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Receptor Tyrosine Kinase Gene Amplification

MedGen UID:
1654532
•Concept ID:
C4744518
•
Cell or Molecular Dysfunction
Synonyms: Receptor Tyrosine Kinase Amplification; Receptor Tyrosine Kinase Family Gene Amplification; RTK Amplification; RTK Family Amplification; RTK Family Gene Amplification; RTK Gene Amplification; Tyrosine Kinase Receptor Amplification; Tyrosine Kinase Receptor Family Amplification; Tyrosine Kinase Receptor Gene Amplification

Definition

A molecular abnormality indicating the presence of multiple copies of a receptor tyrosine kinase family gene. [from NCI]

Professional guidelines

PubMed

Anti-HER2 Drugs for the Treatment of Advanced HER2 Positive Breast Cancer.
Stanowicka-Grada M, Senkus E
Curr Treat Options Oncol 2023 Nov;24(11):1633-1650. Epub 2023 Oct 25 doi: 10.1007/s11864-023-01137-5. PMID: 37878202Free PMC Article
A review of treatment options in HER2-low breast cancer and proposed treatment sequencing algorithm.
Roy AM, Kumarasamy VM, Dhakal A, O'Regan R, Gandhi S
Cancer 2023 Sep 15;129(18):2773-2788. Epub 2023 Jun 22 doi: 10.1002/cncr.34904. PMID: 37349954Free PMC Article
Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013.
Goldhirsch A, Winer EP, Coates AS, Gelber RD, Piccart-Gebhart M, Thürlimann B, Senn HJ; Panel members
Ann Oncol 2013 Sep;24(9):2206-23. Epub 2013 Aug 4 doi: 10.1093/annonc/mdt303. PMID: 23917950Free PMC Article

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