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FLT1 Gene Amplification

MedGen UID:
1374606
•Concept ID:
C4329959
•
Cell or Molecular Dysfunction
Synonyms: FLT Gene Amplification; FLT-1 Gene Amplification; Fms Related Tyrosine Kinase 1 Gene Amplification; FMS-Related Tyrosine Kinase 1 Gene Amplification; FRT Gene Amplification; Vascular Endothelial Growth Factor Receptor 1 Gene Amplification; Vascular Endothelial Growth Factor/Vascular Permeability Factor Receptor Gene Amplification; VEGFR-1 Gene Amplification; VEGFR1 Amplification; VEGFR1 Gene Amplification

Definition

A molecular genetic abnormality indicating the presence of multiple copies of the FLT1 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFLT1 Gene Amplification

Recent clinical studies

Etiology

Assessment of Predictive Biomarkers of the Response to Pazopanib Based on an Integrative Analysis of High-grade Soft-tissue Sarcomas: Analysis of a Tumor Sample from a Responder and Patients with Other Soft-tissue Sarcomas.
Suehara Y, Kohsaka S, Yamaguchi S, Hayashi T, Kurihara T, Sano K, Sasa K, Akaike K, Ueno T, Kojima S, Ikegami M, Mizuno S, Okubo T, Kim Y, Kaneko K, Saito T, Kato S, Mano H
Clin Orthop Relat Res 2020 Nov;478(11):2461-2476. doi: 10.1097/CORR.0000000000001322. PMID: 32567826Free PMC Article
Consistent MYC and FLT4 gene amplification in radiation-induced angiosarcoma but not in other radiation-associated atypical vascular lesions.
Guo T, Zhang L, Chang NE, Singer S, Maki RG, Antonescu CR
Genes Chromosomes Cancer 2011 Jan;50(1):25-33. doi: 10.1002/gcc.20827. PMID: 20949568Free PMC Article
Neovascularization in human germ cell tumors correlates with a marked increase in the expression of the vascular endothelial growth factor but not the placenta-derived growth factor.
Viglietto G, Romano A, Maglione D, Rambaldi M, Paoletti I, Lago CT, Califano D, Monaco C, Mineo A, Santelli G, Manzo G, Botti G, Chiappetta G, Persico MG
Oncogene 1996 Aug 1;13(3):577-87. PMID: 8760299

Diagnosis

Soft tissue perineurioma involving the kidney: a report of two cases with an emphasis on differential diagnosis.
Ma TS, Zhou L, Zhou Q, He XL, Zhao M
Diagn Pathol 2021 Sep 30;16(1):87. doi: 10.1186/s13000-021-01149-5. PMID: 34592995Free PMC Article
Assessment of Predictive Biomarkers of the Response to Pazopanib Based on an Integrative Analysis of High-grade Soft-tissue Sarcomas: Analysis of a Tumor Sample from a Responder and Patients with Other Soft-tissue Sarcomas.
Suehara Y, Kohsaka S, Yamaguchi S, Hayashi T, Kurihara T, Sano K, Sasa K, Akaike K, Ueno T, Kojima S, Ikegami M, Mizuno S, Okubo T, Kim Y, Kaneko K, Saito T, Kato S, Mano H
Clin Orthop Relat Res 2020 Nov;478(11):2461-2476. doi: 10.1097/CORR.0000000000001322. PMID: 32567826Free PMC Article
A ribonuclease protection assay-based approach for analysis of angiogenic gene expression in archival tissues.
Naldini A, Ardinghi C, Massi D, Santucci M, Franchi A, Tarantini F, Geppetti P, Cirino G, Carraro F
Diagn Mol Pathol 2007 Sep;16(3):147-52. doi: 10.1097/PDM.0b013e31803c5576. PMID: 17721322
Controlled expansion of human endothelial cell populations by Cre-loxP-based reversible immortalization.
Noguchi H, Kobayashi N, Westerman KA, Sakaguchi M, Okitsu T, Totsugawa T, Watanabe T, Matsumura T, Fujiwara T, Ueda T, Miyazaki M, Tanaka N, Leboulch P
Hum Gene Ther 2002 Jan 20;13(2):321-34. doi: 10.1089/10430340252769833. PMID: 11812287

Therapy

Assessment of Predictive Biomarkers of the Response to Pazopanib Based on an Integrative Analysis of High-grade Soft-tissue Sarcomas: Analysis of a Tumor Sample from a Responder and Patients with Other Soft-tissue Sarcomas.
Suehara Y, Kohsaka S, Yamaguchi S, Hayashi T, Kurihara T, Sano K, Sasa K, Akaike K, Ueno T, Kojima S, Ikegami M, Mizuno S, Okubo T, Kim Y, Kaneko K, Saito T, Kato S, Mano H
Clin Orthop Relat Res 2020 Nov;478(11):2461-2476. doi: 10.1097/CORR.0000000000001322. PMID: 32567826Free PMC Article
Consistent MYC and FLT4 gene amplification in radiation-induced angiosarcoma but not in other radiation-associated atypical vascular lesions.
Guo T, Zhang L, Chang NE, Singer S, Maki RG, Antonescu CR
Genes Chromosomes Cancer 2011 Jan;50(1):25-33. doi: 10.1002/gcc.20827. PMID: 20949568Free PMC Article

Prognosis

Soft tissue perineurioma involving the kidney: a report of two cases with an emphasis on differential diagnosis.
Ma TS, Zhou L, Zhou Q, He XL, Zhao M
Diagn Pathol 2021 Sep 30;16(1):87. doi: 10.1186/s13000-021-01149-5. PMID: 34592995Free PMC Article
Assessment of Predictive Biomarkers of the Response to Pazopanib Based on an Integrative Analysis of High-grade Soft-tissue Sarcomas: Analysis of a Tumor Sample from a Responder and Patients with Other Soft-tissue Sarcomas.
Suehara Y, Kohsaka S, Yamaguchi S, Hayashi T, Kurihara T, Sano K, Sasa K, Akaike K, Ueno T, Kojima S, Ikegami M, Mizuno S, Okubo T, Kim Y, Kaneko K, Saito T, Kato S, Mano H
Clin Orthop Relat Res 2020 Nov;478(11):2461-2476. doi: 10.1097/CORR.0000000000001322. PMID: 32567826Free PMC Article
A ribonuclease protection assay-based approach for analysis of angiogenic gene expression in archival tissues.
Naldini A, Ardinghi C, Massi D, Santucci M, Franchi A, Tarantini F, Geppetti P, Cirino G, Carraro F
Diagn Mol Pathol 2007 Sep;16(3):147-52. doi: 10.1097/PDM.0b013e31803c5576. PMID: 17721322
Intronic polyadenylation signal sequences and alternate splicing generate human soluble Flt1 variants and regulate the abundance of soluble Flt1 in the placenta.
Thomas CP, Andrews JI, Liu KZ
FASEB J 2007 Dec;21(14):3885-95. Epub 2007 Jul 5 doi: 10.1096/fj.07-8809com. PMID: 17615362
Expression of VEGF and its receptors by myeloma cells.
Kumar S, Witzig TE, Timm M, Haug J, Wellik L, Fonseca R, Greipp PR, Rajkumar SV
Leukemia 2003 Oct;17(10):2025-31. doi: 10.1038/sj.leu.2403084. PMID: 14513053

Clinical prediction guides

Intrinsic Subtype Switching and Acquired ERBB2/HER2 Amplifications and Mutations in Breast Cancer Brain Metastases.
Priedigkeit N, Hartmaier RJ, Chen Y, Vareslija D, Basudan A, Watters RJ, Thomas R, Leone JP, Lucas PC, Bhargava R, Hamilton RL, Chmielecki J, Puhalla SL, Davidson NE, Oesterreich S, Brufsky AM, Young L, Lee AV
JAMA Oncol 2017 May 1;3(5):666-671. doi: 10.1001/jamaoncol.2016.5630. PMID: 27926948Free PMC Article
Intronic polyadenylation signal sequences and alternate splicing generate human soluble Flt1 variants and regulate the abundance of soluble Flt1 in the placenta.
Thomas CP, Andrews JI, Liu KZ
FASEB J 2007 Dec;21(14):3885-95. Epub 2007 Jul 5 doi: 10.1096/fj.07-8809com. PMID: 17615362
Expression of VEGF and its receptors by myeloma cells.
Kumar S, Witzig TE, Timm M, Haug J, Wellik L, Fonseca R, Greipp PR, Rajkumar SV
Leukemia 2003 Oct;17(10):2025-31. doi: 10.1038/sj.leu.2403084. PMID: 14513053
Controlled expansion of human endothelial cell populations by Cre-loxP-based reversible immortalization.
Noguchi H, Kobayashi N, Westerman KA, Sakaguchi M, Okitsu T, Totsugawa T, Watanabe T, Matsumura T, Fujiwara T, Ueda T, Miyazaki M, Tanaka N, Leboulch P
Hum Gene Ther 2002 Jan 20;13(2):321-34. doi: 10.1089/10430340252769833. PMID: 11812287
Absence of endothelial cells, central necrosis, and fibrosis are associated with aggressive inflammatory breast cancer.
Shirakawa K, Tsuda H, Heike Y, Kato K, Asada R, Inomata M, Sasaki H, Kasumi F, Yoshimoto M, Iwanaga T, Konishi F, Terada M, Wakasugi H
Cancer Res 2001 Jan 15;61(2):445-51. PMID: 11212228

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