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C-Myc Translocation

MedGen UID:
267922
Concept ID:
C1511357
Cell or Molecular Dysfunction
Synonyms: bHLHe39 Gene Translocation; C-MycT; MYC Gene Translocation; MYC Translocation; MYCC Gene Translocation; v-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog Gene Translocation

Definition

A cytogenetic abnormality that refers to the translocation of the MYC gene to a new chromosomal location. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVC-Myc Translocation

Professional guidelines

PubMed

Johnson PC, Abramson JS
Oncology (Williston Park) 2022 Aug 10;36(8):499-505. doi: 10.46883/2022.25920970. PMID: 36001789
Liu Y, Barta SK
Am J Hematol 2019 May;94(5):604-616. doi: 10.1002/ajh.25460. PMID: 30859597
Cai Q, Medeiros LJ, Xu X, Young KH
Oncotarget 2015 Nov 17;6(36):38591-616. doi: 10.18632/oncotarget.5774. PMID: 26416427Free PMC Article

Recent clinical studies

Etiology

Muriuki BM, Forconi CS, Oluoch PO, Bailey JA, Ghansah A, Moormann AM, Ong'echa JM
Sci Rep 2021 May 31;11(1):11343. doi: 10.1038/s41598-021-90596-7. PMID: 34059753Free PMC Article
Wang D, Zheng Y, Zeng D, Yang Y, Zhang X, Feng Y, Lu H
Int J STD AIDS 2017 Mar;28(4):380-388. Epub 2016 Jul 10 doi: 10.1177/0956462416650124. PMID: 27164966
Gisselbrecht C
Hematology Am Soc Hematol Educ Program 2012;2012:410-6. doi: 10.1182/asheducation-2012.1.410. PMID: 23233612
Gualco G, Weiss LM, Harrington WJ Jr, Bacchi CE
Am J Surg Pathol 2009 Dec;33(12):1815-22. doi: 10.1097/PAS.0b013e3181bb9a18. PMID: 19816150Free PMC Article
Dave SS, Fu K, Wright GW, Lam LT, Kluin P, Boerma EJ, Greiner TC, Weisenburger DD, Rosenwald A, Ott G, Müller-Hermelink HK, Gascoyne RD, Delabie J, Rimsza LM, Braziel RM, Grogan TM, Campo E, Jaffe ES, Dave BJ, Sanger W, Bast M, Vose JM, Armitage JO, Connors JM, Smeland EB, Kvaloy S, Holte H, Fisher RI, Miller TP, Montserrat E, Wilson WH, Bahl M, Zhao H, Yang L, Powell J, Simon R, Chan WC, Staudt LM; Lymphoma/Leukemia Molecular Profiling Project
N Engl J Med 2006 Jun 8;354(23):2431-42. doi: 10.1056/NEJMoa055759. PMID: 16760443

Diagnosis

Wang D, Zheng Y, Zeng D, Yang Y, Zhang X, Feng Y, Lu H
Int J STD AIDS 2017 Mar;28(4):380-388. Epub 2016 Jul 10 doi: 10.1177/0956462416650124. PMID: 27164966
Liu Y, Gong LP, Dong XL, Liu HG
Diagn Cytopathol 2013 Jun;41(6):515-9. Epub 2012 Jun 20 doi: 10.1002/dc.22879. PMID: 22715132
Ruzinova MB, Caron T, Rodig SJ
Am J Surg Pathol 2010 Jun;34(6):882-91. doi: 10.1097/PAS.0b013e3181db83af. PMID: 20442643
Dong XY, Lu YJ, Tong T, Wang YJ, Guo SP, Bai JF, Han NJ, Cheng SJ
J Cell Biochem Suppl 1997;28-29:74-80. PMID: 9589351
Dalla-Favera R, Ye BH, Lo Coco F, Gaidano G, Lista F, Knowles DM, Louie DC, Offit K, Chaganti RS
Ann Oncol 1994;5 Suppl 1:55-60. doi: 10.1093/annonc/5.suppl_1.s55. PMID: 8172819

Therapy

Jan Z, Khan AU, Ilyas A, Faiz S
J Ayub Med Coll Abbottabad 2023 Oct-Dec;35(Suppl 1)(4):S807-S809. doi: 10.55519/JAMC-S4-12410. PMID: 38406915
Matsumoto Y, Horiike S, Maekawa S, Isohisa T, Sakamoto N, Chinen Y, Nakayama R, Kiyota M, Nagoshi H, Mizutani S, Shimura Y, Sugitani M, Kobayashi T, Nakai N, Kuroda J, Taniwaki M
Intern Med 2014;53(11):1177-81. Epub 2014 Jun 1 doi: 10.2169/internalmedicine.53.1735. PMID: 24881744
Gisselbrecht C
Hematology Am Soc Hematol Educ Program 2012;2012:410-6. doi: 10.1182/asheducation-2012.1.410. PMID: 23233612
Dave SS, Fu K, Wright GW, Lam LT, Kluin P, Boerma EJ, Greiner TC, Weisenburger DD, Rosenwald A, Ott G, Müller-Hermelink HK, Gascoyne RD, Delabie J, Rimsza LM, Braziel RM, Grogan TM, Campo E, Jaffe ES, Dave BJ, Sanger W, Bast M, Vose JM, Armitage JO, Connors JM, Smeland EB, Kvaloy S, Holte H, Fisher RI, Miller TP, Montserrat E, Wilson WH, Bahl M, Zhao H, Yang L, Powell J, Simon R, Chan WC, Staudt LM; Lymphoma/Leukemia Molecular Profiling Project
N Engl J Med 2006 Jun 8;354(23):2431-42. doi: 10.1056/NEJMoa055759. PMID: 16760443
Macpherson N, Lesack D, Klasa R, Horsman D, Connors JM, Barnett M, Gascoyne RD
J Clin Oncol 1999 May;17(5):1558-67. doi: 10.1200/JCO.1999.17.5.1558. PMID: 10334544

Prognosis

Tsang HC, Mathew S, Magro CM
Am J Dermatopathol 2017 Mar;39(3):e44-e49. doi: 10.1097/DAD.0000000000000738. PMID: 27759694
Wang D, Zheng Y, Zeng D, Yang Y, Zhang X, Feng Y, Lu H
Int J STD AIDS 2017 Mar;28(4):380-388. Epub 2016 Jul 10 doi: 10.1177/0956462416650124. PMID: 27164966
Gisselbrecht C
Hematology Am Soc Hematol Educ Program 2012;2012:410-6. doi: 10.1182/asheducation-2012.1.410. PMID: 23233612
Ruzinova MB, Caron T, Rodig SJ
Am J Surg Pathol 2010 Jun;34(6):882-91. doi: 10.1097/PAS.0b013e3181db83af. PMID: 20442643
Dalla-Favera R, Ye BH, Lo Coco F, Gaidano G, Lista F, Knowles DM, Louie DC, Offit K, Chaganti RS
Ann Oncol 1994;5 Suppl 1:55-60. doi: 10.1093/annonc/5.suppl_1.s55. PMID: 8172819

Clinical prediction guides

Muriuki BM, Forconi CS, Oluoch PO, Bailey JA, Ghansah A, Moormann AM, Ong'echa JM
Sci Rep 2021 May 31;11(1):11343. doi: 10.1038/s41598-021-90596-7. PMID: 34059753Free PMC Article
Granato M, Rizzello C, Romeo MA, Yadav S, Santarelli R, D'Orazi G, Faggioni A, Cirone M
Int J Biochem Cell Biol 2016 Oct;79:393-400. Epub 2016 Sep 9 doi: 10.1016/j.biocel.2016.09.006. PMID: 27620077
Liu Y, Gong LP, Dong XL, Liu HG
Diagn Cytopathol 2013 Jun;41(6):515-9. Epub 2012 Jun 20 doi: 10.1002/dc.22879. PMID: 22715132
Ruzinova MB, Caron T, Rodig SJ
Am J Surg Pathol 2010 Jun;34(6):882-91. doi: 10.1097/PAS.0b013e3181db83af. PMID: 20442643
Nitsu N, Okamoto M, Miura I, Hirano M
Cancer Sci 2009 Feb;100(2):233-7. doi: 10.1111/j.1349-7006.2008.01035.x. PMID: 19038003

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