Erythrokeratodermia variabilis et progressiva-4 is characterized by severe lesions of thick scaly skin on the face and genitals, as well as thickened, red, and scaly skin on the hands and feet (summary by Boyden et al., 2017).
For a discussion of genetic heterogeneity of EKVP, see EKVP1 (133200). [from
OMIM]