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C-Myc Translocation

MedGen UID:
267922
•Concept ID:
C1511357
•
Cell or Molecular Dysfunction
Synonyms: bHLHe39 Gene Translocation; C-MycT; MYC Gene Translocation; MYC Translocation; MYCC Gene Translocation; v-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog Gene Translocation

Definition

A cytogenetic abnormality that refers to the translocation of the MYC gene to a new chromosomal location. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVC-Myc Translocation

Professional guidelines

PubMed

Current Treatment of Burkitt Lymphoma and High-Grade B-Cell Lymphomas.
Johnson PC, Abramson JS
Oncology (Williston Park) 2022 Aug 10;36(8):499-505. doi: 10.46883/2022.25920970. PMID: 36001789
Diffuse large B-cell lymphoma: 2019 update on diagnosis, risk stratification, and treatment.
Liu Y, Barta SK
Am J Hematol 2019 May;94(5):604-616. doi: 10.1002/ajh.25460. PMID: 30859597
MYC-driven aggressive B-cell lymphomas: biology, entity, differential diagnosis and clinical management.
Cai Q, Medeiros LJ, Xu X, Young KH
Oncotarget 2015 Nov 17;6(36):38591-616. doi: 10.18632/oncotarget.5774. PMID: 26416427Free PMC Article

Recent clinical studies

Etiology

Association of killer cell immunoglobulin-like receptors with endemic Burkitt lymphoma in Kenyan children.
Muriuki BM, Forconi CS, Oluoch PO, Bailey JA, Ghansah A, Moormann AM, Ong'echa JM
Sci Rep 2021 May 31;11(1):11343. doi: 10.1038/s41598-021-90596-7. PMID: 34059753Free PMC Article
Clinicopathologic characteristics of HIV/AIDS-related plasmablastic lymphoma.
Wang D, Zheng Y, Zeng D, Yang Y, Zhang X, Feng Y, Lu H
Int J STD AIDS 2017 Mar;28(4):380-388. Epub 2016 Jul 10 doi: 10.1177/0956462416650124. PMID: 27164966
Is there any role for transplantation in the rituximab era for diffuse large B-cell lymphoma?
Gisselbrecht C
Hematology Am Soc Hematol Educ Program 2012;2012:410-6. doi: 10.1182/asheducation-2012.1.410. PMID: 23233612
Nodal diffuse large B-cell lymphomas in children and adolescents: immunohistochemical expression patterns and c-MYC translocation in relation to clinical outcome.
Gualco G, Weiss LM, Harrington WJ Jr, Bacchi CE
Am J Surg Pathol 2009 Dec;33(12):1815-22. doi: 10.1097/PAS.0b013e3181bb9a18. PMID: 19816150Free PMC Article
Clinical significance of 8q24/c-MYC translocation in diffuse large B-cell lymphoma.
Nitsu N, Okamoto M, Miura I, Hirano M
Cancer Sci 2009 Feb;100(2):233-7. doi: 10.1111/j.1349-7006.2008.01035.x. PMID: 19038003

Diagnosis

Clinicopathologic characteristics of HIV/AIDS-related plasmablastic lymphoma.
Wang D, Zheng Y, Zeng D, Yang Y, Zhang X, Feng Y, Lu H
Int J STD AIDS 2017 Mar;28(4):380-388. Epub 2016 Jul 10 doi: 10.1177/0956462416650124. PMID: 27164966
Detection of C-MYC oncogene translocation and copy number change in the normal-dysplasia-carcinoma sequence of the larynx by fluorescence in situ hybridization.
Liu Y, Gong LP, Dong XL, Liu HG
Diagn Cytopathol 2013 Jun;41(6):515-9. Epub 2012 Jun 20 doi: 10.1002/dc.22879. PMID: 22715132
Altered subcellular localization of c-Myc protein identifies aggressive B-cell lymphomas harboring a c-MYC translocation.
Ruzinova MB, Caron T, Rodig SJ
Am J Surg Pathol 2010 Jun;34(6):882-91. doi: 10.1097/PAS.0b013e3181db83af. PMID: 20442643
Nodal diffuse large B-cell lymphomas in children and adolescents: immunohistochemical expression patterns and c-MYC translocation in relation to clinical outcome.
Gualco G, Weiss LM, Harrington WJ Jr, Bacchi CE
Am J Surg Pathol 2009 Dec;33(12):1815-22. doi: 10.1097/PAS.0b013e3181bb9a18. PMID: 19816150Free PMC Article
Identification of genetic lesions associated with diffuse large-cell lymphoma.
Dalla-Favera R, Ye BH, Lo Coco F, Gaidano G, Lista F, Knowles DM, Louie DC, Offit K, Chaganti RS
Ann Oncol 1994;5 Suppl 1:55-60. doi: 10.1093/annonc/5.suppl_1.s55. PMID: 8172819

Therapy

Rheumatoid arthritis/methotrexate-associated primary cutaneous diffuse large B-cell lymphoma, leg type.
Matsumoto Y, Horiike S, Maekawa S, Isohisa T, Sakamoto N, Chinen Y, Nakayama R, Kiyota M, Nagoshi H, Mizutani S, Shimura Y, Sugitani M, Kobayashi T, Nakai N, Kuroda J, Taniwaki M
Intern Med 2014;53(11):1177-81. Epub 2014 Jun 1 doi: 10.2169/internalmedicine.53.1735. PMID: 24881744
Is there any role for transplantation in the rituximab era for diffuse large B-cell lymphoma?
Gisselbrecht C
Hematology Am Soc Hematol Educ Program 2012;2012:410-6. doi: 10.1182/asheducation-2012.1.410. PMID: 23233612
Molecular diagnosis of Burkitt's lymphoma.
Dave SS, Fu K, Wright GW, Lam LT, Kluin P, Boerma EJ, Greiner TC, Weisenburger DD, Rosenwald A, Ott G, Müller-Hermelink HK, Gascoyne RD, Delabie J, Rimsza LM, Braziel RM, Grogan TM, Campo E, Jaffe ES, Dave BJ, Sanger W, Bast M, Vose JM, Armitage JO, Connors JM, Smeland EB, Kvaloy S, Holte H, Fisher RI, Miller TP, Montserrat E, Wilson WH, Bahl M, Zhao H, Yang L, Powell J, Simon R, Chan WC, Staudt LM; Lymphoma/Leukemia Molecular Profiling Project
N Engl J Med 2006 Jun 8;354(23):2431-42. doi: 10.1056/NEJMoa055759. PMID: 16760443
Atypical Burkitt lymphoma arising from follicular lymphoma: demonstration by polymerase chain reaction following laser capture microdissection and by fluorescence in situ hybridization on paraffin-embedded tissue sections.
Tomita N, Nakamura N, Kanamori H, Fujimaki K, Fujisawa S, Ishigatsubo Y, Nomura K
Am J Surg Pathol 2005 Jan;29(1):121-4. doi: 10.1097/01.pas.0000146027.76706.50. PMID: 15613866
Small noncleaved, non-Burkitt's (Burkit-Like) lymphoma: cytogenetics predict outcome and reflect clinical presentation.
Macpherson N, Lesack D, Klasa R, Horsman D, Connors JM, Barnett M, Gascoyne RD
J Clin Oncol 1999 May;17(5):1558-67. doi: 10.1200/JCO.1999.17.5.1558. PMID: 10334544

Prognosis

An Aggressive Primary Cutaneous Follicle Center Lymphoma With c-MYC Translocation and CDKN2A (9p21) Deletion: A Case Report and Review of the Literature.
Tsang HC, Mathew S, Magro CM
Am J Dermatopathol 2017 Mar;39(3):e44-e49. doi: 10.1097/DAD.0000000000000738. PMID: 27759694
Clinicopathologic characteristics of HIV/AIDS-related plasmablastic lymphoma.
Wang D, Zheng Y, Zeng D, Yang Y, Zhang X, Feng Y, Lu H
Int J STD AIDS 2017 Mar;28(4):380-388. Epub 2016 Jul 10 doi: 10.1177/0956462416650124. PMID: 27164966
Is there any role for transplantation in the rituximab era for diffuse large B-cell lymphoma?
Gisselbrecht C
Hematology Am Soc Hematol Educ Program 2012;2012:410-6. doi: 10.1182/asheducation-2012.1.410. PMID: 23233612
Clinical significance of 8q24/c-MYC translocation in diffuse large B-cell lymphoma.
Nitsu N, Okamoto M, Miura I, Hirano M
Cancer Sci 2009 Feb;100(2):233-7. doi: 10.1111/j.1349-7006.2008.01035.x. PMID: 19038003
The clinical presentation and prognosis of diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC rearrangement.
Le Gouill S, Talmant P, Touzeau C, Moreau A, Garand R, Juge-Morineau N, Gaillard F, Gastinne T, Milpied N, Moreau P, Harousseau JL, Avet-Loiseau H
Haematologica 2007 Oct;92(10):1335-42. doi: 10.3324/haematol.11305. PMID: 18024371

Clinical prediction guides

Concomitant reduction of c-Myc expression and PI3K/AKT/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt's lymphoma.
Granato M, Rizzello C, Romeo MA, Yadav S, Santarelli R, D'Orazi G, Faggioni A, Cirone M
Int J Biochem Cell Biol 2016 Oct;79:393-400. Epub 2016 Sep 9 doi: 10.1016/j.biocel.2016.09.006. PMID: 27620077
Detection of C-MYC oncogene translocation and copy number change in the normal-dysplasia-carcinoma sequence of the larynx by fluorescence in situ hybridization.
Liu Y, Gong LP, Dong XL, Liu HG
Diagn Cytopathol 2013 Jun;41(6):515-9. Epub 2012 Jun 20 doi: 10.1002/dc.22879. PMID: 22715132
Is there any role for transplantation in the rituximab era for diffuse large B-cell lymphoma?
Gisselbrecht C
Hematology Am Soc Hematol Educ Program 2012;2012:410-6. doi: 10.1182/asheducation-2012.1.410. PMID: 23233612
Clinical significance of 8q24/c-MYC translocation in diffuse large B-cell lymphoma.
Nitsu N, Okamoto M, Miura I, Hirano M
Cancer Sci 2009 Feb;100(2):233-7. doi: 10.1111/j.1349-7006.2008.01035.x. PMID: 19038003
The clinical presentation and prognosis of diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC rearrangement.
Le Gouill S, Talmant P, Touzeau C, Moreau A, Garand R, Juge-Morineau N, Gaillard F, Gastinne T, Milpied N, Moreau P, Harousseau JL, Avet-Loiseau H
Haematologica 2007 Oct;92(10):1335-42. doi: 10.3324/haematol.11305. PMID: 18024371

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