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ABL2 Gene Rearrangement

MedGen UID:
1373063
•Concept ID:
C4329223
•
Cell or Molecular Dysfunction
Synonyms: Abelson-Related Gene Rearrangement; ABL Proto-Oncogene 2, Non-Receptor Tyrosine Kinase Gene Rearrangement; ABLL Gene Rearrangement; ARG Gene Rearrangement; v-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the ABL2 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVABL2 Gene Rearrangement

Recent clinical studies

Etiology

Philadelphia-Like Genetic Rearrangements in Adults With B-Cell ALL: Refractoriness to Chemotherapy and Response to Tyrosine Kinase Inhibitor in ABL Class Rearrangements.
Senapati J, Jabbour E, Konopleva M, Short NJ, Tang G, Daver N, Kebriaei P, Kadia T, Pemmaraju N, Takahashi K, DiNardo C, Sasaki K, Borthakur G, Thakral B, Kanagal-Shamanna R, Patel K, Ravandi F, Roberts K, Mullighan C, Kantarjian H, Jain N
JCO Precis Oncol 2023 May;7:e2200707. doi: 10.1200/PO.22.00707. PMID: 37196217Free PMC Article
Rapid molecular response to dasatinib in Ph-like acute lymphoblastic leukemia patients with ABL1 rearrangements: case series and literature review.
Tan KW, Zhu YY, Qiu QC, Wang M, Shen HJ, Huang SM, Cao HY, Wan CL, Li YY, Dai HP, Xue SL
Ann Hematol 2023 Sep;102(9):2397-2402. Epub 2023 Apr 27 doi: 10.1007/s00277-023-05236-z. PMID: 37103615
Philadelphia chromosome-negative B-cell acute lymphoblastic leukaemia with kinase fusions in Taiwan.
Hsu YC, Yu CH, Chen YM, Roberts KG, Ni YL, Lin KH, Jou ST, Lu MY, Chen SH, Wu KH, Chang HH, Lin DT, Lin SW, Lin ZS, Chiu WT, Chang CC, Ho BC, Mullighan CG, Yu SL, Yang YL
Sci Rep 2021 Mar 11;11(1):5802. doi: 10.1038/s41598-021-85213-6. PMID: 33707599Free PMC Article
Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group.
Reshmi SC, Harvey RC, Roberts KG, Stonerock E, Smith A, Jenkins H, Chen IM, Valentine M, Liu Y, Li Y, Shao Y, Easton J, Payne-Turner D, Gu Z, Tran TH, Nguyen JV, Devidas M, Dai Y, Heerema NA, Carroll AJ 3rd, Raetz EA, Borowitz MJ, Wood BL, Angiolillo AL, Burke MJ, Salzer WL, Zweidler-McKay PA, Rabin KR, Carroll WL, Zhang J, Loh ML, Mullighan CG, Willman CL, Gastier-Foster JM, Hunger SP
Blood 2017 Jun 22;129(25):3352-3361. Epub 2017 Apr 13 doi: 10.1182/blood-2016-12-758979. PMID: 28408464Free PMC Article

Diagnosis

Philadelphia-Like Genetic Rearrangements in Adults With B-Cell ALL: Refractoriness to Chemotherapy and Response to Tyrosine Kinase Inhibitor in ABL Class Rearrangements.
Senapati J, Jabbour E, Konopleva M, Short NJ, Tang G, Daver N, Kebriaei P, Kadia T, Pemmaraju N, Takahashi K, DiNardo C, Sasaki K, Borthakur G, Thakral B, Kanagal-Shamanna R, Patel K, Ravandi F, Roberts K, Mullighan C, Kantarjian H, Jain N
JCO Precis Oncol 2023 May;7:e2200707. doi: 10.1200/PO.22.00707. PMID: 37196217Free PMC Article
Philadelphia chromosome-negative B-cell acute lymphoblastic leukaemia with kinase fusions in Taiwan.
Hsu YC, Yu CH, Chen YM, Roberts KG, Ni YL, Lin KH, Jou ST, Lu MY, Chen SH, Wu KH, Chang HH, Lin DT, Lin SW, Lin ZS, Chiu WT, Chang CC, Ho BC, Mullighan CG, Yu SL, Yang YL
Sci Rep 2021 Mar 11;11(1):5802. doi: 10.1038/s41598-021-85213-6. PMID: 33707599Free PMC Article
Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group.
Reshmi SC, Harvey RC, Roberts KG, Stonerock E, Smith A, Jenkins H, Chen IM, Valentine M, Liu Y, Li Y, Shao Y, Easton J, Payne-Turner D, Gu Z, Tran TH, Nguyen JV, Devidas M, Dai Y, Heerema NA, Carroll AJ 3rd, Raetz EA, Borowitz MJ, Wood BL, Angiolillo AL, Burke MJ, Salzer WL, Zweidler-McKay PA, Rabin KR, Carroll WL, Zhang J, Loh ML, Mullighan CG, Willman CL, Gastier-Foster JM, Hunger SP
Blood 2017 Jun 22;129(25):3352-3361. Epub 2017 Apr 13 doi: 10.1182/blood-2016-12-758979. PMID: 28408464Free PMC Article
Detection of ETV6 gene rearrangements in adult acute lymphoblastic leukemia.
Zhou MH, Gao L, Jing Y, Xu YY, Ding Y, Wang N, Wang W, Li MY, Han XP, Sun JZ, Wang LL, Yu L
Ann Hematol 2012 Aug;91(8):1235-43. Epub 2012 Feb 29 doi: 10.1007/s00277-012-1431-4. PMID: 22373549

Therapy

Rapid molecular response to dasatinib in Ph-like acute lymphoblastic leukemia patients with ABL1 rearrangements: case series and literature review.
Tan KW, Zhu YY, Qiu QC, Wang M, Shen HJ, Huang SM, Cao HY, Wan CL, Li YY, Dai HP, Xue SL
Ann Hematol 2023 Sep;102(9):2397-2402. Epub 2023 Apr 27 doi: 10.1007/s00277-023-05236-z. PMID: 37103615
Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group.
Reshmi SC, Harvey RC, Roberts KG, Stonerock E, Smith A, Jenkins H, Chen IM, Valentine M, Liu Y, Li Y, Shao Y, Easton J, Payne-Turner D, Gu Z, Tran TH, Nguyen JV, Devidas M, Dai Y, Heerema NA, Carroll AJ 3rd, Raetz EA, Borowitz MJ, Wood BL, Angiolillo AL, Burke MJ, Salzer WL, Zweidler-McKay PA, Rabin KR, Carroll WL, Zhang J, Loh ML, Mullighan CG, Willman CL, Gastier-Foster JM, Hunger SP
Blood 2017 Jun 22;129(25):3352-3361. Epub 2017 Apr 13 doi: 10.1182/blood-2016-12-758979. PMID: 28408464Free PMC Article
Short-term weightlessness produced by parabolic flight maneuvers altered gene expression patterns in human endothelial cells.
Grosse J, Wehland M, Pietsch J, Ma X, Ulbrich C, Schulz H, Saar K, Hübner N, Hauslage J, Hemmersbach R, Braun M, van Loon J, Vagt N, Infanger M, Eilles C, Egli M, Richter P, Baltz T, Einspanier R, Sharbati S, Grimm D
FASEB J 2012 Feb;26(2):639-55. Epub 2011 Oct 24 doi: 10.1096/fj.11-194886. PMID: 22024737

Prognosis

Philadelphia-Like Genetic Rearrangements in Adults With B-Cell ALL: Refractoriness to Chemotherapy and Response to Tyrosine Kinase Inhibitor in ABL Class Rearrangements.
Senapati J, Jabbour E, Konopleva M, Short NJ, Tang G, Daver N, Kebriaei P, Kadia T, Pemmaraju N, Takahashi K, DiNardo C, Sasaki K, Borthakur G, Thakral B, Kanagal-Shamanna R, Patel K, Ravandi F, Roberts K, Mullighan C, Kantarjian H, Jain N
JCO Precis Oncol 2023 May;7:e2200707. doi: 10.1200/PO.22.00707. PMID: 37196217Free PMC Article
Rapid molecular response to dasatinib in Ph-like acute lymphoblastic leukemia patients with ABL1 rearrangements: case series and literature review.
Tan KW, Zhu YY, Qiu QC, Wang M, Shen HJ, Huang SM, Cao HY, Wan CL, Li YY, Dai HP, Xue SL
Ann Hematol 2023 Sep;102(9):2397-2402. Epub 2023 Apr 27 doi: 10.1007/s00277-023-05236-z. PMID: 37103615
Detection of ETV6 gene rearrangements in adult acute lymphoblastic leukemia.
Zhou MH, Gao L, Jing Y, Xu YY, Ding Y, Wang N, Wang W, Li MY, Han XP, Sun JZ, Wang LL, Yu L
Ann Hematol 2012 Aug;91(8):1235-43. Epub 2012 Feb 29 doi: 10.1007/s00277-012-1431-4. PMID: 22373549

Clinical prediction guides

Detection of ETV6 gene rearrangements in adult acute lymphoblastic leukemia.
Zhou MH, Gao L, Jing Y, Xu YY, Ding Y, Wang N, Wang W, Li MY, Han XP, Sun JZ, Wang LL, Yu L
Ann Hematol 2012 Aug;91(8):1235-43. Epub 2012 Feb 29 doi: 10.1007/s00277-012-1431-4. PMID: 22373549

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