrics 2017 Dec;140(6) doi: 10.1542/peds.2017-0842. PMID: 29184035
Rambaud-Althaus C, Althaus F, Genton B, D'Acremont V
Lancet Infect Dis 2015 Apr;15(4):439-50. Epub 2015 Mar 11 doi: 10.1016/S1473-3099(15)70017-4. PMID: 25769269
Usen S, Webert M
Int J Tuberc Lung Dis 2001 Jun;5(6):505-10. PMID: 11409575

Clinical prediction guides

Chaitanya, Ravikiran
J Assoc Physicians India 2022 Apr;70(4):11-12. PMID: 35443455
Nascimento-Carvalho CM
J Pediatr (Rio J) 2020 Mar-Apr;96 Suppl 1(Suppl 1):29-38. Epub 2019 Sep 10 doi: 10.1016/j.jped.2019.08.003. PMID: 31518547Free PMC Article
O'Neill G, Tolley NS
J Appl Physiol (1985) 2019 Nov 1;127(5):1215-1223. Epub 2019 Aug 1 doi: 10.1152/japplphysiol.01118.2018. PMID: 31369336
Zorrilla-Riveiro JG, Arnau-Bartés A, Rafat-Sellarés R, García-Pérez D, Mas-Serra A, Fernández-Fernández R
Am J Emerg Med 2017 Apr;35(4):548-553. Epub 2016 Dec 10 doi: 10.1016/j.ajem.2016.12.008. PMID: 28007319
Chaves GS, Fregonezi GA, Dias FA, Ribeiro CT, Guerra RO, Freitas DA, Parreira VF, Mendonca KM
Cochrane Database Syst Rev 2013 Sep 20;(9):CD010277. doi: 10.1002/14651858.CD010277.pub2. PMID: 24057988

Recent systematic reviews

Rambaud-Althaus C, Althaus F, Genton B, D'Acremont V
Lancet Infect Dis 2015 Apr;15(4):439-50. Epub 2015 Mar 11 doi: 10.1016/S1473-3099(15)70017-4. PMID: 25769269
Chaves GS, Fregonezi GA, Dias FA, Ribeiro CT, Guerra RO, Freitas DA, Parreira VF, Mendonca KM
Cochrane Database Syst Rev 2013 Sep 20;(9):CD010277. doi: 10.1002/14651858.CD010277.pub2. PMID: 24057988

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