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Abnormal circulating estrogen level

MedGen UID:
1369064
•Concept ID:
C4476605
•
Finding
Synonyms: Abnormal estrogen level; Abnormal oestrogen level
 
HPO: HP:0025132

Definition

A deviation from normal concentration of the hormone estrogen in the blood circulation. [from HPO]

Conditions with this feature

Oocyte maturation defect 8
MedGen UID:
1776094
•Concept ID:
C5436597
•
Disease or Syndrome
Oocyte/zygote/embryo maturation arrest-8 (OZEMA8) is characterized by female infertility due to failure of the fertilized ovum to undergo zygotic cleavage (Zheng et al., 2020). For a discussion of genetic heterogeneity of OZEMA, see 615774.
See: Condition Record
Oocyte maturation defect 8

Professional guidelines

PubMed

Noninvasive assessment of coronary microvascular function in women at risk for ischaemic heart disease.
Campisi R
Int J Clin Pract 2008 Feb;62(2):300-7. Epub 2007 Oct 22 doi: 10.1111/j.1742-1241.2007.01391.x. PMID: 17956559
Turner syndrome and the heart: cardiovascular complications and treatment strategies.
Gravholt CH
Am J Cardiovasc Drugs 2002;2(6):401-13. doi: 10.2165/00129784-200202060-00005. PMID: 14727955
Clinical utility of sex hormone-binding globulin measurement.
Pugeat M, Crave JC, Tourniaire J, Forest MG
Horm Res 1996;45(3-5):148-55. doi: 10.1159/000184778. PMID: 8964574

Recent clinical studies

Etiology

The adenomyosis/endometriosis IVF patient - call for clinical focus.
Cozzolino M, Alsbjerg B, Pellicer A, Garcia-Velasco JA, Humaidan P
Reprod Biomed Online 2024 Apr;48(4):103737. Epub 2023 Nov 25 doi: 10.1016/j.rbmo.2023.103737. PMID: 38342076
Impact of sex hormones dysregulation and adiposity on the outcome of postmenopausal breast cancer patients.
Coradini D, Oriana S
Clin Obes 2021 Feb;11(1):e12423. Epub 2020 Nov 1 doi: 10.1111/cob.12423. PMID: 33135396
Alzheimer, mitochondria and gender.
Grimm A, Mensah-Nyagan AG, Eckert A
Neurosci Biobehav Rev 2016 Aug;67:89-101. Epub 2016 Apr 29 doi: 10.1016/j.neubiorev.2016.04.012. PMID: 27139022
The epidemiology and molecular mechanisms linking obesity, diabetes, and cancer.
Ferguson RD, Gallagher EJ, Scheinman EJ, Damouni R, LeRoith D
Vitam Horm 2013;93:51-98. doi: 10.1016/B978-0-12-416673-8.00010-1. PMID: 23810003
Diabetes, cancer, and metformin: connections of metabolism and cell proliferation.
Gallagher EJ, LeRoith D
Ann N Y Acad Sci 2011 Dec;1243:54-68. doi: 10.1111/j.1749-6632.2011.06285.x. PMID: 22211893

Diagnosis

The development of the human uterus: morphogenesis to menarche.
Habiba M, Heyn R, Bianchi P, Brosens I, Benagiano G
Hum Reprod Update 2021 Jan 4;27(1):1-26. doi: 10.1093/humupd/dmaa036. PMID: 33395479
Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women.
Ko SH, Kim HS
Nutrients 2020 Jan 13;12(1) doi: 10.3390/nu12010202. PMID: 31941004Free PMC Article
Hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes: sex differences in regulation of stress responsivity.
Oyola MG, Handa RJ
Stress 2017 Sep;20(5):476-494. Epub 2017 Aug 31 doi: 10.1080/10253890.2017.1369523. PMID: 28859530Free PMC Article
Minireview: Lymphangioleiomyomatosis (LAM): The "Other" Steroid-Sensitive Cancer.
Prizant H, Hammes SR
Endocrinology 2016 Sep;157(9):3374-83. Epub 2016 Jul 13 doi: 10.1210/en.2016-1395. PMID: 27409646Free PMC Article
Diabetes, cancer, and metformin: connections of metabolism and cell proliferation.
Gallagher EJ, LeRoith D
Ann N Y Acad Sci 2011 Dec;1243:54-68. doi: 10.1111/j.1749-6632.2011.06285.x. PMID: 22211893

Therapy

Neuroendocrine contribution to sex-related variations in adverse air pollution health effects.
Alewel DI, Kodavanti UP
J Toxicol Environ Health B Crit Rev 2024 Nov 16;27(8):287-314. Epub 2024 Jul 29 doi: 10.1080/10937404.2024.2383637. PMID: 39075643
Hepatic-Specific FGF21 Knockout Abrogates Ovariectomy-Induced Obesity by Reversing Corticosterone Production.
Xu J, Shao X, Zeng H, Wang C, Li J, Peng X, Zhuo Y, Hua L, Meng F, Han X
Int J Mol Sci 2023 Oct 5;24(19) doi: 10.3390/ijms241914922. PMID: 37834368Free PMC Article
Alzheimer, mitochondria and gender.
Grimm A, Mensah-Nyagan AG, Eckert A
Neurosci Biobehav Rev 2016 Aug;67:89-101. Epub 2016 Apr 29 doi: 10.1016/j.neubiorev.2016.04.012. PMID: 27139022
Sex hormones and breast cancer risk and prognosis.
Folkerd E, Dowsett M
Breast 2013 Aug;22 Suppl 2:S38-43. doi: 10.1016/j.breast.2013.07.007. PMID: 24074790
Migraine.
Spector RH
Surv Ophthalmol 1984 Nov-Dec;29(3):193-207. doi: 10.1016/0039-6257(84)90205-4. PMID: 6440302

Prognosis

NTCP Deficiency Affects the Levels of Circulating Bile Acids and Induces Osteoporosis.
Yang F, Xu W, Wu L, Yang L, Zhu S, Wang L, Wu W, Zhang Y, Chong Y, Peng L
Front Endocrinol (Lausanne) 2022;13:898750. Epub 2022 Jul 22 doi: 10.3389/fendo.2022.898750. PMID: 35937832Free PMC Article
Biomarkers for personalized oncology: recent advances and future challenges.
Kalia M
Metabolism 2015 Mar;64(3 Suppl 1):S16-21. Epub 2014 Oct 30 doi: 10.1016/j.metabol.2014.10.027. PMID: 25468140
Sex hormones and breast cancer risk and prognosis.
Folkerd E, Dowsett M
Breast 2013 Aug;22 Suppl 2:S38-43. doi: 10.1016/j.breast.2013.07.007. PMID: 24074790
Diabetes, cancer, and metformin: connections of metabolism and cell proliferation.
Gallagher EJ, LeRoith D
Ann N Y Acad Sci 2011 Dec;1243:54-68. doi: 10.1111/j.1749-6632.2011.06285.x. PMID: 22211893
Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy.
Reyes H, Sjövall J
Ann Med 2000 Mar;32(2):94-106. doi: 10.3109/07853890009011758. PMID: 10766400

Clinical prediction guides

The development of the human uterus: morphogenesis to menarche.
Habiba M, Heyn R, Bianchi P, Brosens I, Benagiano G
Hum Reprod Update 2021 Jan 4;27(1):1-26. doi: 10.1093/humupd/dmaa036. PMID: 33395479
Abnormal steroidogenesis and aromatase activity in preeclampsia.
Berkane N, Liere P, Lefevre G, Alfaidy N, Nahed RA, Vincent J, Oudinet JP, Pianos A, Cambourg A, Rozenberg P, Galichon P, Rousseau A, Simon T, Schumacher M, Chabbert-Buffet N, Hertig A
Placenta 2018 Sep;69:40-49. Epub 2018 Jul 7 doi: 10.1016/j.placenta.2018.07.004. PMID: 30213483
Uterine Function: From Normal to Polycystic Ovarian Syndrome Alterations.
Ferreira SR, Motta AB
Curr Med Chem 2018;25(15):1792-1804. doi: 10.2174/0929867325666171205144119. PMID: 29210631
Alzheimer, mitochondria and gender.
Grimm A, Mensah-Nyagan AG, Eckert A
Neurosci Biobehav Rev 2016 Aug;67:89-101. Epub 2016 Apr 29 doi: 10.1016/j.neubiorev.2016.04.012. PMID: 27139022
Biomarkers for personalized oncology: recent advances and future challenges.
Kalia M
Metabolism 2015 Mar;64(3 Suppl 1):S16-21. Epub 2014 Oct 30 doi: 10.1016/j.metabol.2014.10.027. PMID: 25468140

Recent systematic reviews

Animal models of hyperandrogenism and ovarian morphology changes as features of polycystic ovary syndrome: a systematic review.
Paixão L, Ramos RB, Lavarda A, Morsh DM, Spritzer PM
Reprod Biol Endocrinol 2017 Feb 10;15(1):12. doi: 10.1186/s12958-017-0231-z. PMID: 28183310Free PMC Article
Hormone replacement therapy in postmenopausal women: endometrial hyperplasia and irregular bleeding.
Lethaby A, Suckling J, Barlow D, Farquhar CM, Jepson RG, Roberts H
Cochrane Database Syst Rev 2004;(3):CD000402. doi: 10.1002/14651858.CD000402.pub2. PMID: 15266429

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