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Granular Renal Cell Carcinoma

MedGen UID:
124647
•Concept ID:
C0279703
•
Neoplastic Process
Synonym: Renal granular cell carcinoma
SNOMED CT: Renal granular cell carcinoma (878805009)

Definition

A renal cell carcinoma with eosinophilic cytoplasm and high nuclear grade. Granular cells can be seen in any subtype of renal cell carcinoma, including conventional clear cell carcinoma. This term does not represent a specific subtype of renal cell carcinoma and should no longer be used. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGranular Renal Cell Carcinoma

Professional guidelines

PubMed

Histological differential diagnostics of renal oncocytoma.
Baranovska VV *, Romanenko АМ, Zakhartseva LM
Exp Oncol 2020 Sep;42(3):233-237. doi: 10.32471/exp-oncology.2312-8852.vol-42-no-3.14968. PMID: 32996740
An immunohistochemical approach to the differential diagnosis of renal tumors.
Skinnider BF, Amin MB
Semin Diagn Pathol 2005 Feb;22(1):51-68. doi: 10.1053/j.semdp.2005.11.004. PMID: 16512599
Renal cell carcinoma: natural history and results of treatment.
Patel NP, Lavengood RW
J Urol 1978 Jun;119(6):722-6. doi: 10.1016/s0022-5347(17)57611-9. PMID: 660755

Recent clinical studies

Etiology

Renal oncocytoma with hyaline globules: cytologic diagnosis by guided fine needle aspiration, a case report.
Deshpande A, Munshi M
Indian J Pathol Microbiol 2005 Apr;48(2):230-5. PMID: 16758678

Diagnosis

Renal oncocytoma with hyaline globules: cytologic diagnosis by guided fine needle aspiration, a case report.
Deshpande A, Munshi M
Indian J Pathol Microbiol 2005 Apr;48(2):230-5. PMID: 16758678
Hyaline globules in renal cell carcinoma and hepatocellular carcinoma. A clue or a diagnostic pitfall on fine-needle aspiration?
Nayar R, Bourtsos E, DeFrias DV
Am J Clin Pathol 2000 Oct;114(4):576-82. doi: 10.1309/F4TU-6AFE-R7NU-39Y3. PMID: 11026104
Ultrastructural evaluation of renal cell oncocytomas.
Simmons JL, Jaqua RA, Peterson KG
Ultrastruct Pathol 1996 Jul-Aug;20(4):395-7. doi: 10.3109/01913129609016341. PMID: 8837347
Renal adenoma and oncocytoma.
Licht MR
Semin Urol Oncol 1995 Nov;13(4):262-6. PMID: 8595549

Prognosis

Renal oncocytoma with hyaline globules: cytologic diagnosis by guided fine needle aspiration, a case report.
Deshpande A, Munshi M
Indian J Pathol Microbiol 2005 Apr;48(2):230-5. PMID: 16758678
Renal adenoma and oncocytoma.
Licht MR
Semin Urol Oncol 1995 Nov;13(4):262-6. PMID: 8595549
Renal oncocytoma and granular renal cell carcinoma. A comparative clinicopathologic and DNA flow cytometric study.
Hartwick RW, el-Naggar AK, Ro JY, Srigley JR, McLemore DD, Jones EC, Grignon DJ, Thomas MJ, Ayala AG
Am J Clin Pathol 1992 Dec;98(6):587-93. doi: 10.1093/ajcp/98.6.587. PMID: 1462956

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