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Malignant Lymphoma, Non-Cleaved, Diffuse

MedGen UID:
137792
•Concept ID:
C0334642
•
Neoplastic Process
Synonym: Diffuse malignant lymphoma - large non-cleaved cell
SNOMED CT: Diffuse malignant lymphoma - large non-cleaved cell (277629008)

Definition

Antiquated term for diffuse non-Hodgkin lymphomas composed of non-cleaved cells. The vast majority of cases are mature B-cell lymphomas (Burkitts or diffuse large B-cell lymphomas). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Lymphoma, Non-Cleaved, Diffuse

Professional guidelines

PubMed

Childhood non-Hodgkin's lymphoma--results of treatment with ALL high-risk protocol.
Chu HY, Shu SG, Law KL, Chi CS
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi 1993 Mar-Apr;34(2):118-24. PMID: 8372667
Childhood non-Hodgkin's lymphoma in Egypt: preliminary results of treatment with a new ifosfamide-containing regimen.
Gad-el-Mawla N, Hussein MH, Abdel-Hadi S, el-Taneer O, Adde M, Magrath I
Cancer Chemother Pharmacol 1989;24 Suppl 1:S20-3. doi: 10.1007/BF00253233. PMID: 2758567
Immunoblastic sarcoma: morphologic criteria and the distinction of B and T cell types.
Maurer R, Taylor CR, Parker JW, Cramer A, Lukes RJ
Oncology 1982;39(1):42-50. doi: 10.1159/000225603. PMID: 7036027

Recent clinical studies

Etiology

Primary central nervous system non-Hodgkin's lymphoma (PCNSL): does age and histology at presentation affect outcome?
Schaller C, Kelly PJ
Zentralbl Neurochir 1996;57(3):156-62. PMID: 8794548
AIDS-associated lymphoma.
Kaplan LD
Baillieres Clin Haematol 1990 Jan;3(1):139-51. doi: 10.1016/s0950-3536(05)80085-x. PMID: 2182138
Prognostic implications of karyotype and morphology in patients with non-Hodgkin's lymphoma.
Kaneko Y, Rowley JD, Variakojis D, Haren JM, Ueshima Y, Daly K, Kluskens LF
Int J Cancer 1983 Dec 15;32(6):683-92. doi: 10.1002/ijc.2910320606. PMID: 6654522
The influence of histologic type on survival in non-Hodgkin's lymphoma.
Barcos M, Herrmann R, Pickren JW, Naeher C, Han T, Stutzman L, Henderson ES
Cancer 1981 Jun 15;47(12):2894-900. doi: 10.1002/1097-0142(19810615)47:12<2894::aid-cncr2820471224>3.0.co;2-8. PMID: 7020920
New approaches to the classification of the lymphomata.
Lukes RJ, Collins RD
Br J Cancer Suppl 1975 Mar;2:1-28. PMID: 1101914Free PMC Article

Diagnosis

Oral follicular lymphoma: a clinicopathologic and molecular study.
Souza LL, Cáceres CVBL, Sant'Ana MSP, Penafort PVM, Andrade BAB, Pontes HAR, Castro WH, Mesquita RA, Xavier-Júnior JCC, Santos-Silva AR, Lopes MA, Soares CD, Robinson L, van Heerden WFP, Burbano RMR, Assis-Mendonça GR, Vassallo J, Sousa SF, Vargas PA, Fonseca FP
J Hematop 2023 Dec;16(4):199-208. Epub 2023 Nov 2 doi: 10.1007/s12308-023-00563-6. PMID: 38175434
Unusual presentation of diffuse large B-cell non-Hodgkin's lymphoma in children: bilateral ureteral involvement.
Kantar M, Hekimgil M, Harman M, Oral A, Öge Ö, Avanoglu A
Pediatr Hematol Oncol 2019 Nov;36(8):504-509. Epub 2019 Sep 28 doi: 10.1080/08880018.2019.1663325. PMID: 31566047
Atypical Burkitt's lymphoma transforming from follicular lymphoma.
Hwang YY, Loong F, Chung LP, Chim CS
Diagn Pathol 2011 Jul 8;6:63. doi: 10.1186/1746-1596-6-63. PMID: 21736761Free PMC Article
AIDS-associated lymphoma.
Kaplan LD
Baillieres Clin Haematol 1990 Jan;3(1):139-51. doi: 10.1016/s0950-3536(05)80085-x. PMID: 2182138
Prognostic implications of karyotype and morphology in patients with non-Hodgkin's lymphoma.
Kaneko Y, Rowley JD, Variakojis D, Haren JM, Ueshima Y, Daly K, Kluskens LF
Int J Cancer 1983 Dec 15;32(6):683-92. doi: 10.1002/ijc.2910320606. PMID: 6654522

Therapy

Atypical Burkitt's lymphoma transforming from follicular lymphoma.
Hwang YY, Loong F, Chung LP, Chim CS
Diagn Pathol 2011 Jul 8;6:63. doi: 10.1186/1746-1596-6-63. PMID: 21736761Free PMC Article
AIDS lymphoma.
Sandler AS, Kaplan L
Curr Opin Oncol 1996 Sep;8(5):377-85. doi: 10.1097/00001622-199609000-00008. PMID: 8914804
Diffuse small noncleaved-cell, non-Burkitt's lymphoma in adults: a high-grade lymphoma responsive to ProMACE-based combination chemotherapy.
Longo DL, Duffey PL, Jaffe ES, Raffeld M, Hubbard SM, Fisher RI, Wittes RE, DeVita VT Jr, Young RC
J Clin Oncol 1994 Oct;12(10):2153-9. doi: 10.1200/JCO.1994.12.10.2153. PMID: 7523607
Burkitt's lymphoma: a model for clinical oncology.
Bouffet E, Frappaz D, Pinkerton R, Favrot M, Philip T
Eur J Cancer 1991;27(4):504-9. doi: 10.1016/0277-5379(91)90397-v. PMID: 1827731
AIDS-associated lymphoma.
Kaplan LD
Baillieres Clin Haematol 1990 Jan;3(1):139-51. doi: 10.1016/s0950-3536(05)80085-x. PMID: 2182138

Prognosis

Atypical Burkitt's lymphoma transforming from follicular lymphoma.
Hwang YY, Loong F, Chung LP, Chim CS
Diagn Pathol 2011 Jul 8;6:63. doi: 10.1186/1746-1596-6-63. PMID: 21736761Free PMC Article
AIDS-associated lymphoma.
Kaplan LD
Baillieres Clin Haematol 1990 Jan;3(1):139-51. doi: 10.1016/s0950-3536(05)80085-x. PMID: 2182138
Prognostic implications of karyotype and morphology in patients with non-Hodgkin's lymphoma.
Kaneko Y, Rowley JD, Variakojis D, Haren JM, Ueshima Y, Daly K, Kluskens LF
Int J Cancer 1983 Dec 15;32(6):683-92. doi: 10.1002/ijc.2910320606. PMID: 6654522
The influence of histologic type on survival in non-Hodgkin's lymphoma.
Barcos M, Herrmann R, Pickren JW, Naeher C, Han T, Stutzman L, Henderson ES
Cancer 1981 Jun 15;47(12):2894-900. doi: 10.1002/1097-0142(19810615)47:12<2894::aid-cncr2820471224>3.0.co;2-8. PMID: 7020920
New approaches to the classification of the lymphomata.
Lukes RJ, Collins RD
Br J Cancer Suppl 1975 Mar;2:1-28. PMID: 1101914Free PMC Article

Clinical prediction guides

Clinical significance of morphologic subdivision in diffuse large cell lymphoma.
Kwak LW, Wilson M, Weiss LM, Horning SJ, Warnke RA, Dorfman RF
Cancer 1991 Nov 1;68(9):1988-93. doi: 10.1002/1097-0142(19911101)68:9<1988::aid-cncr2820680924>3.0.co;2-a. PMID: 1913547
HIV-associated non-Hodgkin's lymphomas: clinical characteristics and outcome. The experience of the French Registry of HIV-associated tumors.
Roithmann S, Toledano M, Tourani JM, Raphael M, Gentilini M, Gastaut JA, Armengaud M, Morlat P, Tilly H, Dupont B
Ann Oncol 1991 Apr;2(4):289-95. doi: 10.1093/oxfordjournals.annonc.a057938. PMID: 1868025
AIDS-associated lymphoma.
Kaplan LD
Baillieres Clin Haematol 1990 Jan;3(1):139-51. doi: 10.1016/s0950-3536(05)80085-x. PMID: 2182138
Prognostic implications of karyotype and morphology in patients with non-Hodgkin's lymphoma.
Kaneko Y, Rowley JD, Variakojis D, Haren JM, Ueshima Y, Daly K, Kluskens LF
Int J Cancer 1983 Dec 15;32(6):683-92. doi: 10.1002/ijc.2910320606. PMID: 6654522
New approaches to the classification of the lymphomata.
Lukes RJ, Collins RD
Br J Cancer Suppl 1975 Mar;2:1-28. PMID: 1101914Free PMC Article

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