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MISSED ABORTION

MedGen UID:
1260
•Concept ID:
C0000814
•
Disease or Syndrome
Synonyms: Abortion, Missed; Abortions, Missed; Missed Abortion; Missed Abortions
SNOMED CT: MA - Missed abortion (16607004); Silent miscarriage (16607004); Missed miscarriage (16607004); Missed abortion (16607004)

Definition

Retention in uterus of an abortus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • MISSED ABORTION

Professional guidelines

PubMed

Association between uterine position and transvaginal misoprostol treatment for early pregnancy failure.
Chill HH, Malyanker N, Karavani G, Haj-Yahya R, Herzberg S, Bahar R, Shveiky D, Dior UP
J Obstet Gynaecol Res 2018 Feb;44(2):248-252. Epub 2017 Nov 2 doi: 10.1111/jog.13512. PMID: 29094502
Management of spontaneous abortion.
Griebel CP, Halvorsen J, Golemon TB, Day AA
Am Fam Physician 2005 Oct 1;72(7):1243-50. PMID: 16225027
Management of early pregnancy loss.
Graziosi GC, Mol BW, Ankum WM, Bruinse HW
Int J Gynaecol Obstet 2004 Sep;86(3):337-46. doi: 10.1016/j.ijgo.2004.04.038. PMID: 15325850

Recent clinical studies

Etiology

Single-cell profiling of the microenvironment in decidual tissue from women with missed abortions.
Hou R, Huang R, Zhou Y, Lin D, Xu J, Yang L, Wei X, Xie Z, Zhou Q
Fertil Steril 2023 Mar;119(3):492-503. Epub 2022 Dec 15 doi: 10.1016/j.fertnstert.2022.12.016. PMID: 36528108
Methods for managing miscarriage: a network meta-analysis.
Ghosh J, Papadopoulou A, Devall AJ, Jeffery HC, Beeson LE, Do V, Price MJ, Tobias A, Tunçalp Ö, Lavelanet A, Gülmezoglu AM, Coomarasamy A, Gallos ID
Cochrane Database Syst Rev 2021 Jun 1;6(6):CD012602. doi: 10.1002/14651858.CD012602.pub2. PMID: 34061352Free PMC Article
Mifepristone and misoprostol versus misoprostol alone for the management of missed miscarriage (MifeMiso): a randomised, double-blind, placebo-controlled trial.
Chu JJ, Devall AJ, Beeson LE, Hardy P, Cheed V, Sun Y, Roberts TE, Ogwulu CO, Williams E, Jones LL, La Fontaine Papadopoulos JH, Bender-Atik R, Brewin J, Hinshaw K, Choudhary M, Ahmed A, Naftalin J, Nunes N, Oliver A, Izzat F, Bhatia K, Hassan I, Jeve Y, Hamilton J, Deb S, Bottomley C, Ross J, Watkins L, Underwood M, Cheong Y, Kumar CS, Gupta P, Small R, Pringle S, Hodge F, Shahid A, Gallos ID, Horne AW, Quenby S, Coomarasamy A
Lancet 2020 Sep 12;396(10253):770-778. Epub 2020 Aug 24 doi: 10.1016/S0140-6736(20)31788-8. PMID: 32853559Free PMC Article
Management of spontaneous abortion.
Griebel CP, Halvorsen J, Golemon TB, Day AA
Am Fam Physician 2005 Oct 1;72(7):1243-50. PMID: 16225027
Spontaneous abortion.
McBride WZ
Am Fam Physician 1991 Jan;43(1):175-82. PMID: 1986486

Diagnosis

Protein glycosylation: bridging maternal-fetal crosstalk during embryo implantation†.
Sun X, Feng Y, Ma Q, Wang Y, Ma F
Biol Reprod 2023 Dec 11;109(6):785-798. doi: 10.1093/biolre/ioad105. PMID: 37658761
Single-cell profiling of the microenvironment in decidual tissue from women with missed abortions.
Hou R, Huang R, Zhou Y, Lin D, Xu J, Yang L, Wei X, Xie Z, Zhou Q
Fertil Steril 2023 Mar;119(3):492-503. Epub 2022 Dec 15 doi: 10.1016/j.fertnstert.2022.12.016. PMID: 36528108
Mifepristone and misoprostol versus misoprostol alone for the management of missed miscarriage (MifeMiso): a randomised, double-blind, placebo-controlled trial.
Chu JJ, Devall AJ, Beeson LE, Hardy P, Cheed V, Sun Y, Roberts TE, Ogwulu CO, Williams E, Jones LL, La Fontaine Papadopoulos JH, Bender-Atik R, Brewin J, Hinshaw K, Choudhary M, Ahmed A, Naftalin J, Nunes N, Oliver A, Izzat F, Bhatia K, Hassan I, Jeve Y, Hamilton J, Deb S, Bottomley C, Ross J, Watkins L, Underwood M, Cheong Y, Kumar CS, Gupta P, Small R, Pringle S, Hodge F, Shahid A, Gallos ID, Horne AW, Quenby S, Coomarasamy A
Lancet 2020 Sep 12;396(10253):770-778. Epub 2020 Aug 24 doi: 10.1016/S0140-6736(20)31788-8. PMID: 32853559Free PMC Article
Management of spontaneous abortion.
Griebel CP, Halvorsen J, Golemon TB, Day AA
Am Fam Physician 2005 Oct 1;72(7):1243-50. PMID: 16225027
Spontaneous abortion.
McBride WZ
Am Fam Physician 1991 Jan;43(1):175-82. PMID: 1986486

Therapy

Single-cell profiling of the microenvironment in decidual tissue from women with missed abortions.
Hou R, Huang R, Zhou Y, Lin D, Xu J, Yang L, Wei X, Xie Z, Zhou Q
Fertil Steril 2023 Mar;119(3):492-503. Epub 2022 Dec 15 doi: 10.1016/j.fertnstert.2022.12.016. PMID: 36528108
Risk factors for missed abortion: retrospective analysis of a single institution's experience.
Jiang WZ, Yang XL, Luo JR
Reprod Biol Endocrinol 2022 Aug 9;20(1):115. doi: 10.1186/s12958-022-00987-2. PMID: 35945583Free PMC Article
Methods for managing miscarriage: a network meta-analysis.
Ghosh J, Papadopoulou A, Devall AJ, Jeffery HC, Beeson LE, Do V, Price MJ, Tobias A, Tunçalp Ö, Lavelanet A, Gülmezoglu AM, Coomarasamy A, Gallos ID
Cochrane Database Syst Rev 2021 Jun 1;6(6):CD012602. doi: 10.1002/14651858.CD012602.pub2. PMID: 34061352Free PMC Article
Mifepristone and misoprostol versus misoprostol alone for the management of missed miscarriage (MifeMiso): a randomised, double-blind, placebo-controlled trial.
Chu JJ, Devall AJ, Beeson LE, Hardy P, Cheed V, Sun Y, Roberts TE, Ogwulu CO, Williams E, Jones LL, La Fontaine Papadopoulos JH, Bender-Atik R, Brewin J, Hinshaw K, Choudhary M, Ahmed A, Naftalin J, Nunes N, Oliver A, Izzat F, Bhatia K, Hassan I, Jeve Y, Hamilton J, Deb S, Bottomley C, Ross J, Watkins L, Underwood M, Cheong Y, Kumar CS, Gupta P, Small R, Pringle S, Hodge F, Shahid A, Gallos ID, Horne AW, Quenby S, Coomarasamy A
Lancet 2020 Sep 12;396(10253):770-778. Epub 2020 Aug 24 doi: 10.1016/S0140-6736(20)31788-8. PMID: 32853559Free PMC Article
Ovarian hyperstimulation syndrome.
Schenker JG, Polishuk WZ
Obstet Gynecol 1975 Jul;46(1):23-8. doi: 10.1097/00006250-197507000-00004. PMID: 1153133

Prognosis

High Expression and Significance of Siglec10/CD24 in Unexplained Missed Abortion.
Lin H, Gao L, Huang Y
Immunol Invest 2023 Nov;52(8):997-1007. Epub 2023 Nov 24 doi: 10.1080/08820139.2023.2279653. PMID: 37933581
Female reproductive tract microbiome and early miscarriages.
Lebedeva OP, Popov VN, Syromyatnikov MY, Starkova NN, Maslov AY, Kozarenko ON, Gryaznova MV
APMIS 2023 Feb;131(2):61-76. Epub 2023 Jan 2 doi: 10.1111/apm.13288. PMID: 36511842Free PMC Article
Pregnancy loss: A 40-year nationwide assessment.
Lidegaard Ø, Mikkelsen AP, Egerup P, Kolte AM, Rasmussen SC, Nielsen HS
Acta Obstet Gynecol Scand 2020 Nov;99(11):1492-1496. Epub 2020 Apr 26 doi: 10.1111/aogs.13860. PMID: 32255196
Spontaneous abortion.
McBride WZ
Am Fam Physician 1991 Jan;43(1):175-82. PMID: 1986486
Spontaneous abortion.
Boyd ME
Can J Surg 1989 Jul;32(4):260-4. PMID: 2660972

Clinical prediction guides

High Expression and Significance of Siglec10/CD24 in Unexplained Missed Abortion.
Lin H, Gao L, Huang Y
Immunol Invest 2023 Nov;52(8):997-1007. Epub 2023 Nov 24 doi: 10.1080/08820139.2023.2279653. PMID: 37933581
Prediction model for missed abortion of patients treated with IVF-ET based on XGBoost: a retrospective study.
Yuan G, Lv B, Du X, Zhang H, Zhao M, Liu Y, Hao C
PeerJ 2023;11:e14762. Epub 2023 Jan 30 doi: 10.7717/peerj.14762. PMID: 36743954Free PMC Article
Single-cell profiling of the microenvironment in decidual tissue from women with missed abortions.
Hou R, Huang R, Zhou Y, Lin D, Xu J, Yang L, Wei X, Xie Z, Zhou Q
Fertil Steril 2023 Mar;119(3):492-503. Epub 2022 Dec 15 doi: 10.1016/j.fertnstert.2022.12.016. PMID: 36528108
The association between vaginal microbiota disorders and early missed abortion: A prospective study.
Sun D, Zhao X, Pan Q, Li F, Gao B, Zhang A, Huang H, Xu D, Cheng C
Acta Obstet Gynecol Scand 2022 Sep;101(9):960-971. Epub 2022 Jul 24 doi: 10.1111/aogs.14410. PMID: 35871770Free PMC Article
Mifepristone and misoprostol versus misoprostol alone for the management of missed miscarriage (MifeMiso): a randomised, double-blind, placebo-controlled trial.
Chu JJ, Devall AJ, Beeson LE, Hardy P, Cheed V, Sun Y, Roberts TE, Ogwulu CO, Williams E, Jones LL, La Fontaine Papadopoulos JH, Bender-Atik R, Brewin J, Hinshaw K, Choudhary M, Ahmed A, Naftalin J, Nunes N, Oliver A, Izzat F, Bhatia K, Hassan I, Jeve Y, Hamilton J, Deb S, Bottomley C, Ross J, Watkins L, Underwood M, Cheong Y, Kumar CS, Gupta P, Small R, Pringle S, Hodge F, Shahid A, Gallos ID, Horne AW, Quenby S, Coomarasamy A
Lancet 2020 Sep 12;396(10253):770-778. Epub 2020 Aug 24 doi: 10.1016/S0140-6736(20)31788-8. PMID: 32853559Free PMC Article

Recent systematic reviews

Diagnostic value of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio to predict recurrent pregnancy loss and abortion; a systematic review and meta-analysis.
Hantoushzadeh S, Gargar OK, Jafarabady K, Rezaei MM, Asadi F, Eshraghi N, Panahi Z, Shirdel S, Mirzamoradi M, Ghaemi M
Immun Inflamm Dis 2024 Mar;12(3):e1210. doi: 10.1002/iid3.1210. PMID: 38506423Free PMC Article
Methods for managing miscarriage: a network meta-analysis.
Ghosh J, Papadopoulou A, Devall AJ, Jeffery HC, Beeson LE, Do V, Price MJ, Tobias A, Tunçalp Ö, Lavelanet A, Gülmezoglu AM, Coomarasamy A, Gallos ID
Cochrane Database Syst Rev 2021 Jun 1;6(6):CD012602. doi: 10.1002/14651858.CD012602.pub2. PMID: 34061352Free PMC Article
Misoprostol for medical treatment of missed abortion: a systematic review and network meta-analysis.
Wu HL, Marwah S, Wang P, Wang QM, Chen XW
Sci Rep 2017 May 10;7(1):1664. doi: 10.1038/s41598-017-01892-0. PMID: 28490770Free PMC Article
A systematic review of validated methods to capture stillbirth and spontaneous abortion using administrative or claims data.
Likis FE, Sathe NA, Carnahan R, McPheeters ML
Vaccine 2013 Dec 30;31 Suppl 10:K74-82. doi: 10.1016/j.vaccine.2013.03.076. PMID: 24331077

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