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FLT4 Gene Amplification

MedGen UID:
1379627
•Concept ID:
C4329961
•
Cell or Molecular Dysfunction
Synonyms: FMS Related Tyrosine Kinase 4 Gene Amplification; PCL Gene Amplification; Vascular Endothelial Growth Factor Receptor 3 Gene Amplification; VEGFR-3 Gene Amplification; VEGFR3 Amplification; VEGFR3 Gene Amplification; VGR3 Gene Amplification

Definition

A molecular genetic abnormality indicating the presence of multiple copies of the FLT4 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFLT4 Gene Amplification

Professional guidelines

PubMed

The utility of MYC and FLT4 in the diagnosis and treatment of postradiation atypical vascular lesion and angiosarcoma of the breast.
Cornejo KM, Deng A, Wu H, Cosar EF, Khan A, St Cyr M, Tomaszewicz K, Dresser K, O'Donnell P, Hutchinson L
Hum Pathol 2015 Jun;46(6):868-75. Epub 2015 Mar 10 doi: 10.1016/j.humpath.2015.02.014. PMID: 25864386

Recent clinical studies

Etiology

Consistent MYC and FLT4 gene amplification in radiation-induced angiosarcoma but not in other radiation-associated atypical vascular lesions.
Guo T, Zhang L, Chang NE, Singer S, Maki RG, Antonescu CR
Genes Chromosomes Cancer 2011 Jan;50(1):25-33. doi: 10.1002/gcc.20827. PMID: 20949568Free PMC Article

Diagnosis

The utility of MYC and FLT4 in the diagnosis and treatment of postradiation atypical vascular lesion and angiosarcoma of the breast.
Cornejo KM, Deng A, Wu H, Cosar EF, Khan A, St Cyr M, Tomaszewicz K, Dresser K, O'Donnell P, Hutchinson L
Hum Pathol 2015 Jun;46(6):868-75. Epub 2015 Mar 10 doi: 10.1016/j.humpath.2015.02.014. PMID: 25864386
Malignant vascular tumors--an update.
Antonescu C
Mod Pathol 2014 Jan;27 Suppl 1:S30-8. doi: 10.1038/modpathol.2013.176. PMID: 24384851

Therapy

Consistent MYC and FLT4 gene amplification in radiation-induced angiosarcoma but not in other radiation-associated atypical vascular lesions.
Guo T, Zhang L, Chang NE, Singer S, Maki RG, Antonescu CR
Genes Chromosomes Cancer 2011 Jan;50(1):25-33. doi: 10.1002/gcc.20827. PMID: 20949568Free PMC Article

Prognosis

Malignant vascular tumors--an update.
Antonescu C
Mod Pathol 2014 Jan;27 Suppl 1:S30-8. doi: 10.1038/modpathol.2013.176. PMID: 24384851

Clinical prediction guides

Malignant vascular tumors--an update.
Antonescu C
Mod Pathol 2014 Jan;27 Suppl 1:S30-8. doi: 10.1038/modpathol.2013.176. PMID: 24384851

Supplemental Content

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    Practice guidelines

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    • PMC Articles
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