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Chromosome 1 Abnormality

MedGen UID:
267625
•Concept ID:
C1510712
•
Cell or Molecular Dysfunction
Synonym: Aberrant Chromosome 1

Definition

An irregularity in the structure of chromosome 1. [from NCI]

Professional guidelines

PubMed

Genetic screening and evaluation for chromosomal abnormalities of infertile males in Jilin Province, China.
Zhang M, Fan HT, Zhang QS, Wang XY, Yang X, Tian WJ, Li RW
Genet Mol Res 2015 Dec 8;14(4):16178-84. doi: 10.4238/2015.December.8.7. PMID: 26662410
Cytogenetic technology--genotype and phenotype.
Ledbetter DH
N Engl J Med 2008 Oct 16;359(16):1728-30. Epub 2008 Sep 10 doi: 10.1056/NEJMe0806570. PMID: 18784093
Pyruvate kinase deficiency: the genotype-phenotype association.
Zanella A, Fermo E, Bianchi P, Chiarelli LR, Valentini G
Blood Rev 2007 Jul;21(4):217-31. Epub 2007 Mar 13 doi: 10.1016/j.blre.2007.01.001. PMID: 17360088

Recent clinical studies

Etiology

Allogeneic Hematopoietic Cell Transplantation in Multiple Myeloma: Impact of Disease Risk and Post Allograft Minimal Residual Disease on Survival.
Dhakal B, D'Souza A, Martens M, Kapke J, Harrington AM, Pasquini M, Saber W, Drobyski WR, Zhang MJ, Hamadani M, Hari PN
Clin Lymphoma Myeloma Leuk 2016 Jul;16(7):379-86. Epub 2016 Mar 30 doi: 10.1016/j.clml.2016.03.001. PMID: 27160644
Molecular cytogenetic aberrations in 21 Chinese patients with plasma cell leukemia.
Xu W, Li JY, Fan L, Chen LJ, Qiu HR, Qiu HX, Lu H
Int J Lab Hematol 2009 Jun;31(3):338-43. Epub 2008 Feb 18 doi: 10.1111/j.1751-553X.2008.01037.x. PMID: 18284415

Diagnosis

Allogeneic Hematopoietic Cell Transplantation in Multiple Myeloma: Impact of Disease Risk and Post Allograft Minimal Residual Disease on Survival.
Dhakal B, D'Souza A, Martens M, Kapke J, Harrington AM, Pasquini M, Saber W, Drobyski WR, Zhang MJ, Hamadani M, Hari PN
Clin Lymphoma Myeloma Leuk 2016 Jul;16(7):379-86. Epub 2016 Mar 30 doi: 10.1016/j.clml.2016.03.001. PMID: 27160644
Molecular cytogenetic aberrations in 21 Chinese patients with plasma cell leukemia.
Xu W, Li JY, Fan L, Chen LJ, Qiu HR, Qiu HX, Lu H
Int J Lab Hematol 2009 Jun;31(3):338-43. Epub 2008 Feb 18 doi: 10.1111/j.1751-553X.2008.01037.x. PMID: 18284415
Molecular cytogenetic aberrations in patients with multiple myeloma studied by interphase fluorescence in situ hybridization.
Chen L, Li J, Xu W, Qiu H, Zhu Y, Zhang Y, Duan L, Qian S, Lu H
Exp Oncol 2007 Jun;29(2):116-20. PMID: 17704743
An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension.
Bonnet S, Michelakis ED, Porter CJ, Andrade-Navarro MA, Thébaud B, Bonnet S, Haromy A, Harry G, Moudgil R, McMurtry MS, Weir EK, Archer SL
Circulation 2006 Jun 6;113(22):2630-41. Epub 2006 May 30 doi: 10.1161/CIRCULATIONAHA.105.609008. PMID: 16735674

Therapy

Allogeneic Hematopoietic Cell Transplantation in Multiple Myeloma: Impact of Disease Risk and Post Allograft Minimal Residual Disease on Survival.
Dhakal B, D'Souza A, Martens M, Kapke J, Harrington AM, Pasquini M, Saber W, Drobyski WR, Zhang MJ, Hamadani M, Hari PN
Clin Lymphoma Myeloma Leuk 2016 Jul;16(7):379-86. Epub 2016 Mar 30 doi: 10.1016/j.clml.2016.03.001. PMID: 27160644
Molecular cytogenetic aberrations in patients with multiple myeloma studied by interphase fluorescence in situ hybridization.
Chen L, Li J, Xu W, Qiu H, Zhu Y, Zhang Y, Duan L, Qian S, Lu H
Exp Oncol 2007 Jun;29(2):116-20. PMID: 17704743

Prognosis

Allogeneic Hematopoietic Cell Transplantation in Multiple Myeloma: Impact of Disease Risk and Post Allograft Minimal Residual Disease on Survival.
Dhakal B, D'Souza A, Martens M, Kapke J, Harrington AM, Pasquini M, Saber W, Drobyski WR, Zhang MJ, Hamadani M, Hari PN
Clin Lymphoma Myeloma Leuk 2016 Jul;16(7):379-86. Epub 2016 Mar 30 doi: 10.1016/j.clml.2016.03.001. PMID: 27160644
Cytogenetic studies of endometrial malignancies.
Milatovich A, Heerema NA, Palmer CG
Cancer Genet Cytogenet 1990 May;46(1):41-53. doi: 10.1016/0165-4608(90)90007-w. PMID: 2331682

Clinical prediction guides

CUMC-6, a new diploid human cell line derived from a squamous carcinoma of the uterine cervix.
Kim JW, Lee CG, Cho YH, Kim JH, Kim SJ, Kim HK, Park TC, Song SK, Namkoong SE
Gynecol Oncol 1996 Aug;62(2):230-40. doi: 10.1006/gyno.1996.0221. PMID: 8751555
Molecular events including p53 and k-ras alterations in the in vitro progression of a human colorectal adenoma cell line to an adenocarcinoma.
Williams AC, Browne SJ, Yeudal WA, Paterson IC, Marshall CJ, Lane DP, Paraskeva C
Oncogene 1993 Nov;8(11):3063-72. PMID: 8414507
Cytogenetic studies of endometrial malignancies.
Milatovich A, Heerema NA, Palmer CG
Cancer Genet Cytogenet 1990 May;46(1):41-53. doi: 10.1016/0165-4608(90)90007-w. PMID: 2331682

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