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Decreased hepatic echogenicity

MedGen UID:
1379023
•Concept ID:
C4477002
•
Finding
Synonym: Hypoechogenic liver
 
HPO: HP:0031143

Definition

Reduced echogenicity of liver tissue on sonography, manifested as an increased amount of black on the screen of the sonography device. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased hepatic echogenicity

Conditions with this feature

Hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase
MedGen UID:
462408
•Concept ID:
C3151058
•
Disease or Syndrome
Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency is an autosomal recessive severe neurometabolic disorder affecting the muscles, liver, and nervous system, resulting in death in infancy (summary by Bas et al., 2020). Other causes of hypermethioninemia include hereditary tyrosinemia (276700), cystathionine beta-synthase deficiency (236200), and methionine adenosyltransferase deficiency (250850).
See: Condition Record
Hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase

Professional guidelines

PubMed

Improvement of ultrasonographic and serologic changes in Schistosoma japonicum-infected patients after treatment with praziquantel.
Ohmae H, Tanaka M, Hayashi M, Matsuzaki Y, Kurosaki Y, Blas BL, Portillo GG, Sy OS, Irie Y, Yasuraoka K
Am J Trop Med Hyg 1992 Jan;46(1):99-104. doi: 10.4269/ajtmh.1992.46.99. PMID: 1536391
Echinococcus granulosus cysts in the liver: management with percutaneous drainage.
Khuroo MS, Zargar SA, Mahajan R
Radiology 1991 Jul;180(1):141-5. doi: 10.1148/radiology.180.1.2052682. PMID: 2052682
Abdominal hydatid disease: US findings during medical treatment.
Bezzi M, Teggi A, De Rosa F, Capozzi A, Tucci G, Bonifacino A, Angelini L
Radiology 1987 Jan;162(1 Pt 1):91-5. doi: 10.1148/radiology.162.1.3538157. PMID: 3538157

Recent clinical studies

Etiology

Effects of Robuvit® on the progression of non-alcoholic fatty liver disease.
Belcaro G, Cox DM, Cesarone MR, Gizzi G, Pellegrini L, Scipione C, Scipione V, Dugall M, Hu S, Corsi M, Feragalli B, Cotellese R
Minerva Gastroenterol (Torino) 2022 Dec;68(4):434-441. doi: 10.23736/S2724-5985.22.03201-6. PMID: 36507829
Chronic liver disease and impaired hepatic glycogen metabolism in argininosuccinate lyase deficiency.
Burrage LC, Madan S, Li X, Ali S, Mohammad M, Stroup BM, Jiang MM, Cela R, Bertin T, Jin Z, Dai J, Guffey D, Finegold M; Members of the Urea Cycle Disorders Consortium (UCDC), Nagamani S, Minard CG, Marini J, Masand P, Schady D, Shneider BL, Leung DH, Bali D, Lee B
JCI Insight 2020 Feb 27;5(4) doi: 10.1172/jci.insight.132342. PMID: 31990680Free PMC Article
Nonalcoholic Fatty Pancreas Disease: Clinical Consequences.
Dite P, Blaho M, Bojkova M, Jabandziev P, Kunovsky L
Dig Dis 2020;38(2):143-149. Epub 2019 Dec 19 doi: 10.1159/000505366. PMID: 31865317
Serial evaluation of hepatic function profile after Fontan operation.
Kaulitz R, Haber P, Sturm E, Schäfer J, Hofbeck M
Herz 2014 Feb;39(1):98-104. Epub 2013 May 8 doi: 10.1007/s00059-013-3811-5. PMID: 23649317
J type diabetes revisited.
Morrison EY, Ragoobirsingh D
J Natl Med Assoc 1992 Jul;84(7):603-8. PMID: 1629924Free PMC Article

Diagnosis

Increased 18F-FAPI Uptake in Radiation-Induced Liver Injury.
Zhang J, Jiang S, Zhang R, Zhang L
Clin Nucl Med 2023 Oct 1;48(10):e474-e476. Epub 2023 Aug 30 doi: 10.1097/RLU.0000000000004801. PMID: 37682614
Newborn with Lethargy, Jaundice, and Coagulopathy.
Ekambaram M, Najar F, Shetty A, Govande V
Pediatr Rev 2022 Feb 1;43(2):100-103. doi: 10.1542/pir.2020-003046. PMID: 35102400
Nonalcoholic Fatty Pancreas Disease: Clinical Consequences.
Dite P, Blaho M, Bojkova M, Jabandziev P, Kunovsky L
Dig Dis 2020;38(2):143-149. Epub 2019 Dec 19 doi: 10.1159/000505366. PMID: 31865317
J type diabetes revisited.
Morrison EY, Ragoobirsingh D
J Natl Med Assoc 1992 Jul;84(7):603-8. PMID: 1629924Free PMC Article
Oriental cholangiohepatitis: pathologic, clinical, and radiologic features.
Lim JH
AJR Am J Roentgenol 1991 Jul;157(1):1-8. doi: 10.2214/ajr.157.1.2048504. PMID: 2048504

Therapy

Increased 18F-FAPI Uptake in Radiation-Induced Liver Injury.
Zhang J, Jiang S, Zhang R, Zhang L
Clin Nucl Med 2023 Oct 1;48(10):e474-e476. Epub 2023 Aug 30 doi: 10.1097/RLU.0000000000004801. PMID: 37682614
Serial evaluation of hepatic function profile after Fontan operation.
Kaulitz R, Haber P, Sturm E, Schäfer J, Hofbeck M
Herz 2014 Feb;39(1):98-104. Epub 2013 May 8 doi: 10.1007/s00059-013-3811-5. PMID: 23649317
Bright liver, body composition and insulin resistance changes with nutritional intervention: a follow-up study.
Catalano D, Trovato GM, Martines GF, Randazzo M, Tonzuso A
Liver Int 2008 Nov;28(9):1280-7. Epub 2008 Apr 23 doi: 10.1111/j.1478-3231.2008.01742.x. PMID: 18435716
Hepatosplenic morbidity in schistosomiasis japonica: evaluation with Doppler sonography.
Kardorff R, Olveda RM, Acosta LP, Duebbelde UJ, Aligui GD, Alcorn NJ, Doehring E
Am J Trop Med Hyg 1999 Jun;60(6):954-9. doi: 10.4269/ajtmh.1999.60.954. PMID: 10403327
Improvement of ultrasonographic and serologic changes in Schistosoma japonicum-infected patients after treatment with praziquantel.
Ohmae H, Tanaka M, Hayashi M, Matsuzaki Y, Kurosaki Y, Blas BL, Portillo GG, Sy OS, Irie Y, Yasuraoka K
Am J Trop Med Hyg 1992 Jan;46(1):99-104. doi: 10.4269/ajtmh.1992.46.99. PMID: 1536391

Prognosis

Successful living donor liver transplantation for giant extensive venous malformation.
Hatanaka M, Nakazawa A, Nakano N, Matsuoka K, Ikeda H, Hamano I, Sakamoto S, Kasahara M
Pediatr Transplant 2014 Aug;18(5):E152-6. Epub 2014 May 12 doi: 10.1111/petr.12280. PMID: 24815871
Effect of body weight and lifestyle changes on long-term course of nonalcoholic fatty liver disease in Koreans.
Kim HK, Park JY, Lee KU, Lee GE, Jeon SH, Kim JH, Kim CH
Am J Med Sci 2009 Feb;337(2):98-102. doi: 10.1097/MAJ.0b013e3181812879. PMID: 19214024
Bright liver, body composition and insulin resistance changes with nutritional intervention: a follow-up study.
Catalano D, Trovato GM, Martines GF, Randazzo M, Tonzuso A
Liver Int 2008 Nov;28(9):1280-7. Epub 2008 Apr 23 doi: 10.1111/j.1478-3231.2008.01742.x. PMID: 18435716
Focal hepatic lesions: contrast-enhancement patterns at pulse-inversion harmonic US using a microbubble contrast agent.
Kim EA, Yoon KH, Lee YH, Kim HW, Juhng SK, Won JJ
Korean J Radiol 2003 Oct-Dec;4(4):224-33. doi: 10.3348/kjr.2003.4.4.224. PMID: 14726639Free PMC Article
Veno-occlusive disease and peliosis of the liver complicating the course of Wilms' tumour.
Björk O, Eklöf O, Willi U, Ahström L
Acta Radiol Diagn (Stockh) 1985 Sep-Oct;26(5):589-97. doi: 10.1177/028418518502600515. PMID: 3000141

Clinical prediction guides

Sonographic Markers Are Useful for Detection of Early Vascular Deterioration in Children with Overweight/Obesity: Effect of a 1-Year Combined Nutritional Education and Physical Exercise Program.
Abellaneda Millán M, Morillas-Ruiz JM, Ballester Sajardo R, Guillén Martínez D, Morales Moreno I, Hernández Morante JJ
Nutrients 2023 Feb 10;15(4) doi: 10.3390/nu15040894. PMID: 36839251Free PMC Article
Effects of Robuvit® on the progression of non-alcoholic fatty liver disease.
Belcaro G, Cox DM, Cesarone MR, Gizzi G, Pellegrini L, Scipione C, Scipione V, Dugall M, Hu S, Corsi M, Feragalli B, Cotellese R
Minerva Gastroenterol (Torino) 2022 Dec;68(4):434-441. doi: 10.23736/S2724-5985.22.03201-6. PMID: 36507829
Chronic liver disease and impaired hepatic glycogen metabolism in argininosuccinate lyase deficiency.
Burrage LC, Madan S, Li X, Ali S, Mohammad M, Stroup BM, Jiang MM, Cela R, Bertin T, Jin Z, Dai J, Guffey D, Finegold M; Members of the Urea Cycle Disorders Consortium (UCDC), Nagamani S, Minard CG, Marini J, Masand P, Schady D, Shneider BL, Leung DH, Bali D, Lee B
JCI Insight 2020 Feb 27;5(4) doi: 10.1172/jci.insight.132342. PMID: 31990680Free PMC Article
Serial evaluation of hepatic function profile after Fontan operation.
Kaulitz R, Haber P, Sturm E, Schäfer J, Hofbeck M
Herz 2014 Feb;39(1):98-104. Epub 2013 May 8 doi: 10.1007/s00059-013-3811-5. PMID: 23649317
Bright liver, body composition and insulin resistance changes with nutritional intervention: a follow-up study.
Catalano D, Trovato GM, Martines GF, Randazzo M, Tonzuso A
Liver Int 2008 Nov;28(9):1280-7. Epub 2008 Apr 23 doi: 10.1111/j.1478-3231.2008.01742.x. PMID: 18435716

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