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Impaired convulxin-induced platelet aggregation

MedGen UID:
1381508
•Concept ID:
C4476986
•
Cell or Molecular Dysfunction
HPO: HP:0031127

Definition

Abnormal response to convulxin as manifested by reduced or lacking aggregation of platelets upon addition of convulxin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImpaired convulxin-induced platelet aggregation

Recent clinical studies

Therapy

Nox2-mediated platelet activation by glycoprotein (GP) VI: Effect of rivaroxaban alone and in combination with aspirin.
Cammisotto V, Carnevale R, Nocella C, Stefanini L, Bartimoccia S, Coluccia A, Silvestri R, Pignatelli P, Pastori D, Violi F
Biochem Pharmacol 2019 May;163:111-118. Epub 2019 Feb 13 doi: 10.1016/j.bcp.2019.02.016. PMID: 30771281

Prognosis

D-Dimer and Fibrin Degradation Products Impair Platelet Signaling: Plasma D-Dimer Is a Predictor and Mediator of Platelet Dysfunction During Trauma.
Verni CC, Davila A, Sims CA, Diamond SL
J Appl Lab Med 2020 Nov 1;5(6):1253-1264. doi: 10.1093/jalm/jfaa047. PMID: 32674119Free PMC Article

Clinical prediction guides

D-Dimer and Fibrin Degradation Products Impair Platelet Signaling: Plasma D-Dimer Is a Predictor and Mediator of Platelet Dysfunction During Trauma.
Verni CC, Davila A, Sims CA, Diamond SL
J Appl Lab Med 2020 Nov 1;5(6):1253-1264. doi: 10.1093/jalm/jfaa047. PMID: 32674119Free PMC Article
Hypoxia impairs agonist-induced integrin α(IIb)β(3) activation and platelet aggregation.
Kiouptsi K, Gambaryan S, Walter E, Walter U, Jurk K, Reinhardt C
Sci Rep 2017 Aug 8;7(1):7621. doi: 10.1038/s41598-017-07988-x. PMID: 28790378Free PMC Article

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