U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Small Cell Carcinoma, Fusiform Cell Type

MedGen UID:
137729
•Concept ID:
C0334238
•
Neoplastic Process
Synonyms: Small cell carcinoma - fusiform cell; Small cell carcinoma, fusiform cell
SNOMED CT: Small cell carcinoma, fusiform cell (74042001); Small cell carcinoma - fusiform cell (74042001)

Definition

A neuroendocrine carcinoma composed of malignant fusiform small cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Cell Carcinoma, Fusiform Cell Type

Recent clinical studies

Etiology

Fine needle aspiration cytology of solitary fibrous tumours of the pleura.
Cho EY, Han JJ, Han J, Oh YL
Cytopathology 2007 Feb;18(1):20-7. doi: 10.1111/j.1365-2303.2007.00378.x. PMID: 17250599
Neuroendocrine carcinomas of the colon and rectum: a clinicopathologic evaluation.
Staren ED, Gould VE, Warren WH, Wool NL, Bines S, Baker J, Bonomi P, Roseman DL, Economou SG
Surgery 1988 Dec;104(6):1080-9. PMID: 3194834
Immunohistochemical and ultrastructural analysis of bronchopulmonary neuroendocrine neoplasms. II. Well-differentiated neuroendocrine carcinomas.
Warren WH, Memoli VA, Gould VE
Ultrastruct Pathol 1984;7(2-3):185-99. doi: 10.3109/01913128409141476. PMID: 6085431
Morphologic and clinical determinants of response to therapy in small cell carcinoma of the lung.
Strauchen JA, Egbert BM, Kosek JC, Mackintosh R, Misfeldt DS
Cancer 1983 Sep 15;52(6):1088-92. doi: 10.1002/1097-0142(19830915)52:6<1088::aid-cncr2820520626>3.0.co;2-u. PMID: 6309354
Influence of histologic type on survival after curative resection for undifferentiated lung cancer.
Mayer JE Jr, Ewing SL, Ophoven JJ, Sumner HW, Humphrey EW
J Thorac Cardiovasc Surg 1982 Nov;84(5):641-8. PMID: 6290802

Diagnosis

Small cell lung cancer, an epithelial to mesenchymal transition (EMT)-like cancer: significance of inactive Notch signaling and expression of achaete-scute complex homologue 1.
Ito T, Kudoh S, Ichimura T, Fujino K, Hassan WA, Udaka N
Hum Cell 2017 Jan;30(1):1-10. Epub 2016 Oct 26 doi: 10.1007/s13577-016-0149-3. PMID: 27785690
Immunohistochemical detection of p53 homolog p63 in solid cell nests, papillary thyroid carcinoma, and hashimoto's thyroiditis: A stem cell hypothesis of papillary carcinoma oncogenesis.
Burstein DE, Nagi C, Wang BY, Unger P
Hum Pathol 2004 Apr;35(4):465-73. doi: 10.1016/j.humpath.2003.10.027. PMID: 15116328
Small cell carcinoma arising from the outer urethral orifice: a case report examined by histologic, ultrastructural and immunohistochemical methods.
Fukuda T, Kamishima T, Saito T, Itoh S, Suzuki T
Pathol Int 1997 Jul;47(7):497-501. doi: 10.1111/j.1440-1827.1997.tb04530.x. PMID: 9234390
Immunohistochemical and ultrastructural analysis of bronchopulmonary neuroendocrine neoplasms. II. Well-differentiated neuroendocrine carcinomas.
Warren WH, Memoli VA, Gould VE
Ultrastruct Pathol 1984;7(2-3):185-99. doi: 10.3109/01913128409141476. PMID: 6085431
Demonstration of argyrophil granules in small cell carcinoma of the lung.
Tateishi R, Horai T, Hattori S
Virchows Arch A Pathol Anat Histol 1978 Mar 10;377(3):203-10. doi: 10.1007/BF00426930. PMID: 205993

Therapy

Morphologic and clinical determinants of response to therapy in small cell carcinoma of the lung.
Strauchen JA, Egbert BM, Kosek JC, Mackintosh R, Misfeldt DS
Cancer 1983 Sep 15;52(6):1088-92. doi: 10.1002/1097-0142(19830915)52:6<1088::aid-cncr2820520626>3.0.co;2-u. PMID: 6309354
Relationship between survival and histologic type in small cell anaplastic carcinoma of the lung.
Nixon DW, Murphy GF, Sewell CW, Kutner M, Lynn MJ
Cancer 1979 Sep;44(3):1045-9. doi: 10.1002/1097-0142(197909)44:3<1045::aid-cncr2820440336>3.0.co;2-c. PMID: 225003

Prognosis

Rhabdomyosarcoma of the urinary bladder in adults: predilection for alveolar morphology with anaplasia and significant morphologic overlap with small cell carcinoma.
Paner GP, McKenney JK, Epstein JI, Amin MB
Am J Surg Pathol 2008 Jul;32(7):1022-8. doi: 10.1097/PAS.0b013e3181650e4a. PMID: 18469707
Endometrioid carcinoma of the fallopian tube: a clinicopathologic analysis of 26 cases.
Navani SS, Alvarado-Cabrero I, Young RH, Scully RE
Gynecol Oncol 1996 Dec;63(3):371-8. doi: 10.1006/gyno.1996.0338. PMID: 8946874
The cytodiagnosis of well-differentiated neuroendocrine carcinoma. A distinct clinicopathologic entity.
Jordan AG, Predmore L, Sullivan MM, Memoli VA
Acta Cytol 1987 Jul-Aug;31(4):464-70. PMID: 3037831
Morphologic and clinical determinants of response to therapy in small cell carcinoma of the lung.
Strauchen JA, Egbert BM, Kosek JC, Mackintosh R, Misfeldt DS
Cancer 1983 Sep 15;52(6):1088-92. doi: 10.1002/1097-0142(19830915)52:6<1088::aid-cncr2820520626>3.0.co;2-u. PMID: 6309354
Influence of histologic type on survival after curative resection for undifferentiated lung cancer.
Mayer JE Jr, Ewing SL, Ophoven JJ, Sumner HW, Humphrey EW
J Thorac Cardiovasc Surg 1982 Nov;84(5):641-8. PMID: 6290802

Clinical prediction guides

Interference of suppressor of cytokine signaling 3 promotes epithelial-mesenchymal transition in MHCC97H cells.
Ji YY, Wang ZD, Li ZF, Li K
World J Gastroenterol 2013 Feb 14;19(6):866-73. doi: 10.3748/wjg.v19.i6.866. PMID: 23430705Free PMC Article
NCAM (neural cell adhesion molecules) expression in malignant mesotheliomas.
Lantuéjoul S, Laverrière MH, Sturm N, Moro D, Frey G, Brambilla C, Brambilla E
Hum Pathol 2000 Apr;31(4):415-21. doi: 10.1053/hp.2000.6552. PMID: 10821486
Immunohistochemical and ultrastructural analysis of bronchopulmonary neuroendocrine neoplasms. II. Well-differentiated neuroendocrine carcinomas.
Warren WH, Memoli VA, Gould VE
Ultrastruct Pathol 1984;7(2-3):185-99. doi: 10.3109/01913128409141476. PMID: 6085431
Peritoneoscopy in the staging of 190 patients with small-cell anaplastic carcinoma of the lung with special reference to subtyping.
Dombernowsky P, Hirsch F, Hansen HH, Hainau B
Cancer 1978 May;41(5):2008-12. doi: 10.1002/1097-0142(197805)41:5<2008::aid-cncr2820410548>3.0.co;2-i. PMID: 206345
Bone-marrow examination in the staging of small-cell anaplastic carcinoma of the lung with special reference to subtyping. An evaluation of 203 consecutive patients.
Hirsch F, Hansen HH, Dombernowsky P, Hainau B
Cancer 1977 Jun;39(6):2563-7. doi: 10.1002/1097-0142(197706)39:6<2563::aid-cncr2820390638>3.0.co;2-i. PMID: 194670

Supplemental Content

Table of contents

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...