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Abnormal platelet function

MedGen UID:
488944
•Concept ID:
C0855740
•
Finding
HPO: HP:0011869

Definition

Any anomaly in the function of thrombocytes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Abnormal platelet function

Professional guidelines

PubMed

Cardiovascular complications after acute spinal cord injury: pathophysiology, diagnosis, and management.
Furlan JC, Fehlings MG
Neurosurg Focus 2008;25(5):E13. doi: 10.3171/FOC.2008.25.11.E13. PMID: 18980473
The role of PFA-100 testing in the investigation and management of haemostatic defects in children and adults.
Harrison P
Br J Haematol 2005 Jul;130(1):3-10. doi: 10.1111/j.1365-2141.2005.05511.x. PMID: 15982339
Cardiac anesthesia risk management. Hemorrhage, coagulation, and transfusion: a risk-benefit analysis.
Spiess BD
J Cardiothorac Vasc Anesth 1994 Feb;8(1 Suppl 1):19-22. doi: 10.1016/1053-0770(94)90612-2. PMID: 8167299

Recent clinical studies

Etiology

Humanized mouse models for inherited thrombocytopenia studies.
Wang X, Chen M, Hu L, Tan C, Li X, Xue P, Jiang Y, Bao P, Yu T, Li F, Xiao Y, Ran Q, Li Z, Chen L
Platelets 2023 Dec;34(1):2267676. Epub 2023 Oct 17 doi: 10.1080/09537104.2023.2267676. PMID: 37849076
Non-Traditional Pathways for Platelet Pathophysiology in Diabetes: Implications for Future Therapeutic Targets.
Sagar RC, Ajjan RA, Naseem KM
Int J Mol Sci 2022 Apr 29;23(9) doi: 10.3390/ijms23094973. PMID: 35563363Free PMC Article
Platelet Dysfunction and Its Role in the Pathogenesis of Psoriasis.
Fan Z, Wang L, Jiang H, Lin Y, Wang Z
Dermatology 2021;237(1):56-65. Epub 2020 Apr 29 doi: 10.1159/000505536. PMID: 32349003
Flavonoids and Platelet-Derived Thrombotic Disorders.
Lopez JJ, El Haouari M, Jardin I, Alonso N, Regodon S, Diez-Bello R, Redondo PC, Rosado JA
Curr Med Chem 2019;26(39):7035-7047. doi: 10.2174/0929867325666180417170218. PMID: 29667548
Hematological manifestations and complications of Gaucher disease.
Linari S, Castaman G
Expert Rev Hematol 2016 Jan;9(1):51-8. Epub 2015 Nov 13 doi: 10.1586/17474086.2016.1112732. PMID: 26565753

Diagnosis

Performance evaluation of the Anysis-200 platelet function analyzer in cardiac patients.
Park SJ, Yoon J, Seo HS, Lim CS
Clin Hemorheol Microcirc 2022;80(1):17-24. doi: 10.3233/CH-190801. PMID: 32116240
Platelet Function Tests and Inflammatory Markers for the Differentiation of Primary Thrombocytosis and Secondary Thrombocytosis.
Kanya P, Rattarittamrong E, Wongtakan O, Rattanathammethee T, Chai-Adisaksopha C, Tantiworawit A, Norrasethada L
Asian Pac J Cancer Prev 2019 Jul 1;20(7):2079-2085. doi: 10.31557/APJCP.2019.20.7.2079. PMID: 31350969Free PMC Article
Jacobsen syndrome.
Mattina T, Perrotta CS, Grossfeld P
Orphanet J Rare Dis 2009 Mar 7;4:9. doi: 10.1186/1750-1172-4-9. PMID: 19267933Free PMC Article
von Willebrand disease.
Zimmerman TS, Ruggeri ZM
Hum Pathol 1987 Feb;18(2):140-52. doi: 10.1016/s0046-8177(87)80332-5. PMID: 3100416
Sulfonylureas and platelet function.
Klaff LJ, Kernoff L, Vinik AI, Jackson WP, Jacobs P
Am J Med 1981 Mar;70(3):627-30. doi: 10.1016/0002-9343(81)90585-4. PMID: 6782875

Therapy

RASopathies and hemostatic abnormalities: key role of platelet dysfunction.
Di Candia F, Marchetti V, Cirillo F, Di Minno A, Rosano C, Pagano S, Siano MA, Falco M, Assunto A, Boccia G, Magliacane G, Pinna V, De Luca A, Tartaglia M, Di Minno G, Strisciuglio P, Melis D
Orphanet J Rare Dis 2021 Dec 2;16(1):499. doi: 10.1186/s13023-021-02122-7. PMID: 34857025Free PMC Article
Importance of platelet aggregation in patients with end-stage renal disease.
Martinović Z, Basić-Jukić N, Pavlović DB, Kes P
Acta Clin Croat 2013 Dec;52(4):472-7. PMID: 24696998
Platelet activation in heart failure.
Schäfer A, Eigenthaler M, Bauersachs J
Clin Lab 2004;50(9-10):559-66. PMID: 15481631
von Willebrand disease.
Zimmerman TS, Ruggeri ZM
Hum Pathol 1987 Feb;18(2):140-52. doi: 10.1016/s0046-8177(87)80332-5. PMID: 3100416
Sulfonylureas and platelet function.
Klaff LJ, Kernoff L, Vinik AI, Jackson WP, Jacobs P
Am J Med 1981 Mar;70(3):627-30. doi: 10.1016/0002-9343(81)90585-4. PMID: 6782875

Prognosis

Correlation of Platelet Function with Postpartum Hemorrhage and Venous Thromboembolism in Patients with Gestational Hypertension Complicated with Diabetes.
Li N, Liu Y, Yun A, Song S
Comput Math Methods Med 2022;2022:2423333. Epub 2022 Jul 18 doi: 10.1155/2022/2423333. PMID: 35898483Free PMC Article
Platelet Function Tests and Inflammatory Markers for the Differentiation of Primary Thrombocytosis and Secondary Thrombocytosis.
Kanya P, Rattarittamrong E, Wongtakan O, Rattanathammethee T, Chai-Adisaksopha C, Tantiworawit A, Norrasethada L
Asian Pac J Cancer Prev 2019 Jul 1;20(7):2079-2085. doi: 10.31557/APJCP.2019.20.7.2079. PMID: 31350969Free PMC Article
Hematological manifestations and complications of Gaucher disease.
Linari S, Castaman G
Expert Rev Hematol 2016 Jan;9(1):51-8. Epub 2015 Nov 13 doi: 10.1586/17474086.2016.1112732. PMID: 26565753
Impaired platelet function and peripartum bleeding in women with Gaucher disease.
Simchen MJ, Oz R, Shenkman B, Zimran A, Elstein D, Kenet G
Thromb Haemost 2011 Mar;105(3):509-14. Epub 2011 Feb 8 doi: 10.1160/TH10-07-0503. PMID: 21301776
Platelet function and its clinical significance in the myelodysplastic syndromes.
Zeidman A, Sokolover N, Fradin Z, Cohen A, Redlich O, Mittelman M
Hematol J 2004;5(3):234-8. doi: 10.1038/sj.thj.6200364. PMID: 15167910

Clinical prediction guides

Correlation of Platelet Function with Postpartum Hemorrhage and Venous Thromboembolism in Patients with Gestational Hypertension Complicated with Diabetes.
Li N, Liu Y, Yun A, Song S
Comput Math Methods Med 2022;2022:2423333. Epub 2022 Jul 18 doi: 10.1155/2022/2423333. PMID: 35898483Free PMC Article
RASopathies and hemostatic abnormalities: key role of platelet dysfunction.
Di Candia F, Marchetti V, Cirillo F, Di Minno A, Rosano C, Pagano S, Siano MA, Falco M, Assunto A, Boccia G, Magliacane G, Pinna V, De Luca A, Tartaglia M, Di Minno G, Strisciuglio P, Melis D
Orphanet J Rare Dis 2021 Dec 2;16(1):499. doi: 10.1186/s13023-021-02122-7. PMID: 34857025Free PMC Article
Hematological manifestations and complications of Gaucher disease.
Linari S, Castaman G
Expert Rev Hematol 2016 Jan;9(1):51-8. Epub 2015 Nov 13 doi: 10.1586/17474086.2016.1112732. PMID: 26565753
From genetics to epigenetics in platelet research.
Freson K, Izzi B, Van Geet C
Thromb Res 2012 Mar;129(3):325-9. Epub 2011 Dec 20 doi: 10.1016/j.thromres.2011.11.050. PMID: 22192152
Impaired platelet function and peripartum bleeding in women with Gaucher disease.
Simchen MJ, Oz R, Shenkman B, Zimran A, Elstein D, Kenet G
Thromb Haemost 2011 Mar;105(3):509-14. Epub 2011 Feb 8 doi: 10.1160/TH10-07-0503. PMID: 21301776

Recent systematic reviews

Screening for Platelet Dysfunction and Use of Prophylactic Tranexamic Acid in Patients Undergoing Deep Brain Stimulation: A Retrospective Analysis of Incidence and Outcome of Intracranial Hemorrhage.
Helmers AK, Kubelt C, Birkenfeld F, Deuschl G, Falk D, Mehdorn HM, Witt K, Nowak-Göttl U, Synowitz M, Paschen S
Stereotact Funct Neurosurg 2020;98(3):176-181. Epub 2020 Mar 30 doi: 10.1159/000505714. PMID: 32224614

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