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Adenofibroma

MedGen UID:
1325
•Concept ID:
C0001422
•
Neoplastic Process
Synonym: Adenofibromas
SNOMED CT: Benign adenofibroma (1157241000)
 
Monarch Initiative: MONDO:0006071

Definition

A benign neoplasm characterized by the presence of connective tissue stroma and epithelial structures. It occurs in the ovary, fallopian tube, uterine corpus, and cervix. Cases of adenofibroma of the ovary with low grade malignant potential have also been reported. [from MONDO]

Professional guidelines

PubMed

Mammotome biopsy under ultrasound control in the diagnostics and treatment of nodular breast lesions - own experience.
Kibil W, Hodorowicz-Zaniewska D, Kulig J
Pol Przegl Chir 2012 May;84(5):242-6. doi: 10.2478/v10035-012-0040-1. PMID: 22763299
Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article
Uterine adenosarcoma: a clinicopathologic study of 11 cases with a reevaluation of histologic criteria.
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Arch Gynecol 1983;233(4):281-94. doi: 10.1007/BF02133803. PMID: 6318673

Recent clinical studies

Etiology

Intrahepatic cholangiocarcinoma: typical features, uncommon variants, and controversial related entities.
Zen Y
Hum Pathol 2023 Feb;132:197-207. Epub 2022 Jun 11 doi: 10.1016/j.humpath.2022.06.001. PMID: 35697170
Robotic enucleation of a biliary adenofibroma.
Blears E, Uemura T, Bunker M
BMJ Case Rep 2021 Aug 10;14(8) doi: 10.1136/bcr-2021-242737. PMID: 34376413Free PMC Article
Benign clear cell adenofibroma of the ovary. A case report with literature review.
Paşaoğlu O, Ciftçi E, Tel N, Ozalp S, Acikalin MF
Gynecol Obstet Invest 2007;64(1):36-9. Epub 2007 Jan 5 doi: 10.1159/000098425. PMID: 17202822
Fibroadenoma.
Dent DM, Cant PJ
World J Surg 1989 Nov-Dec;13(6):706-10. doi: 10.1007/BF01658418. PMID: 2696223
Heterogeneity in gingival fibromatosis.
Witkop CJ Jr
Birth Defects Orig Artic Ser 1971 Jun;7(7):210-21. PMID: 4950923

Diagnosis

Endometrioid adenofibroma of ovary: A case report and review of literature.
Tong HC, Li YC, Li LY, Xu HT, Ma S, Zhang WL, Wildes T, Yang LH, Wang E
Medicine (Baltimore) 2023 Feb 22;102(8):e32965. doi: 10.1097/MD.0000000000032965. PMID: 36827035Free PMC Article
My approach to the interpretation of endometrial biopsies and curettings.
McCluggage WG
J Clin Pathol 2006 Aug;59(8):801-12. doi: 10.1136/jcp.2005.029702. PMID: 16873562Free PMC Article
Paratesticular adenofibroma.
Janane A, Ghadouane M, Alami M, Abbar M
Scand J Urol Nephrol 2003;37(2):179-80. doi: 10.1080/00365590310008956. PMID: 12745730
Fibroadenoma.
Dent DM, Cant PJ
World J Surg 1989 Nov-Dec;13(6):706-10. doi: 10.1007/BF01658418. PMID: 2696223
Tumorigenic aspects.
Kirk ME
Int J Gynaecol Obstet 1978-1979;16(6):473-8. doi: 10.1002/j.1879-3479.1979.tb00952.x. PMID: 39811

Therapy

Papillary Cystadenofibroma of Fallopian Tube: Case Report with a Literature Review.
Hodzic E, Pusina S, Bajramagic S, Salibasic M, Holjan S
Med Arch 2020 Feb;74(1):73-76. doi: 10.5455/medarh.2020.74.73-76. PMID: 32317841Free PMC Article
Metanephric adenofibroma: report of a case and review of the literature.
Shek TW, Luk IS, Peh WC, Chan KL, Chan GC
Am J Surg Pathol 1999 Jun;23(6):727-33. doi: 10.1097/00000478-199906000-00014. PMID: 10366157
Tumorigenic aspects.
Kirk ME
Int J Gynaecol Obstet 1978-1979;16(6):473-8. doi: 10.1002/j.1879-3479.1979.tb00952.x. PMID: 39811
Influence of oral contraceptives on breast diseases.
Fechner RE
Cancer 1977 Jun;39(6 Suppl):2764-71. doi: 10.1002/1097-0142(197706)39:6<2764::aid-cncr2820390664>3.0.co;2-i. PMID: 406035
Breast adenomas.
Hertel BF, Zaloudek C, Kempson RL
Cancer 1976 Jun;37(6):2891-905. doi: 10.1002/1097-0142(197606)37:6<2891::aid-cncr2820370647>3.0.co;2-p. PMID: 949710

Prognosis

Endometrioid adenofibroma of ovary: A case report and review of literature.
Tong HC, Li YC, Li LY, Xu HT, Ma S, Zhang WL, Wildes T, Yang LH, Wang E
Medicine (Baltimore) 2023 Feb 22;102(8):e32965. doi: 10.1097/MD.0000000000032965. PMID: 36827035Free PMC Article
Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary.
Fadare O, Parkash V
Surg Pathol Clin 2019 Jun;12(2):529-564. doi: 10.1016/j.path.2019.01.009. PMID: 31097114
Synchronous Pulmonary Adenofibroma and Solitary Fibrous Tumor: Case Report and Review of the Literature.
Olson NJ, Czum JM, de Abreu FB, Linos K, Black CC
Int J Surg Pathol 2019 May;27(3):322-327. Epub 2018 Oct 26 doi: 10.1177/1066896918807302. PMID: 30360665
Pathology of mixed Müllerian tumours.
D'Angelo E, Prat J
Best Pract Res Clin Obstet Gynaecol 2011 Dec;25(6):705-18. Epub 2011 Jul 13 doi: 10.1016/j.bpobgyn.2011.05.010. PMID: 21742560
Age-related breast diagnosis.
Sterns EE
Can J Surg 1992 Feb;35(1):41-5. PMID: 1739898

Clinical prediction guides

Intrahepatic cholangiocarcinoma: typical features, uncommon variants, and controversial related entities.
Zen Y
Hum Pathol 2023 Feb;132:197-207. Epub 2022 Jun 11 doi: 10.1016/j.humpath.2022.06.001. PMID: 35697170
Robotic enucleation of a biliary adenofibroma.
Blears E, Uemura T, Bunker M
BMJ Case Rep 2021 Aug 10;14(8) doi: 10.1136/bcr-2021-242737. PMID: 34376413Free PMC Article
Advances in salivary gland pathology.
Cheuk W, Chan JK
Histopathology 2007 Jul;51(1):1-20. Epub 2007 May 31 doi: 10.1111/j.1365-2559.2007.02719.x. PMID: 17539914
Uterine adenomyoma: a clinicopathologic review of 26 cases and a review of the literature.
Tahlan A, Nanda A, Mohan H
Int J Gynecol Pathol 2006 Oct;25(4):361-5. doi: 10.1097/01.pgp.0000209570.08716.b3. PMID: 16990713
Breast masses in adolescent females.
Goldstein DP, Miler V
Clin Pediatr (Phila) 1982 Jan;21(1):17-9. doi: 10.1177/000992288202100102. PMID: 7055997

Recent systematic reviews

Imaging features of biliary adenofibroma of the liver with malignant transformation: a case report with literature review.
Hu W, Zhao Y, Liu Y, Hua Z, Liu A
BMC Med Imaging 2022 Mar 17;22(1):47. doi: 10.1186/s12880-022-00775-9. PMID: 35296268Free PMC Article

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