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MYC Gene Rearrangement

MedGen UID:
1376603
•Concept ID:
C0807034
•
Cell or Molecular Dysfunction
Synonyms: bHLHe39 Gene Rearrangement; c-myc Gene Rearrangement; C-MYC Gene Rearrangement; MRTL Gene Rearrangement; MYCC Gene Rearrangement; v-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the MYC gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMYC Gene Rearrangement

Professional guidelines

PubMed

Diffuse large B-cell lymphoma with MYC gene rearrangements: Current perspective on treatment of diffuse large B-cell lymphoma with MYC gene rearrangements; case series and review of the literature.
de Jonge AV, Roosma TJ, Houtenbos I, Vasmel WL, van de Hem K, de Boer JP, van Maanen T, Lindauer-van der Werf G, Beeker A, Timmers GJ, Schaar CG, Soesan M, Poddighe PJ, de Jong D, Chamuleau ME
Eur J Cancer 2016 Mar;55:140-6. Epub 2016 Jan 25 doi: 10.1016/j.ejca.2015.12.001. PMID: 26820684
Report of the fifteenth international symposium of the foundation for promotion of cancer research: new horizons in the diagnosis and treatment of hematological malignancies based on molecular genetic features.
Multani PS, Tobinai K, Kakizoe T, Armitage JO, Ohno R, Sugimura T
Jpn J Clin Oncol 2002 Sep;32(9):371-85. doi: 10.1093/jjco/hyf080. PMID: 12417606

Recent clinical studies

Etiology

The clinicopathological characteristics of C-MYC protein in angioimmunoblastic T-cell lymphoma.
Peng Y, Yan H, Wang J, Zhang M, He J
Acta Biochim Pol 2022 Jul 25;69(3):559-565. doi: 10.18388/abp.2020_5833. PMID: 35878052
Dose-adjusted EPOCH-R (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab) in untreated aggressive diffuse large B-cell lymphoma with MYC rearrangement: a prospective, multicentre, single-arm phase 2 study.
Dunleavy K, Fanale MA, Abramson JS, Noy A, Caimi PF, Pittaluga S, Parekh S, Lacasce A, Hayslip JW, Jagadeesh D, Nagpal S, Lechowicz MJ, Gaur R, Lucas A, Melani C, Roschewski M, Steinberg SM, Jaffe ES, Kahl B, Friedberg JW, Little RF, Bartlett NL, Wilson WH
Lancet Haematol 2018 Dec;5(12):e609-e617. doi: 10.1016/S2352-3026(18)30177-7. PMID: 30501868Free PMC Article
CD30 expression and its correlation with MYC and BCL2 in de novo diffuse large B-cell lymphoma.
Gong QX, Wang Z, Liu C, Li X, Lu TX, Liang JH, Xu W, Li JY, Zhang ZH
J Clin Pathol 2018 Sep;71(9):795-801. Epub 2018 Apr 17 doi: 10.1136/jclinpath-2018-205039. PMID: 29666157
Expression profiles of MYC protein and MYC gene rearrangement in lymphomas.
Chisholm KM, Bangs CD, Bacchi CE, Molina-Kirsch H, Cherry A, Natkunam Y
Am J Surg Pathol 2015 Mar;39(3):294-303. doi: 10.1097/PAS.0000000000000365. PMID: 25581730
Hematopoietic cell transplantation for plasmablastic lymphoma: a review.
Al-Malki MM, Castillo JJ, Sloan JM, Re A
Biol Blood Marrow Transplant 2014 Dec;20(12):1877-84. Epub 2014 Jun 16 doi: 10.1016/j.bbmt.2014.06.009. PMID: 24946718

Diagnosis

The clinicopathological characteristics of C-MYC protein in angioimmunoblastic T-cell lymphoma.
Peng Y, Yan H, Wang J, Zhang M, He J
Acta Biochim Pol 2022 Jul 25;69(3):559-565. doi: 10.18388/abp.2020_5833. PMID: 35878052
CD30 expression and its correlation with MYC and BCL2 in de novo diffuse large B-cell lymphoma.
Gong QX, Wang Z, Liu C, Li X, Lu TX, Liang JH, Xu W, Li JY, Zhang ZH
J Clin Pathol 2018 Sep;71(9):795-801. Epub 2018 Apr 17 doi: 10.1136/jclinpath-2018-205039. PMID: 29666157
Diffuse large B-cell lymphoma with MYC gene rearrangements: Current perspective on treatment of diffuse large B-cell lymphoma with MYC gene rearrangements; case series and review of the literature.
de Jonge AV, Roosma TJ, Houtenbos I, Vasmel WL, van de Hem K, de Boer JP, van Maanen T, Lindauer-van der Werf G, Beeker A, Timmers GJ, Schaar CG, Soesan M, Poddighe PJ, de Jong D, Chamuleau ME
Eur J Cancer 2016 Mar;55:140-6. Epub 2016 Jan 25 doi: 10.1016/j.ejca.2015.12.001. PMID: 26820684
Clinicopathological study of sporadic Burkitt lymphoma in children.
Huang H, Liu ZL, Zeng H, Zhang SH, Huang CS, Xu HY, Wu Y, Zeng ST, Xiong F, Yang WP
Chin Med J (Engl) 2015 Feb 20;128(4):510-4. doi: 10.4103/0366-6999.151106. PMID: 25673455Free PMC Article
Expression profiles of MYC protein and MYC gene rearrangement in lymphomas.
Chisholm KM, Bangs CD, Bacchi CE, Molina-Kirsch H, Cherry A, Natkunam Y
Am J Surg Pathol 2015 Mar;39(3):294-303. doi: 10.1097/PAS.0000000000000365. PMID: 25581730

Therapy

Clinical Significance of BCL2, C-MYC, and BCL6 Genetic Abnormalities, Epstein-Barr Virus Infection, CD5 Protein Expression, Germinal Center B Cell/Non-Germinal Center B-Cell Subtypes, Co-expression of MYC/BCL2 Proteins and Co-expression of MYC/BCL2/BCL6 Proteins in Diffuse Large B-Cell Lymphoma: A Clinical and Pathological Correlation Study of 120 Patients.
Ting CY, Chang KM, Kuan JW, Sathar J, Chew LP, Wong OJ, Yusuf Y, Wong L, Samsudin AT, Pana MNBM, Lee SK, Gopal NSR, Puri R, Ong TC, Bahari SK, Goh AS, Teoh CS
Int J Med Sci 2019;16(4):556-566. Epub 2019 Apr 20 doi: 10.7150/ijms.27610. PMID: 31171907Free PMC Article
Dose-adjusted EPOCH-R (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab) in untreated aggressive diffuse large B-cell lymphoma with MYC rearrangement: a prospective, multicentre, single-arm phase 2 study.
Dunleavy K, Fanale MA, Abramson JS, Noy A, Caimi PF, Pittaluga S, Parekh S, Lacasce A, Hayslip JW, Jagadeesh D, Nagpal S, Lechowicz MJ, Gaur R, Lucas A, Melani C, Roschewski M, Steinberg SM, Jaffe ES, Kahl B, Friedberg JW, Little RF, Bartlett NL, Wilson WH
Lancet Haematol 2018 Dec;5(12):e609-e617. doi: 10.1016/S2352-3026(18)30177-7. PMID: 30501868Free PMC Article
Diffuse large B-cell lymphoma with MYC gene rearrangements: Current perspective on treatment of diffuse large B-cell lymphoma with MYC gene rearrangements; case series and review of the literature.
de Jonge AV, Roosma TJ, Houtenbos I, Vasmel WL, van de Hem K, de Boer JP, van Maanen T, Lindauer-van der Werf G, Beeker A, Timmers GJ, Schaar CG, Soesan M, Poddighe PJ, de Jong D, Chamuleau ME
Eur J Cancer 2016 Mar;55:140-6. Epub 2016 Jan 25 doi: 10.1016/j.ejca.2015.12.001. PMID: 26820684
Clinical features, tumor biology, and prognosis associated with MYC rearrangement and Myc overexpression in diffuse large B-cell lymphoma patients treated with rituximab-CHOP.
Xu-Monette ZY, Dabaja BS, Wang X, Tu M, Manyam GC, Tzankov A, Xia Y, Zhang L, Sun R, Visco C, Dybkaer K, Yin L, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WW, van Krieken JH, Huh J, Ponzoni M, Ferreri AJ, Møller MB, Parsons BM, Zhao X, Winter JN, Piris MA, McDonnell TJ, Miranda RN, Li Y, Medeiros LJ, Young KH
Mod Pathol 2015 Dec;28(12):1555-73. Epub 2015 Nov 6 doi: 10.1038/modpathol.2015.118. PMID: 26541272
Prognostic significance of MYC, BCL2, and BCL6 rearrangements in patients with diffuse large B-cell lymphoma treated with cyclophosphamide, doxorubicin, vincristine, and prednisone plus rituximab.
Akyurek N, Uner A, Benekli M, Barista I
Cancer 2012 Sep 1;118(17):4173-83. Epub 2011 Dec 27 doi: 10.1002/cncr.27396. PMID: 22213394

Prognosis

The clinicopathological characteristics of C-MYC protein in angioimmunoblastic T-cell lymphoma.
Peng Y, Yan H, Wang J, Zhang M, He J
Acta Biochim Pol 2022 Jul 25;69(3):559-565. doi: 10.18388/abp.2020_5833. PMID: 35878052
Dose-adjusted EPOCH-R (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab) in untreated aggressive diffuse large B-cell lymphoma with MYC rearrangement: a prospective, multicentre, single-arm phase 2 study.
Dunleavy K, Fanale MA, Abramson JS, Noy A, Caimi PF, Pittaluga S, Parekh S, Lacasce A, Hayslip JW, Jagadeesh D, Nagpal S, Lechowicz MJ, Gaur R, Lucas A, Melani C, Roschewski M, Steinberg SM, Jaffe ES, Kahl B, Friedberg JW, Little RF, Bartlett NL, Wilson WH
Lancet Haematol 2018 Dec;5(12):e609-e617. doi: 10.1016/S2352-3026(18)30177-7. PMID: 30501868Free PMC Article
Diffuse large B-cell lymphoma with MYC gene rearrangements: Current perspective on treatment of diffuse large B-cell lymphoma with MYC gene rearrangements; case series and review of the literature.
de Jonge AV, Roosma TJ, Houtenbos I, Vasmel WL, van de Hem K, de Boer JP, van Maanen T, Lindauer-van der Werf G, Beeker A, Timmers GJ, Schaar CG, Soesan M, Poddighe PJ, de Jong D, Chamuleau ME
Eur J Cancer 2016 Mar;55:140-6. Epub 2016 Jan 25 doi: 10.1016/j.ejca.2015.12.001. PMID: 26820684
Expression profiles of MYC protein and MYC gene rearrangement in lymphomas.
Chisholm KM, Bangs CD, Bacchi CE, Molina-Kirsch H, Cherry A, Natkunam Y
Am J Surg Pathol 2015 Mar;39(3):294-303. doi: 10.1097/PAS.0000000000000365. PMID: 25581730
Hematopoietic cell transplantation for plasmablastic lymphoma: a review.
Al-Malki MM, Castillo JJ, Sloan JM, Re A
Biol Blood Marrow Transplant 2014 Dec;20(12):1877-84. Epub 2014 Jun 16 doi: 10.1016/j.bbmt.2014.06.009. PMID: 24946718

Clinical prediction guides

The clinicopathological characteristics of C-MYC protein in angioimmunoblastic T-cell lymphoma.
Peng Y, Yan H, Wang J, Zhang M, He J
Acta Biochim Pol 2022 Jul 25;69(3):559-565. doi: 10.18388/abp.2020_5833. PMID: 35878052
Dose-adjusted EPOCH-R (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab) in untreated aggressive diffuse large B-cell lymphoma with MYC rearrangement: a prospective, multicentre, single-arm phase 2 study.
Dunleavy K, Fanale MA, Abramson JS, Noy A, Caimi PF, Pittaluga S, Parekh S, Lacasce A, Hayslip JW, Jagadeesh D, Nagpal S, Lechowicz MJ, Gaur R, Lucas A, Melani C, Roschewski M, Steinberg SM, Jaffe ES, Kahl B, Friedberg JW, Little RF, Bartlett NL, Wilson WH
Lancet Haematol 2018 Dec;5(12):e609-e617. doi: 10.1016/S2352-3026(18)30177-7. PMID: 30501868Free PMC Article
CD30 expression and its correlation with MYC and BCL2 in de novo diffuse large B-cell lymphoma.
Gong QX, Wang Z, Liu C, Li X, Lu TX, Liang JH, Xu W, Li JY, Zhang ZH
J Clin Pathol 2018 Sep;71(9):795-801. Epub 2018 Apr 17 doi: 10.1136/jclinpath-2018-205039. PMID: 29666157
Diffuse large B-cell lymphoma with MYC gene rearrangements: Current perspective on treatment of diffuse large B-cell lymphoma with MYC gene rearrangements; case series and review of the literature.
de Jonge AV, Roosma TJ, Houtenbos I, Vasmel WL, van de Hem K, de Boer JP, van Maanen T, Lindauer-van der Werf G, Beeker A, Timmers GJ, Schaar CG, Soesan M, Poddighe PJ, de Jong D, Chamuleau ME
Eur J Cancer 2016 Mar;55:140-6. Epub 2016 Jan 25 doi: 10.1016/j.ejca.2015.12.001. PMID: 26820684
Expression profiles of MYC protein and MYC gene rearrangement in lymphomas.
Chisholm KM, Bangs CD, Bacchi CE, Molina-Kirsch H, Cherry A, Natkunam Y
Am J Surg Pathol 2015 Mar;39(3):294-303. doi: 10.1097/PAS.0000000000000365. PMID: 25581730

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