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Malignant Tumor, Small Cell Type

MedGen UID:
137727
•Concept ID:
C0334228
•
Neoplastic Process
Synonyms: Malignant tumor - small cell type; Malignant tumor, small cell type
SNOMED CT: Malignant tumor - small cell type (82267002); Malignant tumor, small cell type (82267002)

Definition

A malignant neoplasm characterized by the presence of small atypical cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Tumor, Small Cell Type

Professional guidelines

PubMed

Renal cell carcinoma: an overview of the epidemiology, diagnosis, and treatment.
Bahadoram S, Davoodi M, Hassanzadeh S, Bahadoram M, Barahman M, Mafakher L
G Ital Nefrol 2022 Jun 20;39(3) PMID: 35819037
Non-Small Cell Lung Cancer: Epidemiology, Screening, Diagnosis, and Treatment.
Duma N, Santana-Davila R, Molina JR
Mayo Clin Proc 2019 Aug;94(8):1623-1640. doi: 10.1016/j.mayocp.2019.01.013. PMID: 31378236
Lung cancer: diagnosis and management.
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705

Recent clinical studies

Etiology

γδ T cells as a potential therapeutic agent for glioblastoma.
Kang I, Kim Y, Lee HK
Front Immunol 2023;14:1273986. Epub 2023 Oct 20 doi: 10.3389/fimmu.2023.1273986. PMID: 37928546Free PMC Article
Very Small Embryonic-Like Stem Cells Transform Into Cancer Stem Cells and Are Novel Candidates for Detecting/Monitoring Cancer by a Simple Blood Test.
Bhartiya D, Sharma N, Dutta S, Kumar P, Tripathi A, Tripathi A
Stem Cells 2023 Apr 25;41(4):310-318. doi: 10.1093/stmcls/sxad015. PMID: 36881778
Extracellular matrix profiles determine risk and prognosis of the squamous cell carcinoma subtype of non-small cell lung carcinoma.
Parker AL, Bowman E, Zingone A, Ryan BM, Cooper WA, Kohonen-Corish M, Harris CC, Cox TR
Genome Med 2022 Nov 21;14(1):126. doi: 10.1186/s13073-022-01127-6. PMID: 36404344Free PMC Article
Antigen Capture and Immune Modulation by Bacterial Outer Membrane Vesicles as In Situ Vaccine for Cancer Immunotherapy Post-Photothermal Therapy.
Li Y, Zhang K, Wu Y, Yue Y, Cheng K, Feng Q, Ma X, Liang J, Ma N, Liu G, Nie G, Ren L, Zhao X
Small 2022 Apr;18(14):e2107461. Epub 2022 Feb 12 doi: 10.1002/smll.202107461. PMID: 35152555
Extracellular HMGB1 blockade inhibits tumor growth through profoundly remodeling immune microenvironment and enhances checkpoint inhibitor-based immunotherapy.
Hubert P, Roncarati P, Demoulin S, Pilard C, Ancion M, Reynders C, Lerho T, Bruyere D, Lebeau A, Radermecker C, Meunier M, Nokin MJ, Hendrick E, Peulen O, Delvenne P, Herfs M
J Immunother Cancer 2021 Mar;9(3) doi: 10.1136/jitc-2020-001966. PMID: 33712445Free PMC Article

Diagnosis

The important role of miR-1-3p in cancers.
Dai S, Li F, Xu S, Hu J, Gao L
J Transl Med 2023 Oct 31;21(1):769. doi: 10.1186/s12967-023-04649-8. PMID: 37907984Free PMC Article
Very Small Embryonic-Like Stem Cells Transform Into Cancer Stem Cells and Are Novel Candidates for Detecting/Monitoring Cancer by a Simple Blood Test.
Bhartiya D, Sharma N, Dutta S, Kumar P, Tripathi A, Tripathi A
Stem Cells 2023 Apr 25;41(4):310-318. doi: 10.1093/stmcls/sxad015. PMID: 36881778
Tumor-derived small extracellular vesicles: potential roles and mechanism in glioma.
Guo X, Sui R, Piao H
J Nanobiotechnology 2022 Aug 23;20(1):383. doi: 10.1186/s12951-022-01584-6. PMID: 35999601Free PMC Article
Single-cell analysis of diverse immune phenotypes in malignant pleural effusion.
Huang ZY, Shao MM, Zhang JC, Yi FS, Du J, Zhou Q, Wu FY, Li S, Li W, Huang XZ, Zhai K, Shi HZ
Nat Commun 2021 Nov 18;12(1):6690. doi: 10.1038/s41467-021-27026-9. PMID: 34795282Free PMC Article
Immune Cell Membrane-Coated Biomimetic Nanoparticles for Targeted Cancer Therapy.
Oroojalian F, Beygi M, Baradaran B, Mokhtarzadeh A, Shahbazi MA
Small 2021 Mar;17(12):e2006484. Epub 2021 Feb 12 doi: 10.1002/smll.202006484. PMID: 33577127

Therapy

Phase I trial of the DLL3/CD3 bispecific T-cell engager BI 764532 in DLL3-positive small-cell lung cancer and neuroendocrine carcinomas.
Wermke M, Felip E, Gambardella V, Kuboki Y, Morgensztern D, Hamed ZO, Liu M, Studeny M, Owonikoko TK
Future Oncol 2022 Aug;18(24):2639-2649. Epub 2022 Jul 11 doi: 10.2217/fon-2022-0196. PMID: 35815644
5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas.
Mahmoudi K, Garvey KL, Bouras A, Cramer G, Stepp H, Jesu Raj JG, Bozec D, Busch TM, Hadjipanayis CG
J Neurooncol 2019 Feb;141(3):595-607. Epub 2019 Jan 18 doi: 10.1007/s11060-019-03103-4. PMID: 30659522Free PMC Article
Immunomodulatory Nanomedicine.
Bartneck M
Macromol Biosci 2017 Oct;17(10) Epub 2017 Apr 6 doi: 10.1002/mabi.201700021. PMID: 28383783
Therapeutic cancer vaccines.
Schlom J, Hodge JW, Palena C, Tsang KY, Jochems C, Greiner JW, Farsaci B, Madan RA, Heery CR, Gulley JL
Adv Cancer Res 2014;121:67-124. doi: 10.1016/B978-0-12-800249-0.00002-0. PMID: 24889529Free PMC Article
Nanomedicine therapeutic approaches to overcome cancer drug resistance.
Markman JL, Rekechenetskiy A, Holler E, Ljubimova JY
Adv Drug Deliv Rev 2013 Nov;65(13-14):1866-79. Epub 2013 Oct 10 doi: 10.1016/j.addr.2013.09.019. PMID: 24120656Free PMC Article

Prognosis

Natural killer cell therapy targeting cancer stem cells: Old wine in a new bottle.
Guo F, Zhang Y, Bai L, Cui J
Cancer Lett 2023 Aug 28;570:216328. Epub 2023 Jul 26 doi: 10.1016/j.canlet.2023.216328. PMID: 37499742
Association of Telomere Length With Risk of Disease and Mortality.
Schneider CV, Schneider KM, Teumer A, Rudolph KL, Hartmann D, Rader DJ, Strnad P
JAMA Intern Med 2022 Mar 1;182(3):291-300. doi: 10.1001/jamainternmed.2021.7804. PMID: 35040871Free PMC Article
Metal-Polyphenol-Network Coated Prussian Blue Nanoparticles for Synergistic Ferroptosis and Apoptosis via Triggered GPX4 Inhibition and Concurrent In Situ Bleomycin Toxification.
Zhou L, Chen J, Li R, Wei L, Xiong H, Wang C, Chai K, Chen M, Zhu Z, Yao T, Lin Y, Dong C, Shi S
Small 2021 Nov;17(47):e2103919. Epub 2021 Oct 8 doi: 10.1002/smll.202103919. PMID: 34623753
Cancer Modeling-on-a-Chip with Future Artificial Intelligence Integration.
Fetah KL, DiPardo BJ, Kongadzem EM, Tomlinson JS, Elzagheid A, Elmusrati M, Khademhosseini A, Ashammakhi N
Small 2019 Dec;15(50):e1901985. Epub 2019 Nov 13 doi: 10.1002/smll.201901985. PMID: 31724305Free PMC Article
Systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio can predict clinical outcomes in patients with metastatic non-small-cell lung cancer treated with nivolumab.
Liu J, Li S, Zhang S, Liu Y, Ma L, Zhu J, Xin Y, Wang Y, Yang C, Cheng Y
J Clin Lab Anal 2019 Oct;33(8):e22964. Epub 2019 Jul 8 doi: 10.1002/jcla.22964. PMID: 31282096Free PMC Article

Clinical prediction guides

Immune cellular patterns of distribution affect outcomes of patients with non-small cell lung cancer.
Parra ER, Zhang J, Jiang M, Tamegnon A, Pandurengan RK, Behrens C, Solis L, Haymaker C, Heymach JV, Moran C, Lee JJ, Gibbons D, Wistuba II
Nat Commun 2023 Apr 25;14(1):2364. doi: 10.1038/s41467-023-37905-y. PMID: 37185575Free PMC Article
Construction of TME and Identification of crosstalk between malignant cells and macrophages by SPP1 in hepatocellular carcinoma.
Liu L, Zhang R, Deng J, Dai X, Zhu X, Fu Q, Zhang H, Tong Z, Zhao P, Fang W, Zheng Y, Bao X
Cancer Immunol Immunother 2022 Jan;71(1):121-136. Epub 2021 May 24 doi: 10.1007/s00262-021-02967-8. PMID: 34028567
Extracellular vesicles as biomarkers and therapeutic targets for cancer.
Urabe F, Kosaka N, Ito K, Kimura T, Egawa S, Ochiya T
Am J Physiol Cell Physiol 2020 Jan 1;318(1):C29-C39. Epub 2019 Nov 6 doi: 10.1152/ajpcell.00280.2019. PMID: 31693397
Cancer Modeling-on-a-Chip with Future Artificial Intelligence Integration.
Fetah KL, DiPardo BJ, Kongadzem EM, Tomlinson JS, Elzagheid A, Elmusrati M, Khademhosseini A, Ashammakhi N
Small 2019 Dec;15(50):e1901985. Epub 2019 Nov 13 doi: 10.1002/smll.201901985. PMID: 31724305Free PMC Article
Hereditary SWI/SNF complex deficiency syndromes.
Agaimy A, Foulkes WD
Semin Diagn Pathol 2018 May;35(3):193-198. Epub 2018 Feb 1 doi: 10.1053/j.semdp.2018.01.002. PMID: 29397238

Recent systematic reviews

Anti-TIGIT therapies for solid tumors: a systematic review.
Rousseau A, Parisi C, Barlesi F
ESMO Open 2023 Apr;8(2):101184. Epub 2023 Mar 16 doi: 10.1016/j.esmoop.2023.101184. PMID: 36933320Free PMC Article
Cutaneous T-cell lymphoma following dupilumab use: a systematic review.
Park A, Wong L, Lang A, Kraus C, Anderson N, Elsensohn A
Int J Dermatol 2023 Jul;62(7):862-876. Epub 2022 Sep 8 doi: 10.1111/ijd.16388. PMID: 36073768
Cardiac Toxicity Associated with Immune Checkpoint Inhibitors: A Systematic Review.
Cozma A, Sporis ND, Lazar AL, Buruiana A, Ganea AM, Malinescu TV, Berechet BM, Fodor A, Sitar-Taut AV, Vlad VC, Negrean V, Orasan OH
Int J Mol Sci 2022 Sep 19;23(18) doi: 10.3390/ijms231810948. PMID: 36142866Free PMC Article
Role of STAT3 signaling pathway in breast cancer.
Ma JH, Qin L, Li X
Cell Commun Signal 2020 Feb 28;18(1):33. doi: 10.1186/s12964-020-0527-z. PMID: 32111215Free PMC Article
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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