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Childhood Acute Myeloid Leukemia with Maturation

MedGen UID:
124638
•Concept ID:
C0279636
•
Neoplastic Process
Synonyms: Childhood Acute M2 Leukemia; Childhood Acute Myeloblastic Leukemia with Maturation; Childhood Acute Myeloblastic Leukemia with Maturation (M2); Childhood Acute Myelogenous Leukemia with Maturation; M2 Childhood Acute Myeloblastic Leukemia with Maturation; M2 Childhood Acute Myelogenous Leukemia; M2 Childhood Acute Myelogenous Leukemia with Maturation; M2 Childhood Acute Myeloid Leukemia with Maturation; M2 Pediatric Acute Myeloblastic Leukemia with Maturation; M2 Pediatric Acute Myelogenous Leukemia; M2 Pediatric Acute Myelogenous Leukemia with Maturation; M2 Pediatric Acute Myeloid Leukemia with Maturation; M2 Pediatric AGL; Pediatric Acute M2 Leukemia; Pediatric Acute Myeloblastic Leukemia with Maturation; Pediatric Acute Myelogenous Leukemia with Maturation; Pediatric Acute Myeloid Leukemia with Maturation

Definition

An acute myeloid leukemia with maturation occurring in children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Acute Myeloid Leukemia with Maturation

Professional guidelines

PubMed

Treatment outcomes of childhood PICALM::MLLT10 acute leukaemias.
Mark C, Meshinchi S, Joyce B, Gibson B, Harrison C, Bergmann AK, Goemans BF, Pronk CJH, Lapillonne H, Leverger G, Antoniou E, Schneider M, Attarbaschi A, Dworzak M, Stary J, Tomizawa D, Ebert S, Lejman M, Kolb EA, Schmiegelow K, Hasle H, Abla O
Br J Haematol 2024 Feb;204(2):576-584. Epub 2023 Sep 24 doi: 10.1111/bjh.19067. PMID: 37743097
Current Management of Childhood Acute Myeloid Leukemia.
Rubnitz JE
Paediatr Drugs 2017 Feb;19(1):1-10. doi: 10.1007/s40272-016-0200-6. PMID: 27785777
Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel.
Creutzig U, van den Heuvel-Eibrink MM, Gibson B, Dworzak MN, Adachi S, de Bont E, Harbott J, Hasle H, Johnston D, Kinoshita A, Lehrnbecher T, Leverger G, Mejstrikova E, Meshinchi S, Pession A, Raimondi SC, Sung L, Stary J, Zwaan CM, Kaspers GJ, Reinhardt D; AML Committee of the International BFM Study Group
Blood 2012 Oct 18;120(16):3187-205. Epub 2012 Aug 9 doi: 10.1182/blood-2012-03-362608. PMID: 22879540

Recent clinical studies

Etiology

Relapsed pediatric acute myeloid leukaemia: state-of-the-art in 2023.
Egan G, Tasian SK
Haematologica 2023 Sep 1;108(9):2275-2288. doi: 10.3324/haematol.2022.281106. PMID: 36861399Free PMC Article
A global study for acute myeloid leukemia with RARG rearrangement.
Zhu HH, Qin YZ, Zhang ZL, Liu YJ, Wen LJ, You MJ, Zhang C, Such E, Luo H, Yuan HJ, Zhou HS, Liu HX, Xu R, Li J, Li JH, Hao JP, Jin J, Yu L, Zhang JY, Liu LP, Zhang LP, Huang RB, Shen SH, Gao SJ, Wang W, Yan XJ, Zhang XY, Du X, Chu XX, Yu YF, Wang Y, Mi YC, Lu Y, Cai Z, Su Z, Taussig DC, MacMahon S, Ball ED, Wang HY, Welch JS, Yin CC, Borthakur G, Sanz MA, Kantarjian HM, Huang JY, Hu J, Chen SN
Blood Adv 2023 Jul 11;7(13):2972-2982. doi: 10.1182/bloodadvances.2022008364. PMID: 36799929Free PMC Article
Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia.
Duncavage EJ, Bagg A, Hasserjian RP, DiNardo CD, Godley LA, Iacobucci I, Jaiswal S, Malcovati L, Vannucchi AM, Patel KP, Arber DA, Arcila ME, Bejar R, Berliner N, Borowitz MJ, Branford S, Brown AL, Cargo CA, Döhner H, Falini B, Garcia-Manero G, Haferlach T, Hellström-Lindberg E, Kim AS, Klco JM, Komrokji R, Lee-Cheun Loh M, Loghavi S, Mullighan CG, Ogawa S, Orazi A, Papaemmanuil E, Reiter A, Ross DM, Savona M, Shimamura A, Skoda RC, Solé F, Stone RM, Tefferi A, Walter MJ, Wu D, Ebert BL, Cazzola M
Blood 2022 Nov 24;140(21):2228-2247. doi: 10.1182/blood.2022015853. PMID: 36130297Free PMC Article
Pediatric acute myeloid leukemia: updates on biology, risk stratification, and therapy.
Elgarten CW, Aplenc R
Curr Opin Pediatr 2020 Feb;32(1):57-66. doi: 10.1097/MOP.0000000000000855. PMID: 31815781
How I treat myelodysplastic syndromes of childhood.
Locatelli F, Strahm B
Blood 2018 Mar 29;131(13):1406-1414. Epub 2018 Feb 8 doi: 10.1182/blood-2017-09-765214. PMID: 29438960

Diagnosis

Relapsed pediatric acute myeloid leukaemia: state-of-the-art in 2023.
Egan G, Tasian SK
Haematologica 2023 Sep 1;108(9):2275-2288. doi: 10.3324/haematol.2022.281106. PMID: 36861399Free PMC Article
Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia.
Duncavage EJ, Bagg A, Hasserjian RP, DiNardo CD, Godley LA, Iacobucci I, Jaiswal S, Malcovati L, Vannucchi AM, Patel KP, Arber DA, Arcila ME, Bejar R, Berliner N, Borowitz MJ, Branford S, Brown AL, Cargo CA, Döhner H, Falini B, Garcia-Manero G, Haferlach T, Hellström-Lindberg E, Kim AS, Klco JM, Komrokji R, Lee-Cheun Loh M, Loghavi S, Mullighan CG, Ogawa S, Orazi A, Papaemmanuil E, Reiter A, Ross DM, Savona M, Shimamura A, Skoda RC, Solé F, Stone RM, Tefferi A, Walter MJ, Wu D, Ebert BL, Cazzola M
Blood 2022 Nov 24;140(21):2228-2247. doi: 10.1182/blood.2022015853. PMID: 36130297Free PMC Article
Pediatric acute myeloid leukemia: updates on biology, risk stratification, and therapy.
Elgarten CW, Aplenc R
Curr Opin Pediatr 2020 Feb;32(1):57-66. doi: 10.1097/MOP.0000000000000855. PMID: 31815781
Hematologic malignancies and Li-Fraumeni syndrome.
Swaminathan M, Bannon SA, Routbort M, Naqvi K, Kadia TM, Takahashi K, Alvarado Y, Ravandi-Kashani F, Patel KP, Champlin R, Kantarjian H, Strong L, DiNardo CD
Cold Spring Harb Mol Case Stud 2019 Feb;5(1) Epub 2019 Feb 1 doi: 10.1101/mcs.a003210. PMID: 30709875Free PMC Article
Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel.
Creutzig U, van den Heuvel-Eibrink MM, Gibson B, Dworzak MN, Adachi S, de Bont E, Harbott J, Hasle H, Johnston D, Kinoshita A, Lehrnbecher T, Leverger G, Mejstrikova E, Meshinchi S, Pession A, Raimondi SC, Sung L, Stary J, Zwaan CM, Kaspers GJ, Reinhardt D; AML Committee of the International BFM Study Group
Blood 2012 Oct 18;120(16):3187-205. Epub 2012 Aug 9 doi: 10.1182/blood-2012-03-362608. PMID: 22879540

Therapy

Relapsed pediatric acute myeloid leukaemia: state-of-the-art in 2023.
Egan G, Tasian SK
Haematologica 2023 Sep 1;108(9):2275-2288. doi: 10.3324/haematol.2022.281106. PMID: 36861399Free PMC Article
A global study for acute myeloid leukemia with RARG rearrangement.
Zhu HH, Qin YZ, Zhang ZL, Liu YJ, Wen LJ, You MJ, Zhang C, Such E, Luo H, Yuan HJ, Zhou HS, Liu HX, Xu R, Li J, Li JH, Hao JP, Jin J, Yu L, Zhang JY, Liu LP, Zhang LP, Huang RB, Shen SH, Gao SJ, Wang W, Yan XJ, Zhang XY, Du X, Chu XX, Yu YF, Wang Y, Mi YC, Lu Y, Cai Z, Su Z, Taussig DC, MacMahon S, Ball ED, Wang HY, Welch JS, Yin CC, Borthakur G, Sanz MA, Kantarjian HM, Huang JY, Hu J, Chen SN
Blood Adv 2023 Jul 11;7(13):2972-2982. doi: 10.1182/bloodadvances.2022008364. PMID: 36799929Free PMC Article
Immune dysfunction signatures predict outcomes and define checkpoint blockade-unresponsive microenvironments in acute myeloid leukemia.
Rutella S, Vadakekolathu J, Mazziotta F, Reeder S, Yau TO, Mukhopadhyay R, Dickins B, Altmann H, Kramer M, Knaus HA, Blazar BR, Radojcic V, Zeidner JF, Arruda A, Wang B, Abbas HA, Minden MD, Tasian SK, Bornhäuser M, Gojo I, Luznik L
J Clin Invest 2022 Nov 1;132(21) doi: 10.1172/JCI159579. PMID: 36099049Free PMC Article
Pediatric acute myeloid leukemia: updates on biology, risk stratification, and therapy.
Elgarten CW, Aplenc R
Curr Opin Pediatr 2020 Feb;32(1):57-66. doi: 10.1097/MOP.0000000000000855. PMID: 31815781
Current Management of Childhood Acute Myeloid Leukemia.
Rubnitz JE
Paediatr Drugs 2017 Feb;19(1):1-10. doi: 10.1007/s40272-016-0200-6. PMID: 27785777

Prognosis

A global study for acute myeloid leukemia with RARG rearrangement.
Zhu HH, Qin YZ, Zhang ZL, Liu YJ, Wen LJ, You MJ, Zhang C, Such E, Luo H, Yuan HJ, Zhou HS, Liu HX, Xu R, Li J, Li JH, Hao JP, Jin J, Yu L, Zhang JY, Liu LP, Zhang LP, Huang RB, Shen SH, Gao SJ, Wang W, Yan XJ, Zhang XY, Du X, Chu XX, Yu YF, Wang Y, Mi YC, Lu Y, Cai Z, Su Z, Taussig DC, MacMahon S, Ball ED, Wang HY, Welch JS, Yin CC, Borthakur G, Sanz MA, Kantarjian HM, Huang JY, Hu J, Chen SN
Blood Adv 2023 Jul 11;7(13):2972-2982. doi: 10.1182/bloodadvances.2022008364. PMID: 36799929Free PMC Article
Immune dysfunction signatures predict outcomes and define checkpoint blockade-unresponsive microenvironments in acute myeloid leukemia.
Rutella S, Vadakekolathu J, Mazziotta F, Reeder S, Yau TO, Mukhopadhyay R, Dickins B, Altmann H, Kramer M, Knaus HA, Blazar BR, Radojcic V, Zeidner JF, Arruda A, Wang B, Abbas HA, Minden MD, Tasian SK, Bornhäuser M, Gojo I, Luznik L
J Clin Invest 2022 Nov 1;132(21) doi: 10.1172/JCI159579. PMID: 36099049Free PMC Article
Pediatric acute myeloid leukemia: updates on biology, risk stratification, and therapy.
Elgarten CW, Aplenc R
Curr Opin Pediatr 2020 Feb;32(1):57-66. doi: 10.1097/MOP.0000000000000855. PMID: 31815781
Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel.
Creutzig U, van den Heuvel-Eibrink MM, Gibson B, Dworzak MN, Adachi S, de Bont E, Harbott J, Hasle H, Johnston D, Kinoshita A, Lehrnbecher T, Leverger G, Mejstrikova E, Meshinchi S, Pession A, Raimondi SC, Sung L, Stary J, Zwaan CM, Kaspers GJ, Reinhardt D; AML Committee of the International BFM Study Group
Blood 2012 Oct 18;120(16):3187-205. Epub 2012 Aug 9 doi: 10.1182/blood-2012-03-362608. PMID: 22879540
Acute myeloid leukemia: epidemiology and etiology.
Deschler B, Lübbert M
Cancer 2006 Nov 1;107(9):2099-107. doi: 10.1002/cncr.22233. PMID: 17019734

Clinical prediction guides

Mapping the cellular biogeography of human bone marrow niches using single-cell transcriptomics and proteomic imaging.
Bandyopadhyay S, Duffy MP, Ahn KJ, Sussman JH, Pang M, Smith D, Duncan G, Zhang I, Huang J, Lin Y, Xiong B, Imtiaz T, Chen CH, Thadi A, Chen C, Xu J, Reichart M, Martinez Z, Diorio C, Chen C, Pillai V, Snaith O, Oldridge D, Bhattacharyya S, Maillard I, Carroll M, Nelson C, Qin L, Tan K
Cell 2024 Jun 6;187(12):3120-3140.e29. Epub 2024 May 6 doi: 10.1016/j.cell.2024.04.013. PMID: 38714197Free PMC Article
Immune dysfunction signatures predict outcomes and define checkpoint blockade-unresponsive microenvironments in acute myeloid leukemia.
Rutella S, Vadakekolathu J, Mazziotta F, Reeder S, Yau TO, Mukhopadhyay R, Dickins B, Altmann H, Kramer M, Knaus HA, Blazar BR, Radojcic V, Zeidner JF, Arruda A, Wang B, Abbas HA, Minden MD, Tasian SK, Bornhäuser M, Gojo I, Luznik L
J Clin Invest 2022 Nov 1;132(21) doi: 10.1172/JCI159579. PMID: 36099049Free PMC Article
Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell-like blasts in KMT2A-rearranged leukemia.
Chen C, Yu W, Alikarami F, Qiu Q, Chen CH, Flournoy J, Gao P, Uzun Y, Fang L, Davenport JW, Hu Y, Zhu Q, Wang K, Libbrecht C, Felmeister A, Rozich I, Ding YY, Hunger SP, Felix CA, Wu H, Brown PA, Guest EM, Barrett DM, Bernt KM, Tan K
Blood 2022 Apr 7;139(14):2198-2211. doi: 10.1182/blood.2021013442. PMID: 34864916Free PMC Article
How I treat myelodysplastic syndromes of childhood.
Locatelli F, Strahm B
Blood 2018 Mar 29;131(13):1406-1414. Epub 2018 Feb 8 doi: 10.1182/blood-2017-09-765214. PMID: 29438960
Childhood myelodysplastic syndrome.
Chatterjee T, Choudhry VP
Indian J Pediatr 2013 Sep;80(9):764-71. Epub 2013 Aug 3 doi: 10.1007/s12098-013-1130-8. PMID: 23912822

Recent systematic reviews

Early Life Nutrition Factors and Risk of Acute Leukemia in Children: Systematic Review and Meta-Analysis.
Kintossou AK, Blanco-Lopez J, Iguacel I, Pisanu S, Almeida CCB, Steliarova-Foucher E, Sierens C, Gunter MJ, Ladas EJ, Barr RD, Van Herck K, Kozlakidis Z, Huybrechts I
Nutrients 2023 Aug 29;15(17) doi: 10.3390/nu15173775. PMID: 37686807Free PMC Article
Role of Maternal Diet in the Risk of Childhood Acute Leukemia: A Systematic Review and Meta-Analysis.
Blanco-Lopez J, Iguacel I, Pisanu S, Almeida CCB, Steliarova-Foucher E, Sierens C, Gunter MJ, Ladas EJ, Barr RD, Van Herck K, Huybrechts I
Int J Environ Res Public Health 2023 Apr 6;20(7) doi: 10.3390/ijerph20075428. PMID: 37048042Free PMC Article
Dexrazoxane for preventing or reducing cardiotoxicity in adults and children with cancer receiving anthracyclines.
de Baat EC, Mulder RL, Armenian S, Feijen EA, Grotenhuis H, Hudson MM, Mavinkurve-Groothuis AM, Kremer LC, van Dalen EC
Cochrane Database Syst Rev 2022 Sep 27;9(9):CD014638. doi: 10.1002/14651858.CD014638.pub2. PMID: 36162822Free PMC Article
Exposure to pesticides and childhood leukemia risk: A systematic review and meta-analysis.
Karalexi MA, Tagkas CF, Markozannes G, Tseretopoulou X, Hernández AF, Schüz J, Halldorsson TI, Psaltopoulou T, Petridou ET, Tzoulaki I, Ntzani EE
Environ Pollut 2021 Sep 15;285:117376. Epub 2021 May 18 doi: 10.1016/j.envpol.2021.117376. PMID: 34380208
Measurable residual disease in pediatric acute myeloid leukemia: a systematic review.
Segerink WH, de Haas V, Kaspers GJL
Expert Rev Anticancer Ther 2021 Apr;21(4):451-459. Epub 2021 Mar 11 doi: 10.1080/14737140.2021.1860763. PMID: 33706635

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