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Borderline Ovarian Serous Cystadenofibroma

MedGen UID:
307300
•Concept ID:
C1511267
•
Neoplastic Process

Definition

A neoplasm of low malignant potential arising from the ovary. It is characterized by the presence of cystic spaces which are lined by atypical serous epithelial cells. The surrounding ovarian stroma is fibrotic. There is no evidence of stromal invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBorderline Ovarian Serous Cystadenofibroma

Professional guidelines

PubMed

Paraovarian/paratubal cysts: comparison of transvaginal sonographic and pathological findings to establish diagnostic criteria.
Savelli L, Ghi T, De Iaco P, Ceccaroni M, Venturoli S, Cacciatore B
Ultrasound Obstet Gynecol 2006 Sep;28(3):330-4. doi: 10.1002/uog.2829. PMID: 16823765

Recent clinical studies

Etiology

Determining the significance of psammoma bodies in pelvic washings: A 10-year retrospective review.
Sun T, Pitman MB, Torous VF
Cancer Cytopathol 2021 Jan;129(1):83-89. Epub 2020 Sep 15 doi: 10.1002/cncy.22346. PMID: 32931128
When to Worry about Cancer: Concurrent Carcinoma and Recurrence in Borderline Ovarian Tumors.
Sullivan MW, Modesitt SC
South Med J 2019 Dec;112(12):634-638. doi: 10.14423/SMJ.0000000000001048. PMID: 31796975
Clinical Predictors of Recurrence and Prognostic Value of Lymph Node Involvement in the Serous Borderline Ovarian Tumor.
Qian XQ, Hua XP, Wu JH, Shen YM, Cheng XD, Wan XY
Int J Gynecol Cancer 2018 Feb;28(2):279-284. doi: 10.1097/IGC.0000000000001154. PMID: 29194193
TFF3 Expression as Stratification Marker in Borderline Epithelial Tumors of the Ovary.
El-Balat A, Schmeil I, Karn T, Becker S, Sänger N, Holtrich U, Arsenic R
Pathol Oncol Res 2018 Apr;24(2):277-282. Epub 2017 May 3 doi: 10.1007/s12253-017-0240-4. PMID: 28470574
Is MRI a useful tool to distinguish between serous and mucinous borderline ovarian tumours?
Bazot M, Haouy D, Daraï E, Cortez A, Dechoux-Vodovar S, Thomassin-Naggara I
Clin Radiol 2013 Jan;68(1):e1-8. Epub 2012 Oct 6 doi: 10.1016/j.crad.2012.08.021. PMID: 23044365

Diagnosis

MRI of Borderline Epithelial Ovarian Tumors: Pathologic Correlation and Diagnostic Challenges.
Tsuboyama T, Sato K, Ota T, Fukui H, Onishi H, Nakamoto A, Tatsumi M, Tomiyama N
Radiographics 2022 Nov-Dec;42(7):2095-2111. Epub 2022 Sep 9 doi: 10.1148/rg.220068. PMID: 36083804
A case of ovarian serous cystadenofibroma with scattered lesions in pelvic cavity, like malignant disseminations.
Fujita K, Ogawa C, Sako T, Utsumi F, Inada KI, Shibata K
J Obstet Gynaecol Res 2021 Dec;47(12):4496-4501. Epub 2021 Sep 6 doi: 10.1111/jog.15018. PMID: 34490687Free PMC Article
Multimodality Imaging Approach to Ovarian Neoplasms with Pathologic Correlation.
Taylor EC, Irshaid L, Mathur M
Radiographics 2021 Jan-Feb;41(1):289-315. Epub 2020 Nov 13 doi: 10.1148/rg.2021200086. PMID: 33186060
Determining the significance of psammoma bodies in pelvic washings: A 10-year retrospective review.
Sun T, Pitman MB, Torous VF
Cancer Cytopathol 2021 Jan;129(1):83-89. Epub 2020 Sep 15 doi: 10.1002/cncy.22346. PMID: 32931128
Is MRI a useful tool to distinguish between serous and mucinous borderline ovarian tumours?
Bazot M, Haouy D, Daraï E, Cortez A, Dechoux-Vodovar S, Thomassin-Naggara I
Clin Radiol 2013 Jan;68(1):e1-8. Epub 2012 Oct 6 doi: 10.1016/j.crad.2012.08.021. PMID: 23044365

Therapy

Clinical Predictors of Recurrence and Prognostic Value of Lymph Node Involvement in the Serous Borderline Ovarian Tumor.
Qian XQ, Hua XP, Wu JH, Shen YM, Cheng XD, Wan XY
Int J Gynecol Cancer 2018 Feb;28(2):279-284. doi: 10.1097/IGC.0000000000001154. PMID: 29194193
Coffee, tea, and caffeine consumption and risk of epithelial ovarian cancer and borderline ovarian tumors: Results from a Danish case-control study.
Gosvig CF, Kjaer SK, Blaakær J, Høgdall E, Høgdall C, Jensen A
Acta Oncol 2015;54(8):1144-51. Epub 2015 Jan 28 doi: 10.3109/0284186X.2014.1001035. PMID: 25629440
An unusual case of a borderline Brenner tumor associated with bilateral serous cystadenoma and endometrial carcinoma.
Cruz-Galarza D, Pérez-Rodríguez O, Laboy-Torres J, Gutiérrez-Rivera S
Bol Asoc Med P R 2014;106(1):54-6. PMID: 24791367
Outpatient minilaparotomy for ovarian cysts.
Flynn MK, Niloff JM
J Reprod Med 1999 May;44(5):399-404. PMID: 10360250

Prognosis

MRI of Borderline Epithelial Ovarian Tumors: Pathologic Correlation and Diagnostic Challenges.
Tsuboyama T, Sato K, Ota T, Fukui H, Onishi H, Nakamoto A, Tatsumi M, Tomiyama N
Radiographics 2022 Nov-Dec;42(7):2095-2111. Epub 2022 Sep 9 doi: 10.1148/rg.220068. PMID: 36083804
Clinical Predictors of Recurrence and Prognostic Value of Lymph Node Involvement in the Serous Borderline Ovarian Tumor.
Qian XQ, Hua XP, Wu JH, Shen YM, Cheng XD, Wan XY
Int J Gynecol Cancer 2018 Feb;28(2):279-284. doi: 10.1097/IGC.0000000000001154. PMID: 29194193
TFF3 Expression as Stratification Marker in Borderline Epithelial Tumors of the Ovary.
El-Balat A, Schmeil I, Karn T, Becker S, Sänger N, Holtrich U, Arsenic R
Pathol Oncol Res 2018 Apr;24(2):277-282. Epub 2017 May 3 doi: 10.1007/s12253-017-0240-4. PMID: 28470574
Is MRI a useful tool to distinguish between serous and mucinous borderline ovarian tumours?
Bazot M, Haouy D, Daraï E, Cortez A, Dechoux-Vodovar S, Thomassin-Naggara I
Clin Radiol 2013 Jan;68(1):e1-8. Epub 2012 Oct 6 doi: 10.1016/j.crad.2012.08.021. PMID: 23044365
On the histogenesis and morphology of ovarian carcinomas.
Dallenbach-Hellweg G
J Cancer Res Clin Oncol 1984;107(2):71-80. doi: 10.1007/BF00399375. PMID: 6715398

Clinical prediction guides

MRI of Borderline Epithelial Ovarian Tumors: Pathologic Correlation and Diagnostic Challenges.
Tsuboyama T, Sato K, Ota T, Fukui H, Onishi H, Nakamoto A, Tatsumi M, Tomiyama N
Radiographics 2022 Nov-Dec;42(7):2095-2111. Epub 2022 Sep 9 doi: 10.1148/rg.220068. PMID: 36083804
A case of ovarian serous cystadenofibroma with scattered lesions in pelvic cavity, like malignant disseminations.
Fujita K, Ogawa C, Sako T, Utsumi F, Inada KI, Shibata K
J Obstet Gynaecol Res 2021 Dec;47(12):4496-4501. Epub 2021 Sep 6 doi: 10.1111/jog.15018. PMID: 34490687Free PMC Article
Clinical Predictors of Recurrence and Prognostic Value of Lymph Node Involvement in the Serous Borderline Ovarian Tumor.
Qian XQ, Hua XP, Wu JH, Shen YM, Cheng XD, Wan XY
Int J Gynecol Cancer 2018 Feb;28(2):279-284. doi: 10.1097/IGC.0000000000001154. PMID: 29194193
TFF3 Expression as Stratification Marker in Borderline Epithelial Tumors of the Ovary.
El-Balat A, Schmeil I, Karn T, Becker S, Sänger N, Holtrich U, Arsenic R
Pathol Oncol Res 2018 Apr;24(2):277-282. Epub 2017 May 3 doi: 10.1007/s12253-017-0240-4. PMID: 28470574
Is MRI a useful tool to distinguish between serous and mucinous borderline ovarian tumours?
Bazot M, Haouy D, Daraï E, Cortez A, Dechoux-Vodovar S, Thomassin-Naggara I
Clin Radiol 2013 Jan;68(1):e1-8. Epub 2012 Oct 6 doi: 10.1016/j.crad.2012.08.021. PMID: 23044365

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