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Increased serum estriol

MedGen UID:
1370429
•Concept ID:
C4476607
•
Finding
HPO: HP:0025136

Definition

An elevation above normal limits of estriol concentration in the circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased serum estriol

Professional guidelines

PubMed

Second-trimester Maternal Serum Screening Biomarkers in the Risk Assessment for Preeclampsia.
Long W, Zhou Q, Wang H, Lu B, Chen Y, Zhang B, Zhou W, Yu B
Ann Clin Lab Sci 2018 May;48(3):308-313. PMID: 29970433
Genetic Screening and the Obese Gravida.
Rose NC
Clin Obstet Gynecol 2016 Mar;59(1):140-7. doi: 10.1097/GRF.0000000000000172. PMID: 26670835
Prenatal diagnosis and pediatric neurosurgery.
Bell WO, Nelson LH, Block SM, Rhoney JC
Pediatr Neurosurg 1996;24(3):134-7; discussion 138. doi: 10.1159/000121029. PMID: 8870016

Recent clinical studies

Etiology

Prenatal Exposure to PFAS, Associations with Preterm Birth and Modification by Maternal Estrogen Levels: The Maoming Birth Study.
Qin XD, Zhou Y, Bloom MS, Qian ZM, Geiger SD, Vaughn MG, Chu C, Li QQ, Yang BY, Hu LW, Yu Y, Zeng XW, Dong GH
Environ Health Perspect 2023 Nov;131(11):117006. Epub 2023 Nov 14 doi: 10.1289/EHP11377. PMID: 37962440Free PMC Article
Safety and Serum Estradiol Levels in Hormonal Treatments for Vulvovaginal Atrophy in Breast Cancer Survivors: A Systematic Review and Meta-Analysis.
Comini ACM, Carvalho BM, Moreira MJB, Reis PCA, Colapietro L, Northern J, Batalini F
Clin Breast Cancer 2023 Dec;23(8):835-846. Epub 2023 Aug 22 doi: 10.1016/j.clbc.2023.08.003. PMID: 37806915
First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening.
Alldred SK, Takwoingi Y, Guo B, Pennant M, Deeks JJ, Neilson JP, Alfirevic Z
Cochrane Database Syst Rev 2017 Mar 15;3(3):CD012600. doi: 10.1002/14651858.CD012600. PMID: 28295158Free PMC Article
Genetic Screening and the Obese Gravida.
Rose NC
Clin Obstet Gynecol 2016 Mar;59(1):140-7. doi: 10.1097/GRF.0000000000000172. PMID: 26670835
Risks of estrogens and progestogens.
L'Hermite M
Maturitas 1990 Sep;12(3):215-46. doi: 10.1016/0378-5122(90)90005-q. PMID: 2170823

Diagnosis

New aspects characterizing non-obese NAFLD by the analysis of the intestinal flora and metabolites using a mouse model.
Zhang W, Cheng W, Li J, Huang Z, Lin H, Zhang W
mSystems 2024 Mar 19;9(3):e0102723. Epub 2024 Feb 29 doi: 10.1128/msystems.01027-23. PMID: 38421203Free PMC Article
First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening.
Alldred SK, Takwoingi Y, Guo B, Pennant M, Deeks JJ, Neilson JP, Alfirevic Z
Cochrane Database Syst Rev 2017 Mar 15;3(3):CD012600. doi: 10.1002/14651858.CD012600. PMID: 28295158Free PMC Article
Maternal serum screening markers and nuchal translucency measurements in in vitro fertilization pregnancies: a systematic review.
Lanes A, Huang T, Sprague AE, Leader A, Potter B, Walker M
Fertil Steril 2016 Nov;106(6):1463-1469.e2. Epub 2016 Aug 13 doi: 10.1016/j.fertnstert.2016.07.1120. PMID: 27530061
Genetic Screening and the Obese Gravida.
Rose NC
Clin Obstet Gynecol 2016 Mar;59(1):140-7. doi: 10.1097/GRF.0000000000000172. PMID: 26670835
Urine tests for Down's syndrome screening.
Alldred SK, Guo B, Takwoingi Y, Pennant M, Wisniewski S, Deeks JJ, Neilson JP, Alfirevic Z
Cochrane Database Syst Rev 2015 Dec 10;2015(12):CD011984. doi: 10.1002/14651858.CD011984. PMID: 26662198Free PMC Article

Therapy

Safety and Serum Estradiol Levels in Hormonal Treatments for Vulvovaginal Atrophy in Breast Cancer Survivors: A Systematic Review and Meta-Analysis.
Comini ACM, Carvalho BM, Moreira MJB, Reis PCA, Colapietro L, Northern J, Batalini F
Clin Breast Cancer 2023 Dec;23(8):835-846. Epub 2023 Aug 22 doi: 10.1016/j.clbc.2023.08.003. PMID: 37806915
The efficacy and safety of estriol to treat vulvovaginal atrophy in postmenopausal women: a systematic literature review.
Rueda C, Osorio AM, Avellaneda AC, Pinzón CE, Restrepo OI
Climacteric 2017 Aug;20(4):321-330. Epub 2017 Jun 16 doi: 10.1080/13697137.2017.1329291. PMID: 28622049
Exposure to exogenous estrogen through intake of commercial milk produced from pregnant cows.
Maruyama K, Oshima T, Ohyama K
Pediatr Int 2010 Feb;52(1):33-8. Epub 2009 May 22 doi: 10.1111/j.1442-200X.2009.02890.x. PMID: 19496976
Risks of estrogens and progestogens.
L'Hermite M
Maturitas 1990 Sep;12(3):215-46. doi: 10.1016/0378-5122(90)90005-q. PMID: 2170823
Estrogens and the human male.
Marcus R, Korenman SG
Annu Rev Med 1976;27:357-70. doi: 10.1146/annurev.me.27.020176.002041. PMID: 779604

Prognosis

New aspects characterizing non-obese NAFLD by the analysis of the intestinal flora and metabolites using a mouse model.
Zhang W, Cheng W, Li J, Huang Z, Lin H, Zhang W
mSystems 2024 Mar 19;9(3):e0102723. Epub 2024 Feb 29 doi: 10.1128/msystems.01027-23. PMID: 38421203Free PMC Article
First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening.
Alldred SK, Takwoingi Y, Guo B, Pennant M, Deeks JJ, Neilson JP, Alfirevic Z
Cochrane Database Syst Rev 2017 Mar 15;3(3):CD012600. doi: 10.1002/14651858.CD012600. PMID: 28295158Free PMC Article
Maternal serum screening markers and nuchal translucency measurements in in vitro fertilization pregnancies: a systematic review.
Lanes A, Huang T, Sprague AE, Leader A, Potter B, Walker M
Fertil Steril 2016 Nov;106(6):1463-1469.e2. Epub 2016 Aug 13 doi: 10.1016/j.fertnstert.2016.07.1120. PMID: 27530061
Urine tests for Down's syndrome screening.
Alldred SK, Guo B, Takwoingi Y, Pennant M, Wisniewski S, Deeks JJ, Neilson JP, Alfirevic Z
Cochrane Database Syst Rev 2015 Dec 10;2015(12):CD011984. doi: 10.1002/14651858.CD011984. PMID: 26662198Free PMC Article
Risks of estrogens and progestogens.
L'Hermite M
Maturitas 1990 Sep;12(3):215-46. doi: 10.1016/0378-5122(90)90005-q. PMID: 2170823

Clinical prediction guides

Prenatal Exposure to PFAS, Associations with Preterm Birth and Modification by Maternal Estrogen Levels: The Maoming Birth Study.
Qin XD, Zhou Y, Bloom MS, Qian ZM, Geiger SD, Vaughn MG, Chu C, Li QQ, Yang BY, Hu LW, Yu Y, Zeng XW, Dong GH
Environ Health Perspect 2023 Nov;131(11):117006. Epub 2023 Nov 14 doi: 10.1289/EHP11377. PMID: 37962440Free PMC Article
First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening.
Alldred SK, Takwoingi Y, Guo B, Pennant M, Deeks JJ, Neilson JP, Alfirevic Z
Cochrane Database Syst Rev 2017 Mar 15;3(3):CD012600. doi: 10.1002/14651858.CD012600. PMID: 28295158Free PMC Article
Maternal serum screening markers and nuchal translucency measurements in in vitro fertilization pregnancies: a systematic review.
Lanes A, Huang T, Sprague AE, Leader A, Potter B, Walker M
Fertil Steril 2016 Nov;106(6):1463-1469.e2. Epub 2016 Aug 13 doi: 10.1016/j.fertnstert.2016.07.1120. PMID: 27530061
Urine tests for Down's syndrome screening.
Alldred SK, Guo B, Takwoingi Y, Pennant M, Wisniewski S, Deeks JJ, Neilson JP, Alfirevic Z
Cochrane Database Syst Rev 2015 Dec 10;2015(12):CD011984. doi: 10.1002/14651858.CD011984. PMID: 26662198Free PMC Article
Relationship of serum estrogens and metabolites with area and volume mammographic densities.
Gierach GL, Patel DA, Falk RT, Pfeiffer RM, Geller BM, Vacek PM, Weaver DL, Chicoine RE, Shepherd JA, Mahmoudzadeh AP, Wang J, Fan B, Herschorn SD, Xu X, Veenstra T, Fuhrman B, Sherman ME, Brinton LA
Horm Cancer 2015 Jun;6(2-3):107-19. Epub 2015 Mar 11 doi: 10.1007/s12672-015-0216-3. PMID: 25757805Free PMC Article

Recent systematic reviews

Impact of vaginal estriol on serum hormone levels: a systematic review.
Kolokythas A, Betschart C, Wunder D, Janka H, Stute P
Climacteric 2024 Apr;27(2):137-153. Epub 2024 Jan 2 doi: 10.1080/13697137.2023.2287624. PMID: 38164918
Safety and Serum Estradiol Levels in Hormonal Treatments for Vulvovaginal Atrophy in Breast Cancer Survivors: A Systematic Review and Meta-Analysis.
Comini ACM, Carvalho BM, Moreira MJB, Reis PCA, Colapietro L, Northern J, Batalini F
Clin Breast Cancer 2023 Dec;23(8):835-846. Epub 2023 Aug 22 doi: 10.1016/j.clbc.2023.08.003. PMID: 37806915
The efficacy and safety of estriol to treat vulvovaginal atrophy in postmenopausal women: a systematic literature review.
Rueda C, Osorio AM, Avellaneda AC, Pinzón CE, Restrepo OI
Climacteric 2017 Aug;20(4):321-330. Epub 2017 Jun 16 doi: 10.1080/13697137.2017.1329291. PMID: 28622049
First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening.
Alldred SK, Takwoingi Y, Guo B, Pennant M, Deeks JJ, Neilson JP, Alfirevic Z
Cochrane Database Syst Rev 2017 Mar 15;3(3):CD012600. doi: 10.1002/14651858.CD012600. PMID: 28295158Free PMC Article
Maternal serum screening markers and nuchal translucency measurements in in vitro fertilization pregnancies: a systematic review.
Lanes A, Huang T, Sprague AE, Leader A, Potter B, Walker M
Fertil Steril 2016 Nov;106(6):1463-1469.e2. Epub 2016 Aug 13 doi: 10.1016/j.fertnstert.2016.07.1120. PMID: 27530061

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