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Reduced brain glutamate level by MRS

MedGen UID:
1380742
Concept ID:
C4477012
Finding
HPO: HP:0031161

Definition

An decrease in the level of glutamate (Glu) in the brain identified by magnetic resonance spectroscopy (MRS). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced brain glutamate level by MRS

Professional guidelines

PubMed

Pillinger T, Rogdaki M, McCutcheon RA, Hathway P, Egerton A, Howes OD
Psychopharmacology (Berl) 2019 Jul;236(7):1985-1997. Epub 2019 Feb 28 doi: 10.1007/s00213-019-5188-5. PMID: 30820633Free PMC Article
Szulc A, Wiedlocha M, Waszkiewicz N, Galińska-Skok B, Marcinowicz P, Gierus J, Mosiolek A
Psychiatry Res Neuroimaging 2018 Mar 30;273:1-8. Epub 2018 Jan 17 doi: 10.1016/j.pscychresns.2018.01.001. PMID: 29414126
Njau S, Joshi SH, Espinoza R, Leaver AM, Vasavada M, Marquina A, Woods RP, Narr KL
J Psychiatry Neurosci 2017 Jan;42(1):6-16. doi: 10.1503/jpn.150177. PMID: 27327561Free PMC Article

Recent clinical studies

Etiology

John NA, Solanky BS, De Angelis F, Parker RA, Weir CJ, Stutters J, Carrasco FP, Schneider T, Doshi A, Calvi A, Williams T, Plantone D, Monteverdi A, MacManus D, Marshall I, Barkhof F, Gandini Wheeler-Kingshott CAM, Chataway J; MS‐SMART Investigators
J Magn Reson Imaging 2024 Jun;59(6):2192-2201. Epub 2023 Oct 3 doi: 10.1002/jmri.29017. PMID: 37787109
Ritter C, Buchmann A, Müller ST, Volleberg M, Haynes M, Ghisleni C, Noeske R, Tuura R, Hasler G
JAMA Psychiatry 2022 Dec 1;79(12):1209-1216. doi: 10.1001/jamapsychiatry.2022.3384. PMID: 36260322Free PMC Article
Vakulin A, Green MA, D'Rozario AL, Stevens D, Openshaw H, Bartlett D, Wong K, McEvoy RD, Grunstein RR, Rae CD
J Sleep Res 2022 Apr;31(2):e13482. Epub 2021 Sep 15 doi: 10.1111/jsr.13482. PMID: 34528315
Kozhuharova P, Diaconescu AO, Allen P
Psychopharmacology (Berl) 2021 Sep;238(9):2459-2470. Epub 2021 Jun 19 doi: 10.1007/s00213-021-05867-y. PMID: 34146134Free PMC Article
Puts NA, Ryan M, Oeltzschner G, Horska A, Edden RAE, Mahone EM
Psychiatry Res Neuroimaging 2020 Jul 30;301:111082. Epub 2020 May 18 doi: 10.1016/j.pscychresns.2020.111082. PMID: 32438277

Diagnosis

Sheikh-Bahaei N, Chen M, Pappas I
Methods Mol Biol 2024;2785:115-142. doi: 10.1007/978-1-0716-3774-6_9. PMID: 38427192
Ritter C, Buchmann A, Müller ST, Volleberg M, Haynes M, Ghisleni C, Noeske R, Tuura R, Hasler G
JAMA Psychiatry 2022 Dec 1;79(12):1209-1216. doi: 10.1001/jamapsychiatry.2022.3384. PMID: 36260322Free PMC Article
Pierce S, Kadlaskar G, Edmondson DA, McNally Keehn R, Dydak U, Keehn B
J Neurodev Disord 2021 Jan 6;13(1):5. doi: 10.1186/s11689-020-09351-0. PMID: 33407072Free PMC Article
Zhang Y, Shen J
J Magn Reson 2020 May;314:106732. Epub 2020 Apr 13 doi: 10.1016/j.jmr.2020.106732. PMID: 32361510Free PMC Article
Rupsingh R, Borrie M, Smith M, Wells JL, Bartha R
Neurobiol Aging 2011 May;32(5):802-10. Epub 2009 Jun 6 doi: 10.1016/j.neurobiolaging.2009.05.002. PMID: 19501936

Therapy

John NA, Solanky BS, De Angelis F, Parker RA, Weir CJ, Stutters J, Carrasco FP, Schneider T, Doshi A, Calvi A, Williams T, Plantone D, Monteverdi A, MacManus D, Marshall I, Barkhof F, Gandini Wheeler-Kingshott CAM, Chataway J; MS‐SMART Investigators
J Magn Reson Imaging 2024 Jun;59(6):2192-2201. Epub 2023 Oct 3 doi: 10.1002/jmri.29017. PMID: 37787109
Fan L, Liang L, Wang Y, Ma X, Yuan L, Ouyang L, He Y, Li Z, Li C, Chen X, Palaniyappan L
Neuropsychopharmacology 2024 Apr;49(5):845-853. Epub 2023 Sep 26 doi: 10.1038/s41386-023-01741-x. PMID: 37752221Free PMC Article
Lengu K, Ryan S, Peltier SJ, Tyszkowski T, Kairys A, Giordani B, Hampstead BM
J Alzheimers Dis 2021;84(3):1091-1102. doi: 10.3233/JAD-201091. PMID: 34602464Free PMC Article
Schmitz B, Pflugrad H, Tryc AB, Lanfermann H, Jäckel E, Schrem H, Beneke J, Barg-Hock H, Klempnauer J, Weissenborn K, Ding XQ
Aliment Pharmacol Ther 2019 Jun;49(11):1431-1441. Epub 2019 Apr 21 doi: 10.1111/apt.15256. PMID: 31006881
Kaufman MJ, Janes AC, Hudson JI, Brennan BP, Kanayama G, Kerrigan AR, Jensen JE, Pope HG Jr
Drug Alcohol Depend 2015 Jul 1;152:47-56. Epub 2015 May 7 doi: 10.1016/j.drugalcdep.2015.04.023. PMID: 25986964Free PMC Article

Prognosis

Lea-Carnall CA, El-Deredy W, Stagg CJ, Williams SR, Trujillo-Barreto NJ
Neuroimage 2023 Feb 1;266:119813. Epub 2022 Dec 14 doi: 10.1016/j.neuroimage.2022.119813. PMID: 36528313Free PMC Article
Hervella P, Alonso-Alonso ML, Pérez-Mato M, Rodríguez-Yáñez M, Arias-Rivas S, López-Dequidt I, Pumar JM, Sobrino T, Campos F, Castillo J, Iglesias-Rey R
BMC Neurol 2022 Jun 9;22(1):215. doi: 10.1186/s12883-022-02740-z. PMID: 35681147Free PMC Article
Hjelmervik H, Craven AR, Johnsen E, Kompus K, Bless JJ, Sinkeviciute I, Kroken RA, Løberg EM, Ersland L, Grüner R, Sommer IE, Hugdahl K
Brain Behav 2022 Jan;12(1):e2446. Epub 2021 Dec 7 doi: 10.1002/brb3.2446. PMID: 34874613Free PMC Article
Ousdal OT, Milde AM, Craven AR, Ersland L, Endestad T, Melinder A, Huys QJ, Hugdahl K
Psychol Med 2019 Aug;49(11):1822-1830. Epub 2018 Sep 18 doi: 10.1017/S0033291718002519. PMID: 30223909Free PMC Article
Caravaggio F, Nakajima S, Plitman E, Gerretsen P, Chung JK, Iwata Y, Graff-Guerrero A
Prog Neuropsychopharmacol Biol Psychiatry 2016 Feb 4;65:49-53. Epub 2015 Sep 1 doi: 10.1016/j.pnpbp.2015.08.013. PMID: 26334687Free PMC Article

Clinical prediction guides

Li H, Rodríguez-Nieto G, Chalavi S, Seer C, Mikkelsen M, Edden RAE, Swinnen SP
Behav Brain Funct 2024 Aug 31;20(1):22. doi: 10.1186/s12993-024-00248-9. PMID: 39217354Free PMC Article
John NA, Solanky BS, De Angelis F, Parker RA, Weir CJ, Stutters J, Carrasco FP, Schneider T, Doshi A, Calvi A, Williams T, Plantone D, Monteverdi A, MacManus D, Marshall I, Barkhof F, Gandini Wheeler-Kingshott CAM, Chataway J; MS‐SMART Investigators
J Magn Reson Imaging 2024 Jun;59(6):2192-2201. Epub 2023 Oct 3 doi: 10.1002/jmri.29017. PMID: 37787109
Lea-Carnall CA, El-Deredy W, Stagg CJ, Williams SR, Trujillo-Barreto NJ
Neuroimage 2023 Feb 1;266:119813. Epub 2022 Dec 14 doi: 10.1016/j.neuroimage.2022.119813. PMID: 36528313Free PMC Article
Hjelmervik H, Craven AR, Johnsen E, Kompus K, Bless JJ, Sinkeviciute I, Kroken RA, Løberg EM, Ersland L, Grüner R, Sommer IE, Hugdahl K
Brain Behav 2022 Jan;12(1):e2446. Epub 2021 Dec 7 doi: 10.1002/brb3.2446. PMID: 34874613Free PMC Article
Caravaggio F, Nakajima S, Plitman E, Gerretsen P, Chung JK, Iwata Y, Graff-Guerrero A
Prog Neuropsychopharmacol Biol Psychiatry 2016 Feb 4;65:49-53. Epub 2015 Sep 1 doi: 10.1016/j.pnpbp.2015.08.013. PMID: 26334687Free PMC Article

Recent systematic reviews

Zahid U, Onwordi EC, Hedges EP, Wall MB, Modinos G, Murray RM, Egerton A
Neurosci Biobehav Rev 2023 Jan;144:105010. Epub 2022 Dec 19 doi: 10.1016/j.neubiorev.2022.105010. PMID: 36549375
Moriguchi S, Takamiya A, Noda Y, Horita N, Wada M, Tsugawa S, Plitman E, Sano Y, Tarumi R, ElSalhy M, Katayama N, Ogyu K, Miyazaki T, Kishimoto T, Graff-Guerrero A, Meyer JH, Blumberger DM, Daskalakis ZJ, Mimura M, Nakajima S
Mol Psychiatry 2019 Jul;24(7):952-964. Epub 2018 Oct 12 doi: 10.1038/s41380-018-0252-9. PMID: 30315224Free PMC Article
Szulc A, Wiedlocha M, Waszkiewicz N, Galińska-Skok B, Marcinowicz P, Gierus J, Mosiolek A
Psychiatry Res Neuroimaging 2018 Mar 30;273:1-8. Epub 2018 Jan 17 doi: 10.1016/j.pscychresns.2018.01.001. PMID: 29414126
Younis S, Hougaard A, Vestergaard MB, Larsson HBW, Ashina M
Curr Opin Neurol 2017 Jun;30(3):246-262. doi: 10.1097/WCO.0000000000000436. PMID: 28240609
Wang H, Tan L, Wang HF, Liu Y, Yin RH, Wang WY, Chang XL, Jiang T, Yu JT
J Alzheimers Dis 2015;46(4):1049-70. doi: 10.3233/JAD-143225. PMID: 26402632

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