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Acinetobacter infectious disease

MedGen UID:
1299
•Concept ID:
C0001139
•
Disease or Syndrome
Synonyms: Acinetobacter Infection; Acinetobacter Infections; Infection, Acinetobacter; Infection, Mimae; Infections, Acinetobacter; Infections, Mimae; Mimae Infection; Mimae Infections
SNOMED CT: Acinetobacter infection (840588006); Infection caused by Acinetobacter (840588006)
 
HPO: HP:0032250
Monarch Initiative: MONDO:0006635

Definition

An infection by Acinetobacter baumannii, a Gram-negative bacillus that is aerobic, pleomorphic and non-motile. An opportunistic pathogen, A. baumannii has a high incidence among immunocompromised individuals, particularly those who have experienced a prolonged (over 90 d) hospital stay. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcinetobacter infectious disease

Professional guidelines

PubMed

Executive summary of the consensus document of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) on the diagnosis and antimicrobial treatment of infections due to carbapenem-resistant Gram-negative bacteria.
Pintado V, Ruiz-Garbajosa P, Aguilera-Alonso D, Baquero-Artigao F, Bou G, Cantón R, Grau S, Gutiérrez-Gutiérrez B, Larrosa N, Machuca I, Martínez Martínez L, Montero MM, Morte-Romea E, Oliver A, Paño-Pardo JR, Sorlí L
Enferm Infecc Microbiol Clin (Engl Ed) 2023 Jun-Jul;41(6):360-370. Epub 2022 Dec 13 doi: 10.1016/j.eimce.2022.06.014. PMID: 36522272
Recommendations and guidelines for the treatment of infections due to multidrug resistant organisms.
Sy CL, Chen PY, Cheng CW, Huang LJ, Wang CH, Chang TH, Chang YC, Chang CJ, Hii IM, Hsu YL, Hu YL, Hung PL, Kuo CY, Lin PC, Liu PY, Lo CL, Lo SH, Ting PJ, Tseng CF, Wang HW, Yang CH, Lee SS, Chen YS, Liu YC, Wang FD
J Microbiol Immunol Infect 2022 Jun;55(3):359-386. Epub 2022 Mar 16 doi: 10.1016/j.jmii.2022.02.001. PMID: 35370082
European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines for the treatment of infections caused by multidrug-resistant Gram-negative bacilli (endorsed by European society of intensive care medicine).
Paul M, Carrara E, Retamar P, Tängdén T, Bitterman R, Bonomo RA, de Waele J, Daikos GL, Akova M, Harbarth S, Pulcini C, Garnacho-Montero J, Seme K, Tumbarello M, Lindemann PC, Gandra S, Yu Y, Bassetti M, Mouton JW, Tacconelli E, Rodríguez-Baño J
Clin Microbiol Infect 2022 Apr;28(4):521-547. Epub 2021 Dec 16 doi: 10.1016/j.cmi.2021.11.025. PMID: 34923128

Recent clinical studies

Etiology

Efficacy and safety of sulbactam-durlobactam versus colistin for the treatment of patients with serious infections caused by Acinetobacter baumannii-calcoaceticus complex: a multicentre, randomised, active-controlled, phase 3, non-inferiority clinical trial (ATTACK).
Kaye KS, Shorr AF, Wunderink RG, Du B, Poirier GE, Rana K, Miller A, Lewis D, O'Donnell J, Chen L, Reinhart H, Srinivasan S, Isaacs R, Altarac D
Lancet Infect Dis 2023 Sep;23(9):1072-1084. Epub 2023 May 11 doi: 10.1016/S1473-3099(23)00184-6. PMID: 37182534
Recommendations and guidelines for the treatment of infections due to multidrug resistant organisms.
Sy CL, Chen PY, Cheng CW, Huang LJ, Wang CH, Chang TH, Chang YC, Chang CJ, Hii IM, Hsu YL, Hu YL, Hung PL, Kuo CY, Lin PC, Liu PY, Lo CL, Lo SH, Ting PJ, Tseng CF, Wang HW, Yang CH, Lee SS, Chen YS, Liu YC, Wang FD
J Microbiol Immunol Infect 2022 Jun;55(3):359-386. Epub 2022 Mar 16 doi: 10.1016/j.jmii.2022.02.001. PMID: 35370082
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.
Antimicrobial Resistance Collaborators
Lancet 2022 Feb 12;399(10325):629-655. Epub 2022 Jan 19 doi: 10.1016/S0140-6736(21)02724-0. PMID: 35065702Free PMC Article
European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines for the treatment of infections caused by multidrug-resistant Gram-negative bacilli (endorsed by European society of intensive care medicine).
Paul M, Carrara E, Retamar P, Tängdén T, Bitterman R, Bonomo RA, de Waele J, Daikos GL, Akova M, Harbarth S, Pulcini C, Garnacho-Montero J, Seme K, Tumbarello M, Lindemann PC, Gandra S, Yu Y, Bassetti M, Mouton JW, Tacconelli E, Rodríguez-Baño J
Clin Microbiol Infect 2022 Apr;28(4):521-547. Epub 2021 Dec 16 doi: 10.1016/j.cmi.2021.11.025. PMID: 34923128
Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis.
Tacconelli E, Carrara E, Savoldi A, Harbarth S, Mendelson M, Monnet DL, Pulcini C, Kahlmeter G, Kluytmans J, Carmeli Y, Ouellette M, Outterson K, Patel J, Cavaleri M, Cox EM, Houchens CR, Grayson ML, Hansen P, Singh N, Theuretzbacher U, Magrini N; WHO Pathogens Priority List Working Group
Lancet Infect Dis 2018 Mar;18(3):318-327. Epub 2017 Dec 21 doi: 10.1016/S1473-3099(17)30753-3. PMID: 29276051

Diagnosis

Patterns of antibiotic use, pathogens, and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoOBS).
Russell NJ, Stöhr W, Plakkal N, Cook A, Berkley JA, Adhisivam B, Agarwal R, Ahmed NU, Balasegaram M, Ballot D, Bekker A, Berezin EN, Bilardi D, Boonkasidecha S, Carvalheiro CG, Chami N, Chaurasia S, Chiurchiu S, Colas VRF, Cousens S, Cressey TR, de Assis ACD, Dien TM, Ding Y, Dung NT, Dong H, Dramowski A, Ds M, Dudeja A, Feng J, Glupczynski Y, Goel S, Goossens H, Hao DTH, Khan MI, Huertas TM, Islam MS, Jarovsky D, Khavessian N, Khorana M, Kontou A, Kostyanev T, Laoyookhon P, Lochindarat S, Larsson M, Luca M, Malhotra-Kumar S, Mondal N, Mundhra N, Musoke P, Mussi-Pinhata MM, Nanavati R, Nakwa F, Nangia S, Nankunda J, Nardone A, Nyaoke B, Obiero CW, Owor M, Ping W, Preedisripipat K, Qazi S, Qi L, Ramdin T, Riddell A, Romani L, Roysuwan P, Saggers R, Roilides E, Saha SK, Sarafidis K, Tusubira V, Thomas R, Velaphi S, Vilken T, Wang X, Wang Y, Yang Y, Zunjie L, Ellis S, Bielicki JA, Walker AS, Heath PT, Sharland M
PLoS Med 2023 Jun;20(6):e1004179. Epub 2023 Jun 8 doi: 10.1371/journal.pmed.1004179. PMID: 37289666Free PMC Article
Executive summary of the consensus document of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) on the diagnosis and antimicrobial treatment of infections due to carbapenem-resistant Gram-negative bacteria.
Pintado V, Ruiz-Garbajosa P, Aguilera-Alonso D, Baquero-Artigao F, Bou G, Cantón R, Grau S, Gutiérrez-Gutiérrez B, Larrosa N, Machuca I, Martínez Martínez L, Montero MM, Morte-Romea E, Oliver A, Paño-Pardo JR, Sorlí L
Enferm Infecc Microbiol Clin (Engl Ed) 2023 Jun-Jul;41(6):360-370. Epub 2022 Dec 13 doi: 10.1016/j.eimce.2022.06.014. PMID: 36522272
Bacterial Epidemiology and Antimicrobial Resistance Profiles in Children Reported by the ISPED Program in China, 2016 to 2020.
Fu P, Xu H, Jing C, Deng J, Wang H, Hua C, Chen Y, Chen X, Zhang T, Zhang H, Chen Y, Yang J, Lin A, Wang S, Cao Q, Wang X, Deng H, Cao S, Hao J, Gao W, Huang Y, Yu H, Wang C
Microbiol Spectr 2021 Dec 22;9(3):e0028321. Epub 2021 Nov 3 doi: 10.1128/Spectrum.00283-21. PMID: 34730410Free PMC Article
Aetiology and Significance of Hospital-Acquired Infections in Mexico.
Alonso-Aguilar NM, Juarez-Enriquez SR, Castro-Escarpulli G, Rivera G, Bocanegra-Garcia V, Guo X, Luna-Herrera J, Aguilera-Arreola MG
Clin Lab 2017 Feb 1;63(2):207-218. doi: 10.7754/Clin.Lab.2016.151119. PMID: 28182358
Emerging infections in burns.
Branski LK, Al-Mousawi A, Rivero H, Jeschke MG, Sanford AP, Herndon DN
Surg Infect (Larchmt) 2009 Oct;10(5):389-97. doi: 10.1089/sur.2009.024. PMID: 19810827Free PMC Article

Therapy

Efficacy and safety of sulbactam-durlobactam versus colistin for the treatment of patients with serious infections caused by Acinetobacter baumannii-calcoaceticus complex: a multicentre, randomised, active-controlled, phase 3, non-inferiority clinical trial (ATTACK).
Kaye KS, Shorr AF, Wunderink RG, Du B, Poirier GE, Rana K, Miller A, Lewis D, O'Donnell J, Chen L, Reinhart H, Srinivasan S, Isaacs R, Altarac D
Lancet Infect Dis 2023 Sep;23(9):1072-1084. Epub 2023 May 11 doi: 10.1016/S1473-3099(23)00184-6. PMID: 37182534
Recommendations and guidelines for the treatment of infections due to multidrug resistant organisms.
Sy CL, Chen PY, Cheng CW, Huang LJ, Wang CH, Chang TH, Chang YC, Chang CJ, Hii IM, Hsu YL, Hu YL, Hung PL, Kuo CY, Lin PC, Liu PY, Lo CL, Lo SH, Ting PJ, Tseng CF, Wang HW, Yang CH, Lee SS, Chen YS, Liu YC, Wang FD
J Microbiol Immunol Infect 2022 Jun;55(3):359-386. Epub 2022 Mar 16 doi: 10.1016/j.jmii.2022.02.001. PMID: 35370082
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.
Antimicrobial Resistance Collaborators
Lancet 2022 Feb 12;399(10325):629-655. Epub 2022 Jan 19 doi: 10.1016/S0140-6736(21)02724-0. PMID: 35065702Free PMC Article
European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines for the treatment of infections caused by multidrug-resistant Gram-negative bacilli (endorsed by European society of intensive care medicine).
Paul M, Carrara E, Retamar P, Tängdén T, Bitterman R, Bonomo RA, de Waele J, Daikos GL, Akova M, Harbarth S, Pulcini C, Garnacho-Montero J, Seme K, Tumbarello M, Lindemann PC, Gandra S, Yu Y, Bassetti M, Mouton JW, Tacconelli E, Rodríguez-Baño J
Clin Microbiol Infect 2022 Apr;28(4):521-547. Epub 2021 Dec 16 doi: 10.1016/j.cmi.2021.11.025. PMID: 34923128
Clinical and Pathophysiological Overview of Acinetobacter Infections: a Century of Challenges.
Wong D, Nielsen TB, Bonomo RA, Pantapalangkoor P, Luna B, Spellberg B
Clin Microbiol Rev 2017 Jan;30(1):409-447. doi: 10.1128/CMR.00058-16. PMID: 27974412Free PMC Article

Prognosis

Impact of air pollution on respiratory microbiome: A narrative review.
Vieceli T, Tejada S, Martinez-Reviejo R, Pumarola T, Schrenzel J, Waterer GW, Rello J
Intensive Crit Care Nurs 2023 Feb;74:103336. Epub 2022 Oct 28 doi: 10.1016/j.iccn.2022.103336. PMID: 37440188
Patterns of antibiotic use, pathogens, and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoOBS).
Russell NJ, Stöhr W, Plakkal N, Cook A, Berkley JA, Adhisivam B, Agarwal R, Ahmed NU, Balasegaram M, Ballot D, Bekker A, Berezin EN, Bilardi D, Boonkasidecha S, Carvalheiro CG, Chami N, Chaurasia S, Chiurchiu S, Colas VRF, Cousens S, Cressey TR, de Assis ACD, Dien TM, Ding Y, Dung NT, Dong H, Dramowski A, Ds M, Dudeja A, Feng J, Glupczynski Y, Goel S, Goossens H, Hao DTH, Khan MI, Huertas TM, Islam MS, Jarovsky D, Khavessian N, Khorana M, Kontou A, Kostyanev T, Laoyookhon P, Lochindarat S, Larsson M, Luca M, Malhotra-Kumar S, Mondal N, Mundhra N, Musoke P, Mussi-Pinhata MM, Nanavati R, Nakwa F, Nangia S, Nankunda J, Nardone A, Nyaoke B, Obiero CW, Owor M, Ping W, Preedisripipat K, Qazi S, Qi L, Ramdin T, Riddell A, Romani L, Roysuwan P, Saggers R, Roilides E, Saha SK, Sarafidis K, Tusubira V, Thomas R, Velaphi S, Vilken T, Wang X, Wang Y, Yang Y, Zunjie L, Ellis S, Bielicki JA, Walker AS, Heath PT, Sharland M
PLoS Med 2023 Jun;20(6):e1004179. Epub 2023 Jun 8 doi: 10.1371/journal.pmed.1004179. PMID: 37289666Free PMC Article
The burden of bacterial antimicrobial resistance in the WHO European region in 2019: a cross-country systematic analysis.
European Antimicrobial Resistance Collaborators
Lancet Public Health 2022 Nov;7(11):e897-e913. Epub 2022 Oct 14 doi: 10.1016/S2468-2667(22)00225-0. PMID: 36244350Free PMC Article
Multidrug-Resistant and Virulent Organisms Trauma Infections: Trauma Infectious Disease Outcomes Study Initiative.
Mende K, Akers KS, Tyner SD, Bennett JW, Simons MP, Blyth DM, Li P, Stewart L, Tribble DR
Mil Med 2022 May 4;187(Suppl 2):42-51. doi: 10.1093/milmed/usab131. PMID: 35512375Free PMC Article
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.
Antimicrobial Resistance Collaborators
Lancet 2022 Feb 12;399(10325):629-655. Epub 2022 Jan 19 doi: 10.1016/S0140-6736(21)02724-0. PMID: 35065702Free PMC Article

Clinical prediction guides

Clinical Outcomes and Bacterial Characteristics of Carbapenem-resistant Acinetobacter baumannii Among Patients From Different Global Regions.
Wang M, Ge L, Chen L, Komarow L, Hanson B, Reyes J, Cober E, Alenazi T, Zong Z, Xie Q, Liu Z, Li L, Yu Y, Gao H, Kanj SS, Figueroa J, Herc E, Cordova E, Weston G, Ananth Tambyah P, Garcia-Diaz J, Kaye KS, Dhar S, Munita JM, Salata RA, Vilchez S, Stryjewski ME, Villegas Botero MV, Iovleva A, Evans SR, Baum K, Hill C, Kreiswirth BN, Patel R, Paterson DL, Arias CA, Bonomo RA, Chambers HF, Fowler VG Jr, Satlin MJ, van Duin D, Doi Y; Multi-Drug Resistant Organism Network Investigators
Clin Infect Dis 2024 Feb 17;78(2):248-258. doi: 10.1093/cid/ciad556. PMID: 37738153Free PMC Article
Patterns of antibiotic use, pathogens, and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoOBS).
Russell NJ, Stöhr W, Plakkal N, Cook A, Berkley JA, Adhisivam B, Agarwal R, Ahmed NU, Balasegaram M, Ballot D, Bekker A, Berezin EN, Bilardi D, Boonkasidecha S, Carvalheiro CG, Chami N, Chaurasia S, Chiurchiu S, Colas VRF, Cousens S, Cressey TR, de Assis ACD, Dien TM, Ding Y, Dung NT, Dong H, Dramowski A, Ds M, Dudeja A, Feng J, Glupczynski Y, Goel S, Goossens H, Hao DTH, Khan MI, Huertas TM, Islam MS, Jarovsky D, Khavessian N, Khorana M, Kontou A, Kostyanev T, Laoyookhon P, Lochindarat S, Larsson M, Luca M, Malhotra-Kumar S, Mondal N, Mundhra N, Musoke P, Mussi-Pinhata MM, Nanavati R, Nakwa F, Nangia S, Nankunda J, Nardone A, Nyaoke B, Obiero CW, Owor M, Ping W, Preedisripipat K, Qazi S, Qi L, Ramdin T, Riddell A, Romani L, Roysuwan P, Saggers R, Roilides E, Saha SK, Sarafidis K, Tusubira V, Thomas R, Velaphi S, Vilken T, Wang X, Wang Y, Yang Y, Zunjie L, Ellis S, Bielicki JA, Walker AS, Heath PT, Sharland M
PLoS Med 2023 Jun;20(6):e1004179. Epub 2023 Jun 8 doi: 10.1371/journal.pmed.1004179. PMID: 37289666Free PMC Article
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.
Antimicrobial Resistance Collaborators
Lancet 2022 Feb 12;399(10325):629-655. Epub 2022 Jan 19 doi: 10.1016/S0140-6736(21)02724-0. PMID: 35065702Free PMC Article
European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines for the treatment of infections caused by multidrug-resistant Gram-negative bacilli (endorsed by European society of intensive care medicine).
Paul M, Carrara E, Retamar P, Tängdén T, Bitterman R, Bonomo RA, de Waele J, Daikos GL, Akova M, Harbarth S, Pulcini C, Garnacho-Montero J, Seme K, Tumbarello M, Lindemann PC, Gandra S, Yu Y, Bassetti M, Mouton JW, Tacconelli E, Rodríguez-Baño J
Clin Microbiol Infect 2022 Apr;28(4):521-547. Epub 2021 Dec 16 doi: 10.1016/j.cmi.2021.11.025. PMID: 34923128
Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis.
Tacconelli E, Carrara E, Savoldi A, Harbarth S, Mendelson M, Monnet DL, Pulcini C, Kahlmeter G, Kluytmans J, Carmeli Y, Ouellette M, Outterson K, Patel J, Cavaleri M, Cox EM, Houchens CR, Grayson ML, Hansen P, Singh N, Theuretzbacher U, Magrini N; WHO Pathogens Priority List Working Group
Lancet Infect Dis 2018 Mar;18(3):318-327. Epub 2017 Dec 21 doi: 10.1016/S1473-3099(17)30753-3. PMID: 29276051

Recent systematic reviews

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.
Antimicrobial Resistance Collaborators
Lancet 2022 Feb 12;399(10325):629-655. Epub 2022 Jan 19 doi: 10.1016/S0140-6736(21)02724-0. PMID: 35065702Free PMC Article
The challenge of preventing and containing outbreaks of multidrug-resistant organisms and Candida auris during the coronavirus disease 2019 pandemic: report of a carbapenem-resistant Acinetobacter baumannii outbreak and a systematic review of the literature.
Thoma R, Seneghini M, Seiffert SN, Vuichard Gysin D, Scanferla G, Haller S, Flury D, Boggian K, Kleger GR, Filipovic M, Nolte O, Schlegel M, Kohler P
Antimicrob Resist Infect Control 2022 Jan 21;11(1):12. doi: 10.1186/s13756-022-01052-8. PMID: 35063032Free PMC Article
Antibiotic resistance in hospital-acquired ESKAPE-E infections in low- and lower-middle-income countries: a systematic review and meta-analysis.
Ayobami O, Brinkwirth S, Eckmanns T, Markwart R
Emerg Microbes Infect 2022 Dec;11(1):443-451. doi: 10.1080/22221751.2022.2030196. PMID: 35034585Free PMC Article
European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines for the treatment of infections caused by multidrug-resistant Gram-negative bacilli (endorsed by European society of intensive care medicine).
Paul M, Carrara E, Retamar P, Tängdén T, Bitterman R, Bonomo RA, de Waele J, Daikos GL, Akova M, Harbarth S, Pulcini C, Garnacho-Montero J, Seme K, Tumbarello M, Lindemann PC, Gandra S, Yu Y, Bassetti M, Mouton JW, Tacconelli E, Rodríguez-Baño J
Clin Microbiol Infect 2022 Apr;28(4):521-547. Epub 2021 Dec 16 doi: 10.1016/j.cmi.2021.11.025. PMID: 34923128
ESCMID guidelines for the management of the infection control measures to reduce transmission of multidrug-resistant Gram-negative bacteria in hospitalized patients.
Tacconelli E, Cataldo MA, Dancer SJ, De Angelis G, Falcone M, Frank U, Kahlmeter G, Pan A, Petrosillo N, Rodríguez-Baño J, Singh N, Venditti M, Yokoe DS, Cookson B; European Society of Clinical Microbiology
Clin Microbiol Infect 2014 Jan;20 Suppl 1:1-55. doi: 10.1111/1469-0691.12427. PMID: 24329732

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