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Decreased platelet thromboxane A2 receptor

MedGen UID:
1379435
•Concept ID:
C4476983
•
Finding
HPO: HP:0031124

Definition

Decreased cell membrane concentration of thromboxane A2 receptor that is stimulated by thromboxane A2 (TBXA2). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased platelet thromboxane A2 receptor

Professional guidelines

PubMed

Perioperative management of patients on adenosine diphosphate inhibitors in the era of drug-eluting stents: review of the literature and clinical implications.
Khoynezhad A, Movahed MR, Hashemzadeh M, Emaminia A, Jalali Z
Curr Med Chem 2009;16(5):591-8. doi: 10.2174/092986709787458443. PMID: 19199924

Recent clinical studies

Etiology

On-treatment platelet reactivity through the thromboxane A(2) or P2Y12 platelet receptor pathways is not affected by pelacarsen.
Karwatowska-Prokopczuk E, Li L, Yang J, Witztum JL, Tsimikas S
J Thromb Thrombolysis 2023 Aug;56(2):226-232. Epub 2023 Jun 20 doi: 10.1007/s11239-023-02818-6. PMID: 37338713
IL-1 induces throboxane-A2 (TxA2) in COVID-19 causing inflammation and micro-thrombi: inhibitory effect of the IL-1 receptor antagonist (IL-1Ra).
Conti P, Caraffa A, Gallenga CE, Ross R, Kritas SK, Frydas I, Younes A, Di Emidio P, Ronconi G, Toniato E
J Biol Regul Homeost Agents 2020 Sep-Oct,;34(5):1623-1627. doi: 10.23812/20-34-4EDIT-65. PMID: 32744052
Oral Antiplatelet Therapy for Secondary Prevention of Acute Coronary Syndrome.
Berger JS
Am J Cardiovasc Drugs 2018 Dec;18(6):457-472. doi: 10.1007/s40256-018-0291-2. PMID: 29987548Free PMC Article
Basic principles of platelet biology and clinical implications.
Angiolillo DJ, Ueno M, Goto S
Circ J 2010 Apr;74(4):597-607. Epub 2010 Mar 3 doi: 10.1253/circj.cj-09-0982. PMID: 20197627
Synthesis and thromboxane A2/prostaglandin H2 receptor antagonistic activity of phenol derivatives.
Fukumoto S, Shiraishi M, Terashita Z, Ashida Y, Inada Y
J Med Chem 1992 Jun 12;35(12):2202-9. doi: 10.1021/jm00090a009. PMID: 1535377

Diagnosis

Trial of thromboxane receptor inhibition with ifetroban: TP receptors regulate eicosanoid homeostasis in aspirin-exacerbated respiratory disease.
Laidlaw TM, Buchheit KM, Cahill KN, Hacker J, Cho L, Cui J, Feng C, Chen CC, Le M, Israel E, Boyce JA
J Allergy Clin Immunol 2023 Sep;152(3):700-710.e3. Epub 2023 Apr 15 doi: 10.1016/j.jaci.2023.03.030. PMID: 37068712Free PMC Article
ALOX12 mutation in a family with dominantly inherited bleeding diathesis.
Mitsui T, Makino S, Tamiya G, Sato H, Kawakami Y, Takahashi Y, Meguro T, Izumino H, Sudo Y, Norota I, Ishii K, Hayasaka K
J Hum Genet 2021 Aug;66(8):753-759. Epub 2021 Feb 10 doi: 10.1038/s10038-020-00887-6. PMID: 33564083
Regulation of coronary blood flow during exercise.
Duncker DJ, Bache RJ
Physiol Rev 2008 Jul;88(3):1009-86. doi: 10.1152/physrev.00045.2006. PMID: 18626066
Role of membrane cholesterol in platelet calcium signalling in response to VWF and collagen under stasis and flow.
van Lier M, Verhoef S, Cauwenberghs S, Heemskerk JW, Akkerman JW, Heijnen HF
Thromb Haemost 2008 Jun;99(6):1068-78. doi: 10.1160/TH07-08-0528. PMID: 18521510
Thromboxane A2 causes feedback amplification involving extensive thromboxane A2 formation on close contact of human platelets in media with a low concentration of ionized calcium.
Packham MA, Kinlough-Rathbone RL, Mustard JF
Blood 1987 Sep;70(3):647-51. PMID: 3620698

Therapy

Trial of thromboxane receptor inhibition with ifetroban: TP receptors regulate eicosanoid homeostasis in aspirin-exacerbated respiratory disease.
Laidlaw TM, Buchheit KM, Cahill KN, Hacker J, Cho L, Cui J, Feng C, Chen CC, Le M, Israel E, Boyce JA
J Allergy Clin Immunol 2023 Sep;152(3):700-710.e3. Epub 2023 Apr 15 doi: 10.1016/j.jaci.2023.03.030. PMID: 37068712Free PMC Article
IL-1 induces throboxane-A2 (TxA2) in COVID-19 causing inflammation and micro-thrombi: inhibitory effect of the IL-1 receptor antagonist (IL-1Ra).
Conti P, Caraffa A, Gallenga CE, Ross R, Kritas SK, Frydas I, Younes A, Di Emidio P, Ronconi G, Toniato E
J Biol Regul Homeost Agents 2020 Sep-Oct,;34(5):1623-1627. doi: 10.23812/20-34-4EDIT-65. PMID: 32744052
Oral Antiplatelet Therapy for Secondary Prevention of Acute Coronary Syndrome.
Berger JS
Am J Cardiovasc Drugs 2018 Dec;18(6):457-472. doi: 10.1007/s40256-018-0291-2. PMID: 29987548Free PMC Article
Basic principles of platelet biology and clinical implications.
Angiolillo DJ, Ueno M, Goto S
Circ J 2010 Apr;74(4):597-607. Epub 2010 Mar 3 doi: 10.1253/circj.cj-09-0982. PMID: 20197627
Advances in antiplatelet therapy for ACS and PCI.
Moliterno DJ
J Interv Cardiol 2008 Dec;21 Suppl 1:S18-24. doi: 10.1111/j.1540-8183.2008.00409.x. PMID: 19090933

Prognosis

Trial of thromboxane receptor inhibition with ifetroban: TP receptors regulate eicosanoid homeostasis in aspirin-exacerbated respiratory disease.
Laidlaw TM, Buchheit KM, Cahill KN, Hacker J, Cho L, Cui J, Feng C, Chen CC, Le M, Israel E, Boyce JA
J Allergy Clin Immunol 2023 Sep;152(3):700-710.e3. Epub 2023 Apr 15 doi: 10.1016/j.jaci.2023.03.030. PMID: 37068712Free PMC Article
A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis.
Mumford AD, Dawood BB, Daly ME, Murden SL, Williams MD, Protty MB, Spalton JC, Wheatley M, Mundell SJ, Watson SP
Blood 2010 Jan 14;115(2):363-9. Epub 2009 Oct 14 doi: 10.1182/blood-2009-08-236976. PMID: 19828703Free PMC Article
Regulation of the human thromboxane A2 receptor gene in human megakaryoblastic MEG-01 cells.
Saffak T, Schäfer S, Haas C, Nüsing RM
Prostaglandins Leukot Essent Fatty Acids 2003 Nov;69(5):299-306. doi: 10.1016/s0952-3278(03)00112-1. PMID: 14580363
Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor.
Raychowdhury MK, Yukawa M, Collins LJ, McGrail SH, Kent KC, Ware JA
J Biol Chem 1994 Jul 29;269(30):19256-61. PMID: 8034687
Cyclic oxidation-reduction reactions regulate thromboxane A2/prostaglandin H2 receptor number and affinity in human platelet membranes.
Dorn GW 2nd
J Biol Chem 1990 Mar 15;265(8):4240-6. PMID: 2137820

Clinical prediction guides

Trial of thromboxane receptor inhibition with ifetroban: TP receptors regulate eicosanoid homeostasis in aspirin-exacerbated respiratory disease.
Laidlaw TM, Buchheit KM, Cahill KN, Hacker J, Cho L, Cui J, Feng C, Chen CC, Le M, Israel E, Boyce JA
J Allergy Clin Immunol 2023 Sep;152(3):700-710.e3. Epub 2023 Apr 15 doi: 10.1016/j.jaci.2023.03.030. PMID: 37068712Free PMC Article
Changes in platelet function and coagulation after transcatheter aortic valve implantation evaluated with thromboelastography.
Harada M, Sajima T, Onimaru T, Honjo T, Hioki H, Watanabe Y, Sawamura S
Open Heart 2022 Nov;9(2) doi: 10.1136/openhrt-2022-002132. PMID: 36344109Free PMC Article
Role of Tyrosine Kinase Syk in Thrombus Stabilisation at High Shear.
Perrella G, Montague SJ, Brown HC, Garcia Quintanilla L, Slater A, Stegner D, Thomas M, Heemskerk JWM, Watson SP
Int J Mol Sci 2022 Jan 1;23(1) doi: 10.3390/ijms23010493. PMID: 35008919Free PMC Article
Regulation of coronary blood flow during exercise.
Duncker DJ, Bache RJ
Physiol Rev 2008 Jul;88(3):1009-86. doi: 10.1152/physrev.00045.2006. PMID: 18626066
Angiotensin II AT(1) receptor antagonists and platelet activation.
López-Farré A, Sánchez de Miguel L, Montón M, Jiménez A, Lopez-Bloya A, Gómez J, Núñez A, Rico L, Casado S
Nephrol Dial Transplant 2001;16 Suppl 1:45-9. doi: 10.1093/ndt/16.suppl_1.45. PMID: 11369820

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