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Malignant Tumor, Small Cell Type

MedGen UID:
137727
•Concept ID:
C0334228
•
Neoplastic Process
Synonyms: Malignant tumor - small cell type; Malignant tumor, small cell type
SNOMED CT: Malignant tumor - small cell type (82267002); Malignant tumor, small cell type (82267002)

Definition

A malignant neoplasm characterized by the presence of small atypical cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Tumor, Small Cell Type

Professional guidelines

PubMed

Renal cell carcinoma: an overview of the epidemiology, diagnosis, and treatment.
Bahadoram S, Davoodi M, Hassanzadeh S, Bahadoram M, Barahman M, Mafakher L
G Ital Nefrol 2022 Jun 20;39(3) PMID: 35819037
Non-Small Cell Lung Cancer: Epidemiology, Screening, Diagnosis, and Treatment.
Duma N, Santana-Davila R, Molina JR
Mayo Clin Proc 2019 Aug;94(8):1623-1640. doi: 10.1016/j.mayocp.2019.01.013. PMID: 31378236
Lung cancer: diagnosis and management.
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705

Recent clinical studies

Etiology

Cuproptosis-Inducible Chemotherapeutic/Cascade Catalytic Reactor System for Combating with Breast Cancer.
Lee SY, Seo JH, Kim S, Hwang C, Jeong DI, Park J, Yang M, Huh JW, Cho HJ
Small 2023 Aug;19(35):e2301402. Epub 2023 May 10 doi: 10.1002/smll.202301402. PMID: 37162448
Is the neutrophil-to-lymphocyte ratio a prognostic factor in non-small cell lung cancer patients who receive adjuvant chemotherapy?
Smith D, Raices M, Cayol F, Corvatta F, Caram L, Dietrich A
Semin Oncol 2022 Dec;49(6):482-489. Epub 2023 Feb 6 doi: 10.1053/j.seminoncol.2023.01.006. PMID: 36775797
Artificial Glycoproteins as a Scaffold for Targeted Drug Therapy.
Vong K, Yamamoto T, Tanaka K
Small 2020 Jul;16(27):e1906890. Epub 2020 Feb 18 doi: 10.1002/smll.201906890. PMID: 32068952
Affinity Versus Label-Free Isolation of Circulating Tumor Cells: Who Wins?
Murlidhar V, Rivera-Báez L, Nagrath S
Small 2016 Sep;12(33):4450-63. Epub 2016 Jul 20 doi: 10.1002/smll.201601394. PMID: 27436104
Desmoplastic nested spindle cell tumours and nested stromal epithelial tumours of the liver.
Misra S, Bihari C
APMIS 2016 Apr;124(4):245-51. Epub 2016 Jan 14 doi: 10.1111/apm.12502. PMID: 26994733

Diagnosis

Imidazolyl Lipids Enhanced LNP Endosomal Escape for Ferroptosis RNAi Treatment of Cancer.
Liu Y, He F, Chen L, Zhang Y, Zhang H, Xiao J, Meng Q
Small 2024 Oct;20(40):e2402362. Epub 2024 Jun 3 doi: 10.1002/smll.202402362. PMID: 38829038
Extracellular Vesicles as Delivery Shippers for Noncoding RNA-Based Modulation of Angiogenesis: Insights from Ischemic Stroke and Cancer.
Pan Y, Liu Y, Wei W, Yang X, Wang Z, Xin W
Small 2023 Apr;19(17):e2205739. Epub 2023 Jan 2 doi: 10.1002/smll.202205739. PMID: 36592424
Recent Progress in Detection and Profiling of Cancer Cell-Derived Exosomes.
Xiong H, Huang Z, Yang Z, Lin Q, Yang B, Fang X, Liu B, Chen H, Kong J
Small 2021 Sep;17(35):e2007971. Epub 2021 Jun 2 doi: 10.1002/smll.202007971. PMID: 34075696
Desmoplastic nested spindle cell tumours and nested stromal epithelial tumours of the liver.
Misra S, Bihari C
APMIS 2016 Apr;124(4):245-51. Epub 2016 Jan 14 doi: 10.1111/apm.12502. PMID: 26994733
Role of MicroRNAs in Prostate Cancer Pathogenesis.
Wang YL, Wu S, Jiang B, Yin FF, Zheng SS, Hou SC
Clin Genitourin Cancer 2015 Aug;13(4):261-270. Epub 2015 Jan 24 doi: 10.1016/j.clgc.2015.01.003. PMID: 25733057

Therapy

Tumor-Derived Extracellular Vesicles as Complementary Prognostic Factors to Circulating Tumor Cells in Metastatic Breast Cancer.
Nanou A, Miao J, Coumans FAW, Dolce EM, Darga E, Barlow W, Smerage JB, Paoletti C, Godwin AK, Pusztai L, Sharma P, Thompson A, Hortobagyi GN, Terstappen LWMM, Hayes DF
JCO Precis Oncol 2023 Jan;7:e2200372. doi: 10.1200/PO.22.00372. PMID: 36634296Free PMC Article
RNA Activation-A Novel Approach to Therapeutically Upregulate Gene Transcription.
Tan CP, Sinigaglia L, Gomez V, Nicholls J, Habib NA
Molecules 2021 Oct 28;26(21) doi: 10.3390/molecules26216530. PMID: 34770939Free PMC Article
Immune Oncology Biomarkers in Lung Cancer: an Overview.
Travert C, Barlesi F, Greillier L, Tomasini P
Curr Oncol Rep 2020 Aug 15;22(11):107. doi: 10.1007/s11912-020-00970-3. PMID: 32803433
Development of "CLAN" Nanomedicine for Nucleic Acid Therapeutics.
Xu CF, Iqbal S, Shen S, Luo YL, Yang X, Wang J
Small 2019 Apr;15(16):e1900055. Epub 2019 Mar 18 doi: 10.1002/smll.201900055. PMID: 30884095
Dendritic cell vaccination and immune monitoring.
Aarntzen EH, Figdor CG, Adema GJ, Punt CJ, de Vries IJ
Cancer Immunol Immunother 2008 Oct;57(10):1559-68. Epub 2008 Jul 10 doi: 10.1007/s00262-008-0553-y. PMID: 18618110Free PMC Article

Prognosis

Extracellular Vesicles as Delivery Shippers for Noncoding RNA-Based Modulation of Angiogenesis: Insights from Ischemic Stroke and Cancer.
Pan Y, Liu Y, Wei W, Yang X, Wang Z, Xin W
Small 2023 Apr;19(17):e2205739. Epub 2023 Jan 2 doi: 10.1002/smll.202205739. PMID: 36592424
Photothermal Therapy of Neuroblastoma via Polysialic Acid-Targeting Nanomissiles.
Xu S, Zhao M, Gu Z, Lu H, Liu Z
Small 2022 Nov;18(46):e2201671. Epub 2022 Sep 26 doi: 10.1002/smll.202201671. PMID: 36161701
Metal-Polyphenol-Network Coated Prussian Blue Nanoparticles for Synergistic Ferroptosis and Apoptosis via Triggered GPX4 Inhibition and Concurrent In Situ Bleomycin Toxification.
Zhou L, Chen J, Li R, Wei L, Xiong H, Wang C, Chai K, Chen M, Zhu Z, Yao T, Lin Y, Dong C, Shi S
Small 2021 Nov;17(47):e2103919. Epub 2021 Oct 8 doi: 10.1002/smll.202103919. PMID: 34623753
Does sarcopenia have any impact on survival of patients with surgically treated non-small-cell lung cancer?
Deng HY, Zha P, Hou L, Huang KL
Interact Cardiovasc Thorac Surg 2019 Jul 1;29(1):144-147. doi: 10.1093/icvts/ivz039. PMID: 30843065
Circulating Tumor Cell Phenotyping via High-Throughput Acoustic Separation.
Wu M, Huang PH, Zhang R, Mao Z, Chen C, Kemeny G, Li P, Lee AV, Gyanchandani R, Armstrong AJ, Dao M, Suresh S, Huang TJ
Small 2018 Aug;14(32):e1801131. Epub 2018 Jul 3 doi: 10.1002/smll.201801131. PMID: 29968402Free PMC Article

Clinical prediction guides

Extracellular vesicles as biomarkers and therapeutic targets for cancer.
Urabe F, Kosaka N, Ito K, Kimura T, Egawa S, Ochiya T
Am J Physiol Cell Physiol 2020 Jan 1;318(1):C29-C39. Epub 2019 Nov 6 doi: 10.1152/ajpcell.00280.2019. PMID: 31693397
Molecular detection of pancreatic neoplasia: Current status and future promise.
Majumder S, Chari ST, Ahlquist DA
World J Gastroenterol 2015 Oct 28;21(40):11387-95. doi: 10.3748/wjg.v21.i40.11387. PMID: 26526068Free PMC Article
Neuroendocrine neoplasms of the lung: Concepts and terminology.
Wick MR, Marchevsky AM
Semin Diagn Pathol 2015 Nov;32(6):445-55. Epub 2015 Sep 25 doi: 10.1053/j.semdp.2015.09.012. PMID: 26500079
miRNA profiling for diagnosis and prognosis of human cancer.
Jay C, Nemunaitis J, Chen P, Fulgham P, Tong AW
DNA Cell Biol 2007 May;26(5):293-300. doi: 10.1089/dna.2006.0554. PMID: 17504025
Evidence for the clinical use of tumour markers.
Duffy MJ
Ann Clin Biochem 2004 Sep;41(Pt 5):370-7. doi: 10.1258/0004563041731529. PMID: 15333188

Recent systematic reviews

Anti-TIGIT therapies for solid tumors: a systematic review.
Rousseau A, Parisi C, Barlesi F
ESMO Open 2023 Apr;8(2):101184. Epub 2023 Mar 16 doi: 10.1016/j.esmoop.2023.101184. PMID: 36933320Free PMC Article
SALL4 and microRNA: The Role of Let-7.
Liu J, Sauer MA, Hussein SG, Yang J, Tenen DG, Chai L
Genes (Basel) 2021 Aug 24;12(9) doi: 10.3390/genes12091301. PMID: 34573282Free PMC Article
Neutrophil to lymphocyte ratio and cancer prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies.
Cupp MA, Cariolou M, Tzoulaki I, Aune D, Evangelou E, Berlanga-Taylor AJ
BMC Med 2020 Nov 20;18(1):360. doi: 10.1186/s12916-020-01817-1. PMID: 33213430Free PMC Article
Role of STAT3 signaling pathway in breast cancer.
Ma JH, Qin L, Li X
Cell Commun Signal 2020 Feb 28;18(1):33. doi: 10.1186/s12964-020-0527-z. PMID: 32111215Free PMC Article
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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