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Childhood Acute Monoblastic Leukemia

MedGen UID:
124640
•Concept ID:
C0279645
•
Neoplastic Process
Synonyms: Childhood Acute M5a Leukemia; Childhood Acute Monoblastic Leukemia without Differentiation; M5a Childhood Acute Monoblastic Leukemia without Differentiation; M5a Pediatric Acute Monoblastic Leukemia without Differentiation; Pediatric Acute M5a Leukemia; Pediatric Acute Monoblastic Leukemia without Differentiation

Definition

An acute monoblastic leukemia occurring in children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Acute Monoblastic Leukemia

Professional guidelines

PubMed

Recent advances in the pathogenesis and treatment of juvenile myelomonocytic leukaemia.
Loh ML
Br J Haematol 2011 Mar;152(6):677-87. doi: 10.1111/j.1365-2141.2010.08525.x. PMID: 21623760
Childhood myelodysplastic syndrome: focus on the approach to diagnosis and treatment of juvenile myelomonocytic leukemia.
Loh ML
Hematology Am Soc Hematol Educ Program 2010;2010:357-62. doi: 10.1182/asheducation-2010.1.357. PMID: 21239819
Acute monoblastic leukemia in infancy and early childhood: successful treatment with an epipodophyllotoxin.
Odom LF, Gordon EM
Blood 1984 Oct;64(4):875-82. PMID: 6592009

Recent clinical studies

Etiology

Pediatric acute myeloid leukemia and hyperleukocytosis with WBC count greater than 50 × 10(9)/L.
Zhang A, Liu L, Zong S, Chang L, Chen X, Yang W, Guo Y, Zhang L, Zou Y, Chen Y, Zhang Y, Ruan M, Zhu X
Int J Hematol 2023 Dec;118(6):737-744. Epub 2023 Sep 21 doi: 10.1007/s12185-023-03665-0. PMID: 37733171
Novel therapies for children with acute myeloid leukaemia.
Moore AS, Kearns PR, Knapper S, Pearson AD, Zwaan CM
Leukemia 2013 Jul;27(7):1451-60. Epub 2013 Apr 8 doi: 10.1038/leu.2013.106. PMID: 23563239
Somatic PTPN11 mutations in childhood acute myeloid leukaemia.
Tartaglia M, Martinelli S, Iavarone I, Cazzaniga G, Spinelli M, Giarin E, Petrangeli V, Carta C, Masetti R, Aricò M, Locatelli F, Basso G, Sorcini M, Pession A, Biondi A
Br J Haematol 2005 May;129(3):333-9. doi: 10.1111/j.1365-2141.2005.05457.x. PMID: 15842656
Chromosome studies on acute nonlymphocytic leukaemia in children.
Slater RM, Behrendt H, De Waal FC
Pediatr Res 1983 May;17(5):398-405. doi: 10.1203/00006450-198305000-00016. PMID: 6574421
The classification of acute leukaemia in childhood.
Bird AR, Karabus CD, Pearl R, Hartley P
S Afr Med J 1981 Nov 14;60(20):769-73. PMID: 6171040

Diagnosis

CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XL inhibition by navitoclax and DT2216.
Gress V, Roussy M, Boulianne L, Bilodeau M, Cardin S, El-Hachem N, Lisi V, Khakipoor B, Rouette A, Farah A, Théret L, Aubert L, Fatima F, Audemard É, Thibault P, Bonneil É, Chagraoui J, Laramée L, Gendron P, Jouan L, Jammali S, Paré B, Simpson SM, Tran TH, Duval M, Teira P, Bittencourt H, Santiago R, Barabé F, Sauvageau G, Smith MA, Hébert J, Roux PP, Gruber TA, Lavallée VP, Wilhelm BT, Cellot S
Blood Adv 2024 Jan 9;8(1):112-129. doi: 10.1182/bloodadvances.2022008899. PMID: 37729615Free PMC Article
Pediatric acute myeloid leukemia and hyperleukocytosis with WBC count greater than 50 × 10(9)/L.
Zhang A, Liu L, Zong S, Chang L, Chen X, Yang W, Guo Y, Zhang L, Zou Y, Chen Y, Zhang Y, Ruan M, Zhu X
Int J Hematol 2023 Dec;118(6):737-744. Epub 2023 Sep 21 doi: 10.1007/s12185-023-03665-0. PMID: 37733171
Hemophagocytic lymphohistiocytosis with MUNC13-4 gene mutation or reduced natural killer cell function prior to onset of childhood leukemia.
Chang TY, Jaffray J, Woda B, Newburger PE, Usmani GN
Pediatr Blood Cancer 2011 May;56(5):856-8. Epub 2010 Dec 15 doi: 10.1002/pbc.22846. PMID: 21370424Free PMC Article
Chromosome studies on acute nonlymphocytic leukaemia in children.
Slater RM, Behrendt H, De Waal FC
Pediatr Res 1983 May;17(5):398-405. doi: 10.1203/00006450-198305000-00016. PMID: 6574421
Nonlymphocytic leukemia in childhood.
Burgert EO Jr, Nieri RL, Mills SD, Linman JW
Mayo Clin Proc 1973 Apr;48(4):255-9. PMID: 4511911

Therapy

Novel therapies for children with acute myeloid leukaemia.
Moore AS, Kearns PR, Knapper S, Pearson AD, Zwaan CM
Leukemia 2013 Jul;27(7):1451-60. Epub 2013 Apr 8 doi: 10.1038/leu.2013.106. PMID: 23563239
Somatic PTPN11 mutations in childhood acute myeloid leukaemia.
Tartaglia M, Martinelli S, Iavarone I, Cazzaniga G, Spinelli M, Giarin E, Petrangeli V, Carta C, Masetti R, Aricò M, Locatelli F, Basso G, Sorcini M, Pession A, Biondi A
Br J Haematol 2005 May;129(3):333-9. doi: 10.1111/j.1365-2141.2005.05457.x. PMID: 15842656
Advances in the management of childhood leukemia.
Bowman WP
Tex Med 1985 Mar;81(3):39-44. PMID: 3885465
Acute monoblastic leukemia in infancy and early childhood: successful treatment with an epipodophyllotoxin.
Odom LF, Gordon EM
Blood 1984 Oct;64(4):875-82. PMID: 6592009
Cyclic chemotherapy in childhood acute leukaemia.
Willoughby ML, Laurie HC
Arch Dis Child 1968 Apr;43(228):187-94. doi: 10.1136/adc.43.228.187. PMID: 5239002Free PMC Article

Prognosis

Pediatric acute myeloid leukemia and hyperleukocytosis with WBC count greater than 50 × 10(9)/L.
Zhang A, Liu L, Zong S, Chang L, Chen X, Yang W, Guo Y, Zhang L, Zou Y, Chen Y, Zhang Y, Ruan M, Zhu X
Int J Hematol 2023 Dec;118(6):737-744. Epub 2023 Sep 21 doi: 10.1007/s12185-023-03665-0. PMID: 37733171
Hemophagocytic lymphohistiocytosis with MUNC13-4 gene mutation or reduced natural killer cell function prior to onset of childhood leukemia.
Chang TY, Jaffray J, Woda B, Newburger PE, Usmani GN
Pediatr Blood Cancer 2011 May;56(5):856-8. Epub 2010 Dec 15 doi: 10.1002/pbc.22846. PMID: 21370424Free PMC Article
Advances in the management of childhood leukemia.
Bowman WP
Tex Med 1985 Mar;81(3):39-44. PMID: 3885465
Morphological heterogeneity in childhood B cell acute lymphoblastic leukaemia.
Al-Rubei K, Rose PE, Hill FG
J Clin Pathol 1984 Dec;37(12):1348-52. doi: 10.1136/jcp.37.12.1348. PMID: 6334698Free PMC Article
Fetal haemoglobin levels in acute myeloid leukaemia of childhood: their value in predicting remission.
O'Gorman Hughes DW, Lam-Po-Tang PR, Webster B
Med J Aust 1973 Dec 1;2(22):1003-4. doi: 10.5694/j.1326-5377.1973.tb129905.x. PMID: 4521039

Clinical prediction guides

IL-1 signaling pathway molecules as key markers in childhood asthma.
Wei W, Huang J, Ma Y, Ma X, Fang L, Fang W, Hao C
Pediatr Allergy Immunol 2021 Feb;32(2):305-313. Epub 2020 Nov 4 doi: 10.1111/pai.13388. PMID: 33025692
Lysosomal isoenzyme profiles used to classify a case of acute undifferentiated leukaemia.
Eden OB, Darbyshire P, Simpson RM, Besley GT, Moss S, Gentle T
Br J Haematol 1985 Jan;59(1):109-14. doi: 10.1111/j.1365-2141.1985.tb02970.x. PMID: 3155960
Morphological heterogeneity in childhood B cell acute lymphoblastic leukaemia.
Al-Rubei K, Rose PE, Hill FG
J Clin Pathol 1984 Dec;37(12):1348-52. doi: 10.1136/jcp.37.12.1348. PMID: 6334698Free PMC Article
In vitro characteristics of childhood leukemic monoblasts.
Weetman RM, Chilcote RR, Rierden WJ, Baehner RL
Exp Hematol 1978 Jan;6(1):9-17. PMID: 304810
Fetal haemoglobin levels in acute myeloid leukaemia of childhood: their value in predicting remission.
O'Gorman Hughes DW, Lam-Po-Tang PR, Webster B
Med J Aust 1973 Dec 1;2(22):1003-4. doi: 10.5694/j.1326-5377.1973.tb129905.x. PMID: 4521039

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